Presentation
There was no significant difference in the symptom onset-to-presentation time or door-to-balloon time between the two groups. [ncbi.nlm.nih.gov]
[…] infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). [revmie.sld.cu]
Entire Body System
- Intravenous Administration
The intravenous administration of IgG immunoglobulin completely resolved both the anemia and the thrombocytopenia. [ncbi.nlm.nih.gov]
administration; (III) intervention: trial group received intracoronary Tirofiban during PCI, and control group took intravenous Tirofiban during operation. [oncotarget.com]
Moreover, a meta-analysis showed that compared with intravenous administration of tirofiban, intracoronary administration of tirofiban significantly increased TIMI grade 3 flow (odds ratio [OR] = 2.11; 95% CI 1.02–4.37; P = .04) and TMP grade 3 flow [journals.lww.com]
To date, there has been no comprehensive evaluation of the efficacy and safety of intracoronary (IC) tirofiban administration for ACS patients undergoing PCI compared with intravenous (IV) administration. [journals.plos.org]
- Turkish
We report a 64-year-old Turkish man who presented with unstable angina pectoris. Coronary angiography revealed massive intracoronary thrombus, which completely occluded the distal part of the left circumflex coronary artery. [ncbi.nlm.nih.gov]
Treatment
Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Randomized Controlled Clinical Study to Compare the Efficacy and Safety of Different Dose of Tirofiban in Interventional Treatment of Complex Coronary Artery [clinicaltrials.gov]
[…] of clinical treatment. [ncbi.nlm.nih.gov]
(PCI) / Thrombolytic Therapy 1 4 Completed Treatment No Reflow Phenomenon 1 4 Completed Treatment Non ST Segment Elevation Myocardial Infarction (NSTEMI) 1 4 Not Yet Recruiting Treatment Acute Ischemic Stroke 1 Manufacturers Medicure international inc [go.drugbank.com]
Prognosis
Our findings indicate that combined antithrombotic and antiplatelet treatment improves the prognosis in patients with ACS and renal insufficiency who received PCI treatment. [ncbi.nlm.nih.gov]
TIMI myocardial perfusion frame count: a new method to assess myocardial perfusion and its predictive value for short-term prognosis. Catheter Cardiovasc Interv 2010;75:722–32. [14]. He B, Ding S, Qiao Z, et al. [journals.lww.com]
Therefore, treatment for intracoronary thrombosis in emergency PCI directly affects operation success rate and prognosis [ 21 ]. [alliedacademies.org]
No-reflow phenomenon (NR) is one of the serious complications of PCI, which could lead to poor prognosis [ 1 – 3 ]. [bmccardiovascdisord.biomedcentral.com]
Etiology
Etiologic classification of target arterial lesion The etiology of target arterial lesion was classified based on angiographic findings during ERT. [bmcneurol.biomedcentral.com]
Analysis of variance revealed a significant interaction between stroke etiology (small-vessel vs. large-vessel occlusion) and NIHSS during treatment with tirofiban: patients with small-vessel occlusion showed significant improvement, while patients with [karger.com]
It has also been reported to be more feasible and effective in AIS patients with large artery atherosclerosis (LAA) compared to those with cardioembolic stroke etiology (15, 16). [frontiersin.org]
Epidemiology
Bizzaro N (1995) EDTA-dependant pseudothrombocytopenia: a clinical and epidemiological study of 112 cases, with 10-year follow-up. Am J Hematol 50: 103-109. [esciencecentral.org]
Cardiovascular disease epidemiology in Asia: an overview. Circ J. 2013;77(7):1646–1652. 2. Chan MY, Du X, Eccleston D, et al. Acute coronary syndrome in the Asia-Pacific region. Int J Cardiol. 2016;202:861–869. 3. [dovepress.com]
Pathophysiology
This important new book: Begins with a concise but thorough discussion of platelet biology and pathophysiology so that readers understand how these therapies work and why they can also produce such a varied range of complications, from minor gastrointestinal [books.google.de]
[…] following tirofiban, discusses the relevant mechanism of action and pharmacodynamics, and analyses the strategies available in patients who need emergency coronary artery grafting after tirofiban. 1 Introduction Thrombotic coronary occlusion is the central pathophysiologic [academic.oup.com]
This finding carries relevant clinical and pathophysiological implications and emphasizes the importance of the intravenous route to deliver effective inhibition of platelet activity in critically ill patients, such as those presenting with STEMI. [interventions.onlinejacc.org]
Prevention
Platelet glycoprotein (GP)IIb/IIIa inhibitors prevent fibrinogen binding and platelet aggregation. Inhibition of platelet activity at the injured coronary plaque is a target for novel therapeutic strategies. [ncbi.nlm.nih.gov]