Three patients presented with ovarian cancer that was initially treated with paclitaxel and platinum-based compounds. [ncbi.nlm.nih.gov]

The present study demonstrated that topotecan has significant advantages in controlling disease-related symptoms 8. [erj.ersjournals.com]

Conference: 12th Annual ENETS Conference (2015) Category: Medical treatment - Chemotherapy Presenting Author: Dr. med. Leonidas Apostolidis [enets.org]

• Fever

  Treatment toxicities included low-grade fever and minimal headache. The duration of treatment response from IO topotecan was 18 weeks. The survival time from CNS recurrence in this patient was 13 months. [ncbi.nlm.nih.gov]

  […] or chills fever or chills irregular or fast breathing large welts on the face, eyelids, mouth, lips, or tongue lower back or side pain with fever or chills painful or difficult urination with fever or chills pinpoint red spots on skin puffiness or swelling [chealth.canoe.com]

  Call your doctor at once if you have: new or worsening cough, fever, trouble breathing; diarrhea with fever and stomach cramps; pain or burning when you urinate; or low blood cell counts--fever, chills, flu-like symptoms, mouth sores, skin sores, pale [drugs.com]

• Rigor

  Peer Review All articles undergo a rigorous, double-blind peer review, conducted by at least two independent experts in the field to ensure articles are balanced, objective, and relevant to the current clinical landscape. [touchoncology.com]

  URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. [umms.org]

  "Constitutional" is a composite term that includes fatigue ( lethargy, malaise, asthenia), fever (in the absence of neutropenia), rigors, chills, sweating, and weight gain or loss. [drugs.com]

  Clinical trials of topotecan have been conducted using rigorous definitions of response rate and stable disease [ 10 ]. [academic.oup.com]

  Indeed, of the available anticancer agents, only carboplatin has been rigorously evaluated in clinical pharmacodynamic models relating drug exposure and antitumor activity. [clincancerres.aacrjournals.org]

• Nausea

  Other adverse effects are abdominal pain, constipation, diarrhea, obstruction, nausea, stomatitis, vomiting, increased alanine aminotransferase and aspartate aminotransferase, anorexia, arthralgia, asthenia, headache, myalgia, pain, dyspnea, and total [medical-dictionary.thefreedictionary.com]

  NAUSEA This can happen on the first few days after chemotherapy. Your doctor will prescribe you antiemetic drugs to help prevent or control your nausea. It is easier to prevent nausea than it is to treat it once it has begun. [oncohealth.eu]

  Nausea, vomiting, diarrhea, tiredness, loss of appetite, weakness, and fever may occur. If these effects persist or worsen, tell your doctor or pharmacist promptly. Nausea and vomiting can be severe. [webmd.com]

  Nausea and vomiting were infrequent; many patients were pretreated with ondansetron or granisetron. A recurrent rash developed in 16 patients and was usually well controlled with diphenhydramine and hydrocortisone. [ncbi.nlm.nih.gov]

  Cancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen. [umms.org]

• Suggestibility

  Docking studies suggested that there are more interactions between the novel analogues and the binding site of Topo I. Copyright © 2014 Elsevier Ltd. All rights reserved. [ncbi.nlm.nih.gov]

  The drug's mechanism of action suggests a potential efficacy of drug combinations incorporating DNA-damaging agents. [link.springer.com]

• Withdrawn

  List item Human medicine European public assessment report (EPAR): Topotecan Actavis topotecan, Uterine Cervical Neoplasms, Small Cell Lung Carcinoma Date of authorisation: 24/07/2009,, Revision: 6, Withdrawn, Last updated: 07/03/2019 Public statement [ema.europa.eu]

  Treatment Cervical Cancers 1 2 Withdrawn Treatment Lung Cancers 1 2 Withdrawn Treatment Neuroblastomas 1 2 Withdrawn Treatment Prostate Cancer 1 2, 3 Active Not Recruiting Treatment Low Grade Ovarian Serous Adenocarcinoma / Micropapillary Serous Carcinoma [drugbank.ca]

  Voluntary written informed consent before performance of any study-related procedure not part of normal medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to future medical care. [clinicaltrials.gov]

• Renal Insufficiency

  The pharmacokinetics of topotecan have been extensively studied in patients with normal renal function and there is one study of patients with mild to moderate renal insufficiency. [ncbi.nlm.nih.gov]

• Insomnia

  Organisation for Research and Treatment of Cancer Quality of Life (EORTC QOL)-C30 questionnaire was also used to measure eight symptoms at baseline and during each course (pain, anorexia, diarrhoea, fatigue, nausea and vomiting, dyspnea, constipation and insomnia [academic.oup.com]

  Cancer Connect 3 days Cancer Survivorship: Insomnia and Sleep Disturbance Dr. Barrie Cassileth Chief of Integrative Medicine MSKCC. Mind body therapy, medication, exercise, CAM all play a role. [news.cancerconnect.com]

  (16.1) Progressive disease 257 (53.7) 158 (47.9) 99 (66.4) Not determined 55 (11.5) 35 (10.6) 20 (13.4) Table 3 Proportion of patients with SCLC treated with topotecan who had symptom improvement Symptom Patients showing improvement, n (%) N = 260 a Insomnia [ncbi.nlm.nih.gov]

We have included a review of the literature of weekly topotecan in the treatment of patients with gynecologic cancer. [ncbi.nlm.nih.gov]

Treatment Neoplasms, Breast 1 2 Terminated Treatment Neuroblastomas 1 2 Terminated Treatment Recurrent Ovarian Epithelial Cancer 1 2 Terminated Treatment Sarcomas 1 2 Unknown Status Treatment Cancer of the Ovary 1 2 Unknown Status Treatment Central Nervous [drugbank.ca]

As patients who relapse have a poor prognosis and treatment options are limited, there is an urgent need to develop new agents with novel mechanisms of action for use as a second-line, non-cross-resistant chemotherapy in ovarian cancer. [ncbi.nlm.nih.gov]

Govindan R, Page N, Morgensztern D, et al: Changing epidemiology of small-cell lung cancer in the Untied States over the last 30 years: Analysis of the surveillance, epidemiologic, and end results database. [jco.ascopubs.org]

One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008Jan20; 26 :3063-3072 10. [jcancer.org]

Epidemiology. 24, 337–8 (2013). 24. Anonymous Wilson, E. B. Probable inference, the law of succession, and statistical inference. J. Am. Stat. Assoc. 22, 209–212 (1927). 25. Higgins, J. P., Thompson, S. G., Deeks, J. J. & Altman D. G. [nature.com]

The pathophysiology of these effects is unknown. These effects may relate to intestinal damage due to unabsorbed drug. (b) Hematological toxicity was the predominant toxicity associated with shorter administration schedules. [clincancerres.aacrjournals.org]

Following treatment with camptothecin, endogenous or overexpressed PPARγ becomes destabilized; this was prevented in the presence of MG132, a proteasome inhibitor. [ncbi.nlm.nih.gov]

Topotecan binds to the topoisomerase I-DNA complex and prevents religation of these single strand breaks. [centerwatch.com]

Cancer Connect 3 days Overview of Melanoma Melanoma: Signs & Symptoms, Diagnosis, Screening, Prevention & Early Detection Cancer Connect 3 days Sunscreen May Reduce Risk of Melanoma Regular use of sunscreen may help prevent melanoma. [news.cancerconnect.com]