Adverse drug interactions, including topical medications, are relevant in the differential diagnosis of many presenting complaints. [ncbi.nlm.nih.gov]

• Spontaneous Hemorrhage

  All lesions decreased in friability and frequency of spontaneous hemorrhage. Le- sions remained stable in size throughout treatment duration, with no growth observed in any lesion. [ncbi.nlm.nih.gov]

• Pleural Effusion

  The patient developed fever, malaise, pleurisy and recurrent sterile pleural effusions while taking no medication other than timolol. [ncbi.nlm.nih.gov]

• Nausea

  On the part of the gastrointestinal tract: nausea, vomiting, diarrhea. Allergic reaction: hives, eczema. Rhinitis, nasal bleeding, chest pain, decreased potency, alopecia. [sentisspharma.com]

  Digestive Nausea, diarrhea, dyspepsia, anorexia, and dry mouth. Immunologic Systemic lupus erythematosus. [rxlist.com]

  Minor side effects of timolol include: abdominal cramps, diarrhea, constipation, fatigue, insomnia, nausea, and vomiting. [medicinenet.com]

• Eczema

  Allergic reaction: hives, eczema. Rhinitis, nasal bleeding, chest pain, decreased potency, alopecia. In the case of side effects, discontinue use of the drug as soon as possible contact your doctor. [sentisspharma.com]

  Within skin, receptors are present on keratinocytes, fibroblasts, and melanocytes, and they may have a role in the pathophysiology of dermatologic conditions, including atopic eczema, psoriasis, and vitiligo. 5 In acute partial-thickness donor site wounds [jamanetwork.com]

  […] lung disease) diabetes or other blood sugar problems thyroid disease 3. you are already using another beta-blocker eye drop It is not recommended to use two beta-blocker eye drops at the same time. 4. you have a history of allergic problems, including eczema [news-medical.net]

• Alopecia

  Rhinitis, nasal bleeding, chest pain, decreased potency, alopecia. In the case of side effects, discontinue use of the drug as soon as possible contact your doctor. [sentisspharma.com]

  Skin Alopecia and psoriasiform rash or exacerbation of psoriasis. Hypersensitivity Signs and symptoms of systemic allergic reactions, including anaphylaxis, angioedema, urticaria, and localized and generalized rash. [rxlist.com]

• Skin Lesion

  Persistent ulcerated skin lesions were successfully treated with topical timolol, although a flare of the underlying bowel disease temporarily interrupted the improvement. [ncbi.nlm.nih.gov]

• Angiomatosis

  Topical timolol remains a promising therapeutic option in the treat- ment of GVHD-associated angiomatosis. [ncbi.nlm.nih.gov]

• Arthralgia

  […] arterial thrombosis, ischemic colitis ; Hematologic: Nonthrombocytopenic purpura ; thrombocytopenic purpura, agranulocytosis ; Endocrine: Hyperglycemia, hypoglycemia; Skin: Pruritus, skin irritation, increased pigmentation, sweating; Musculoskeletal: Arthralgia [rxlist.com]

  Retroperitoneal fibrosis · Micturition difficulties · Impotence · Peyronie’s disease · Decreased libido Hematologic Unreported frequency : · Agranulocytosis · Thrombocytopenic purpura · Non-thrombocytopenic purpura Musculoskeletal Unreported frequency : · Arthralgia [whatisdryeye.com]

• Loss of Initiative

  BACKGROUD: Postlaser in situ keratomileusis (post-LASIK) refractive regression is defined as the gradual, partial, or total loss of initial correction that limits the predictability, efficiency, and long-term stability of LASIK. [ncbi.nlm.nih.gov]

The patient was asked to return in a few days for a more in-depth examination/workup of her eyes which included: additional cranial nerve testing (V1, V2, V3, and VII), formal threshold Humphrey SITA threshold 24-2 visual field testing, ocular coherence [journalofoptometry.org]

• Pleural Effusion

  The patient developed fever, malaise, pleurisy and recurrent sterile pleural effusions while taking no medication other than timolol. [ncbi.nlm.nih.gov]

The maximal treatment duration was planned for 8 months. [ncbi.nlm.nih.gov]

Few published studies have investigated the long-term efficacy and prognosis comparing FCLT to FCDT. Thus, one may focus on these outcomes to better address mechanical differences underlining FCLT and FCDT. [journals.plos.org]

[…] the viewpoint that invasive craniotomy surgical procedures should be justified only by the presence of intractable and absolutely unbearable symptoms. 21,23 In the end, the decision for surgery regarding SOM of any kind should be based on the known etiology [journalofoptometry.org]

Description of the condition Glaucoma is part of a heterogeneous group of conditions with multiple etiologies (causes). [doi.org]

BACKGROUND Description of the condition Glaucoma is part of a heterogeneous group of conditions with multiple etiologies (causes). [ncbi.nlm.nih.gov]

Clinical support In an epidemiologic survey, patients who were switched to a preservative-free timolol experienced fewer ocular symptoms, such as pain and discomfort upon instillation. 2 INDICATIONS AND USAGE Preservative-free TIMOPTIC in OCUDOSE is indicated [bausch.com]

Synthesizes a classical approach to the glaucomas-based on seven earlier editions spanning over 40 years-with the most up-to-date evidence-based and epidemiologically-derived classifications and outcomes.Coherently correlates with authoritative consensus [books.google.ro]

Classic Kaposi’s sarcoma in morocco: Clinico – epidemiological study at the national institute of oncology. BMC Dermatol 2011; 11:15. doi: 10.1186/1471-5945-11-15 9. Wu X-J, Kang X-J, An C-X, et al. [dergipark.org.tr]

Part 2, short-term reductions in blood pressure: an overview of randomized drug trials in their epidemiological context. Lancet. 1990; 335:827-38. [IDIS 264836] [PubMed 1969567] 135. Alderman MH. Which antihypertensive drugs first—and why! [web.archive.org]

Ophthalmic Epidemiology. 2012; 19 (2):74–82. doi: 10.3109/09286586.2011.638743. [ PubMed ] [ CrossRef ] [ Google Scholar ] 42. Pringle S. D., MacEwen C. J. Severe bradycardia due to interaction of timolol eye drops and verapamil. [ncbi.nlm.nih.gov]

Within skin, receptors are present on keratinocytes, fibroblasts, and melanocytes, and they may have a role in the pathophysiology of dermatologic conditions, including atopic eczema, psoriasis, and vitiligo. 5 In acute partial-thickness donor site wounds [jamanetwork.com]

Since the loss of RGCs is the terminal process in the pathophysiology of glaucoma, neuroprotection may be helpful in preserving visual function ( Chader 2012 ) however, there is still no consensus on what precisely causes glaucomatous optic neuropathy [doi.org]

Additionally, it has been mentioned that some β-blockers nicely prevented the development of heart failure in both experimental and clinical studies by restoring sarcoplasmic reticulum (SR) Ca(2 ) release channels, RyR2. [ncbi.nlm.nih.gov]

and a low ASCVD risk (10-year risk 1200 For secondary prevention in adults with known cardiovascular disease or for primary prevention in those at higher risk for ASCVD (10-year risk 10%), ACC/AHA recommend initiation of antihypertensive drug therapy [drugs.com]

[…] angina pectoris, glaucoma, migraine headaches and anxiety. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. anti-arrhythmia drug A drug used for the treatment or prevention [ebi.ac.uk]