Clinical and immunohistochemical features of this rare case are presented and discussed. [ncbi.nlm.nih.gov]

The current case shows the value of multiple biopsy sites when the presentation is heterogeneous in appearance, as well as the importance of a high index of suspicion for carcinoma. [nejm.org]

Despite the ease of inspecting the tongue by both patient and physician, they often present late, as they are usually painless and often ignored by the patient. Eventually, they present as a non-healing ulcer which demonstrates growth over time 6. [radiopaedia.org]

• Weight Loss

  Animals suffered from weight loss and died of cachexia. CONCLUSIONS: RSCC-2 is the first animal model for orthotopical transplantation of primary tongue carcinoma. [ncbi.nlm.nih.gov]

  Many treatments make it difficult or painful to eat and swallow, and poor appetite and weight loss are common. Make sure you discuss your diet with your doctor. [healthline.com]

  loss Difficulty opening the mouth Numbness and loosening of teeth Bad breath Your doctor or dentist will examine your mouth area. [medlineplus.gov]

  The possible complications due to Squamous Cell Carcinoma of Tongue could be: Severe discomfort while eating, chewing, or swallowing food; this can even lead to weight loss A partial of complete loss of taste sensation They can metastasize to the lymph [dovemed.com]

• Weakness

  Cell Carcinoma of Tongue include: Smoking and chewing of tobacco are strong risk factors for this type of Tongue Cancer Radiation therapy in the region of the tongue (such as to the face or throat) Arsenic exposure Coal tar exposure Individuals with weak [dovemed.com]

  This can cause side effects such as: hair loss painful mouth and gums bleeding in the mouth severe anemia weakness poor appetite nausea vomiting diarrhea mouth and lip sores numbness in the hands and feet Recovering from targeted therapies is usually [healthline.com]

  Weak immune system is also at risk of cancer of tongue. Tests to Diagnose Cancer of Tongue The first priority of a doctor is to determine the severity of cancer of tongue once it is diagnosed. [epainassist.com]

  A Cochrane review found [ 14 ] : Weak evidence that elective neck dissection of clinically negative neck nodes at the time of removal of the primary tumour results in reduced locoregional recurrence. [patient.info]

• Fatigue

  This is where complementary medications help in getting rid of fatigue. [epainassist.com]

  Radiotherapy has side effects like: sore skin ulcers in the mouth fatigue dry mouth loss of, or changes in, taste loss of appetite nausea bad breath etc. [news-medical.net]

  Chemotherapy Description, Dates & Side Effects: Cisplatin ....nausea and fatigue Read Barbara's Story Alex Bio: Hey everyone. My name is Alex and I’m 24 years old. [blogforacure.com]

  Weight loss and fatigue are not uncommon. Treatment may lead to pain, xerostomia, infections, poor wound healing, dysphagia, fistula formation, trismus, potential disfigurement and fatigue. [patient.info]

• Sore Throat

  […] go away dramatic weight loss lower lip, face, neck, or chin numbness white, red and white, or red patches in or on your mouth or lips a sore throat jaw pain or stiffness tongue pain Some of these symptoms, such as a sore throat or an earache, may indicate [healthline.com]

  Signs of oral, head and neck cancer include a sore in your mouth that doesn’t heal; sore throat; lumps or patches in your mouth; trouble swallowing; changes in your voice; and/or a lump in your neck. [entnet.org]

  In addition, the patches or sores on the tongue may bleed easily. The Cancer Treatment Centers of America recommend seeking medical attention if there is a chronic sore throat or if the pain radiates to the ears. [livestrong.com]

  […] of your ears but without any loss of hearing Trouble moving your jaw or tongue, or problems with chewing, swallowing or speaking Loose teeth with no apparent dental cause Lingering sore throat or hoarseness How It Occurs Although the exact cause of oral [colgate.com]

  Other symptoms of tongue cancer include: A grayish-pink lump or ulcer on the side of the tongue Tongue pain Sore throat Difficulty swallowing or chewing Difficulty moving the tongue Cancer at the base of the tongue rarely has symptoms until the later [ucihealth.org]

• Pharyngitis

  Carcinoma of the tongue remain one of the greatest management challenges for the head and neck surgeon because of the adverse effects of treatment on oral and pharyngeal function. [ncbi.nlm.nih.gov]

  "Transoral resection of pharyngeal cancer: summary of a National Cancer Institute Head and Neck Cancer Steering Committee Clinical Trials Planning Meeting, November 6-7, 2011, Arlington, Virginia." [headandneckcancerguide.org]

• Hemoptysis

  There was no finding suggestive of local recurrence; however, the patient died from hemoptysis and respiratory insufficiency. [ncbi.nlm.nih.gov]

  Case Report A 47-year-old woman presented to her primary care physician with a 5-month history of episodic swallowing difficulties, a sore throat, and a single episode of hemoptysis. [ajnr.org]

  Patients also may complain of referred ear pain or hemoptysis. Delay in diagnosis is not uncommon because of the common and sometimes vague nature of symptoms and the relative inaccessibility of the base of the tongue to examination. [emedicine.medscape.com]

• Dysphagia

  One patient (8.3%) complained of persistent dysphagia for 7 months. In the patient with rhabdomyosacroma total laryngectomy was required 6 months after the operation because of secondary involvement of the larynx. [ncbi.nlm.nih.gov]

  It can affect the appearance of your mouth and make speaking and swallowing difficult (dysphagia). Dysphagia can be a potentially serious problem. [nhs.uk]

• Loss of Appetite

  Radiotherapy has side effects like: sore skin ulcers in the mouth fatigue dry mouth loss of, or changes in, taste loss of appetite nausea bad breath etc. [news-medical.net]

  In general, chemotherapy may cause fatigue, nausea, vomiting, hair loss, dry mouth, hearing loss, loss of appetite (often due to a change in sense of taste), difficulty eating food, weakened immune system, diarrhea, constipation, and open sores in the [cancer.net]

  A normal diet was important for maintaining weight; mashed food, liquid food, and loss of appetite were closely associated with weight loss. [uspharmacist.com]

• Lesion of the Tongue

  The differential diagnosis of squamous cell carcinoma of the tongue is essentially that of other malignant lesions of the oral cavity as well as a few non-neoplastic lesions. [radiopaedia.org]

  These imaging characteristics are nonspecific and may be seen in other salivary gland lesions, as well as other tongue base lesions such as SCC, lymphoma, and schwannoma. [ajnr.org]

  Figure 1: The ulceroproliferative lesion at the anterior 2/3 rd of the tongue Figure 2: The v-shaped excision of the anterior third of the tongue with the lesion. Figure 3: The supraomohyoid neck dissection for removal of level 2 nodes. [journalgateway.com]

  A lesion showing aggressive behavior developed on the patient's lateral border of tongue at age of 16. [scielo.br]

• Aphthous Ulceration

  Viruses such as herpes simplex virus (HSV) are associated with cold sores and aphthous ulcers (canker sores) that can be very painful and persist for weeks. [everydayhealth.com]

• Oral Ulcers

  Click on Pictures to Enlarge Apthosis Ulcers: Apthosis ulcers are shallow small painful ulcers which appear on mobile mucosa in the oral cavity. They are often found in individuals that are under stress. The cause of these ulcers is unknown. [entusa.com]

• Blister

  Blisters first formed with sloughing of the mucosa. The lips, buccal mucosa and soft palate were the main areas of involvement. [entusa.com]

• Otalgia

   Referred otalgia results from innervation by V3,lesser palatine nerve, and the glossopharyngeal nerve.  Lymphatic into Level II nodes. 10. Floor of the Mouth 11. Tongue 12. [slideshare.net]

  Symptoms of tongue base tumors may be odynophagia (pain on swallowing food or fluid), otalgia (pain in the ear), or a mass in the neck. The mass is usually due to metastases that can be felt in three-quarters of cases at the time of the diagnosis. [medicinenet.com]

  CASE DESCRIPTION In December 2005, a 66-year-old woman presented to the otolaryngology clinic at our institution with mild dysphagia and a globus sensation, with no constitutional symptoms, odynophagia, or referred otalgia. [current-oncology.com]

• Referred Otalgia

   Referred otalgia results from innervation by V3,lesser palatine nerve, and the glossopharyngeal nerve.  Lymphatic into Level II nodes. 10. Floor of the Mouth 11. Tongue 12. [slideshare.net]

  CASE DESCRIPTION In December 2005, a 66-year-old woman presented to the otolaryngology clinic at our institution with mild dysphagia and a globus sensation, with no constitutional symptoms, odynophagia, or referred otalgia. [current-oncology.com]

  The evaluation of a patient with tongue cancer begins with a detailed history, specifically inquiring about tobacco and alcohol use, pain, weight loss, dysphagia and odynophagia, referred otalgia, hemoptysis, neck mass, hoarseness, and articulation difficulties [emedicine.medscape.com]

• Neck Mass

  A neck mass may, therefore, be the presenting complaint. A common staging system is used for all squamous cell carcinomas of the oral cavity, with tumor staging being based on size and extension into adjacent structures. [radiopaedia.org]

  Other symptoms include: A sore on the lip that doesn't heal Persistent lip pain or lip numbness A lump or thickening on the lip A white or red patch on the lip A neck mass Treatments for lip cancer Our goal is to treat lip cancer in ways that cause as [cancercenter.com]

• Headache

  The side effects of this treatment can include: fever headache vomiting diarrhea an allergic reaction skin rashes Although these treatments do have side effects, they’re often necessary in beating the cancer. [healthline.com]

  Tianna ~ Age 17 ~ Stage IV Nasopharyngeal Cancer ~ Non Smoker TIANNA from Illinois Symptoms: Persistent headache and sore throat Treatment: Modified neck dissection, radiation and chemotherapy Delay in Diagnosis: 6 weeks I had a headache and a sore throat [sixstepscreening.org]

Hyoid bone invasion may be a possible indication for intensification of treatment and/or may indicate a necessity for increasing the degree of post-treatment surveillance monitoring and imaging. © 2015 John Wiley & Sons Ltd. [ncbi.nlm.nih.gov]

CONCLUSIONS: Bcl-2 is associated with aggressive disease, neck lymph node metastasis, and poor prognosis. Whereas Bax is related with histologic grade. [ncbi.nlm.nih.gov]

If metastasis (such as to the local lymph nodes) is observed, then the prognosis is guarded or unpredictable Tumors in their early stage with complete excisional treatment typically have good prognosis In cases of metastasis, its prognosis depends upon [dovemed.com]

DNA ploidy status such as aneuploid carry worst prognosis Verrucuous Ca has better one 37. Prognosis Stage 1: 80 – 90 % Stage 2: 70 – 80 % Stage 3: 30 – 50 % Stage 4: 20 – 30 % [slideshare.net]

The etiology of the lesion was considered to be ischemia secondary to compression by the necrotic myocutaneous flap. [ncbi.nlm.nih.gov]

Etiology 19. Etiology 20. [slideshare.net]

Thus, other factors should be investigated in order to explain the etiology of SCC in young patients. [indianjcancer.com]

This study emphasizes the current clinico-epidemiological trends of carcinoma tongue in central India and needs more studies on this issue to tackle the situation efficiently. [ccij-online.org]

Key variants in OTSCC and their relationship with habits, clinical and epidemiological parameters. A. [f1000research.com]

The literature is reviewed regarding the embryology, epidemiology, etiology, symptomatology, radiology, histology, and treatment of this cyst and its malignant counterpart. [onlinelibrary.wiley.com]

Epidemiology and risk factors are similar to squamous cell carcinomas elsewhere in the upper aerodigestive tract, with tobacco smoking and alcohol ingestion being major risk factors 1-3,9. [radiopaedia.org]

The fact that expression of the immune-related proteins varied between HPV-positive and HPV-negative cases was considered to be linked to the stronger immune defense activity found in cases of HPV-positive TSCC/BOTSCC. [3] Pathophysiology The tongue is [emedicine.medscape.com]

The 5-year survival rate for patients with localized disease at diagnosis is 83%, compared with 32% for those whose cancer has spread. 1-3 Pathophysiology Oral cancer can develop in any part of the mouth, including the lips, gums, tongue, cheeks, and [uspharmacist.com]

Pathophysiology [ edit ] Oral squamous cell carcinoma is the end product of an unregulated proliferation of mucous basal cells. [en.wikipedia.org]

Preventing mouth cancer The three most effective ways of preventing mouth cancer developing, or preventing it coming back after successful treatment, are: not smoking ensuring you don't drink more than the recommended weekly limits for alcohol eating [nhs.uk]

The role of the dental practitioner in detection and prevention of oral cancer: review of the literature. Dent Update. 2000;27:404-08. Yoleri L, Mavioglu H. [rarediseases.org]

Prevention of Cancer of Tongue As such there is nothing much you can do to prevent occurrence of cancer of tongue but you can take some measures to reduce the chances of occurrence: Stay away from tobacco to prevent cancer of tongue. [epainassist.com]