Edit concept Question Editor Create issue ticket

Tongue Amyloidosis


Presentation

  • RESULTS: Six cases of localized tongue amyloidosis presented to the Mayo Clinic between 1969 and 2011. Mean patient age was 69 years (range, 43-90). Patients presented with asymptomatic tongue mass(es).[ncbi.nlm.nih.gov]
  • They presented in vessel wall, nerve fiber, and muscle cells. CONCLUSION: The biopsy is an important means for the diagnosis of early tongue AL, and the wide variety of amyloid light chain is helpful to differential diagnosis.[ncbi.nlm.nih.gov]
  • A case of localized deposition of systemic amyloidosis secondary to multiple myeloma is reported in a 63-year-old female presenting with restricted tongue movement in the dental setting.[dental-update.co.uk]
  • Our patient survived only for 1 month after presentation and died due to multiorgan dysfunction.[jomfp.in]
  • Although glositis was suspected from the clinical presentation, a tumorous lesion could not be ruled out. Examination of the blood sample revealed anemia.[ci.nii.ac.jp]
Asymptomatic
  • Patients presented with asymptomatic tongue mass(es). Biopsy of the tongue mass in all patients showed amyloid on Congo red stains.[ncbi.nlm.nih.gov]
  • Most patients are asymptomatic otherwise. May be associated with geographic tongue.[pocketdentistry.com]
  • The lesions were asymptomatic and were thought to have been caused by trauma while chewing. Medically the patient suffered occasional migraine-type headaches and had an episode of vertigo six months previously.[nature.com]
  • In most patients, hepatic involvement is asymptomatic. An enlarged liver (hepatomegaly) and an enlarged spleen (splenomegaly) are the most notable signs.[rarediseases.org]
High Fever
  • The patient had a high fever and circulatory failure 8 days after the start of chemotherapy and died 2 days later.[jstage.jst.go.jp]
Macroglossia
  • Dent Update 2016; 43: 641-647 Read article Oral medicine: Amyloidosis Presenting as Macroglossia and Restricted Tongue Movement CPD : 0:24 (closed) Self assess Feedback : 0 comments, 0 ratings Abstract: Amyloidosis (AL) is a well recognized cause of macroglossia[dental-update.co.uk]
  • We encountered and treated a patient with macroglossia who was found to have systemic and reactivity amyloidosis.[ci.nii.ac.jp]
  • Persistent macroglossia was attributed to the non-response to chemotherapy.[aerzteblatt.de]
  • Discussion: While macroglossia is thought to be pathognomonic of AL amyloidosis, we report a case of macroglossia with fibrillar ATTR amyloid deposits diagnosed by immuno-electron microscopy.[bloodjournal.org]
  • Macroglossia means an enlarged tongue. It may be absolute (greater than the 95 th centile) or relative (enlarged compared with oral cavity).[radiopaedia.org]
Lesion of the Tongue
  • Incisional biopsy was done from one of the nodular lesions in the tongue with the diagnostic possibilities of carcinoma tongue/myeloma infiltration.[jomfp.in]
  • The biopsy of the excised lesion of the tongue revealed subepithelial accumulation of an amorphous, nodular, fibrillar material positive for Congo red.[link.springer.com]
  • […] over the tongue and progressive discoloration around the eyes of 1-year duration.[jdrntruhs.org]
  • The histopathological examination of the biopsy taken from the lesion on the tongue revealed homogenous eosinophilic amorphous material and infiltration with lymphocytes seen on haematoxylin and eosin staining ( fig. 4) and revealed metachromatic staining[edoj.org.eg]
Lesion of the Tongue
  • Incisional biopsy was done from one of the nodular lesions in the tongue with the diagnostic possibilities of carcinoma tongue/myeloma infiltration.[jomfp.in]
  • The biopsy of the excised lesion of the tongue revealed subepithelial accumulation of an amorphous, nodular, fibrillar material positive for Congo red.[link.springer.com]
  • […] over the tongue and progressive discoloration around the eyes of 1-year duration.[jdrntruhs.org]
  • The histopathological examination of the biopsy taken from the lesion on the tongue revealed homogenous eosinophilic amorphous material and infiltration with lymphocytes seen on haematoxylin and eosin staining ( fig. 4) and revealed metachromatic staining[edoj.org.eg]
Ulcer
  • Macroscopic observation showed mucosa pallescence, punctuate hemorrhage, red grain particles, and ulcers on the tongue. HE staining indicated amyloid depositions in basement membrane, muscle cell, vessel wall, and nerve fiber.[ncbi.nlm.nih.gov]
  • Because an ulcer developed in the same area, the patient visited our department for the first time on October, and the tooth was extracted. After extraction, the patient's progress was initially favorable.[jstage.jst.go.jp]
  • A tongue biopsy for suspected squamous cell carcinoma revealed only an ulcer with inflammatory epithelial changes, rather than a malignant tumor.[aerzteblatt.de]
  • However, there was no ulceration caused by biting the tongue. Although glositis was suspected from the clinical presentation, a tumorous lesion could not be ruled out. Examination of the blood sample revealed anemia.[ci.nii.ac.jp]
  • Less often, bullous lesions, vesicles, and ulcers can also be seen, particularly on the lips. Infiltration of salivary glands can result in xerostomia.[mdedge.com]
Unilateral Blindness
  • Her medical history included NF type-2 with chromosome-22 abnormal karyotype (mosaicism), multiple intracranial and spinal meningiomas/schwannomas and unilateral blindness/deafness.[link.springer.com]

Treatment

  • Electronic records were reviewed with focus on presenting symptoms, laboratory results (ie, serum or urine immunoelectrophoresis, bone marrow biopsy, and fat aspirate analysis), treatment modality, and status of disease at follow-up.[ncbi.nlm.nih.gov]
  • Clinical relevance: To provide an understanding of what multiple myeloma and amyloidosis are whilst, importantly, relating this to how these conditions can impact on routine dental treatment.[dental-update.co.uk]
  • Chemotherapy with bortezomib, cyclophosphamide, and dexamethasone led to a mild reduction of the kappa light chains (“stable disease” rather than a remission) and was then followed by treatment with lenalidomide and dexamethasone.[aerzteblatt.de]
  • Comprehensive amyloidosis treatment Team-based care is essential if amyloidosis affects tissues and organs throughout your body, as it often does.[seattlecca.org]
  • What is the treatment for amyloidosis? There is no cure for amyloidosis. The treatment of amyloidosis depends on the type of amyloidosis involved.[medicinenet.com]

Prognosis

  • Objective: To assist GDPs in the detection of early warning signs of multiple myeloma and amyloidosis to help improve the prognosis of patients with these conditions.[dental-update.co.uk]
  • The prognosis is uncertain, owing to the rarity of the condition, requiring regular follow-up and monitoring.[ncbi.nlm.nih.gov]
  • The presence of myeloma yields a poor prognosis for the patient.[intelligentdental.com]
  • Amyloidosis associated by multiple myeloma usually has a poor prognosis. Most patients with both diseases die within one to two years. Prevention Genetic couseling may be helpful for patients with hereditary amyloidosis and their families.[encyclopedia.com]
  • The prognosis depends on the type of amyloidosis and the organ system that is affected. Involvement of the heart is the most dangerous form and can have a bleak prognosis.[merckmanuals.com]

Etiology

  • Etiology The etiology of BMS is unknown. Although a variety of causes have been mentioned in the literature, the most common one being an underlying psychiatric disorder, there is no proven causative etiological factor.[pocketdentistry.com]

Epidemiology

  • Epidemiology The estimated prevalence is approximately 1 %. Geographic tongue may occur on all ages, even in young children.[pocketdentistry.com]
  • Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocr Rev. 2004;25(1):102–152. 5. Xavier SD, Bussoloti IF, Müller H. Macroglossia secondary to systemic amyloidosis: case report and literature review.[aafp.org]
  • Epidemiology of multiple myeloma. In Wiernik P H, Canellos G P, Kyle P A, Schiffer C A (Eds) Neoplastic diseases of the blood. Vol 1, 2 nd ed. pp 347–372.[nature.com]
Sex distribution
Age distribution

Pathophysiology

  • Amyloidosis: a clinic-pathophysiological synopsis. Semin Cell Develop Biol. 2004;15:39–44. CrossRef Google Scholar 3. Westermark P, Benson MD, Buxbaum JN, et al. A primer of amyloid nomeclature. Amyloid. 2007;14:179–83.[link.springer.com]
  • Islet amyloid and type 2 diabetes; from molecular misfolding to islet pathophysiology. Biochim Biophys Acta. 2001;1537:179-203. Sanchorawala V, Wright DG, Seldin DC, et al.[rarediseases.org]

Prevention

  • Prevention Because no one knows what causes amyloidosis, there is no way to prevent primary amyloidosis. Secondary amyloidosis can be prevented only by preventing or promptly treating the inflammatory disease that can trigger amyloidosis.[drugs.com]
  • These treatments can give your body time to gradually clear the deposits before they build up again, and can help prevent organ damage. In most cases, the treatment will involve having chemotherapy.[nhs.uk]
  • Is it possible to prevent amyloidosis? There is no prevention for amyloidosis. However, the secondary forms of amyloidosis can be prevented by treating the underlying diseases that are associated with inflammation.[medicinenet.com]
  • The aims of treatment are to prevent further deposits of amyloid proteins and ease the symptoms.[betterhealth.vic.gov.au]
  • NCI comprehensive cancer center We are a comprehensive cancer center, a designation from the National Cancer Institute that reflects our scientific leadership and the depth and breadth of our research to prevent, diagnose and treat cancer.[seattlecca.org]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!