Images
Presentation
He presented with fever and headache, developed severe meningoencephalitis in 3 days, and, after 1 month, died without regaining consciousness. High titers of IgG and IgM antibodies to TBE virus were present in both serum and CSF. [ncbi.nlm.nih.gov]
In the present report, the first isolation and partial genetic analysis of a Lithuanian TBE virus (TBEV) strain isolated from a patient's serum sample is described. [doi.org]
Entire Body System
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Sepsis
[…] a Immediate cause of death Cerebrospinal fluid Brain tissue CSF Serum Other tissues b Protein, mg/dL Cell count, per mm 3 Glucose, mg/dL Donor 44 / M NA NA NA Pos NA NA NA Mechanical brain injury NA NA NA Patient 1 54 / M liver 17 86 Pos Neg Neg Neg Sepsis [academic.oup.com]
Neurologic
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Aphasia
Clinical signs of encephalitis included fever 39 C, headache, meningeal signs, nystagmus, disarthria, aphasia, paralysis of cranial nerves II and IV and positive Babinski sign. [notifylibrary.org]
At admission, the patient presented with meningeal signs: nystagmus, dysarthia and aphasia, paralysis of cranial nerves III and IV, and bilaterally positive Babinski sign. [academic.oup.com]
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Babinski Sign
Clinical signs of encephalitis included fever 39 C, headache, meningeal signs, nystagmus, disarthria, aphasia, paralysis of cranial nerves II and IV and positive Babinski sign. [notifylibrary.org]
At admission, the patient presented with meningeal signs: nystagmus, dysarthia and aphasia, paralysis of cranial nerves III and IV, and bilaterally positive Babinski sign. [academic.oup.com]
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Nystagmus
Clinical signs of encephalitis included fever 39 C, headache, meningeal signs, nystagmus, disarthria, aphasia, paralysis of cranial nerves II and IV and positive Babinski sign. [notifylibrary.org]
At admission, the patient presented with meningeal signs: nystagmus, dysarthia and aphasia, paralysis of cranial nerves III and IV, and bilaterally positive Babinski sign. [academic.oup.com]
Workup
Specific sections for specimen collection and storage, nucleic acid testing, and serological assays cover various aspects of dynamics, performance characteristics, and utility in the diagnostic workup of suspected cases. [ncbi.nlm.nih.gov]
Microbiology
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Toxoplasma Gondii
The results of routine obligatory screening tests for infection with cytomegalovirus (CMV), Toxoplasma gondii, human immunodeficiency virus (HIV), hepatitic C virus (HCV), and hepatitis B virus (HBV) were all negative. [academic.oup.com]
HLA Type
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HLA-A2
An immunodominant HLA-A2-restricted TBEV epitope was identified and utilized to study the characteristics and temporal dynamics of the antigen-specific response. [ncbi.nlm.nih.gov]
Treatment
RESULTS: The FC level in patients 1-8 before treatment (24.1 8.1) was significantly lower than in patients post-treatment (34.4 8.3), lower than in the control group (40.5 7.6), and lower than in patients 9-14 before treatment (40.0 13.5) but not lower [ncbi.nlm.nih.gov]
No specific treatment for the disease is available to date, but it can be prevented by active immunization. [edoc.rki.de]
Prognosis
Prognosis Prognosis depends on age of the patient, but recovery is generally difficult. Mortality rates for European, far-eastern and Siberian subtypes are 1-2%, 20-40% and 2-3%, respectively. [animalabs.com]
Tick-borne encephalitis: clinical findings and prognosis in adults. Wien Med Wochenschr 2012 ; 162 : 239 – 43. 8.. [academic.oup.com]
Tickborne encephalitis in an area of high endemicity in lithuania: disease severity and long-term prognosis. Clin Infect Dis. 2002; 35 :650–658. [ PubMed ] [ Google Scholar ] 25. Arnez M, Avsic-Zupanc T. [ncbi.nlm.nih.gov]
Etiology
Abstract Tick-borne encephalitis virus is the etiological agent of a severe human disease transmitted by hard ticks. It occurs in large parts of eastern, central, and western Asia and in Europe with thousands of human cases each year. [ncbi.nlm.nih.gov]
Tick-borne encephalitis virus (TBEV) is an etiological agent of TBE. [doi.org]
Epidemiology
Author information 1 Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China. 2 Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China. qincf@bmi.ac.cn. [ncbi.nlm.nih.gov]
Pathophysiology
Author information 1 Celica Biomedical Center, Ljubljana, Slovenia ; Laboratory of Neuroendocrinology - Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. 2 Institute of Microbiology [ncbi.nlm.nih.gov]
Prevention
No specific treatment for the disease is available to date, but it can be prevented by active immunization. [edoc.rki.de]
No effective treatment for TBEV infection exists and the primary preventive measure is vaccination. [ncbi.nlm.nih.gov]