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Toxic Effect


Presentation

  • CAP itself and NAPD presented some toxic effect at high concentration (1-2.10(-3) M). CAPG and HAP did not present any cytotoxic effect.[ncbi.nlm.nih.gov]
  • A 10 year-old female patient presented to the outpatient unit of the ophthalmology department of Menelik II Hospital with complaints of inward deviation of the left eye, of three weeks' duration.[ncbi.nlm.nih.gov]
  • Abstract Steroidal glycoalkaloids present in Solanaceae are toxic compounds biosynthesised for the protection of the plants. However, many health benefits of these compounds have been reported so far.[ncbi.nlm.nih.gov]
  • Abstract New advances in the use of NG108-15 cells for marine toxins detection and quantification are presented.[ncbi.nlm.nih.gov]
  • Abstract In the present study, the antiproliferative potential of various solvent extracts of Gracilaria edulis (GE) was tested against various cancer cell lines.[ncbi.nlm.nih.gov]
Anosmia
  • […] unusually rapid heart beat (tachycardia); low levels of iron within the red blood cells (anemia); bluish discoloration (cyanosis) of the skin and mucous membranes due to insufficient oxygen supply to these tissues; and/or an impaired sense of smell (anosmia[rarediseases.org]
Neck Mass
  • The herb was recommended by either traditional Chinese medical doctors or herbal pharmacies for postpartum recovery and treatment of a neck mass, hepatoma, lumbago and dysmenorrhoea.[ncbi.nlm.nih.gov]

Workup

Trichophyton Mentagrophytes
  • Cadmium showed high toxicity effects on isolated fungi at minimal inhibitory concentration of 27 μg ml(-1) for Trichophyton mentagrophytes and of 20 μg ml(-1) for Epidermophyton floccosum, while iron enhanced dermatophytic growth.[ncbi.nlm.nih.gov]

Treatment

  • Moreover, only a few side effects have been reported for this treatment method.[ncbi.nlm.nih.gov]
  • Imatinib is an Abl tyrosine kinase inhibitor used in the treatment of patients with chronic myeloid leukemia. The pre-treatment with DHA for 24 h raised the effect of imatinib at 100 microM concentration only.[ncbi.nlm.nih.gov]
  • The herb was recommended by either traditional Chinese medical doctors or herbal pharmacies for postpartum recovery and treatment of a neck mass, hepatoma, lumbago and dysmenorrhoea.[ncbi.nlm.nih.gov]
  • The results of combined treatment revealed reduced toxicity at the level of fresh biomass, protein content, and chlorophyll; however, the amount of nonenzymatic antioxidant did not significantly (P 0.172) increase as compared to alone treatment.[ncbi.nlm.nih.gov]
  • In each of the two treatment groups, BMDs (measured in grams per square centimeter) were measured at five standard sites (ie, lumbar spine, femoral neck, trochanter, Ward's triangle, and radius) and evaluated against a standardized database to control[ncbi.nlm.nih.gov]

Prognosis

  • Prognosis Premaculopathy is fully reversible [1]. True bull’s eye maculopathy is irreversible. Most patient’s vision remains stable after cessation of treatment. Occasionally, patient’s vision will continue to worsen [1].[eyewiki.aao.org]
  • Patients with cholestatic hepatitis have a better prognosis. Acute cellular necrosis is indistinguishable from viral hepatitis, which is why extremely high aminotransferase levels can be found.[scielo.br]

Etiology

  • Abstract Some Chloramphenicol (CAP) metabolites are suspected to be involved in the etiology of bone marrow aplasia in man.[ncbi.nlm.nih.gov]

Epidemiology

  • Seite 69 - Epidemiology is defined as the study of the distribution and determinants of health-related states or events in specified populations, and the application of this study to control of health problems. ‎[books.google.de]
  • الصفحة 69 - Epidemiology is defined as the study of the distribution and determinants of health-related states or events in specified populations, and the application of this study to control of health problems. ‏[books.google.com]
  • Epidemiology. 1999 ; 10 : 370 – 375 Grandjean P, Weihe P, Burse VW, et al. Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants.[pediatrics.aappublications.org]
  • Another very large scale epidemiology study, led by Habibul Ahsan at the University of Chicago in the US, has provided further proof of the scale of the problem.[rsc.org]
  • Mechanism and epidemiology of bone effects cadmium. IARC Sci Publ 1992 ; 118: 301 – 10. Google Scholar 25. Chambers, RC, McNaulty, RJ, Shock, A, Campa, JS, Newman Taylor, AJ, Laurent, GJ.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • Effective strategies to prevent and treat AD remain elusive despite major efforts to understand its basic biology and clinical pathophysiology. Significant investments in therapeutic ...[doi.org]
  • Pathophysiology Hydroxychloroquine binds to melanin, accumulates in the RPE, and remains there for long periods of time. It is directly toxic to the RPE, causing cellular damage and atrophy [2].[eyewiki.aao.org]

Prevention

  • The best advice to affected individuals is to prevent paresthesia from occurring through appropriate hygiene measures and personal protection.[ncbi.nlm.nih.gov]
  • In conclusion, cadmium and silver are regarded to be the effective metals to prevent the development of two isolated species of dermatophytes. Growth of fungi in the presence of iron was greater than control.[ncbi.nlm.nih.gov]
  • This theory enables us to understand the relationship between humans and diseases by thinking from evolutional perspective, shows an important help for preventive medicine, and is meaningful to consider the future human healthcare.[ncbi.nlm.nih.gov]
  • However, it is not possible to determine a NOEL for non-genotoxic effects. 4-HR could become an interesting alternative to the use of sulphites to prevent black spot. However, a more complete database is needed to achieve a regulatory evaluation.[ncbi.nlm.nih.gov]
  • These results suggest that the enzyme, in the presence of the apolipoproteins, converts 24(S)OH-C into esters restricted to the extracellular environment, thus preventing or limiting oxysterol-induced neurotoxic injuries to neurons in culture. 24-hydroxycholesterol[ncbi.nlm.nih.gov]

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