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Toxic Effect of Chlorine Gas
Toxic Eff Chlorine Gas

Presentation

Many impurities in the water require a large amount of chlorine to react with all the impurities present. The chlorine added must first react with all the impurities in the water before a chlorine residual is present. [safewater.org]

Figure 1 Discussion People usually present after inhalation of noxious smoke or chemicals and may present with cough, shortness of breath and wheezing 1, 2 and sometimes lower epithelial damage with inhalation pneumonitis. [ispub.com]

Disinfecting Water : Chlorine is often present in chemicals used to kill bacteria in drinking water and swimming pools. Chlorine is very effect against e coli bacteria. [ivyroses.com]

Patients were placed in control and treatment groups in a sequential odd-even fashion based on their order of presentation. Treatment of all patients included corticosteroids and nebulized short-acting beta2-agonists. [ncbi.nlm.nih.gov]

Otherwise, treatment is primarily supportive and patients should be observed closely for resolution of the primary presenting symptoms and signs. [clinicaladvisor.com]

Entire Body System

  • Fatigue

    Since poly neuropathy and fatigue could be caused by pesticides or other poisoning, i.e. heavy metals, we have been consulted for taking a detailed exposure history. [occup-med.biomedcentral.com]

    Most symptoms improved, including disturbances such as rigor, muscle pain or cramps, hypersomnia, increased libido, sweating, fatigue, concentration, and anxiety. [gjpsy.uni-goettingen.de]

    Chlorine's odor provides adequate early warning of its presence, but also causes olfactory fatigue or adaptation, reducing awareness of one's prolonged exposure at low concentrations IMMEDIATE SYMPTOMS OF CHLORINE EXPOSURE 10.  Ingestion: Since chlorine [slideshare.net]

    Patients who were closer to the accident spot more frequently complained of symptoms such as shortness of breath, sore throat, eye pain, itching, dizziness, anxiety, general weakness, and fatigue. [aoemj.biomedcentral.com]

    The strong “rotten egg” odor of the gas is not a reliable warning sign for toxicity due to olfactory fatigue at high concentrations or continuous low concentrations. [clinicaladvisor.com]

  • Collapse

    Bleeding is contra-indicated if the patient is pale and collapsed. References: On the Treatment of Wounds in War, London, 1915. Sir J. R. Bradford and T. R. Elliott : British Journal of Surgery, III. 234, 1915. J. Elliott Black, E. T. Glenny, and J. [vlib.us]

    Loss of vision Severe pain in the throat Severe pain or burning in the nose, eyes, ears, lips, or tongue GASTROINTESTINAL SYSTEM Blood in the stool Burns of the food pipe (esophagus) Severe abdominal pain Vomiting Vomiting blood HEART AND BLOOD VESSELS Collapse [medlineplus.gov]

    […] and swallowing difficulties due to swelling of tongue and throat Severe skin irritation and burns (perforations on the skin may be observed) Loss of vision Severe stomach pain Blood in stool and vomit Sudden decrease in blood pressure (hypotension) Collapse [dovemed.com]

    A collapse in the housing market - as Spain suffered in recent years - can make it more expensive to manufacture staple products like soap and paper, which rely on sodium. But PVC is just one of chlorine's many industrial applications. [bbc.co.uk]

    " They finally made it to the warehouse, where Mejia collapsed. More than a year later, the ghost of a chlorine cloud lingers like a vivid nightmare at Tulare Iron and Metal Inc., located in the heart of California’s Central Valley. [scientificamerican.com]

  • Gastric Lavage

    lavage ) Washing of the skin (irrigation) -- perhaps every few hours for several days How well a person does depends on the amount of poison swallowed and how quickly treatment is received. [medlineplus.gov]

    lavage for elimination of the chemical from the stomach (irrigation using special solutions) Administer medications to counter the effects of the ingested substance Administer activated charcoal to avoid absorbance of the substance in the body Wash skin [dovemed.com]

  • Hypersomnia

    Most symptoms improved, including disturbances such as rigor, muscle pain or cramps, hypersomnia, increased libido, sweating, fatigue, concentration, and anxiety. [gjpsy.uni-goettingen.de]

Respiratoric

  • Cough

    [Medscape] High-level chlorine (20%, >30 ppm) acute exposure symptoms [Medscape]: Dyspnea: Upper airway swelling and obstruction may occur Violent cough Nausea and vomiting (with the smell of chlorine in emesis) Lightheadedness Headache Chest pain or [drmz13.wordpress.com]

    Mouth and Throat Irritant Chlorine gas exposure within the mouth and throat causes coughing and throat and mouth dryness. Breathing difficulty and chronic coughing will only result at high concentrations of chlorine gas. [sciencing.com]

    Coughing and bloody nose or sputum. 5 - 10 Moderate upper respiratory irritation 10 - 20 Intense upper respiratory irritation 30 Chest pain, vomiting dyspnoea and cough Clinical features: Respiratory: Cough, sore throat, chest tightness, rhinorrhoea, [lifeinthefastlane.com]

    Exposure to chloramine gases can cause the following symptoms: Coughing. Nausea. Shortness of breath. Watery eyes. Chest pain. Irritation to the throat, nose, and eyes. Wheezing. Pneumonia and fluid in the lungs. [doh.wa.gov]

    Conclusion Our patient initially presented with cough, progressive shortness of breath and chest pain. In view of infiltrate on chest x-ray and CT scan, she was started on antibiotics. [ispub.com]

  • Sore Throat

    Exposure to chloramine causes irritation to the eyes, nose, throat and airway. Symptoms include teary eyes, runny nose, sore throat, coughing and chest congestion. [chop.edu]

    Their most frequent chief complaints was headache (22.7%), followed by eye irritation (18.2%), nausea (11.3%), and sore throat (10.8%). [aoemj.biomedcentral.com]

    Around 150 people needed hospital treatment for burning eyes, vomiting and sore throats after the mystery gas came ashore near Beachy Head on Sunday afternoon. [telegraph.co.uk]

    Coughing and bloody nose or sputum. 5 - 10 Moderate upper respiratory irritation 10 - 20 Intense upper respiratory irritation 30 Chest pain, vomiting dyspnoea and cough Clinical features: Respiratory: Cough, sore throat, chest tightness, rhinorrhoea, [lifeinthefastlane.com]

    Following chlorine exposure, the most common symptoms are: Airway irritation Wheezing Difficulty breathing Sore throat Cough Chest tightness Eye irritation Skin irritation The severity of health effects depend upon the route of exposure, the dose and [health.ny.gov]

  • Dyspnea

    [Medscape] High-level chlorine (20%, >30 ppm) acute exposure symptoms [Medscape]: Dyspnea: Upper airway swelling and obstruction may occur Violent cough Nausea and vomiting (with the smell of chlorine in emesis) Lightheadedness Headache Chest pain or [drmz13.wordpress.com]

    The most common symptoms were dyspnea (82%) and chest tightness (82%). Baseline characteristics of both groups were similar. Compared to the placebo group, the NSB group had significantly higher FEV1 values at 120 and 240 min (p < .05). [ncbi.nlm.nih.gov]

    Upon exposure to chlorine gas, he experienced dyspnea and presented to the emergency department. [aoemj.biomedcentral.com]

    She had severe resting dyspnea during the second hour, diffuse crackles/rhonchi on auscultation, and a partial pressure of oxygen of 32 mm Hg breathing room air. The radiograph shows diffuse pulmonary edema without significant cardiomegaly. [emedicine.medscape.com]

    CASE REPORT A 25-year-old man came to the Hahnemann University Hospital Emergency Room with severe dyspnea. He had a history of mild childhood asthma, which had resolved at the age of 5 years. [nap.edu]

  • Sneezing

    Showering with unfiltered water may also cause the following symptoms: Sneezing Tightness in chest Weak cough Mild sore throat Increased dryness in throat Irritation in nasal passages Apart from monitoring the chlorine content in pools, invest in carbon [filterwater.com]

    There will generally be sneezing, nose irritation, burning sensation, and throat irritation. There may also be skin irritation or chemical burns and eye irritation or conjunctivitis. [en.wikipedia.org]

    Initial German Experiments In the capture of Neuve Chapelle in October 1914 the German army fired shells at the French which contained a chemical irritant whose result was to induce a violent fit of sneezing. [firstworldwar.com]

    Manifestations are as follows: Eye tearing, nose and throat irritation Sneezing Excess salivation General excitement or restlessness High-level (20%, >30 ppm) acute exposure In addition to the symptoms seen with low-level exposure, high-level exposure [emedicine.medscape.com]

    Fragrances added to many cleaners, most notably laundry detergents and fabric softeners, may cause acute effects such as respiratory irritation, headache, sneezing, and watery eyes in sensitive individuals or allergy and asthma sufferers. [organicconsumers.org]

  • Painful Cough

    cough, eye irritation, increased heartbeat, rapid breathing, and death. [globalhealingcenter.com]

    Frequent and painful coughing occurs and some frothy sputum is brought up. [vlib.us]

    […] to high-concentration chlorine products Esophageal perforation Chronic exposure Manifestations of chronic exposure include the following: Acne (chloracne) Chest pain Cough Sore throat Hemoptysis Findings on physical examination may include the following [emedicine.medscape.com]

Gastrointestinal

  • Vomiting

    [Medscape] High-level chlorine (20%, >30 ppm) acute exposure symptoms [Medscape]: Dyspnea: Upper airway swelling and obstruction may occur Violent cough Nausea and vomiting (with the smell of chlorine in emesis) Lightheadedness Headache Chest pain or [drmz13.wordpress.com]

    Headache, vomiting and fainting occur after a long exposure at high concentrations. Skin Irritant Skin exposed to chlorine gas can become frostbitten. The gas fuses into the skin cells and under the epidermal layer. [sciencing.com]

    Vomiting blood HEART AND BLOOD VESSELS Collapse Low blood pressure that develops rapidly SKIN Burns Holes (necrosis) in the skin or tissues underneath Irritation Seek medical help right away. [medlineplus.gov]

    […] in the affected individual Otherwise, following an ingestion of the substance, immediately give milk or water to drink In case of symptoms that indicate difficulty in swallowing including vomiting or decreased alertness, do not give anything by way of [dovemed.com]

    Don’t try to induce vomiting unless instructed by poison control or a medical professional. If you get chlorine on your skin, immediately wash it with soap and water. [healthline.com]

  • Nausea

    [Medscape] High-level chlorine (20%, >30 ppm) acute exposure symptoms [Medscape]: Dyspnea: Upper airway swelling and obstruction may occur Violent cough Nausea and vomiting (with the smell of chlorine in emesis) Lightheadedness Headache Chest pain or [drmz13.wordpress.com]

    Nausea. Shortness of breath. Watery eyes. Chest pain. Irritation to the throat, nose, and eyes. Wheezing. Pneumonia and fluid in the lungs. [doh.wa.gov]

    Their most frequent chief complaints was headache (22.7%), followed by eye irritation (18.2%), nausea (11.3%), and sore throat (10.8%). [aoemj.biomedcentral.com]

    Drinking levels over 4 ppm can cause throat and stomach irritation, nausea and vomiting. By testing lung function and examining your skin and teeth, your doctor can evaluate the health effects of chlorine exposure. [dhs.wisconsin.gov]

    […] difficulty Water filling the lungs Pain or burning in the nose, lips or tongue Low blood pressure Changes in pH balance in the blood When a person swallowing chlorine or a product or liquid containing chlorine, they may experience the following symptoms: Nausea [symptomfind.com]

  • Choking

    'I want him [Assad] to see the faces of the children who woke up choking in the middle of the night.' [aljazeera.com]

    Chlorine is a poisonous, greenish-yellow gas described as having a choking odor. It is a very corrosive, hazardous chemical. [dhs.wisconsin.gov]

    Phosgene as a weapon was more potent than chlorine in that while the latter was potentially deadly it caused the victim to violently cough and choke. [firstworldwar.com]

    At room temperature, it is a greenish-yellow gas with a choking smell, which is denser than air. [newsweek.com]

    […] that long-term exposure to chlorinated pools can cause symptoms of asthma in swimmers. [ 2 ] This can affect athletes who were previously healthy, especially adolescents. [ 3 ] Chlorine is even toxic enough to be a chemical weapon and categorized as a “choking [globalhealingcenter.com]

  • Abdominal Pain

    […] balance in the blood When a person swallowing chlorine or a product or liquid containing chlorine, they may experience the following symptoms: Nausea Vomiting (sometimes blood) Abdominal pain Burning in the throat or esophagus Blood in the stool In severe [symptomfind.com]

    […] in the throat Severe pain or burning in the nose, eyes, ears, lips, or tongue GASTROINTESTINAL SYSTEM Blood in the stool Burns of the food pipe (esophagus) Severe abdominal pain Vomiting Vomiting blood HEART AND BLOOD VESSELS Collapse Low blood pressure [medlineplus.gov]

    Skin: Irritation to the eyes, nose, throat, mucous membranes Other: Headache, fever, tachycardia, abdominal pain, dizziness and confusion. Supportive Care Bronchodilators should be used for bronchospasm. [lifeinthefastlane.com]

    A 59-year-old man with fatigue, abdominal pain, anemia, and abnormal liver function. N Engl J Med. 2014;370:1542–50. View Article PubMed Google Scholar Kwon SY, Bae ON, Noh JY, Kim K, Kang S, Shin YJ, Lim KM, Chung JH. [occup-med.biomedcentral.com]

Cardiovascular

  • Chest Pain

    [Medscape] High-level chlorine (20%, >30 ppm) acute exposure symptoms [Medscape]: Dyspnea: Upper airway swelling and obstruction may occur Violent cough Nausea and vomiting (with the smell of chlorine in emesis) Lightheadedness Headache Chest pain or [drmz13.wordpress.com]

    Chest pain. Irritation to the throat, nose, and eyes. Wheezing. Pneumonia and fluid in the lungs. [doh.wa.gov]

    Conclusion Our patient initially presented with cough, progressive shortness of breath and chest pain. In view of infiltrate on chest x-ray and CT scan, she was started on antibiotics. [ispub.com]

    Immediately or shortly after exposure to 30 ppm or more of chlorine gas, a person may have: Chest pain Vomiting Coughing Difficulty breathing Excess fluid in their lungs Exposure to 430 ppm in air for 30 minutes will cause death. [dhs.wisconsin.gov]

    pains, cough, eye irritation, increased heartbeat, rapid breathing, and death. [globalhealingcenter.com]

  • Cyanosis

    Of interest is the treatment of cyanosis by bleeding. [vlib.us]

    Early cyanosis carries a near-hopeless prognosis. Gastroenterological : nausea and vomiting, oesophageal perforation at high levels. Neurological : headache, disorientation. [patient.info]

    […] high-concentration chlorine products Esophageal perforation Chronic exposure Manifestations of chronic exposure include the following: Acne (chloracne) Chest pain Cough Sore throat Hemoptysis Findings on physical examination may include the following: Tachypnea Cyanosis [emedicine.medscape.com]

    […] developed classic early signs and symptoms of acute exposure. 3 Two children, after brief exposure to fumes from solid chlorine products used in residential pools in Nebraska in 1986, developed lethargy, productive cough, severe hypoxaemia, tachypnoea, cyanosis [oem.bmj.com]

Eyes

  • Blepharospasm

    Dose ppm Signs and symptoms 0.02 - 0.2 Odour threshold 1 - 3 Mild irritation to eyes, nose and throat 3 - 6 Itching, stinging, and boring of the eyes, lacrimation, blepharospasm, burning in the nose and throat. [lifeinthefastlane.com]

    Eye irritation - red eyes, tearing, blepharospasm. ENT irritation: chronic sore throat, rhinorrhoea, hypersalivation, stridor. [patient.info]

    […] during exertion) Tachycardia Wheezing Intercostal retractions Decreased breath sounds Rales (pulmonary edema) Nasal flaring Aphonia, stridor, or laryngeal edema Ulceration or hemorrhage of the respiratory tract Rhinorrhea Lacrimation, salivation, and blepharospasm [emedicine.medscape.com]

  • Burning Eyes

    Around 150 people needed hospital treatment for burning eyes, vomiting and sore throats after the mystery gas came ashore near Beachy Head on Sunday afternoon. [telegraph.co.uk]

    Corrosive chemicals can cause severe burns on eyes, skin and, if ingested, on the throat and esophagus. [organicconsumers.org]

    eyes when bleach/hypochlorite is used for disinfection). [coachsci.sdsu.edu]

  • Eye Pain

    9 12.3 13 10.0 22 10.8 0.608 Dental pain 24 32.9 35 26.9 59 29.1 0.370 Eye Eye pain 31 42.5 31 23.8 62 30.5 0.006 Eye redness 8 11.0 12 9.2 20 9.9 0.692 Blurred vision 9 12.3 11 8.5 20 9.9 0.375 Skin Itching 13 17.8 9 6.9 22 10.8 0.017 Nerve Headache [aoemj.biomedcentral.com]

Neurologic

  • Convulsions

    Those who are having trouble swallowing due to vomiting, convulsions, etc. should not receive anything to drink. If chlorine is inhaled: Get to an area with fresh air immediately. [symptomfind.com]

    If the exposure was great enough, that can progress to convulsions, paralysis, and death within 1 to 10 minutes. [theatlantic.com]

    If you accidentally swallow chlorine, drink milk or water immediately, unless you experience vomiting or convulsions. If you inhale chlorine, seek fresh air as soon as possible. [healthline.com]

    DO NOT give water or milk if the patient is having symptoms (such as vomiting, convulsions, or a decreased level of alertness) that make it hard to swallow. If the person breathed in the poison, immediately move the person to fresh air. [medlineplus.gov]

Workup

He was admitted to Hahnemann University Hospital for management of an acute exacerbation of his illness and a diagnostic workup. Physical examination revealed an afebrile, cushingoid patient in moderate respiratory distress. [nap.edu]

Laboratory examinations including blood, sputum cultures were sterile and all immunological workup were negative and work up for infective and connective tissue disorder did not reveal any abnormality .Chest x-ray revealed bilateral consolidation and [ispub.com]

See Workup for more detail. [emedicine.medscape.com]

Treatment

Patients were placed in control and treatment groups in a sequential odd-even fashion based on their order of presentation. Treatment of all patients included corticosteroids and nebulized short-acting beta2-agonists. [ncbi.nlm.nih.gov]

Treatment: Both hydroxocobalamine or a combination of nitrite/sodium thiosulfate are approved for treatment of cyanide poisoning in the United States. [clinicaladvisor.com]

Chlorination may also be done as the final step in the treatment process, which is when it is usually done in most treatment plants. [safewater.org]

In addition, nearly 125 water treatment plants have switched from chlorine gas to liquid bleach or ultraviolet treatments, according to a 2008 Center for American Progress report. [foreffectivegov.org]

Prognosis

Early hypoxaemia has a poor prognosis. [patient.info]

The prognosis of Chlorine Poisoning is dependent on the amount of substance consumed, time between consumption and treatment, severity of the symptoms, as well as general health status of the patient If the individual can recover from the symptoms with [dovemed.com]

Chapter X describes the effects of chlorine gas poisoning, the patient's symptoms, prognosis and the treatment advocated in 1916. Of interest is the treatment of cyanosis by bleeding. [vlib.us]

9.1.1 Ingestion 9.1.2 Inhalation 9.1.3 Skin exposure 9.1.4 Eye contact 9.1.5 Parenteral exposure 9.1.6 Other 9.2 Chronic poisoning 9.2.1 Ingestion 9.2.2 Inhalation 9.2.3 Skin exposure 9.2.4 Eye contact 9.2.5 Parenteral exposure 9.2.6 Other 9.3 Course, prognosis [inchem.org]

Prognosis A majority of the patients with mild to moderate irritant exposure have a self-limited course with full recovery seen within 48 to 72 hours. [clinicaladvisor.com]

Etiology

Manifestation code identifies conditions for which it is important to record both the etiology and the symptom of the disease. [books.google.com]

However, blood and sputum cultures along with broncho-scopic examination did not reveal infective etiology and she did not improve, open lung biopsy was performed. [ispub.com]

See Etiology. Chlorine gas has also been used repeatedly as a chemical weapon. [3] The respiratory and mucous membrane irritant effects of chlorine have been well known for many years. [emedicine.medscape.com]

Epidemiology

Smoking or pre-existing lung conditions like asthma appear to increase the risk of long term complications. [1] Epidemiology [ edit ] In 2014, the American Association of Poison Control Centers reported that about 6000 exposures to chlorine gas in the [en.wikipedia.org]

Adult Blood Lead Epidemiology & Surveillance (Ables). https://wwwcdcgov/niosh/topics/ables/. Accessed 29 June 2016. National-Toxicology-Program. [occup-med.biomedcentral.com]

American Journal of Epidemiology, 123(4), 641-647. In September 1982, two Charlottesville, Virginia, residents were found by their dentists to have general erosion of dental enamel consistent with exposure to acid. [coachsci.sdsu.edu]

Epidemiology Due to lack of consistent diagnostic methods, the incidence of inhalation injury from all chemical irritants is not readily available. [clinicaladvisor.com]

These concerns about cancer risks associated with chemical contamination from chlorination by-products have resulted in numerous epidemiological studies. [pure-earth.com]

Pathophysiology

Fein A, Leff A, Hopewell PC: Pathophysiology and management of the complications resulting from fire and the inhaled products of combustion. Crit Care Med 8:94–98, 1980 PubMed CrossRef Google Scholar 50. [link.springer.com]

Pathophysiology Inhalation of toxic gases leads to injury through a variety of mechanisms. [clinicaladvisor.com]

Pathophysiology [ 10 ] Chlorine gas is classed as a pulmonary agent or choking agent (others include phosgene, diphosgene and chloropicrin). [patient.info]

[6] The Organization for the Prohibition of Chemical Weapons (OPCW) has confirmed that since 2013, chlorine gas has been the agent used in numberous chemical attacks in Syria affecting thousands of civilians and resulting in hundreds of deaths. [3] Pathophysiology [emedicine.medscape.com]

However, the health effects of chlorine inhalation after swimming pool accidents have been documented in only few studies, and have concentrated on pathophysiology, clinical presentation, and types of treatment. 3 4 Early physiological and clinical pulmonary [oem.bmj.com]

Prevention

Prevention Tips There are several ways you can help prevent chlorine poisoning, including: Read labels carefully when using household cleaning products and follow the instructions accordingly. [symptomfind.com]

How can incidents like this be prevented? Clearly label all chemical containers with the chemical's name and hazards. Use physically different containers for bleach and acid baths. Emphasize the hazard of accidentally mixing acid and bleach. [ehs.berkeley.edu]

[…] id=198&tid=36 Centers for Disease Control and Prevention. 2003. Public Health Emergency Preparedness and Response Sheets. U.S. Department of Health and Human Services. [health.ny.gov]

Ventilate the area to prevent the gas from accumulating, especially in confined spaces. Large spills or leaks: stop or reduce leak if safe to do so. Ventilate the area to prevent the gas from accumulating, especially in confined spaces. [ccohs.ca]

To prevent poisoning it is important to use and store products exactly as their labels say. Keep dangerous products where children can't get to them. Treatment for poisoning depends on the type of poison. [icdlist.com]

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