Abstract A clinical profile of non-traumatic rhabdomyolysis with acute renal failure is presented. Myoglobinuric renal failure is treatable and hence a high index of suspicion is warranted in the etiologies discussed. [ncbi.nlm.nih.gov]

Profound hyperuricemia was present in most patients. Transient hypercalcemia developed during the diuretic phase in 5 patients. One patient died. [annals.org]

• Recurrent Abdominal Pain

  He had no prior history of systemic disease, fever, recurrent abdominal pain, neuro-muscular dysfunction or allergic disorder. [neurologyindia.com]

• Gagging

  The palatal and gag reflexes were sluggish. Motor functions in upper limbs were normal but lower limbs were very stiff and as such the power could not be assessed in a formal manner. [neurologyindia.com]

• Myopathy

  […] query for traumatic rhabdo in which they reference 3 types of rhabdo: -Traumatic or muscle compression (eg, crush syndrome or prolonged immobilization) -Nontraumatic exertional (eg, marked exertion in untrained individuals, hyperthermia, or metabolic myopathies [forums.acdis.org]

  It can be induced by numerous factors, including a crush injury to a limb, overuse of skeletal muscle, heat, alcoholism, viral infections, metabolic disorders, myopathies, drugs, toxins, and hypokalemia. [nejm.org]

  ) muscular dystrophies and myopathies ( G71 - G72 ) myopathy in amyloidosis ( E85.- ) myopathy in polyarteritis nodosa ( M30.0 ) myopathy in rheumatoid arthritis ( M05.32 ) myopathy in scleroderma ( M34.- ) myopathy in Sjögren's syndrome ( M35.03 ) [icd10data.com]

  Longer-term myalgias may be indicative of a metabolic myopathy, some nutritional deficiencies or chronic fatigue syndrome. [dbpedia.org]

• Muscle Swelling

  Lethargy or coma was present in 17 patients and muscle swelling in 11. Evidence of rhabdomyolysis included markedly elevated creatine phosphokinase, myoglobinuria, and aldolase in blood. [annals.org]

  Crush injury is compression of extremities or other parts of the body that causes muscle swelling and/or neurological disturbances in the affected areas of the body, while crush syndrome is localized crush injury with systemic manifestations. [en.wikipedia.org]

  Crush Injury: Compression of extremities or other parts of the body that causes muscle swelling and/or neurological disturbances. Crush Syndrome: Crush injury with systemic manifestations. [clinicaladvisor.com]

  The absence of a pulse or a weak, thread pulse to the distal limb may indicate muscle swelling or compromised circulation. Patients with crush syndrome have historically been described as presenting with muscle weakness, malaise, and fever. [physio-pedia.com]

• Stiffness of the Lower Limbs

  Within two hours from the onset of symptoms he had difficulty in opening the mouth, dysphagia, dysphonia, nasal twang and stiffness of both lower limbs. Later, he passed very dark coloured urine. [neurologyindia.com]

• Exercise-induced Muscle Pain

  No personal or family history of rhabdomyolysis or previous reporting of debilitating exercise-induced muscle pain, cramps, or heat injury d. Existence of other group or team-related cases of ER during the same exercise sessions e. [physio-pedia.com]

Rhabdomyolysis: Differential Diagnoses and Workup. eMedicine 2009. Baxter R, Moore J. Diagnosis and Treatment of Acute Exertional Rhabdomyolysis. Journal of Orthopaedic and Sports Physical Therapy 2003; 33(3): 104-108 [physio-pedia.com]

Magnetic resonance imaging (MRI; assessment of myopathy) Other tests that may be considered include the following: Electrocardiography (ECG) Measurement of compartment pressures Muscle biopsy Immunoblotting, immunofluorescence, and genetic studies See Workup [emedicine.medscape.com]

• Bicarbonate Increased

  Urinary alkalinization (as with sodium bicarbonate) increases myoglobin solubility in the urine and thus its elimination from the body. [medical-dictionary.thefreedictionary.com]

• Base Deficit

  As concerns the other laboratory analysis variables during the rhabdomyolysis episode, these showed the following average levels: LDH of 752.2 369.8 IU/L, GOT 107.4 109.4 IU/L, uric acid 4.2 2.1 mg/dL, albumin 2.9 0.5 g/dL, and a base deficit of 2.6 6.5 [ijccm.org]

Preventing the systemic and renal complications of the crush syndrome requires very early and vigorous treatment to sustain the circulation, preferably started at the site of the catastrophe. [ncbi.nlm.nih.gov]

Get clear, concise descriptions and evidence-based treatment guidelines for a full range of clinical conditions, ranging from the common to the unusual. [books.google.com]

Bicarbonate and mannitol treatment for traumatic rhabdomyolysis revisited. American Journal of Surgery, 213 (1), 73-79. [ohsu.pure.elsevier.com]

Crush syndrome sustained in the 1995 Kobe, Japan, earthquake; treatment and outcome. Ann Emerg Med 1997;30(4):507-12. Sever MS, Erek E, Vanholder R, Ozener C, Yavuz M, Kayacan SM, et al. [acta.tums.ac.ir]

The disease has good prognosis despite severe hypercatabolism and untreated profound hyperuricemia. FULL TEXT [annals.org]

OBJECTIVES: We assessed identification and management of these patients, considering: (i) early adverse parameters used to identify poor prognosis, (ii) the importance of early recognition, and (iii) appropriate management with aggressive fluid therapy [ncbi.nlm.nih.gov]

The vital prognosis of post-traumatic crush injury was good but the sequelae of the compartment syndrome were major. The need for RRT was not linked to CPK levels but rather to acidosis due to intra-abdominal complications. [ccforum.biomedcentral.com]

Identifying the risk of kidney injury would allow for establishing diagnostic and therapeutic strategies relevant to the prognosis. [ijccm.org]

Myoglobinuric renal failure is treatable and hence a high index of suspicion is warranted in the etiologies discussed. [ncbi.nlm.nih.gov]

[…] synonyms: Rhabdomyolysis ICD-10 M62.82 - Rhabdomyolysis Rhabdomyolysis ICD-9 728.88 Rhabdomyolysis 728.88 Etiology / Epidemiology / Natural History muscle necrosis causing the release of myoglobin into the bloodstream. [eorif.com]

The most common causes are muscle overextension, muscle compression and crush injury, but there are also numerous non-traumatic etiologies. The latter group can be broadly divided into toxic, infectious and metabolic causes. [news-medical.net]

Topics for discussion • Background • Pathophysiology • Etiology • Prognosis • Clinical Features • Differential Diagnosis • Management 3. [slideshare.net]

Written by internationally renowned experts, this clinical reference offers helpful advice with the most recent information on the definition, epidemiology, pathophysiology, and clinical causes of acute kidney failure as a fundamental prerequisite for [books.google.com]

[…] synonyms: Rhabdomyolysis ICD-10 M62.82 - Rhabdomyolysis Rhabdomyolysis ICD-9 728.88 Rhabdomyolysis 728.88 Etiology / Epidemiology / Natural History muscle necrosis causing the release of myoglobin into the bloodstream. [eorif.com]

Prognostic and epidemiologic study, level III. Supplemental digital content is available in the text. [journals.lww.com]

Detailed descriptions of epidemiology of the renal patients and offered help have been provided previously [ 8, 9 ]. [ndt.oxfordjournals.org]

We will present and discuss in this article the pathophysiological and clinical features of non-traumatic rhabdomyolysis, focusing specifically on Emergency Department (ED) management. Copyright 2017 The Canadian Society of Clinical Chemists. [ncbi.nlm.nih.gov]

Written by internationally renowned experts, this clinical reference offers helpful advice with the most recent information on the definition, epidemiology, pathophysiology, and clinical causes of acute kidney failure as a fundamental prerequisite for [books.google.com]

Llach F, Felsenfeld AJ, Haussler MR: The pathophysiology of altered calcium metabolism in rhabdomyolysis-induced acute renal failure: Interactions of parathyroid hormone, 25-hydroxycholecalciferol, and 1,25-dihydroxycholecalciferol. [karger.com]

Preventing the systemic and renal complications of the crush syndrome requires very early and vigorous treatment to sustain the circulation, preferably started at the site of the catastrophe. [ncbi.nlm.nih.gov]

It also prevents neutrophil adhesion and prevents secondary injury. It is directly bactericidal to anaerobic organisms. [clinicaladvisor.com]

See: reperfusion Patient care The goals of treatment are to prevent and treat renal dysfunction, reverse electrolyte abnormalities, and correct the underlying cause. [medical-dictionary.thefreedictionary.com]

Background A rhabdomyolysis protocol (RP) with mannitol and bicarbonate to prevent acute renal dysfunction (ARD, creatinine 2.0 mg/dL) remains controversial. [ohsu.pure.elsevier.com]