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Treponema


Presentation

  • We report a patient who presented with left arm swelling, secondary to onion peel periostitis of the humerus, which was caused by Treponema species.[ncbi.nlm.nih.gov]
  • We also present evidence that this region is subject to positive selection in ssp. pallidum, consistent with pressure from the immune system.[www3.interscience.wiley.com]
  • Other presenting problems include aphasia and seizures.[infectiousdiseaseadvisor.com]
  • Laboratory Safety The agent may be present in materials collected from cutaneous and mucosal lesions and in blood.[ehs.unc.edu]
Falling
  • Additionally, titers of FTA-Abs do not fall with successful treatment and so cannot be used to monitor success of therapy.[pathwaymedicine.org]
  • 辞書 RANKING / 単語ランキング 1位 talk 2位 leave 3位 lie 4位 fall 5位 speak 6位 show 7位 begin 8位 bring 9位 say 10位 tell HISTORY / 最近見た単語 履歴を消す treponema INDEX / 英ナビ![ei-navi.jp]
  • BSCI 424 — PATHOGENIC MICROBIOLOGY — Fall 2000 Treponema Summary Treponema pallidum ssp. pallidum : Motile, Gram-negative, microaerophilic spirochaete (with tapered end) (see WebLinked image ) Cause of venereal syphilis Outer sheath encloses axial fibrils[life.umd.edu]
  • The advantage of NTAs is the rise and fall of antibody titers reflect the course of disease including decreasing titers in patients who have been successfully treated.[infectiousdiseaseadvisor.com]
Nausea
  • Besides fever, clinical signs and symptoms may include chills, headache, nausea, vomiting, myalgias, tachycardia, hyperventilation, mild hypotension, vasodilatation with flushing, and the exacerbation and new onset of skin lesions ( 104 ).[antimicrobe.org]
Maculopapular Rash
  • Clinical manifestations of the secondary stage include a symmetric maculopapular rash involving the palms and soles, generalized lymphadenopathy, fever, malaise, raised lesions (condylomata lata), and alopecia Footnote 3.[canada.ca]
Chancroid
  • […] suspicious lesions or body fluids For further testing recommendations, see the Syphilis (Reverse Sequence) Testing Algorithm and the Syphilis (Traditional) Testing Algorithm Differential Diagnosis Genital chancre/ulcer (primary syphilis) Herpes simplex virus Chancroid[arupconsult.com]
Neglect
  • Author information 1 Work Group Neglected Tropical Diseases, Infection Biology Unit, German Primate Center, Leibniz- Institute for Primate Research, Göttingen, Germany. 2 Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic[ncbi.nlm.nih.gov]
  • PLoS neglected tropical diseases. 2008;2(1):e148–e. pmid:18235852 View Article PubMed/NCBI Google Scholar 8. Gray R, Mulligan C, Molini B, Sun E, Giacani L, Godornes C, et al.[journals.plos.org]
  • PLoS Neglected Trop Dis 2 : e148. ( 1996 ) DNA repeats identify novel virulence genes in Haemophilus influenzae. Proc Nat Acad Sci 93 : 11121 – 11125. ( 1996 ) R: a language for data analysis and graphics.[doi.org]
Ataxia
  • […] primary infection) General paresis (includes behavioral changes, dementia, mood changes, hyperreflexia, and pupillary defects) Tabes dorsalis – demyelination of posterior columns, dorsal roots, and dorsal root ganglia Results in weakness, paresthesias, ataxia[arupconsult.com]
  • Hence the symptoms and signs include: neuropathic lower extremity "lightning pains" ataxia bladder malfunction paresthesias absent ankle and knee jerks Romberg sign decreased sensation (most commonly vibratory and position sense) Loss of position sense[infectiousdiseaseadvisor.com]

Workup

Treponema Carateum
  • RECOMMENDED MEDIA For culture: 3 subspecies ( Treponema pallidum, Treponema carateum, and Treponema paraluiscuniculi have not been cultivated successfully in media or tissue culture).[catalog.hardydiagnostics.com]
  • Treponema carateum is the least invasive and causes only cutaneous disease. Treponema pallidum subspp pertenue and endemicum are intermediate in invasiveness and cause destructive lesions in bones and soft tissues.[ncbi.nlm.nih.gov]
  • T reponema pallidum subspp. pallidum, endemicum, and pertenue, the agents of venereal syphilis, endemic syphilis, and yaws, respectively, together with Treponema carateum, the agent of pinta, are primary pathogens of humans that have eluded in vitro cultivation[aac.asm.org]
Treponema Pallidum Endemicum
  • The three subspecies (Treponema pallidum pallidum, Treponema pallidum endemicum, and Treponema pallidum pertenue) are all morphologically indistinguishable and have an approximate diameter of 0.18 µm and length of 6-20 µm.[canada.ca]
Liver Biopsy
  • Sutton Baltimore-9 T.p. pallidum United States 1970s Live strain Liver biopsy CDC Chicago B T.p. pallidum United States 1951 Live strain Lesion on prepuce CDC Dallas-1 T.p. pallidum United States 1988 Live strain Amniotic fluid CDC Grady T.p. pallidum[doi.org]

Treatment

  • Related guidelines WHO guidelines for the treatment of Neisseria gonorrhoeae WHO guidelines for the treatment of Chlamydia trachomatis WHO guidelines for the treatment of Genital Herpes Simplex Virus More publications on STIs[who.int]
  • In addition to mechanical instrumentation, antimicrobial agents are used as an adjunctive treatment modality for periodontitis.[ncbi.nlm.nih.gov]
  • We reviewed medical records to obtain demographic and medical information about syphilis treatment.[nejm.org]

Etiology

  • They were the first investigators to find the etiological agent of syphilis, described under the name of Spirochaeta pallida.[scielo.br]
  • T. hyodysenteriae is the etiologic agent of swine dysentery.[catalog.hardydiagnostics.com]
  • Their participation as etiologic agents in human oral disease has been debated for many years.[caister.com]
  • The etiology of genital ulcer disease by multiplex polymerase chain reaction and relationship to HIV infection among patients attending sexually transmitted disease clinics in Pune, India. Sex. Transm. Dis. 26 : 55 – 62. 131. Rodriguez, I., , E. L.[asmscience.org]

Epidemiology

  • This study suggests that variations in the number and sequence of repeat motifs in the arp gene have clinical, epidemiological, and evolutionary significance. Citing Literature Number of times cited according to CrossRef: 1 George J.[www3.interscience.wiley.com]
  • […] for contact tracing and administration of preventative therapy Prostitution for drugs or for money to purchase drugs remains central epidemiologic aspect of transmission Capacity to invade intact mucus membranes or skin with abrasions Most common sites[life.umd.edu]
  • It is strongly recommended that countries take updated global guidance into account as they establish standardized national protocols and adapt it to the local epidemiological situation and antimicrobial susceptibility data.[who.int]
Sex distribution
Age distribution

Pathophysiology

  • Useful For Suggests clinical disorders or settings where the test may be helpful Identification of Treponema pallidum in tissues Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test[mayocliniclabs.com]
  • The severity of the skeletal response in individual 133 together with the young age at death (6 months, /- 3 months) supports a diagnosis of congenital yaws; however, the known pathophysiology of T. pallidum ssp. pertenue infections, namely that skeletal[journals.plos.org]

Prevention

  • […] subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis First published: 29 July 2008 Cited by: 1 Correspondence: Hsi Liu, Coordinate Center for Infectious Diseases, US Centers for Disease Control and Prevention[www3.interscience.wiley.com]
  • US Preventive Services Task Force. Screening for syphilis infection in pregnancy: US Preventive Services Task Force reaffirmation recommendation statement.[labcorp.com]
  • In addition, future work will provide guidance for syphilis screening and treatment of pregnant women, STI syndromic approach, clinical management, STI prevention, and treatments of other STIs.[who.int]
  • A simplified process might make it easier to develop new ways to detect, treat, or prevent the infection, he says.[drugtargetreview.com]

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