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Treponema

Presentation

Non-treponemal tests, such as RPR and VDRL, detect non-specific antibodies to cardiolipin which are present during acute conditions and can distinguish between active and past infection if the Treponemal test is positive. [diasorin.com]

We report a patient who presented with left arm swelling, secondary to onion peel periostitis of the humerus, which was caused by Treponema species. [ncbi.nlm.nih.gov]

[…] in-house and commercial methods (sensitivity, specificity, limit of detection, precision) Absolute sample quantification by standard curve Objective interpretation of results Overcome limitations of using clinical samples as positive controls Lyophilized presentation [en.vircell.com]

Other presenting problems include aphasia and seizures. [infectiousdiseaseadvisor.com]

Skin

  • Mucocutaneous Rash

    Clinical manifestations include slight fever, generalized lymphadenopathy, malaise, and a mucocutaneous rash. The rash initially appears on the palms and soles and eventually spreads to other areas. [ncbi.nlm.nih.gov]

Urogenital

  • Salpingitis

    The parasite Chlamydia trachomatis causes a variety of disorders—in women, urethritis, cervicitis, and salpingitis (inflammation of the ureter, cervix, and fallopian tubes, respectively) and, in men, nongonococcal urethritis. [britannica.com]

Workup

May aid in the workup of neurosyphilis. Mnemonic Unique test identifier. FTA CSF G Methodology Process(es) used to perform the test. Semi-Quantitative Indirect Fluorescent Antibody Performed Days of the week the test is performed. [ltd.aruplab.com]

Microbiology

  • Capnocytophaga Canimorsus

    canimorsus Porphyromonas gingivalis Prevotella intermedia Fusobacteriota Fusobacterium necrophorum (Lemierre's syndrome) Fusobacterium nucleatum Fusobacterium polymorphum Streptobacillus moniliformis (Rat-bite fever/Haverhill fever) Taxon identifiers [en.wikipedia.org]

Treatment

We reviewed medical records to obtain demographic and medical information about syphilis treatment. [nejm.org]

Treatment decisions are based on past history and nontreponemal titers. [antimicrobe.org]

Antibodies to syphilis can remain elevated despite appropriate antimicrobial treatment and a reactive result does not distinguish between recent or past infection. [mayocliniclabs.com]

Cliggott Publishing, division of CMP Healthcare Media 2. http://www.cdc.gov/std/treatment/2010 [diasorin.com]

Related guidelines WHO guidelines for the treatment of Neisseria gonorrhoeae WHO guidelines for the treatment of Chlamydia trachomatis WHO guidelines for the treatment of Genital Herpes Simplex Virus More publications on STIs [who.int]

Etiology

They were the first investigators to find the etiological agent of syphilis, described under the name of Spirochaeta pallida. [scielo.br]

T. hyodysenteriae is the etiologic agent of swine dysentery. [catalog.hardydiagnostics.com]

"Periodontal Pathogens in the Etiology of Pancreatic Cancer". Gastrointestinal Tumors. 3 (3–4): 125–127. doi:10.1159/000452708. PMC 5465713. PMID 28611978. ^ Marie-Claude Jobin, Mohsen Amin, Richard P. Ellen (2008). [en.wikipedia.org]

The spirochete Treponema pallidum (Tp), the etiologic agent of syphilis, causes a multistage sexually transmitted infection (STI). [certest.es]

Their participation as etiologic agents in human oral disease has been debated for many years. [caister.com]

Epidemiology

[…] for contact tracing and administration of preventative therapy Prostitution for drugs or for money to purchase drugs remains central epidemiologic aspect of transmission Capacity to invade intact mucus membranes or skin with abrasions Most common sites [life.umd.edu]

This test is intended to be used as an aid in the diagnosis of Herpes virus 1, Herpes virus 2 and Treponema pallidum in combination with clinical and epidemiological risk factors. [certest.es]

It is strongly recommended that countries take updated global guidance into account as they establish standardized national protocols and adapt it to the local epidemiological situation and antimicrobial susceptibility data. [who.int]

Pathophysiology

Useful For Suggests clinical disorders or settings where the test may be helpful Identification of Treponema pallidum in tissues Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test [mayocliniclabs.com]

The severity of the skeletal response in individual 133 together with the young age at death (6 months, +/- 3 months) supports a diagnosis of congenital yaws; however, the known pathophysiology of T. pallidum ssp. pertenue infections, namely that skeletal [journals.plos.org]

Prevention

A simplified process might make it easier to develop new ways to detect, treat, or prevent the infection, he says. [drugtargetreview.com]

US Preventive Services Task Force. Screening for syphilis infection in pregnancy: US Preventive Services Task Force reaffirmation recommendation statement. [labcorp.com]

In addition, future work will provide guidance for syphilis screening and treatment of pregnant women, STI syndromic approach, clinical management, STI prevention, and treatments of other STIs. [who.int]

Therapy otherwise involves support of diminished functions and prevention of further deterioration.Read More [britannica.com]

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