Presentation
Petroleum does contain many acutely toxic, chronically toxic, and carcinogenic compounds such as benzene, however, and we must assume that some of them are present in copper naphthenate. [beyondpesticides.org]
Data present means ± standard error based on 3 replicates with 10 fish each. [fisheriessciences.com]
In the present observation, the growth rate directly depending on the rate of food consumption in both size groups. [scialert.net]
Zinc chloride is corrosive and should not be used when copper fixtures are present. This product is toxic to fishes and aquatic invertebrates. Avoid contaminating water sources with zinc chloride. [bryophytes.science.oregonstate.edu]
Copper and other minerals present in the tailings — the waste left over after ore has been extracted from rock — make their way into soil and waterways. [dartmouth.edu]
Entire Body System
- Anemia
Hemolytic anemia and anuria can result and may be fatal. Indian childhood cirrhosis, non-Indian childhood cirrhosis, and idiopathic copper toxicity are probably identical disorders in which excess copper causes cirrhosis. [merckmanuals.com]
Complications If as little as 2gm of a copper salt are ingested, usually with suicidal intent, the resulting copper-induced hemolytic anemia and kidney damage are generally fatal. [diagnose-me.com]
Anemia. Copper is needed for iron metabolism. Therefore, an important cause of anemia, especially in women, is a copper imbalance. [metabolichealing.com]
Hemolytic anemia also occurs sporadically in Wilson's disease, the hemolysis is precipitous in these situations. [digitalfire.com]
According to eMedicine, symptoms of lead toxicity include headaches, low appetite, irritability, digestive problems, lethargy, insomnia, hypertension and iron deficiency anemia. [leaf.tv]
- Weight Gain
Low thyroid action results in a slower metabolism with weight gain, fatigue, low immunity, and feelings of cold. [holistic-back-relief.com]
The under-active thyroid can result in sluggishness, weight gain on the hips and legs, low body temperature and sensitivity to cold. Slow oxidizers tend to be more withdrawn, introverted and less emotionally expressive. [tvernonlac.com]
- Acutely Ill Patient
IV-Management of Toxicity : A-Clinical Examination : Careful history taking is essential to diagnose copper poisoning in acutely ill patients. [digitalfire.com]
- Falling
Zinc chloride should be applied just prior to fall rains or in the early spring. Effectiveness: Zinc chloride is effective in controlling mosses from one year up to five years. [bryophytes.science.oregonstate.edu]
Respiratoric
- Cough
MFF, or "brass founder’s ague," "zinc shakes," or "Monday morning fever" as it is variously known, is characterized by fever, headache, fatigue, dyspnea, cough, and a metallic taste occurring within 3-10 hours after exposure. [emedicine.medscape.com]
Inhalation of copper dust and fumes (from copper producing and processing facilities) can affect the respiratory tract causing coughing, sneezing, and pain in the chest. [dartmouth.edu]
The clinical picture is characterized initially by general symptoms : - weakness, - loss of appetite, - loss of weight; - dyspnea and cough. [digitalfire.com]
- Dyspnea
Symptoms of Exposure : May cause chills, flushing, fatigue, muscle and stomach aches, dyspnea, and nausea if fumes are inhaled. Dusts may irritate skin and eyes. [espimetals.com]
MFF, or "brass founder’s ague," "zinc shakes," or "Monday morning fever" as it is variously known, is characterized by fever, headache, fatigue, dyspnea, cough, and a metallic taste occurring within 3-10 hours after exposure. [emedicine.medscape.com]
The clinical picture is characterized initially by general symptoms : - weakness, - loss of appetite, - loss of weight; - dyspnea and cough. [digitalfire.com]
Gastrointestinal
- Nausea
However, death is rare, owing to copper sulfate's emetic properties : a-Mild forms Mild forms of poisoning produce only : -nausea, -vomiting, -diarrhea, -malaise. [digitalfire.com]
In prolonged contact with copper cooking utensils, an acidic food or beverage can dissolve milligram quantities of copper, sufficient to cause acute toxicity symptoms such as self-limited nausea, vomiting and diarrhea. [diagnose-me.com]
Typical Presentation of the Most Commonly Encountered Metals and Their Treatment (Open Table in a new window) Metal Acute Chronic Toxic Concentration Treatment Arsenic Nausea, vomiting, "rice-water" diarrhea, encephalopathy, MODS, LoQTS, painful neuropathy [emedicine.medscape.com]
According to the MedlinePlus website, symptoms of copper toxicity include nausea, vomiting, digestive discomfort, metallic taste, yellow skin and eyes, depression, anorexia and muscle weakness. [leaf.tv]
It also can adversely affect the gastrointestinal tract causing nausea and diarrhea. Liver and endocrine function may also be affected. [dartmouth.edu]
- Vomiting
Typical Presentation of the Most Commonly Encountered Metals and Their Treatment (Open Table in a new window) Metal Acute Chronic Toxic Concentration Treatment Arsenic Nausea, vomiting, "rice-water" diarrhea, encephalopathy, MODS, LoQTS, painful neuropathy [emedicine.medscape.com]
The symptoms of copper toxicity include nausea, vomiting and abdominal and muscle pain. Excessive body copper is usually removed with the use of specific chelating agents or by the consumption of high levels of zinc. [xbrain.co.uk]
Self-limited gastroenteritis with nausea, vomiting, and diarrhea may occur. [merckmanuals.com]
In prolonged contact with copper cooking utensils, an acidic food or beverage can dissolve milligram quantities of copper, sufficient to cause acute toxicity symptoms such as self-limited nausea, vomiting and diarrhea. [diagnose-me.com]
Do not induce vomiting. Seek medical attention. Never induce vomiting or give anything by mouth to an unconscious person. SKIN : Remove contaminated clothing, brush material off skin, wash affected area with soap and water. [espimetals.com]
- Diarrhea
Self-limited gastroenteritis with nausea, vomiting, and diarrhea may occur. [merckmanuals.com]
painful neuropathy, coma, autonomic instability, MODS Late: Alopecia, Mees lines, residual neurologic symptoms Alopecia, neuropathy Toxic: >3 µg/L (blood) MDAC Prussian blue Zinc MFF (oxide fumes); vomiting, diarrhea, abdominal pain (ingestion) Copper [emedicine.medscape.com]
In prolonged contact with copper cooking utensils, an acidic food or beverage can dissolve milligram quantities of copper, sufficient to cause acute toxicity symptoms such as self-limited nausea, vomiting and diarrhea. [diagnose-me.com]
However, death is rare, owing to copper sulfate's emetic properties : a-Mild forms Mild forms of poisoning produce only : -nausea, -vomiting, -diarrhea, -malaise. [digitalfire.com]
It also can adversely affect the gastrointestinal tract causing nausea and diarrhea. Liver and endocrine function may also be affected. [dartmouth.edu]
- Abdominal Pain
[…] neuropathy, coma, autonomic instability, MODS Late: Alopecia, Mees lines, residual neurologic symptoms Alopecia, neuropathy Toxic: >3 µg/L (blood) MDAC Prussian blue Zinc MFF (oxide fumes); vomiting, diarrhea, abdominal pain (ingestion) Copper deficiency [emedicine.medscape.com]
Some people who drink water with high copper levels may experience nausea, vomiting, abdominal pain, and diarrhea. The amount of copper that is typically found in water from copper plumbing is usually not a health threat. [dartmouth.edu]
It is not recommended ever, due to side effects that can include kidney damage, blurred vision, B6 deficiency, ringing in the ears, ulcers, jaundice and other liver damage, abdominal pain, bloody urine and more. [metabolichealing.com]
Cardiovascular
- Hypotension
[…] nickel carbonyl: myocarditis, ALI, encephalopathy Occupational (inhaled): pulmonary fibrosis, reduced sperm count, nasopharyngeal tumors Excessive exposure: ≥8 µg/L (blood) Severe poisoning: ≥500 µg/L (8-h urine) * Selenium Caustic burns, pneumonitis, hypotension [emedicine.medscape.com]
Vital signs and urine output should be conducted for hypotension and oliguria. The medical history is also cornerstone of investigating dermatits suspected to arise from copper. [digitalfire.com]
Liver, Gall & Pancreas
- Jaundice
Jaundice and pain over the liver have been reported in acute human poisonings. Copper is mainly absorbed through the gastrointestinal tract. All other intakes of copper (inhalation and dermal) are insignificant in comparison to the oral route. [espimetals.com]
Patients who developed intense jaundice from liver centrolobular necrosis after massive acute copper sulfate poisonning had a more fulminant course than did patients with milder jaundice from intravascular hemolysis. [digitalfire.com]
It is not recommended ever, due to side effects that can include kidney damage, blurred vision, B6 deficiency, ringing in the ears, ulcers, jaundice and other liver damage, abdominal pain, bloody urine and more. [metabolichealing.com]
Jaw & Teeth
- Metallic Taste
According to the MedlinePlus website, symptoms of copper toxicity include nausea, vomiting, digestive discomfort, metallic taste, yellow skin and eyes, depression, anorexia and muscle weakness. [leaf.tv]
MFF, or "brass founder’s ague," "zinc shakes," or "Monday morning fever" as it is variously known, is characterized by fever, headache, fatigue, dyspnea, cough, and a metallic taste occurring within 3-10 hours after exposure. [emedicine.medscape.com]
Inhalation of copper fumes may cause nausea, metallic taste, and discoloration of the skin and hair. 4-Renal System : Kidney abnormalities have been observed after copper sulfate ingestion. [digitalfire.com]
Skin
- Flushing
Symptoms of Exposure : May cause chills, flushing, fatigue, muscle and stomach aches, dyspnea, and nausea if fumes are inhaled. Dusts may irritate skin and eyes. [espimetals.com]
Urogenital
- Oliguria
Vital signs and urine output should be conducted for hypotension and oliguria. The medical history is also cornerstone of investigating dermatits suspected to arise from copper. [digitalfire.com]
Neurologic
- Seizure
[…] excretion: 25 µg/24 h (urine) BAL D-Penicillamine Succimer Iron Vomiting, GI hemorrhage, cardiac depression, metabolic acidosis Hepatic cirrhosis Nontoxic: < 300 µg/dL Severe: >500 µg/dL Deferoxamine Lead Nausea, vomiting, encephalopathy (headache, seizures [emedicine.medscape.com]
Physical conditions associated with copper imbalance include arthritis, fatigue, adrenal burnout, insomnia, scoliosis, osteoporosis, heart disease, cancer, migraine headaches, seizures, fungal and bacterial infections including yeast infection, gum disease [healingedge.net]
After any seizure activity is controlled, gastric lavage may be indicated. If necessary to prevent further absorption, activated charcoal may be administered and followed by a cathartic. [digitalfire.com]
[…] upper left pain in the ribs rib pain when running drug and/or alcohol intolerance very chronic constipation crowded upper front teeth poor collagen synthesis affecting joint development tingling sensations, tremors, and cramps in the limbs convulsive seizures [tvernonlac.com]
Treatment
Despite early treatment, many children have abnormal neurodevelopment. [merckmanuals.com]
It is used for the purification of water and treatment of chest infection. Some research show that copper can help prevent arthritis and other join related inflammations. It is being used in radiology for the treatment of cancer, and for epilepsy. [xbrain.co.uk]
Chelating treatment with D-penicillamine gives excellent therapeutic results while the preferred maintenance treatment is 150 mg of zinc orally per day. [digitalfire.com]
Typical Presentation of the Most Commonly Encountered Metals and Their Treatment (Open Table in a new window) Metal Acute Chronic Toxic Concentration Treatment Arsenic Nausea, vomiting, "rice-water" diarrhea, encephalopathy, MODS, LoQTS, painful neuropathy [emedicine.medscape.com]
Both types of treatment must be continual throughout the life of the patient. Reducing dietary copper can also reduce the symptoms, although this alone is not effective treatment. [dartmouth.edu]
Prognosis
Because early diagnosis and treatment seem to result in a better prognosis, the disorder is ideally detected before age 2 wk. However, diagnostic accuracy of these tests is limited. Thus, other tests are being developed. [merckmanuals.com]
[…] toxicity, though sharing some similarities with Wilson's Disease, is different in that the latter is an inherited & rare genetic disorder which, like copper toxicity, causes copper to collect in the liver, brain and other body tissues, but has a more dire prognosis [coppertoxic.com]
Etiology
[…] and multiple body system manifestations due to the underlying etiology. [icd10data.com]
Prevention
Copper sulfate prevents these problems. Test soil regularly, and apply copper sulfate as needed in a spray or fertilizer preparation. [homeguides.sfgate.com]
Copper oxidation, on the other hand, prevents further oxygen exposure and corrosion by solidly adhering to the metal's surface. [sciencing.com]
Most diets contain enough copper (2-5mg daily) to prevent a deficiency and not enough to cause toxicity. The World Health Organization (WHO) suggests that 10-12mg per day may be the upper safe limit for consumption. Diagnose your symptoms now! [diagnose-me.com]
The rates for application should be followed closely to prevent toxicity. Generally, the rates of copper are about 3 to 6 pounds per acre, but this is really dependent on the soil type and plants grown. [gardeningknowhow.com]
Some research show that copper can help prevent arthritis and other join related inflammations. It is being used in radiology for the treatment of cancer, and for epilepsy. Research also suggests its anti-ulcer use. [xbrain.co.uk]