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2.1
Toxic Effect of Benzene
Benzene

Presentation

Cigarette smoke is also responsible for most of the benzene present in indoor environments. Smokers and non-smokers alike are exposed to benzene when they breathe in secondhand smoke. [verywellmind.com]

These mechanisms are complex, affecting not only the DNA, but also the complex intercellular interactions present in the bone marrow microenvironment. [ncbi.nlm.nih.gov]

Gamma benzene hexachloride is present in several products sold under a number of trade names. [jamanetwork.com]

Entire Body System

  • Anemia

    These people have been found to display anemia, leucopenia, and/or thrombocytopenia. [ncbi.nlm.nih.gov]

    Pancytopenia causes chronic anemia and increases risk for serious infections. The low platelet count may cause uncontrolled bleeding. Aplastic Anemia Chronic benzene exposure may cause aplastic anemia, which is a more advanced form of pancytopenia. [livestrong.com]

    Lyon 9:227-233 (1928); Andre, R., et al., "[Grave hemolytic anemia associated with thrombopenic purpura haemorrhagica; probable role of benzol; massive transfusion, splenectomy, recovery]; Bull. Mem. Soc. Hem. [toxictorts.com]

    Diseases Caused From Benzene Aplastic Anemia Also called bone marrow aplasia, aplastic anemia causes your bone marrow's production of blood cells to decrease. [amlbenzene.net]

  • Fishing

    Portable gas was created by dropping whale or fish oil into a hot furnace, compressing the gas which was created and then storing it in containers to use in lamps in private and public buildings. [rigb.org]

    The majority of toxicity studies about the effects of pollution on aquatic organisms under controlled conditions have used either fish or the cladoceran Daphnia magna and there are few studies reported using rotifers. [osti.gov]

    Additional data for bacteria (one species), invertebrates (five species) and fish (two species) were summarised by Hedgecott and Lewis (1997). All from acute studies, apart from one chronic study with an edible crab Scylla serrata. [ukmarinesac.org.uk]

    When aquatic life, like fish, shellfish and other creatures in our rivers, lakes and oceans, is exposed to benzene, it makes them sick and can stop them from having babies. [npi.gov.au]

    In fish and other wildlife, low levels of selenium cause deficiency while high levels cause toxicity. Lead is very toxic and lead compounds in exhaust gases escape into the atmosphere causing pollution. [fi.bab.la]

  • Fatigue

    Some of the side effects of Benzene exposure include: Fatigue Malaise Abnormal bleeding Excessive bruising Weakness Reduced tolerance to exercise Weight loss Bone or joint pain Infection and fever Abdominal pain or discomfort Enlarged spleen, lymph nodes [cleanwaterpartners.org]

    This may be followed by a period of depression, drowsiness, or fatigue. Headache, dizziness, nausea, or a feeling of intoxication may develop. A sensation of tightness in the chest may occur, accompanied by breathlessness. [apps.leg.wa.gov]

    Nearly a decade of chemotherapy, along with diabetes and a rare bowel disorder, have left him battling what he calls “absolutely ridiculous” fatigue. Retired and on disability, he remembers returning to work twice. [publicintegrity.org]

    He had spent the day slumped in a stroller, looking so pale and fatigued that a stranger stopped her to ask if he was all right. It was an encounter Jill couldn’t shake. [theguardian.com]

    He expresses concern that he becomes easily fatigued at work, and 2 months ago he began noticing bruises on his arms and legs, although he does not recall the causes. [nap.edu]

  • Fever

    Some of the side effects of Benzene exposure include: Fatigue Malaise Abnormal bleeding Excessive bruising Weakness Reduced tolerance to exercise Weight loss Bone or joint pain Infection and fever Abdominal pain or discomfort Enlarged spleen, lymph nodes [cleanwaterpartners.org]

    For example, conditions that first bring the patient to medical attention are typically fever due to infection or manifestations of thrombocytopenia, such as hemorrhagic diathesis with bleeding from the gums, nose, skin, gastrointestinal tract, or elsewhere [nap.edu]

  • Malaise

    Some of the side effects of Benzene exposure include: Fatigue Malaise Abnormal bleeding Excessive bruising Weakness Reduced tolerance to exercise Weight loss Bone or joint pain Infection and fever Abdominal pain or discomfort Enlarged spleen, lymph nodes [cleanwaterpartners.org]

Cardiovascular

  • Tachycardia

    In one case report, an oral dose of 10 milliliters (mL) was reported to produce staggering gait, vomiting, tachycardia, pneumonitis, somnolence, delirium, seizures, coma, and death. [nap.edu]

Psychiatrical

  • Denial

    Rely on TCI and avoid unspecified code denials once and for all. [books.google.de]

  • Euphoria

    “Benzol jag” is a term workers use to describe symptoms of confusion, euphoria, and unsteady gait associated with acute benzene exposure. [nap.edu]

Neurologic

  • Tremor

    However, due to acute effects like tremor and convulsions only rather low doses could be tested. Simultaneous administration of toluene dramatically reduced the toxicity of benzene, but gave only a small reduction of the hydroquinone-induced effects. [ncbi.nlm.nih.gov]

    […] high dose of benzene all at once, this kind of exposure through inhalation or ingestion damages the central nervous system and can lead to some dramatic symptoms: Paralysis Coma Convulsions Dizziness Sleepiness Rapid heart rate Tightness in the chest Tremors [verywellmind.com]

    Unconsciousness, tremors and restlessness have been observed. The chemical can cause severe injury to the liver and kidneys. Data indicate that chlorobenzene does not affect reproduction or cause birth defects. [greenspec.co.uk]

    Symptoms of benzene exposure People who breath in high levels of benzene may develop the following signs and symptoms drowsiness dizziness rapid or irregular heart rate headaches tremors confusion and unconsciousness In most cases people will stop feeling [sahealth.sa.gov.au]

    In severe inhalation cases, tremors, convulsions, and death may follow due to respiratory paralysis or circulatory collapse in a few minutes to several hours. [apps.leg.wa.gov]

  • Giddiness

    Acute effects from inhaling high vapor concentrations: An initial stimulatory effect on the central nervous system (brain and spinal cord) can occur, characterized by exhilaration, nervous excitation (irritability), and/or giddiness. [apps.leg.wa.gov]

Treatment

Water from the Tarawa Terrace Treatment Plant was contaminated by PCE (perchloroethylene or tetrachloroethylene). [atsdr.cdc.gov]

Intensive treatment is necessary to prevent death. Inhalation Injuries Benzene irritates the linings of the airways. Exposure to low concentration benzene vapors can cause inflammation of the nasal airways and throat. [livestrong.com]

How well someone does depends on how much benzene they swallowed and how quickly they receive treatment. The faster medical help is given, the better the chance for recovery. Benzene is very poisonous. Poisoning can cause rapid death. [medlineplus.gov]

The most important thing is for victims to seek medical treatment as soon as possible. [emergency.cdc.gov]

× Treatment and Management Acute Exposure ❑ There is no antidote for acute benzene poisoning. ❑ Treatment for benzene toxicity is supportive and symptomatic. Treatment for persons acutely exposed to benzene is generally supportive and symptomatic. [nap.edu]

Prognosis

Prof. 91:274-277 (1948); Morel, P., et al., "[Blood platelets in the diagnosis and prognosis of benzol poisoning]," Bull. Soc. Med. [toxictorts.com]

Severe aplastic anemia typically has a poor prognosis and can progress to leukemia, whereas pancytopenia may be reversible. [nap.edu]

Etiology

The acceptance of benzene as an etiological agent in aplastic anemia in large measure derives from our ability to reproduce the disease in most animals treated with sufficiently high doses of benzene over the necessary time period. [ncbi.nlm.nih.gov]

Epidemiology

The epidemiologic literature shows that benzene is the chemical most strongly associated with CML. [amlbenzene.net]

In a deposition, the scientist touted the research, saying it “inform[ed] with respect to disease specificity to a much greater degree than other previous epidemiological studies.” [publicintegrity.org]

Health Perspect. 82:193-197 (1989); Niazi, G.A., et al., "Blood Dyscrasia in Unofficial Vendors of Petrol and Heavy Oil and Motor Mechanics in Nigeria," Tropical Doctor 19:55-58 (1989); Rothman, N., et al., "An Epidemiologic Study of Early Biologic Effects [toxictorts.com]

Mr President, although the BSE crisis was of an epidemiological nature and the dioxin crisis of a toxic nature, they share worryingly similar characteristics. expand_more Arvoisa puhemies, vaikka BSE-kriisi oli luonteeltaan epidemiologinen ja dioksiinikriisi [fi.bab.la]

Rothman N. et al., «An Epidemiologic Study of Early Biologic Effects of Benzene in Chinese Workers.» Environmental Health Perspectives. [csst.qc.ca]

Prevention

Centers for Disease Control and Prevention has information about how you can protect yourself and what to do if you are exposed. Selected References: International Agency for Research on Cancer. [cancer.gov]

Regulations are now in place in the U.S. to control benzene exposure in the workplace and prevent occupationally induced leukemias. [livestrong.com]

Inhalation: Take precautions to prevent a fire (e.g. remove sources of ignition). Take precautions to ensure your own safety before attempting rescue (e.g. wear appropriate protective equipment). Move victim to fresh air. [ccohs.ca]

Receive information and training (in a language and vocabulary the worker understands) about workplace hazards, methods to prevent them, and the OSHA standards that apply to their workplace. Review records of work-related injuries and illnesses. [osha.gov]

[email protected] Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Pocket Guide to Chemical Hazards [emergency.cdc.gov]

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