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Tinzaparin


Presentation

  • Abstract Low molecular weight heparin (LMWH) has been widely used for the initial treatment of patients presenting with venous thromboembolism.[ncbi.nlm.nih.gov]
Prolonged Bleeding
  • No hemorrhagic complications occurred during her hospitalization except for prolonged bleeding from venipuncture sites.[ncbi.nlm.nih.gov]

Workup

Dyslipidemia
  • […] anticoagulation for hemodialysis (HD) than unfractionated heparin (UFH) with a single bolus dose at the start of hemodialysis effectively prevents clot formation in the dialyzer and bubble trap with fewer side- effects and possible benefits on uremic dyslipidemia[ncbi.nlm.nih.gov]
  • […] anticoagulation for hemodialysis (HD) than unfractionated heparin (UFH) with a single bolus dose at the start of hemodialysis effectively prevents clot formation in the dialyzer and bubble trap with fewer side-effects and possible benefits on uremic dyslipidemia[sjkdt.org]
  • […] impaired renal function. 5–7 For chronic hemodialysis anticoagulation, tinzaparin was associated with less bleeding versus UFH. 1,2 Compared with UFH, LMWHs may cause fewer adverse reactions in the long term, such as less osteoporosis, hyperkalemia, and dyslipidemia[journals.lww.com]
ST Elevation
  • No invasive procedures were canceled due to study drug accumulation. 4 patients experienced serious adverse events (1 major bleed after traumatic arteriovenous fistula puncture in the tinzaparin arm, 2 non-ST-elevation myocardial infarctions [1 in each[ncbi.nlm.nih.gov]
  • O'Gara PT, Kushner FG, Ascheim DD, Casey DE, Chung MK, de Lemos JA (January 2013). “2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association[ja.wikipedia.org]

Treatment

  • Tinzaparin is more cost effective than UFH in the treatment of established thromboembolic disease, and home-based treatment with tinzaparin may offer greater cost benefits than hospital-based therapy.[ncbi.nlm.nih.gov]

Prognosis

  • Whereas, angiogenesis may be the most crucial determinant of the prognosis of cardiovascular diseases, and except some special situation, antiangiogenic effect is not desirable in the most of the cardiovascular disease.[ncbi.nlm.nih.gov]
  • Prognosis of cancers associated with venous thromboembolism. N Engl J Med . 2000;343(25):1846-1850. PubMed Google Scholar Crossref 4. Kearon C, Akl EA, Comerota AJ, et al.[jamanetwork.com]

Etiology

  • The etiology for the SCI and the presence of an inferior vena cava filter were not associated with VTE.[ncbi.nlm.nih.gov]
  • […] administration & Female; Health Care Costs /statistics & Heparin /administration & Heparin, Low-Molecular-Weight /administration & Humans; Male; Middle Aged; Renal Dialysis /adverse effects /economics; Treatment Outcome; Venous Thrombosis /economics /etiology[crd.york.ac.uk]
  • The role of etiology and location of the SVT to the regime, dose and duration of treatment.[vascularnews.com]

Epidemiology

  • Author information 1 1 Public Health and Clinical Epidemiology Service, Instituto de Investigación Biomédica Sant Pau, CIBERESP, Barcelona, Spain. 2 2 Division of Infection, Immunity and Respiratory Medicine, University Hospital of South Manchester NHS[ncbi.nlm.nih.gov]
  • Epidemiological Studies: a practical guide. Cambridge University Press 2002 Neely JL, Carlson SS, Lenhart SE. Tinzaparin sodium: a low-molecular-weight-heparin.[bmj.com]
  • Venous thromboembolism (VTE) in patients with cancer: epidemiology and risk factors . Cancer Invest. 2009 ;27(suppl 1): 63 – 74 . Google Scholar Crossref Medline ISI 5. Louzada, ML, Majeed, H, Dao, V, Wells, PS.[journals.sagepub.com]
Sex distribution
Age distribution

Pathophysiology

  • As such, consideration should be given to determine the underlying pathophysiology and incidence of LMWH-induced priapism. Herein, we present the case of a 33-year-old male with priapism in the setting of tinzaparin treatment.[ncbi.nlm.nih.gov]

Prevention

  • CONCLUSIONS: Tinzaparin is safe and effective for prevention and treatment of DVT. Consistent once-daily dosing may facilitate self-administration of tinzaparin in the outpatient setting.[ncbi.nlm.nih.gov]

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