RESULTS: Six cases of localized tongue amyloidosis presented to the Mayo Clinic between 1969 and 2011. Mean patient age was 69 years (range, 43-90). Patients presented with asymptomatic tongue mass(es). [ncbi.nlm.nih.gov]

A case of localized deposition of systemic amyloidosis secondary to multiple myeloma is reported in a 63-year-old female presenting with restricted tongue movement in the dental setting. [dental-update.co.uk]

Our patient survived only for 1 month after presentation and died due to multiorgan dysfunction. [jomfp.in]

Although glositis was suspected from the clinical presentation, a tumorous lesion could not be ruled out. Examination of the blood sample revealed anemia. [ci.nii.ac.jp]

An extensive workup to differentiate systemic and localized amyloidosis required to treat underlying pathology and to prevent organ damage. [saudijos.org]

Electronic records were reviewed with focus on presenting symptoms, laboratory results (ie, serum or urine immunoelectrophoresis, bone marrow biopsy, and fat aspirate analysis), treatment modality, and status of disease at follow-up. [ncbi.nlm.nih.gov]

Clinical relevance: To provide an understanding of what multiple myeloma and amyloidosis are whilst, importantly, relating this to how these conditions can impact on routine dental treatment. [dental-update.co.uk]

Chemotherapy with bortezomib, cyclophosphamide, and dexamethasone led to a mild reduction of the kappa light chains (“stable disease” rather than a remission) and was then followed by treatment with lenalidomide and dexamethasone. [aerzteblatt.de]

Liver transplantation has been used most successfully for treatment of FAP. [intelligentdental.com]

Comprehensive amyloidosis treatment Team-based care is essential if amyloidosis affects tissues and organs throughout your body, as it often does. [seattlecca.org]

Objective: To assist GDPs in the detection of early warning signs of multiple myeloma and amyloidosis to help improve the prognosis of patients with these conditions. [dental-update.co.uk]

The presence of myeloma yields a poor prognosis for the patient. [intelligentdental.com]

The prognosis is uncertain, owing to the rarity of the condition, requiring regular follow-up and monitoring. [ncbi.nlm.nih.gov]

The prognosis depends on the type of amyloidosis and the organ system that is affected. Involvement of the heart is the most dangerous form and can have a bleak prognosis. [merckmanuals.com]

Amyloidosis associated by multiple myeloma usually has a poor prognosis. Most patients with both diseases die within one to two years. Prevention Genetic couseling may be helpful for patients with hereditary amyloidosis and their families. [encyclopedia.com]

Etiology The etiology of BMS is unknown. Although a variety of causes have been mentioned in the literature, the most common one being an underlying psychiatric disorder, there is no proven causative etiological factor. [pocketdentistry.com]

Our patient's weight loss and the presence of the submandibular mass initially led us to consider a malignant etiology, but this theory was not supported by imaging and laboratory findings. [the-medical-dictionary.com]

He underwent extensive tests to identify the etiologies associated with systemic amyloidosis. [jmedicalcasereports.biomedcentral.com]

It is a plasma cell dyscrasia of unknown etiology with the production of monoclonal chains. [saudijos.org]

[…] least common form, with few previously reported cases. 8 Notably, central nervous system amyloidomas are a different entity from systemic amyloidosis or from the more common congophilic amyloid angiopathy. 27 They occur in isolation and have no known etiologic [ajnr.org]

Epidemiology The estimated prevalence is approximately 1 %. Geographic tongue may occur on all ages, even in young children. [pocketdentistry.com]

Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocr Rev. 2004;25(1):102–152. 5. Xavier SD, Bussoloti IF, Müller H. Macroglossia secondary to systemic amyloidosis: case report and literature review. [aafp.org]

Epidemiology of multiple myeloma. In Wiernik P H, Canellos G P, Kyle P A, Schiffer C A (Eds) Neoplastic diseases of the blood. Vol 1, 2 nd ed. pp 347–372. [nature.com]

Epidemiology United States Annually, one to five cases of immunoglobulin-related amyloidosis per 100,000 people occur. [emedicine.medscape.com]

[…] concentration of serum amyloid A protein. [7] People with ATTR have better prognosis and may survive for over a decade. [6] Senile systemic amyloidosis was determined to be the primary cause of death for 70% of people over 110 who have been autopsied. [20] [21] Epidemiology [en.wikipedia.org]

Amyloidosis: a clinic-pathophysiological synopsis. Semin Cell Develop Biol. 2004;15:39–44. CrossRef Google Scholar 3. Westermark P, Benson MD, Buxbaum JN, et al. A primer of amyloid nomeclature. Amyloid. 2007;14:179–83. [link.springer.com]

New frontiers and insights in pathophysiology, diagnosis, and management". Texas Heart Institute Journal. 32 (2): 178–184. PMC 1163465. PMID 16107109. Mead, Simon; Gandhi, Sonia; et al. (2013). [en.wikipedia.org]

Pathophysiology The most common light chain–type amyloidosis precursor proteins are L chains of the lambda (l) class. [emedicine.medscape.com]

Islet amyloid and type 2 diabetes; from molecular misfolding to islet pathophysiology. Biochim Biophys Acta. 2001;1537:179-203. Sanchorawala V, Wright DG, Seldin DC, et al. [rarediseases.org]

Prevention Because no one knows what causes amyloidosis, there is no way to prevent primary amyloidosis. Secondary amyloidosis can be prevented only by preventing or promptly treating the inflammatory disease that can trigger amyloidosis. [drugs.com]

These treatments can give your body time to gradually clear the deposits before they build up again, and can help prevent organ damage. In most cases, the treatment will involve having chemotherapy. [nhs.uk]

Is it possible to prevent amyloidosis? There is no prevention for amyloidosis. However, the secondary forms of amyloidosis can be prevented by treating the underlying diseases that are associated with inflammation. [medicinenet.com]

The aims of treatment are to prevent further deposits of amyloid proteins and ease the symptoms. [betterhealth.vic.gov.au]

NCI comprehensive cancer center We are a comprehensive cancer center, a designation from the National Cancer Institute that reflects our scientific leadership and the depth and breadth of our research to prevent, diagnose and treat cancer. [seattlecca.org]