There was no significant difference in the symptom onset-to-presentation time or door-to-balloon time between the two groups. [ncbi.nlm.nih.gov]

• Prolonged Bleeding

  Tirofiban is an intravenously administered nonpeptide glycoprotein IIb/IIIa receptor antagonist which specifically inhibits fibrinogen-dependent platelet aggregation and prolongs bleeding times in patients with acute coronary syndromes. [ncbi.nlm.nih.gov]

  The addition of heparin to this regimen does not significantly alter the percentage of subjects with >70% inhibition of platelet aggregation (IPA), but does increase the average bleeding time, as well as the number of patients with bleeding times prolonged [ebmconsult.com]

  Intravenous injection is a dose-dependent inhibition of outside human platelet aggregation, prolonged bleeding time,and thrombosis caused by ADP, collagen, arachidonic acid,thromboxane analog U46619 and thrombin. [chemicalbook.com]

  bleeding times in patients with acute coronary syndromes. [dx.doi.org]

• Intravenous Administration

  The intravenous administration of IgG immunoglobulin completely resolved both the anemia and the thrombocytopenia. [ncbi.nlm.nih.gov]

  administration; (III) intervention: trial group received intracoronary Tirofiban during PCI, and control group took intravenous Tirofiban during operation. [oncotarget.com]

  Moreover, a meta-analysis showed that compared with intravenous administration of tirofiban, intracoronary administration of tirofiban significantly increased TIMI grade 3 flow (odds ratio [OR] = 2.11; 95% CI 1.02–4.37; P = .04) and TMP grade 3 flow [journals.lww.com]

  To date, there has been no comprehensive evaluation of the efficacy and safety of intracoronary (IC) tirofiban administration for ACS patients undergoing PCI compared with intravenous (IV) administration. [journals.plos.org]

• Hypoxemia

  Based on previous reports, an episode of spontaneous haemoptysis, or respiratory distress, or hypoxemia, associated with the evidence of new infiltrates on chest radiography in patients receiving GP IIb/IIIa inhibitors, should alert the physician about [revespcardiol.org]

• Turkish

  We report a 64-year-old Turkish man who presented with unstable angina pectoris. Coronary angiography revealed massive intracoronary thrombus, which completely occluded the distal part of the left circumflex coronary artery. [ncbi.nlm.nih.gov]

• Pulmonary Infiltrate

  […] edema or pulmonary infiltrates. [revespcardiol.org]

• Dyslipidemia

  RESULTS: Hypertension, dyslipidemia, diabetes, smoking, previous coronary artery disease and stroke were similar between the groups. [ncbi.nlm.nih.gov]

  The following data were obtained: age, sex, diabetes, systemic arterial hypertension, smoke, dyslipidemia, previous coronary artery disease (percutaneous coronary intervention or coronary artery bypass graft), hemoglobin, creatinine, higher troponin, [ghrnet.org]

• Bleeding Time Prolonged

  The addition of heparin to this regimen does not significantly alter the percentage of subjects with >70% inhibition of platelet aggregation (IPA), but does increase the average bleeding time, as well as the number of patients with bleeding times prolonged [ebmconsult.com]

[…] of clinical treatment. [ncbi.nlm.nih.gov]

Our findings indicate that combined antithrombotic and antiplatelet treatment improves the prognosis in patients with ACS and renal insufficiency who received PCI treatment. [ncbi.nlm.nih.gov]

TIMI myocardial perfusion frame count: a new method to assess myocardial perfusion and its predictive value for short-term prognosis. Catheter Cardiovasc Interv 2010;75:722–32. [14]. He B, Ding S, Qiao Z, et al. [journals.lww.com]

Therefore, treatment for intracoronary thrombosis in emergency PCI directly affects operation success rate and prognosis [ 21 ]. [alliedacademies.org]

No-reflow phenomenon (NR) is one of the serious complications of PCI, which could lead to poor prognosis [ 1 – 3 ]. [bmccardiovascdisord.biomedcentral.com]

Analysis of variance revealed a significant interaction between stroke etiology (small-vessel vs. large-vessel occlusion) and NIHSS during treatment with tirofiban: patients with small-vessel occlusion showed significant improvement, while patients with [karger.com]

Bizzaro N (1995) EDTA-dependant pseudothrombocytopenia: a clinical and epidemiological study of 112 cases, with 10-year follow-up. Am J Hematol 50: 103-109. [esciencecentral.org]

Cardiovascular disease epidemiology in Asia: an overview. Circ J. 2013;77(7):1646–1652. 2. Chan MY, Du X, Eccleston D, et al. Acute coronary syndrome in the Asia-Pacific region. Int J Cardiol. 2016;202:861–869. 3. [dovepress.com]

This important new book: Begins with a concise but thorough discussion of platelet biology and pathophysiology so that readers understand how these therapies work and why they can also produce such a varied range of complications, from minor gastrointestinal [books.google.de]

[…] following tirofiban, discusses the relevant mechanism of action and pharmacodynamics, and analyses the strategies available in patients who need emergency coronary artery grafting after tirofiban. 1 Introduction Thrombotic coronary occlusion is the central pathophysiologic [academic.oup.com]

This finding carries relevant clinical and pathophysiological implications and emphasizes the importance of the intravenous route to deliver effective inhibition of platelet activity in critically ill patients, such as those presenting with STEMI. [interventions.onlinejacc.org]

Platelet glycoprotein (GP)IIb/IIIa inhibitors prevent fibrinogen binding and platelet aggregation. Inhibition of platelet activity at the injured coronary plaque is a target for novel therapeutic strategies. [ncbi.nlm.nih.gov]