Symptoma

Translocation Renal Cell Carcinoma

Translocation Carcinoma

One patient presented with asymptomatic renal mass detected incidentally during abdominal sonography. Four patients complained of flank or abdominal pain, and the other three complained of gross hematuria at initial presentation. [ncbi.nlm.nih.gov]

  • Hunting

    My 3 1/2 year old twins were so much fun to watch on their egg hunt and opening their baskets. [csn.cancer.org]

  • Aspiration

    Cytopathol. 2017;45:456–462. aspiration cytology Xp11 translocation RCC Pathology and Forensic Medicine Histology Cite this Apa Standard Harvard Vancouver BIBTEX RIS El Naili, R, Nicolas, M, Gorena, A & Policarpio-Nicolas, MLC 2017, ' Fine-needle aspiration [uthscsa.influuent.utsystem.edu]

    Fine-needle aspiration of the lymph node showed tumor cells with voluminous clear to eosinophilic cytoplasm, well-defined cell borders and hyperchromatic nuclei arranged in papillary architecture. [ncbi.nlm.nih.gov]

    Figure 2: (a) Aspirate showing a papillary architecture (Pap x100). (b) Cells with abundant pale to vacuolated cytoplasm and hyperchromatic nuclei (Geimsa x400). [ijpmonline.org]

    Fine-needle aspiration of a Xp11.2 translocation/TFE3 fusion renal cell carcinoma metastatic to the lung: report of a case and review of the literature. Diagn Cytopathol. 2006;34(11):751–6. . Accessed June 24, 2015. [link.springer.com]

  • Upper Abdominal Pain

    A 43-year-old woman presenting with upper abdominal pain was diagnosed with a left renal tumor. Laparoscopic left radical nephrectomy was performed. [ncbi.nlm.nih.gov]

However, the frequency of translocation renal cell carcinoma (TRCC) may be widely underestimated in the adult population due to an inadequate immunohistochemical workup or misdiagnosis from similar gross and histological findings to other RCC. [karger.com]

Staging workup begins with computed tomography of the lungs, as it is the most frequent site of metastasis. [dovepress.com]

  • Pleural Mass

    Six weeks after commencement of treatment with sorafenib, a CT scan of the patient showed increased central necrosis of the kidney mass and para-aortic lymph nodes as well as regression of the lung and pleural masses. [ncbi.nlm.nih.gov]

  • Lymphocytic Infiltrate

    Adjacent kidney shows cortical glomerulosclerosis, occasional tubular red cell casts and patchy lymphocytic infiltration was seen in the interstitium ( Figure 2 ). [hoajonline.com]

    Anti-angiogenic therapy induces T-lymphocyte infiltration associated with poor survival in metastatic renal cell carcinoma patients. Eur J Cancer 20(suppl 6):172, 2014. [faculty.mdanderson.org]

We report an 18-year-old male patient with metastatic Xp11 translocation RCC who was responsive to sorafenib treatment. [ncbi.nlm.nih.gov]

Xp11.2t corresponded to a significantly worse prognosis for overall survival in late onset (after 45 years) subgroup (P .038; hazard ratio, 3.199; 95% confidence interval, 1.065-9.609). [ncbi.nlm.nih.gov]

Etiology Translocation-associated renal cell carcinomas (RCCs) arise from the proximal tubule epithelium, similar to conventional clear cell and papillary RCCs. [1] Location The tumor typically arises within the cortex of the renal parenchyma. [1, 2, [emedicine.medscape.com]

[…] copy number alterations High chromosomal copy number alterations in xp11 translocation renal cell carcinomas detected by array comparative genomic hybridization are associated with aggressive behavior. doi : 10.1097/PAS 0b013e318293d872 ( 23759936 ) Etiology [humpath.com]

You are here: Urology Textbook Kidneys Renal cell carcinoma Pathology Renal cell carcinoma (1/8): Definition and Epidemiology Renal cell carcinoma (2/8): Etiology Renal cell carcinoma (3/8): Pathology Renal cell carcinoma (4/8): Signs and symptoms Renal [urology-textbook.com]

"Etiology of Renal Cell Carcinoma: Incidence, Demographics, and Environmental Factors". Renal Cell Carcinoma Clinical Management. Humana Pr Inc. pp. 3–22. ISBN 978-1-62703-061-8. Lane, Brian R. (2013). [en.wikipedia.org]

A germline mutation in c-Met is the etiology for hereditary papillary renal carcinoma, a familial syndrome that causes bilateral, multifocal papillary type 1 tumors in massive quantities (sometimes greater than 1,000 tumors per kidney) ( 9 ). [frontiersin.org]

Epidemiology There have been approximately 160 reported cases of Xp11.2 translocation-associated renal cell carcinoma (RCC); this subtype occurs predominantly in children and young adults. [emedicine.medscape.com]

In recent years, renal cell carcinoma associated with t(6;11)(p21;q12)/TFEB gene fusions has been found to share similar pathology, epidemiology and genetics characteristics with Xp11.2 tRCC[ 6 ]. [journals.plos.org]

Future Research Future cases of t(6;11) RCC will further delineate the incidence, epidemiology, and nature of this tumor. [karger.com]

Epidemiology Xp11 translocation RCC are the most common RCC in children, and comprises approximately 1% of adult RCC. There are only approximately 50 reported cases of t(6;11) RCC, median age is 31 years. [atlasgeneticsoncology.org]

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Alveolar soft-part sarcoma (ASPS) is a rare malignant tumor typically occurring in patients in their 20s to 30s within the muscle [mayomedicallaboratories.com]

Pathophysiology The molecular characteristics of RCC have been intensively studied during the past 20 years. Approximately 2 to 3% of RCC tumors are familial. [cancertherapyadvisor.com]

[…] sickle cell disease. [23] The most significant disease affecting risk however is not genetically linked – patients with acquired cystic disease of the kidney requiring dialysis are 30 times more likely than the general population to develop RCC. [24] Pathophysiology [en.wikipedia.org]

While the diagnostic importance is evident, the pathophysiology of inhibin A expression by the stromal cells of hemangioblastoma remains unknown and further investigation is required. [thedoctorsdoctor.com]

Public Health Image Library, Centers for Disease Control and Prevention, USA, www.cdc.gov. [urology-textbook.com]

"Risk factors for adult renal cell carcinoma: A systematic review and implications for prevention". BJU International. 86 (1): 20–7. doi : 10.1046/j.1464-410x.2000.00708.x. PMID 10886077. [en.wikipedia.org]

They are typically locally infiltrative into the surrounding normal parenchyma and should be resected with a wide margin to prevent local recurrence ( 15 ). Chromophobe RCC accounts for 5% of all primary renal malignancies. [frontiersin.org]

This complication is not an inflammatory response, but steroid creams may prevent secondary inflammatory changes. [cancertherapyadvisor.com]

Abstract quote The proto-oncogene product Ron is the receptor for macrophage stimulating protein, a scatter factor that stimulates cell proliferation, prevents apoptosis, and induces an invasive cell phenotype. [thedoctorsdoctor.com]