There was no significant difference in the symptom onset-to-presentation time or door-to-balloon time between the two groups. [ncbi.nlm.nih.gov]

[…] infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). [revmie.sld.cu]

• Intravenous Administration

  The intravenous administration of IgG immunoglobulin completely resolved both the anemia and the thrombocytopenia. [ncbi.nlm.nih.gov]

  administration; (III) intervention: trial group received intracoronary Tirofiban during PCI, and control group took intravenous Tirofiban during operation. [oncotarget.com]

  Intravenous Administration of Standard Dose Tirofiban after Mechanical Arterial Recanalization is Safe and Relatively Effective in Acute Ischemic Stroke. Cheng Z, Geng X, Gao J, Hussain M, Moon SJ, Du H, Ding Y. Cheng Z, et al. [pubmed.ncbi.nlm.nih.gov]

  Moreover, a meta-analysis showed that compared with intravenous administration of tirofiban, intracoronary administration of tirofiban significantly increased TIMI grade 3 flow (odds ratio [OR] = 2.11; 95% CI 1.02–4.37; P = .04) and TMP grade 3 flow [journals.lww.com]

  To date, there has been no comprehensive evaluation of the efficacy and safety of intracoronary (IC) tirofiban administration for ACS patients undergoing PCI compared with intravenous (IV) administration. [journals.plos.org]

• Anemia

  The intravenous administration of IgG immunoglobulin completely resolved both the anemia and the thrombocytopenia. [ncbi.nlm.nih.gov]

  Hematologic: Bleeding ( major bleeding ), anemia, thrombocytopenia. Skin: Sweating. Drug: Increased risk of bleeding with anticoagulants, nsaid s, salicylates, antiplatelet agents. [robholland.com]

  Transfusions were required to terminate bleeding and to improve bleeding-related anemia in 4.0% of all patients. Geriatric patients have experienced more bleeding episodes than younger, women more than men. [en.wikipedia.org]

  […] any factors, such as medical conditions or medications, which increase bleeding risk) have acute pericarditis (inflammation of the sac surrounding the heart) have angina brought on by obvious aggravating factors (e.g., abnormal heart rhythms, severe anemia [uniprix.com]

• Hypoxemia

  Based on previous reports, an episode of spontaneous haemoptysis, or respiratory distress, or hypoxemia, associated with the evidence of new infiltrates on chest radiography in patients receiving GP IIb/IIIa inhibitors, should alert the physician about [revespcardiol.org]

• Aspiration

  In the aspiration catheter group, patients received an intra-coronary target injection of tirofiban using the Export aspiration catheter (Medtronic, Inc.). [journals.lww.com]

  The GuideLiner catheter, a monorail guiding device, served a novel role in thrombus aspiration and intracoronary medication delivery. [ncbi.nlm.nih.gov]

  Manual aspiration thrombectomy with Penumbra reperfusion catheter was performed prior to Solitaire thrombectomy in 2 patients. [neurointervention.org]

  The coronary angiography was performed following clinical improvement, and documented intrastent thrombosis, treated with thrombus aspiration alone. Follow-up at 30-day was unremarkable. [revespcardiol.org]

• Pneumonia

  […] reason, the number of patients in whom alveolar haemorrhage might have been incorrectly diagnosed is unknown. 3,4 Moreover, the misdiagnosis may lead to inappropriate treatment with loop diuretics or antibiotic therapy for presumed heart failure or pneumonia [revespcardiol.org]

  Eleven serious adverse events were reported: mechanical ventilation due to pneumonia and hepatic failure (p), neurological deterioration due to cerebral bleedings requiring cessation of infusion (t), neurological deterioration due to cerebral bleedings [ahajournals.org]

• Respiratory Distress

  Based on previous reports, an episode of spontaneous haemoptysis, or respiratory distress, or hypoxemia, associated with the evidence of new infiltrates on chest radiography in patients receiving GP IIb/IIIa inhibitors, should alert the physician about [revespcardiol.org]

• Recurrent Chest Pain

  Nonfatal MI was defined as recurrent chest pain with ST-segment or T-wave changes and recurrent elevation of cardiac enzyme levels. Patients were considered eligible for angiographic follow-up if protocol-mandated PCI had been attempted. [jamanetwork.com]

• Thrombosis

  Very late drug-eluting stent (DES) thrombosis remains a major problem of interventional cardiology due to its high morbidity and mortality. We conclude that tirofiban may be an interesting candidate drug for treatment of very late stent thrombosis. [ncbi.nlm.nih.gov]

  17H2,1H3,(H,25,26) /t21- /m0/s1 COKMIXFXJJXBQG-NRFANRHFSA-N CCCCS(=O)(=O)N[[email protected]@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(O)=O platelet glycoprotein-IIb/IIIa receptor antagonist Antagonist of platelet surface glycoprotein-IIb/IIIa which has a key role in hemostasis and thrombosis [ebi.ac.uk]

• Suggestibility

  Our experience suggests that intracoronary administration of tirofiban can be considered as an option in cases of AST during percutaneous coronary intervention. [ncbi.nlm.nih.gov]

• Fear

  We would like to warn the physicians to keep in mind this fearful complication. The following case will help us in our explanation. A 71-year-old woman presented with a chest pain. [revespcardiol.org]

  And the GP IIb/IlIa receptor is only found in the platelet and macrophage lineage, this feature enables specific treatment of its antagonists, without fearing of causing a wide range of side effects [ 24 ]. [alliedacademies.org]

• Irritability

  Tell your doctor if any of these symptoms are severe or do not go away: upset stomach fever irritation or burning at site of injection If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately [medlineplus.gov]

  SIDE EFFECTS: Dizziness or minor bleeding/irritation at the injection site may occur. [medicinenet.com]

• Agitation

  Six patients who were agitated and uncooperative required general anesthesia. A 6F sheath was placed in the femoral artery, and a 6F or 5F guiding catheter was advanced in the ICA or the vertebral artery. [ajnr.org]

• Pulmonary Infiltrate

  […] edema or pulmonary infiltrates. [revespcardiol.org]

• Hypercholesterolemia

  No differences in age, gender, and history of hypertension, hypercholesterolemia, diabetes, and so on were observed. The patients in the aspiration catheter group generally had a higher incidence of cerebral vascular disease. [journals.lww.com]

  Hypercholesterolemia was classified as patients on lipid-lowering substances as well as diabetes on antidiabetics. Written informed consent was given by all patients or their relatives before participation. [ahajournals.org]

• T Wave Inversion

  […] of 0.1 mV or more, T-wave inversion of 0.3 mV or more in three or more limb leads or four or more precordial leads excluding V 1, or pseudonormalization of 0.1 mV or more) or an elevation of plasma levels of creatine kinase and of the creatine kinase [nejm.org]

Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Randomized Controlled Clinical Study to Compare the Efficacy and Safety of Different Dose of Tirofiban in Interventional Treatment of Complex Coronary Artery [clinicaltrials.gov]

Max duration of treatment: 108 hours. [drugsupdate.com]

[…] of clinical treatment. [ncbi.nlm.nih.gov]

(PCI) / Thrombolytic Therapy 1 4 Completed Treatment No Reflow Phenomenon 1 4 Completed Treatment Non ST Segment Elevation Myocardial Infarction (NSTEMI) 1 4 Not Yet Recruiting Treatment Acute Ischemic Stroke 1 Manufacturers Medicure international inc [go.drugbank.com]

Our findings indicate that combined antithrombotic and antiplatelet treatment improves the prognosis in patients with ACS and renal insufficiency who received PCI treatment. [ncbi.nlm.nih.gov]

TIMI myocardial perfusion frame count: a new method to assess myocardial perfusion and its predictive value for short-term prognosis. Catheter Cardiovasc Interv 2010;75:722–32. [14]. He B, Ding S, Qiao Z, et al. [journals.lww.com]

Therefore, treatment for intracoronary thrombosis in emergency PCI directly affects operation success rate and prognosis [ 21 ]. [alliedacademies.org]

No-reflow phenomenon (NR) is one of the serious complications of PCI, which could lead to poor prognosis [ 1 – 3 ]. [bmccardiovascdisord.biomedcentral.com]

Etiologic classification of target arterial lesion The etiology of target arterial lesion was classified based on angiographic findings during ERT. [bmcneurol.biomedcentral.com]

It has also been reported to be more feasible and effective in AIS patients with large artery atherosclerosis (LAA) compared to those with cardioembolic stroke etiology (15, 16). [frontiersin.org]

Analysis of variance revealed a significant interaction between stroke etiology (small-vessel vs. large-vessel occlusion) and NIHSS during treatment with tirofiban: patients with small-vessel occlusion showed significant improvement, while patients with [karger.com]

Bizzaro N (1995) EDTA-dependant pseudothrombocytopenia: a clinical and epidemiological study of 112 cases, with 10-year follow-up. Am J Hematol 50: 103-109. [esciencecentral.org]

Cardiovascular disease epidemiology in Asia: an overview. Circ J. 2013;77(7):1646–1652. 2. Chan MY, Du X, Eccleston D, et al. Acute coronary syndrome in the Asia-Pacific region. Int J Cardiol. 2016;202:861–869. 3. [dovepress.com]

This important new book: Begins with a concise but thorough discussion of platelet biology and pathophysiology so that readers understand how these therapies work and why they can also produce such a varied range of complications, from minor gastrointestinal [books.google.de]

[…] following tirofiban, discusses the relevant mechanism of action and pharmacodynamics, and analyses the strategies available in patients who need emergency coronary artery grafting after tirofiban. 1 Introduction Thrombotic coronary occlusion is the central pathophysiologic [academic.oup.com]

This finding carries relevant clinical and pathophysiological implications and emphasizes the importance of the intravenous route to deliver effective inhibition of platelet activity in critically ill patients, such as those presenting with STEMI. [interventions.onlinejacc.org]

Platelet glycoprotein (GP)IIb/IIIa inhibitors prevent fibrinogen binding and platelet aggregation. Inhibition of platelet activity at the injured coronary plaque is a target for novel therapeutic strategies. [ncbi.nlm.nih.gov]