Presentation
Affirming that in patients presenting as FWLS also cases of TBE are contained, this disease is underreported. [ncbi.nlm.nih.gov]
Entire Body System
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Fever
In these cases, fever can be the only leading manifestation. We report on four hospitalised children who had TBE and presented as fever without localising signs (FWLS) between 2000 and 2008 in an endemic area in Switzerland. [ncbi.nlm.nih.gov]
In approximately two-thirds of patients infected with the European TBE virus, only an early (viremic) phase is experienced; symptoms are nonspecific and may include fever, malaise, anorexia, muscle aches, headache, nausea, and/or vomiting. [cdc.gov]
It may manifest as meningoencephalitis or a mild illness with fever. [patient.info]
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Fatigue
In addition, the answers concerning tiredness/fatigue, poor concentration/attention, reduced initiative/motivation, balance disturbances, coordination problems, difficulties with short- and long-term memory, learning difficulties and problems with fine [ncbi.nlm.nih.gov]
Symptoms Fever, headache, fatigue, and malaise tend to occur and last for about five days. Following a short period of symptom-free time, more severe manifestations may develop including meningitis, encephalitis, myelitis, and cranial neuritis. [columbia-lyme.org]
Symptoms can last up to 8 days and include fever, headache, fatigue, muscle pain, nausea, and loss of appetite. [iamat.org]
TBE can for instance cause long-term memory issues, severe fatigue and loss of mobility. Symptoms The incubation period is usually 4 – 14 days, but can be up to a month. The first symptoms are typically fever, headache, muscle-ache and fatigue. [vaccination.org.uk]
Tick-borne encephalitis can affect the central nervous system and causes symptoms similar to Lyme disease: headache, fatigue and muscle pain. [stuttgartcitizen.com]
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Malaise
In approximately two-thirds of patients infected with the European TBE virus, only an early (viremic) phase is experienced; symptoms are nonspecific and may include fever, malaise, anorexia, muscle aches, headache, nausea, and/or vomiting. [cdc.gov]
Symptoms Fever, headache, fatigue, and malaise tend to occur and last for about five days. Following a short period of symptom-free time, more severe manifestations may develop including meningitis, encephalitis, myelitis, and cranial neuritis. [columbia-lyme.org]
The earliest symptom of Lyme disease is a rash that looks like a bull’s-eye at the site of the tick bite, and can progress to flu-like symptoms, including muscle soreness, headache, fever and malaise. [stuttgartcitizen.com]
Non specific symptoms of mild fever, malaise, headache, nausea, vomiting and myalgias may be present as first manifestation of the disease and spontaneously resolve within 1 week. After another week the patient may develop neurological symptoms. [en.wikipedia.org]
The incubation period of 7-14 days is followed by a phase in which a patient suffers from fever, fatigue, general malaise and headache. [rivm.nl]
Respiratoric
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Hyposmia
We present a case of hyposmia following administration of a tick-borne encephalitis (TBE) vaccine. The olfactory impairment did not recover during 1-year follow up. [ncbi.nlm.nih.gov]
Gastrointestinal
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Vomiting
For example: Meningitis: high fever, headache, nausea, vomiting, photophobia, vertigo. [patient.info]
Case report A 43-year-old man from the Black Forest area, Germany, who had not had TBE vaccination developed symptoms of gastroenteritis with fever (diarrhoea, nausea and vomiting) lasting for approximately 1 week. [dx.doi.org]
All infected patients had similar clinical and laboratory symptoms and signs, including fever, headache, generalized body aches, arthralgia, anorexia, vomiting, leucopenia, thrombocytopenia, elevated liver enzymes (serum glutamic oxalacetic and serum [ncbi.nlm.nih.gov]
In approximately two-thirds of patients infected with the European TBE virus, only an early (viremic) phase is experienced; symptoms are nonspecific and may include fever, malaise, anorexia, muscle aches, headache, nausea, and/or vomiting. [cdc.gov]
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Nausea
For example: Meningitis: high fever, headache, nausea, vomiting, photophobia, vertigo. [patient.info]
Case report A 43-year-old man from the Black Forest area, Germany, who had not had TBE vaccination developed symptoms of gastroenteritis with fever (diarrhoea, nausea and vomiting) lasting for approximately 1 week. [dx.doi.org]
In approximately two-thirds of patients infected with the European TBE virus, only an early (viremic) phase is experienced; symptoms are nonspecific and may include fever, malaise, anorexia, muscle aches, headache, nausea, and/or vomiting. [cdc.gov]
Sufferers may also complain of nausea, muscle pain, lethargy and general discomfort. Some patients may go on to develop encephalitis, which can cause paralysis and can be fatal in some cases. [heathrowmedical.com]
Musculoskeletal
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Arthralgia
All infected patients had similar clinical and laboratory symptoms and signs, including fever, headache, generalized body aches, arthralgia, anorexia, vomiting, leucopenia, thrombocytopenia, elevated liver enzymes (serum glutamic oxalacetic and serum [ncbi.nlm.nih.gov]
Neurologic
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Headache
In approximately two-thirds of patients infected with the European TBE virus, only an early (viremic) phase is experienced; symptoms are nonspecific and may include fever, malaise, anorexia, muscle aches, headache, nausea, and/or vomiting. [cdc.gov]
Foremost, FWLS characterised by a biphasic fever course and accompanied by headache in patients in a reduced general condition. Affirming that in patients presenting as FWLS also cases of TBE are contained, this disease is underreported. [ncbi.nlm.nih.gov]
Many people experience prolonged convalescence with headache, concentration difficulties and sleep disorders. [fhi.no]
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Confusion
drowsiness, confusion, sensory disturbances, and/or motor abnormalities such as paralysis), or meningoencephalitis. [cdc.gov]
TBE should not be confused with Lyme disease (Lyme borreliosis), which is also transmitted by tick bites. Vaccination People who spend a lot of time in areas with a known risk of TBE infection should consider vaccination against TBE. [fhi.no]
In certain individuals the infection can spread to the brain leading to seizures, confusion and paralysis. [ealingtravelclinic.co.uk]
Tick-borne encephalitis is a rare infection that can cause fever, headache, vomiting, weakness, confusion, seizures, and memory loss. Long-term neurologic problems may occur. [hpepublichealth.ca]
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Neck Stiffness
The disease typically begins as a flu-like illness, including fever, headache, and vomiting, followed by the development of neurologic symptoms, including neck stiffness, dizziness, tremors, drowsiness, delirium, and coma. [redplanet.travel]
A third of patients go on to phase 2 with higher and more prolonged fever than phase 1, with new symptoms and signs of central and / or peripheral neuronal involvement such as headaches, insomnia, confusion, or vomiting, neck stiffness, muscle pain and [fhi.no]
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Cognitive Impairment
impairment Subject categories Neurology, Infectious Medicine Abstract Tick-borne encephalitis (TBE), caused by the TBE virus (TBEV), is a major neurotropic infection throughout Europe and Asia, with a considerable risk of neurological sequelae. [gu.se]
Workup
X-Ray
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Pericardial Effusion
Cardiac involvement was demonstrated by pericardial effusion, elevated serum concentration of troponin-I and cardiac arrhythmia. Co-infections with enteroviruses, Borrelia burgdorferi or the agent of human granulocytic ehrlichiosis were excluded. [ncbi.nlm.nih.gov]
Microbiology
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Treponema Pallidum
Moreover, there was no evidence of further possible aetiologies, such as infection by Treponema pallidum, herpes simplex virus 1 and 2, varicella zoster virus, enterovirus, HIV, Epstein–Barr virus or cytomegalovirus, or evidence of a vasculitis or collagenosis [ncbi.nlm.nih.gov]
Treatment
No specific antiviral treatment is currently available for TBE; indeed, supportive treatment as well as intensive care and assisted ventilation in severe forms may be needed. [ncbi.nlm.nih.gov]
The medicines will usually be tested against another treatment called a control. This will either be a dummy treatment (a placebo) or a standard treatment already in use. [nhs.uk]
Prognosis
The long-term prognosis is unfavorable in about 40% to 50% of patients who sustain sequelae for months to years, mainly in terms of pareses, ataxia, and other gait disturbances. No specific treatment for TBE is known. [ncbi.nlm.nih.gov]
The severity of clinical symptoms at the first presentation correlated well with long-term prognosis. Patients with only “mild” symptoms at the onset mostly had a good prognosis and vice versa. [omicsonline.org]
Etiology
A systematic study was carried out in cooperation between the Department of Neurology of the University of Florence and the Istituto Superiore di Sanità (Rome), in order to understand a possible role of arboviruses as etiologic agents of meningoencephalitis [ncbi.nlm.nih.gov]
Günther G, Haglund M, Lindquist L, Forsgren M, Sköldenberg B (1997) Tick-bone encephalitis in Sweden in relation to aseptic meningo-encephalitis of other etiology: a prospective study of clinical course and outcome. J Neurol 244: 230-238. [omicsonline.org]
Epidemiology
The conference agenda was divided into six sessions: 'National Implementation of EU notifiable disease status', 'Virology', 'Epidemiology and Risk areas & Poster Walk Epidemiological Update', 'Clinic', 'Environmental Factors' and 'New Findings and Diagnosis [ncbi.nlm.nih.gov]
Pathophysiology
BACKGROUND: Magnetic resonance imaging (MRI) changes in tick-borne encephalitis (TBE) are non-specific and the pathophysiological mechanisms leading to their formation remain unclear. [ncbi.nlm.nih.gov]
Prevention
Enhanced surveillance and intervention for human TBE in the high-risk regions, particularly on the forest areas in north-eastern China, is necessary to prevent human infections. Copyright 2017 The Authors. Published by Elsevier GmbH.. [ncbi.nlm.nih.gov]
Prevention includes non-specific (tick-bite prevention, tick checks) and specific prophylaxis in the form of a vaccination. Tick-borne encephalitis vaccines are very effective and available in many disease endemic areas and in travel clinics. [en.wikipedia.org]