Clinical and immunohistochemical features of this rare case are presented and discussed. [ncbi.nlm.nih.gov]

The current case shows the value of multiple biopsy sites when the presentation is heterogeneous in appearance, as well as the importance of a high index of suspicion for carcinoma. [nejm.org]

Only 25 cases (20%) were in early stages and only 3% presented at Stage I. In almost all age groups, the presentation was in advanced stages. [ccij-online.org]

Despite the ease of inspecting the tongue by both patient and physician, they often present late, as they are usually painless and often ignored by the patient. Eventually, they present as a non-healing ulcer which demonstrates growth over time 6. [radiopaedia.org]

• Fatigue

  This is where complementary medications help in getting rid of fatigue. [epainassist.com]

  Weight loss and fatigue are not uncommon. Treatment may lead to pain, xerostomia, infections, poor wound healing, dysphagia, fistula formation, trismus, potential disfigurement and fatigue. [patient.info]

  Radiotherapy has side effects like: sore skin ulcers in the mouth fatigue dry mouth loss of, or changes in, taste loss of appetite nausea bad breath etc. [news-medical.net]

• Lesion of the Tongue

  The differential diagnosis of squamous cell carcinoma of the tongue is essentially that of other malignant lesions of the oral cavity as well as a few non-neoplastic lesions. [radiopaedia.org]

  These imaging characteristics are nonspecific and may be seen in other salivary gland lesions, as well as other tongue base lesions such as SCC, lymphoma, and schwannoma. [ajnr.org]

  Figure 1: The ulceroproliferative lesion at the anterior 2/3 rd of the tongue Figure 2: The v-shaped excision of the anterior third of the tongue with the lesion. Figure 3: The supraomohyoid neck dissection for removal of level 2 nodes. [journalgateway.com]

  A lesion showing aggressive behavior developed on the patient's lateral border of tongue at age of 16. [scielo.br]

• Otalgia

   Referred otalgia results from innervation by V3,lesser palatine nerve, and the glossopharyngeal nerve.  Lymphatic into Level II nodes. 10. Floor of the Mouth 11. Tongue 12. [slideshare.net]

  Symptoms of tongue base tumors may be odynophagia (pain on swallowing food or fluid), otalgia (pain in the ear), or a mass in the neck. The mass is usually due to metastases that can be felt in three-quarters of cases at the time of the diagnosis. [medicinenet.com]

  CASE DESCRIPTION In December 2005, a 66-year-old woman presented to the otolaryngology clinic at our institution with mild dysphagia and a globus sensation, with no constitutional symptoms, odynophagia, or referred otalgia. [current-oncology.com]

• Referred Otalgia

   Referred otalgia results from innervation by V3,lesser palatine nerve, and the glossopharyngeal nerve.  Lymphatic into Level II nodes. 10. Floor of the Mouth 11. Tongue 12. [slideshare.net]

  CASE DESCRIPTION In December 2005, a 66-year-old woman presented to the otolaryngology clinic at our institution with mild dysphagia and a globus sensation, with no constitutional symptoms, odynophagia, or referred otalgia. [current-oncology.com]

  The evaluation of a patient with tongue cancer begins with a detailed history, specifically inquiring about tobacco and alcohol use, pain, weight loss, dysphagia and odynophagia, referred otalgia, hemoptysis, neck mass, hoarseness, and articulation difficulties [emedicine.medscape.com]

• Neck Mass

  A neck mass may, therefore, be the presenting complaint. A common staging system is used for all squamous cell carcinomas of the oral cavity, with tumor staging being based on size and extension into adjacent structures. [radiopaedia.org]

  Other symptoms include: A sore on the lip that doesn't heal Persistent lip pain or lip numbness A lump or thickening on the lip A white or red patch on the lip A neck mass Treatments for lip cancer Our goal is to treat lip cancer in ways that cause as [cancercenter.com]

• Headache

  Tianna ~ Age 17 ~ Stage IV Nasopharyngeal Cancer ~ Non Smoker TIANNA from Illinois Symptoms: Persistent headache and sore throat Treatment: Modified neck dissection, radiation and chemotherapy Delay in Diagnosis: 6 weeks I had a headache and a sore throat [sixstepscreening.org]

  The side effects of this treatment can include: fever headache vomiting diarrhea an allergic reaction skin rashes Although these treatments do have side effects, they’re often necessary in beating the cancer. [healthline.com]

• Cavitary Lesion

  There was a big cavitary lesion in the right lower lobe and bilateral multiple nodular lesions, some of which had cavity formation on computed tomography. [ncbi.nlm.nih.gov]

AIM: The aim of this study was to present the results of the surgical treatment of patients over and under 40, diagnosed with anterolateral carcinoma of the tongue. [ncbi.nlm.nih.gov]

If metastasis (such as to the local lymph nodes) is observed, then the prognosis is guarded or unpredictable Tumors in their early stage with complete excisional treatment typically have good prognosis In cases of metastasis, its prognosis depends upon [dovemed.com]

CONCLUSIONS: Bcl-2 is associated with aggressive disease, neck lymph node metastasis, and poor prognosis. Whereas Bax is related with histologic grade. [ncbi.nlm.nih.gov]

The etiology of the lesion was considered to be ischemia secondary to compression by the necrotic myocutaneous flap. [ncbi.nlm.nih.gov]

Thus, other factors should be investigated in order to explain the etiology of SCC in young patients. [indianjcancer.com]

Etiology 19. Etiology 20. [slideshare.net]

This study emphasizes the current clinico-epidemiological trends of carcinoma tongue in central India and needs more studies on this issue to tackle the situation efficiently. [ccij-online.org]

Key variants in OTSCC and their relationship with habits, clinical and epidemiological parameters. A. [f1000research.com]

"Epidemiology of oral cancer in Arab countries". Saudi Medical Journal. 37 (3): 249–55. doi : 10.15537/smj.2016.3.11388. PMC 4800887. [en.wikipedia.org]

Epidemiology and risk factors are similar to squamous cell carcinomas elsewhere in the upper aerodigestive tract, with tobacco smoking and alcohol ingestion being major risk factors 1-3,9. [radiopaedia.org]

The fact that expression of the immune-related proteins varied between HPV-positive and HPV-negative cases was considered to be linked to the stronger immune defense activity found in cases of HPV-positive TSCC/BOTSCC. [3] Pathophysiology The tongue is [emedicine.medscape.com]

The 5-year survival rate for patients with localized disease at diagnosis is 83%, compared with 32% for those whose cancer has spread. 1-3 Pathophysiology Oral cancer can develop in any part of the mouth, including the lips, gums, tongue, cheeks, and [uspharmacist.com]

Pathophysiology [ edit ] Oral squamous cell carcinoma is the end product of an unregulated proliferation of mucous basal cells. [en.wikipedia.org]

The role of the dental practitioner in detection and prevention of oral cancer: review of the literature. Dent Update. 2000;27:404-08. Yoleri L, Mavioglu H. [rarediseases.org]

Preventing mouth cancer The three most effective ways of preventing mouth cancer developing, or preventing it coming back after successful treatment, are: not smoking ensuring you don't drink more than the recommended weekly limits for alcohol eating [nhs.uk]

They have been shown to prevent most oral HPV infections. It is not clear yet whether they also are able to prevent oral cancers. [medlineplus.gov]