We present a case of MAOI-induced hypertensive crisis leading to significant troponin release after soft cheese intake. [ncbi.nlm.nih.gov]

Among them, tranylcypromine presented the most potency against LSD1 and its derivatives were further developed by medicinal chemists in order to develop potent and selective LSD1 inhibitors. [doi.org]

• Hyperthermia

  Hyperthermia and its possible causative mechanisms and treatments are discussed. [ncbi.nlm.nih.gov]

  Fluoxetine - Possibility of hyperthermia, rigidity, myoclonic movements, death. Ginseng - Risk of headache, mania, or tremor. [psyweb.com]

  Amphetamine intoxication with coagulopathy, hyperthermia, and reversible renal failure. A syndrome resembling heatstroke. Annals of Internal Medicine 73, 81–85.CrossRefGoogle ScholarPubMed Green, A. R. & Youdim, M. B. H. (1975). [cambridge.org]

• Nausea

  Symptoms include a sudden and severe headache, nausea, vomiting, fever, cold sweat, dilated pupils, light sensitivity, fast or pounding heartbeats, neck stiffness, weakness, or problems with vision or speech. [drugs.com]

  Common side effects include nausea, dry mouth, and dizziness. Tranylcypromine can cause drowsiness. Do not drive or operate heavy machinery until you know how it affects you. [rxwiki.com]

  Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. [mayoclinic.org]

  Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.A [reference.medscape.com]

  […] dose can be increased by 10 mg every 1 to 3 weeks until the maximum dosage of 60 mg daily is reached.[8] Adverse Effects Common side effects of tranylcypromine include dry mouth, headaches, diarrhea, urinary hesitancy, insomnia, agitation, anxiety, nausea [ncbi.nlm.nih.gov]

• Mood Swings

  Bipolar I and bipolar II patients had comparable outcomes, but bipolar I patients had a significantly greater risk of treatment-emergent mood swings. [ncbi.nlm.nih.gov]

  If you experience frequent mood swings, change in behaviour, panic, problems while sleeping then contact your doctor. [canadadrugs.com]

  I had been told from the beginning that I needed some mood stabilizer along with parnate bcs of my mood swings but I had already tried a bunch of mood stabilizers that had given me horrible side effects so I didn't want to take any. [socialanxietysupport.com]

• Hyperreflexia

  Tryptophan - Possibility of behavioral and neurologic effects, including disorientation, confusion, amnesia, delirium, agitation, hypomania, ataxia, myoclonus, hyperreflexia, shivering, ocular oscillation,and Babinski signs. [psyweb.com]

  […] for assessing serotonin toxicity include the recent addition of or increase in a serotonergic agent, absence of other etiologies, no recent addition of or increase of a neuroleptic agent, and at least three of the following:[10] Agitation Myoclonus Hyperreflexia [ncbi.nlm.nih.gov]

  Hypomania, sweating, jaw spasms, and hyperreflexia suggest mild serotonin syndrome. [erowid.org]

  The combination of MAOIs and tryptophan has been reported to cause behavioral and neurologic syndromes including disorientation, confusion, amnesia, delirium, agitation, hypomanic signs, ataxia, myoclonus, hyperreflexia, shivering, ocular oscillations [druglib.com]

  Sexual function disorders (2%) Hypertension (1–2 hours after ingestion) (2%) Rash (2%) Urinary retention (2%) Other (unknown incidence) adverse effects include: Increased/decreased appetite Blood dyscrasias Chest pain Diarrhea Edema Hallucinations Hyperreflexia [en.wikipedia.org]

• Myoclonus

  There have been reports of serious, sometimes fatal, reactions (including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital signs, and mental status changes that include extreme agitation progressing to [druglib.com]

  Tryptophan - Possibility of behavioral and neurologic effects, including disorientation, confusion, amnesia, delirium, agitation, hypomania, ataxia, myoclonus, hyperreflexia, shivering, ocular oscillation,and Babinski signs. [psyweb.com]

  Sternbach criteria for assessing serotonin toxicity include the recent addition of or increase in a serotonergic agent, absence of other etiologies, no recent addition of or increase of a neuroleptic agent, and at least three of the following:[10] Agitation Myoclonus [ncbi.nlm.nih.gov]

This review highlights recent advances in the repurposing of tranylcypromine and its derivatives as irreversible LSD1 inhibitors for cancer treatment, which are conventionally used for the treatment of depression. [doi.org]

Evidence-based, pharmacological treatment guideline for depression in Korea, revised edition. [pubmed.ncbi.nlm.nih.gov]

Treatment-Resistant Depression Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study was a four-step, multicenter randomized trial of antidepressant efficacy for depressed outpatients. [psychiatryonline.org]

[…] adequately from several prior treatments. [ncbi.nlm.nih.gov]

Thrombocytopenia features diagnostic value in patients with deliria of unknown etiology. TCP should be administered with great care, especially in dependence-prone patients.·. © Georg Thieme Verlag KG Stuttgart · New York. [ncbi.nlm.nih.gov]

Tranylcypromine also leads to an increase in brain trace amines, which are believed to play a key role in the pathophysiology of depression. It also affects other pathophysiological pathways associated with depression. [ncbi.nlm.nih.gov]

Monoamine oxidase inhibitor withdrawal phenomena: symptoms and pathophysiology. Acta Psychiatrica Scandinavica, Vol. 78, Issue. 1, p. 1. CrossRef Google Scholar Gillin, J. Christian and Wyatt, Richard J. 1975. Vol. 17, Issue., p. 297. [doi.org]

TCP significantly prevented Aβ-induced neuronal death in a concentration-dependent fashion and was maximally protective only at 10 µM. [ncbi.nlm.nih.gov]

Prior to starting tranylcypromine, a washout of a minimum of five half-lives of a serotonin reuptake inhibitor drug is required to prevent serotonin toxicity. Dr. [psychiatryonline.org]

Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106 and the § Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037 1 Recipient of the Jules and Doris Stein Professorship from the Research to Prevent [doi.org]

Recently, TC prevents me from sleeping for longer than two or three hours at a time, with forced periods of wakefulness of at least one hour, and prevents dreaming entirely. [erowid.org]