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Tranylcypromine

Trans 2 Phenylcyclopropylamine


Presentation

  • We present a case of MAOI-induced hypertensive crisis leading to significant troponin release after soft cheese intake.[ncbi.nlm.nih.gov]
  • Among them, tranylcypromine presented the most potency against LSD1 and its derivatives were further developed by medicinal chemists in order to develop potent and selective LSD1 inhibitors.[doi.org]
Hyperthermia
  • Hyperthermia and its possible causative mechanisms and treatments are discussed.[ncbi.nlm.nih.gov]
  • Fluoxetine - Possibility of hyperthermia, rigidity, myoclonic movements, death. Ginseng - Risk of headache, mania, or tremor.[psyweb.com]
  • Serotonin syndrome with severe hyperthermia after ingestion of tranylcypromine combined with serotinin reuptake inhibitors and tyramine-rich food in a case of suicide. Pharmacopsychiatry 2010; 43: 284-285 30 Gillman P.[dx.doi.org]
Asymptomatic
  • On hospital day 10, the patient was asymptomatic and left the hospital on his own recognizance.[ncbi.nlm.nih.gov]
Family History of Suicide
  • ., family history of suicide, bipolar disorder, depression) prior to initiating therapy. 101 104 a Hypertensive Crises Hypertensive crises, sometimes fatal, are one of the most serious adverse effects associated with MAO inhibitors, including tranylcypromine[drugs.com]
Nausea
  • Common side effects include nausea, dry mouth, and dizziness. Tranylcypromine can cause drowsiness. Do not drive or operate heavy machinery until you know how it affects you.[rxwiki.com]
  • Symptoms include a sudden and severe headache , nausea , vomiting , fever, cold sweat, dilated pupils, light sensitivity, fast or pounding heartbeats, neck stiffness, weakness, or problems with vision or speech.[drugs.com]
  • Symptoms include a sudden and severe headache , nausea, vomiting, fever, cold sweat, dilated pupils, light sensitivity, fast or pounding heartbeats, neck stiffness, weakness, or problems with vision or speech.[emedicinehealth.com]
  • Symptoms that may suggest a liver problem include persistent nausea and vomiting, abdominal pain, or the development of jaundice (a yellow colouring to the skin and the whites of the eyes).[netdoctor.co.uk]
Hypertelorism
  • The first pregnancy resulted in fetal death and autopsy revealed facial dysmorphism with ocular hypertelorism, cardiac defect and placental infarcts.[ncbi.nlm.nih.gov]
Hyperreflexia
  • Tryptophan - Possibility of behavioral and neurologic effects, including disorientation, confusion, amnesia, delirium, agitation, hypomania, ataxia, myoclonus, hyperreflexia, shivering, ocular oscillation,and Babinski signs.[psyweb.com]
  • Hypomania, sweating, jaw spasms, and hyperreflexia suggest mild serotonin syndrome.[erowid.org]
  • The combination of MAOIs and tryptophan has been reported to cause behavioral and neurologic syndromes including disorientation, confusion, amnesia, delirium, agitation, hypomanic signs, ataxia, myoclonus, hyperreflexia, shivering, ocular oscillations[druglib.com]
  • MAOIs in combination with tryptophan have been reported to cause behavioural and neurologic syndromes including disorientation, confusion, amnesia, delirium, agitation, hypomanic signs, ataxia, myoclonus, hyperreflexia, shivering, ocular oscillations[medicines.org.uk]
  • ) Sexual function disorders (2%) Hypertension (1–2 hours after ingestion) (2%) Rash (2%) Urinary retention (2%) Other (unknown incidence) adverse effects include: Increased/decreased appetite Blood dyscrasias Chest pain Diarrhea Edema Hallucinations Hyperreflexia[en.wikipedia.org]
Myoclonic Jerking
  • We report the case of a 56-year old woman who developed a neurotoxic syndrome with coma, hyperthermia, muscular rigidity, myoclonic jerks and tachycardia following an intoxication.[ncbi.nlm.nih.gov]
  • Impotence, urinary retention, impaired ejaculation, muscle spasm, tremors, myoclonic jerks, numbness, paresthesia, hnemia, leukopenia, agranulocytosis, thrombocytopenia, blurred vision, chills, impotence, hepatitis, skin rash, impaired water excretion[psyweb.com]
  • Musculoskeletal: muscle spasm, myoclonic jerks. Skin: rash. Other: SIADH, chills. Effects on lab test results • May increase ALT and AST levels. • May decrease hemoglobin and WBC, granulocyte, and platelet counts.[glowm.com]
Altered Mental Status
  • Manifestations included and altered mental status that progressed to hyperthermia and coma. She recovered quickly and without complications.[ncbi.nlm.nih.gov]

Workup

ST Elevation
  • She had a similar episode 2 month prior to this presentation, which resulted in a diagnosis of non-ST elevation myocardial infarction after a troponin of 2768 ng/L (Ref   17 ng/L) with normal cardiac investigations and CT pulmonary angiogram.[ncbi.nlm.nih.gov]
Peaking T Wave
  • A case of tranylcypromine (Parnate) overdose is presented in which the main toxic effects were headache, obtundation, hypertension, and diffusely peaked T-waves on ECG.[ncbi.nlm.nih.gov]

Treatment

  • […] adequately from several prior treatments.[ncbi.nlm.nih.gov]
  • This review highlights recent advances in the repurposing of tranylcypromine and its derivatives as irreversible LSD1 inhibitors for cancer treatment, which are conventionally used for the treatment of depression.[doi.org]

Prognosis

  • Potential clinical use of LSD1 inhibitors The observation of high-level LSD1 expression in malignancies such as those of prostate, breast and neuroblastoma, and its prediction for inferior prognosis, has led to a particular focus on cancer as a potential[dx.doi.org]

Etiology

  • Thrombocytopenia features diagnostic value in patients with deliria of unknown etiology. TCP should be administered with great care, especially in dependence-prone patients.·. Georg Thieme Verlag KG Stuttgart · New York.[ncbi.nlm.nih.gov]
  • Thrombocytopenia features diagnostic value in patients with deliria of unknown etiology.[dx.doi.org]
  • Prevalence, etiology, and treatment of depression in Parkinson's disease. Biol Psychiatry 2003;54:363–375. 91. Mendlewicz J, Youdim MBH. Anti-depressant potentiation of 5-hydroxytrytophan by l-deprenyl, a monoamine oxidase type B inhibitor.[doi.org]

Epidemiology

  • Treatment with antiparkinson and antidepressant drugs: a register-based, pharmaco-epidemiological study. Mov Disord 2007;22:2037–2042. 25. Burn DJ.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • Tranylcypromine also leads to an increase in brain trace amines, which are believed to play a key role in the pathophysiology of depression. It also affects other pathophysiological pathways associated with depression.[ncbi.nlm.nih.gov]
  • Monoamine oxidase inhibitor withdrawal phenomena: symptoms and pathophysiology . Acta Psychiatrica Scandinavica, Vol. 78, Issue. 1, p. 1. CrossRef Google Scholar Gillin, J. Christian and Wyatt, Richard J. 1975. Vol. 17, Issue. , p. 297.[doi.org]

Prevention

  • TCP significantly prevented Aβ-induced neuronal death in a concentration-dependent fashion and was maximally protective only at 10 µM.[ncbi.nlm.nih.gov]
  • Recently, TC prevents me from sleeping for longer than two or three hours at a time, with forced periods of wakefulness of at least one hour, and prevents dreaming entirely.[erowid.org]
  • Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106 and the § Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037 1 Recipient of the Jules and Doris Stein Professorship from the Research to Prevent[doi.org]
  • . • Inform patient to lie down after taking drug and to avoid abrupt postural changes, especially when arising, to prevent dizziness induced by orthostatic blood pressure changes. • Caution patient to take drug exactly as prescribed, not to double a missed[glowm.com]
  • In the brain, MAO breaks down norepinephrine and serotonin, two naturally occurring chemicals that are important for maintaining mental well-being preventing depression.[minddisorders.com]

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