The infection can present itself in a variety of ways. It usually begins as a pruritic, circular or oval, erythematous and scaly plaque which starts enlarging rapidly. After a while, the rash gets the appearance of a ring with raised red edges, and a clearing in the center of the affected area. The classical inflammatory elements, like scales, crusts or vesicles, on the raised edges can be observed, especially on the advancing border [12]. Other classical features include hair loss in the infected spots, with dry and flaky stretches of skin surround them.

• Lymphadenopathy

  Figure 137-5 Lymphadenopathy visible in the neck of this young boy with tinea capitis. The fungal infection shows more scaling and crusting than actual hair loss. The lymphadenopathy is a reaction to the tinea and not a bacterial superinfection. [accessmedicine.mhmedical.com]

  The child with tinea capitis will generally have cervical and suboccipital lymphadenopathy, and the physician may need to broaden the differential diagnosis if lymphadenopathy is absent. 7 However, lymphadenopathy can also occur in nonfungal scalp disease [aafp.org]

  Lymphadenopathy, high IgE antibody levels, and eosinophilia are common. The disorder may be fatal. [visualdx.com]

  Cervical lymphadenopathy is often seen in patients with kerion. [ncbi.nlm.nih.gov]

• Eczema

  (discoid eczema, nummular dermatitis) Bacterial folliculitis The diagnosis should be confirmed by KOH preparation and culture Table 6–2.Useful topical dermatologic therapeutic agents. [accessmedicine.mhmedical.com]

  (see photos) Skin conditions which may be confused as tinea corporis include: a) Psoriasis b) Discoid eczema c) Urticaria d) Bowen’s disease e) Leprosy Treatment Tinea corporis can be cured with antifungal medications. [myhealth.gov.my]

  A, B: Tinea is one of several conditions (granuloma annulare, nummular eczema) that produces circular lesions. [5minuteconsult.com]

  Eczema – Nummular, allergic contact and other eczematous reactions can mimic dermatophytoses, particularly when the lesions are impetiginised and superinfected with bacteria. [dermnetnz.org]

  There are no specific tests that can be performed to test for EAC; tests should be performed to rule out other possible diseases such as: pityriasis rosea, tinea corporis, psoriasis, nummular eczema, atopic dermatitis, drug reaction, erythema migrans [diki.pl]

• Eruptions

  See: illustration tin·e·a cor·po·ris ( tin'ē-ă kōr-pōr'is ) A well-defined, scaling, macular eruption of dermatophytosis that frequently forms anular lesions and may appear on any part of the body. [medical-dictionary.thefreedictionary.com]

  She also noted that the eruption seemed to worsen following exposure to sunlight. She had no prior history of collagen vascular disease and was generally in good health. [escholarship.org]

  The submitted clinical differential diagnoses varied widely, but included some of the diseases 'classically' associated with PPDE, as well as other blistering eruptions. [ncbi.nlm.nih.gov]

• Skin Rash

  Body Ringworm Rash Tinea corporis presents as an itchy skin rash. The typical rash is a pink to red slightly raised and scaly rash. [healthhype.com]

  Definition: Tinea Corporis or ringworm or pityriasis corporis is a fungal infection of the skin characterized by an itchy ring shaped skin rashes. Its other names are tinea circinata and tinea glabrosa. [askdrshah.com]

• Nummular Dermatitis

  Diagnosis and Prevention For diagnosis, laboratory testing called KOH Test for confirmation is necessary as tinea corporis closely resembles impetigo and nummular dermatitis. [creative-biolabs.com]

  Codes ICD10CM: B35.4 – Tinea corporis SNOMEDCT: 84849002 – Tinea corporis Look For Subscription Required Diagnostic Pearls Subscription Required Differential Diagnosis & Pitfalls Nummular dermatitis (round, scaly plaques) Granuloma annulare (ring-like [visualdx.com]

  Secondary syphilis Pityriasis rosea Nummular eczema (discoid eczema, nummular dermatitis) Bacterial folliculitis The diagnosis should be confirmed by KOH preparation and culture Table 6–2.Useful topical dermatologic therapeutic agents. [accessmedicine.mhmedical.com]

• Scalp Rash

  Symptoms of scalp ringworm may include: Red, scaly rash on the scalp Itching of the scalp Hair loss on the scalp Rash elsewhere on the body Ringworm of the scalp can also develop into a kerion, a large, tender lesion over the area of the initial ringworm [childrensnational.org]

  Symptoms may include: Red, scaly rash on the scalp Itchy scalp Hair loss on the scalp Rash elsewhere on the body Bad cases of ringworm of the scalp can also develop into a kerion. A kerion is a thick, pus-filled area on the scalp. [stanfordchildrens.org]

There are 4 main methodologies to diagnose tinea corporis. The first one is the microscopic examination of superficial samples taken from the skin after scraping. Although simple, this method might take several days to complete, because of the slow fungal growth rate, and the case negative results is not sufficient to rule out the presence of infections. Therefore, this method must usually be integrated with more specific ones.

The second diagnostic methodology for the tinea corporis diagnosis is the potassium hydroxide examination (KOH). Potassium hydroxide dissolves the keratin of the epidermal tissue, leaving intact the fungal elements such as the branching hyphane, which is deeply embedded among the epithelial cells. The samples for this clinical procedure must be taken on the borders of the tinea ring, where the fungal yield is highest. The method is effective at detecting fungal elements but not very specific.

Fungal culture, instead, is very specific as procedure, and can be used in addition to potassium hydroxide examination to identify the fungal species responsible for the infection. The culture can grow on several substrata. Sabouraud agar contains neopeptone, polypeptone and glucose but no antibiotics, which means it can easily allow fungal overgrowth. Mycosel, instead, is very similar to sabouraud agar, but contains antibiotics too and can prevent complications due to overgrowth and infections by other microorganisms. Dermatophyte test medium (DTM) is ideal for dermatophyte, because apart from nutrient agar it also contains antibacterial and antifungal agents which prevent other microorganisms from growing, thus allowing a great level of specificity. Whatever is the substratum chosen, the growth must be monitored for at least 2 weeks.

If the above mentioned methodologies are inconclusive to identify the presence of dermatophytes, PCR (polymerase chain reaction) can be employed to amplify the fungal DNA and identify the species of fungus concerned by studying its nucleic acid sequence [13].

• Treponema Pallidum

  pallidum hemagglutination assay (TPHA) was negative for syphilis. [joii-journal.springeropen.com]

• Toxoplasma Gondii

  Various cases of retinochoroiditis have been reported secondary to infective etiology such as Toxoplasma gondii, Candida albicans, Trichosporon beigelii, and Sporotrichum schenkii. [joii-journal.springeropen.com]

• Lymphocytic Infiltrate

  Results of a skin biopsy during therapy with oral antifungal medications showed evidence of tinea corporis; atrophy of the epidermis; a superficial, perivascular, and interstitial lymphocytic infiltrate with numerous atypical lymphocytes; and exocytosis [ncbi.nlm.nih.gov]

  Further fungal infections may mimic many inflammatory skin diseases such as lupus erythematosus (LE), polymorphic light eruption (PLE), psoriasis, nummular eczema, erythema multiformis, granoloma annularis, lymphocytic infiltration of the skin, pytiriasis [e-ijd.org]

• Tinea corporis responds well to daily application of topical antifungals. These include clotrimazole (twice daily), econazole, ketoconazole, miconazole and luicoazole. Nystatin is only effective against candida infections and ineffective against dermatophyte infections. 
• Oral medication may have to be used in extensive infections like antifungals such as fluconazole or itraconazole.
• Topical steroids may exacerbate tinea corporis and should be avoided. Combination topical creams containing steroids should be avoided as they can mask the inflammatory response and not treat the fungal infection leading to a condition known as tinea incognito. Combination products are also more expensive [7] [8] [9]. 

Tinea corporis appears moderately contagious and very uncomfortable. As children are frequently affected by this infection, they should be educated on preventive measures , such as avoiding tight clothes and not sharing personal items. If there are pets in the house, they should be checked for the presence of tinea, especially when on the body of the animals signs of tinea infection can be seen, such as hair loss in patches and excessive scratching [10].

In any case, the prognosis of tinea corporis is excellent, with the 70 to 100% of the affected individuals which recover easily after treatment with antifungal medications, provided that the immune system is intact [11].

As previously said, the fungi responsible for tinea corporis are called dermatophytes, from the word “dermatos”, which means “skin”, and “phyte” , which means “plant”. In other words, fungi that normally live on the skin [3], where they get nutrients from keratinized materials [4]. They form a group of around 40 anamorphic species, which produce spores in asexual reproductive cycles. They normally occur in pets, and this is why they are frequently transmitted through animal-to-human transmission. Frequent is also the transmission by person-to-person contact [5] or from personal items recently touched by affected individuals. The persons who are commonly affected by this infection are children and athletes.

The risk of getting tinea corporis is increased in various situations, like being in crowded and humid conditions, wearing tight clothes or playing sports which require a great deal of physical contact. Tine corporis also occurs with a high frequency rate when the immune system is particularly weak for previous conditions or distressful events, or after excessive sweating, since sweat creates an ideal environment for fungi proliferation in the folds and grooves of the skin.

Tinea corporis is particularly common in hot and humid climates, with the ideal climatic conditions for fungi proliferation. Among the agents causing this infection, some of them appear to be more frequent than others. For example, Trichophyton rubrum is responsible for 47% of tinea corporis cases worldwide [6] [7], whereas Microspores canis for the 14%. According to a 5-year study conducted in Kuwait, the group of most commonly occurring agents also includes Trichophyton mentagrophytes (39%), Epidermophyton floccosum (6.2%), Trichophyton violaceum (2.4%), and Trichophyton verrucosum (0.4%) [8].

No significant mortality or morbidity has ever been found for tinea corporis, although it’s well known to greatly affect the quality of life. The infection appears to affect females and males in equal measure, even though its frequency increases in women of childbearing age who are often in contact with affected children. Furthermore, tinea corporis interests all age groups, but its prevalence reaches the highest levels in preadolescences and adolescences, who frequently touch animals and objects infected.

Dermatophytes tend to invade the cornified layers of the skin, nail and hair, where they find the perfect conditions for proliferation. After spreading on the superficial layers, dermatophytes then begin to invade the deeper layers through the action of keratinases, proteolytic enzymes which break the disulfide bonds in keratin-containing substrata. In any case, the invasion remains limited to epidermis, because the fungi are blocked and neutralized by the defense mechanisms found in deeper strata, like serum inhibitor factors or polymorphonuclear leukocytes.

The period of incubation usually lasts between 1 to 3 weeks, after which the infection begins to spread following a centrifugal pattern of invasion. The host body fights the invasion through cell-mediated immunity, but certain organisms turn out to be hard to destroy. Particularly famous is the case of Trichophyton rubrum, exceptionally resistant to eradication due to its cell wall which contains mannan, a polymer of mannose that is particularly effective at inhibiting cell-mediated immunity, hindering keratinocytes proliferation and enhancing resistance against skin’s defense systems [9].

The fungi responsible for tinea corporis prefer warm and moist environments, as these are ideal for fungal development and growth. Thus, avoiding warm and moist conditions is paramount in tinea corporis prevention. This means first of all keeping the skin dry and avoiding tight clothing, which foster sweating in the folds and grooves of the skin, where the perfect conditions for fungi growth might occur. Other major preventive measures include frequently washing hands, avoiding sports which require a great deal of physical contact, and averting the handling of infectious objects and the sharing of personal items.

Tinea corporis is a superficial dermatophyte infection which presents itself with inflammatory or noninflammatory lesions. The organisms responsible for its occurrence belong to the genera of trichophyton, microsporum, and epidermophyton, collectively known as dermatophytes, which according to their favorite host or source can be defined as anthropophilic, if they mostly infect humans, zoophile, if they mostly infect animals, and geophile, if they tend to be found in soil. Tinea corporis is also known with various other names, like ringworm [1], tinea circinata [2] or tinea glabrosa [1].

Tinea corporis is a fungal infection that affects the skin, with an appearance which is especially frequent on arms and legs. The organisms responsible for the occurrence of this infection belong to the genera of trichophyton, microsporum, and epidermophyton, collectively called as dermatophytes, which might infect both animals and humans.

Tinea corporis is particular frequent in hot and humid climates, with the ideal climatological conditions for fungi proliferation. The condition begins as a small, red, itchy area of skin which slowly becomes ring-shaped, with a raised, sometimes scaly edge and a clearer center. 

The classical treatment for tinea corporis includes the use of topical antifungals in the milder cases and oral medications in the more severe cases. The main measures for preventing tinea corporis are: keeping the skin dry, not wearing tight clothing, frequently washing hands, avoiding sports which require a great deal of physical contact, and averting the handling of infectious objects and the sharing of personal items.

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