Presentation
We report a patient who presented with left arm swelling, secondary to onion peel periostitis of the humerus, which was caused by Treponema species. [ncbi.nlm.nih.gov]
Other presenting problems include aphasia and seizures. [infectiousdiseaseadvisor.com]
We also present evidence that this region is subject to positive selection in ssp. pallidum, consistent with pressure from the immune system. [www3.interscience.wiley.com]
Congenital syphilis is a subtype in neonates acquired from the mother in the second and third trimesters of pregnancy, that presents with facial anomalies like snuffles, a saddle nose, Hutchinson teeth, mulberry molars, short maxillae, saber shins, and [osmosis.org]
Urogenital
-
Chancroid
[…] suspicious lesions or body fluids For further testing recommendations, see the Syphilis (Reverse Sequence) Testing Algorithm and the Syphilis (Traditional) Testing Algorithm Differential Diagnosis Genital chancre/ulcer (primary syphilis) Herpes simplex virus Chancroid [arupconsult.com]
Neurologic
-
Neglect
Author information 1 Work Group Neglected Tropical Diseases, Infection Biology Unit, German Primate Center, Leibniz- Institute for Primate Research, Göttingen, Germany. 2 Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic [ncbi.nlm.nih.gov]
PLoS neglected tropical diseases. 2008;2(1):e148–e. pmid:18235852 View Article PubMed/NCBI Google Scholar 8. Gray R, Mulligan C, Molini B, Sun E, Giacani L, Godornes C, et al. [journals.plos.org]
PLoS Neglected Trop Dis 2 : e148. ( 1996 ) DNA repeats identify novel virulence genes in Haemophilus influenzae. Proc Nat Acad Sci 93 : 11121 – 11125. ( 1996 ) R: a language for data analysis and graphics. [doi.org]
Workup
Microbiology
-
Treponema Carateum
RECOMMENDED MEDIA For culture: 3 subspecies ( Treponema pallidum, Treponema carateum, and Treponema paraluiscuniculi have not been cultivated successfully in media or tissue culture). [catalog.hardydiagnostics.com]
Treponema carateum is the least invasive and causes only cutaneous disease. Treponema pallidum subspp pertenue and endemicum are intermediate in invasiveness and cause destructive lesions in bones and soft tissues. [ncbi.nlm.nih.gov]
T reponema pallidum subspp. pallidum, endemicum, and pertenue, the agents of venereal syphilis, endemic syphilis, and yaws, respectively, together with Treponema carateum, the agent of pinta, are primary pathogens of humans that have eluded in vitro cultivation [aac.asm.org]
-
Trypanosoma Cruzi
cruzi macrophage infectivity potentiator protein) TPANIC_1033 Patatin family phospholipase 1st rank: VipD ( Legionella pneumophila phospholipase effector protein) 2nd rank: ExoU ( Pseudomonas aeruginosa type 3 secretion system effector protein) Our analyses [bmcstructbiol.biomedcentral.com]
Biopsy
-
Liver Biopsy
Sutton Baltimore-9 T.p. pallidum United States 1970s Live strain Liver biopsy CDC Chicago B T.p. pallidum United States 1951 Live strain Lesion on prepuce CDC Dallas-1 T.p. pallidum United States 1988 Live strain Amniotic fluid CDC Grady T.p. pallidum [doi.org]
Treatment
Related guidelines WHO guidelines for the treatment of Neisseria gonorrhoeae WHO guidelines for the treatment of Chlamydia trachomatis WHO guidelines for the treatment of Genital Herpes Simplex Virus More publications on STIs [who.int]
We reviewed medical records to obtain demographic and medical information about syphilis treatment. [nejm.org]
Etiology
They were the first investigators to find the etiological agent of syphilis, described under the name of Spirochaeta pallida. [scielo.br]
T. hyodysenteriae is the etiologic agent of swine dysentery. [catalog.hardydiagnostics.com]
Their participation as etiologic agents in human oral disease has been debated for many years. [caister.com]
The etiology of genital ulcer disease by multiplex polymerase chain reaction and relationship to HIV infection among patients attending sexually transmitted disease clinics in Pune, India. Sex. Transm. Dis. 26 : 55 – 62. 131. Rodriguez, I., , E. L. [asmscience.org]
Epidemiology
[…] for contact tracing and administration of preventative therapy Prostitution for drugs or for money to purchase drugs remains central epidemiologic aspect of transmission Capacity to invade intact mucus membranes or skin with abrasions Most common sites [life.umd.edu]
It is strongly recommended that countries take updated global guidance into account as they establish standardized national protocols and adapt it to the local epidemiological situation and antimicrobial susceptibility data. [who.int]
This study suggests that variations in the number and sequence of repeat motifs in the arp gene have clinical, epidemiological, and evolutionary significance. Citing Literature Number of times cited according to CrossRef: 1 George J. [www3.interscience.wiley.com]
Pathophysiology
Useful For Suggests clinical disorders or settings where the test may be helpful Identification of Treponema pallidum in tissues Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test [mayocliniclabs.com]
The severity of the skeletal response in individual 133 together with the young age at death (6 months, /- 3 months) supports a diagnosis of congenital yaws; however, the known pathophysiology of T. pallidum ssp. pertenue infections, namely that skeletal [journals.plos.org]
Prevention
US Preventive Services Task Force. Screening for syphilis infection in pregnancy: US Preventive Services Task Force reaffirmation recommendation statement. [labcorp.com]
In addition, future work will provide guidance for syphilis screening and treatment of pregnant women, STI syndromic approach, clinical management, STI prevention, and treatments of other STIs. [who.int]
[…] subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis First published: 29 July 2008 Cited by: 1 Correspondence: Hsi Liu, Coordinate Center for Infectious Diseases, US Centers for Disease Control and Prevention [www3.interscience.wiley.com]
A simplified process might make it easier to develop new ways to detect, treat, or prevent the infection, he says. [drugtargetreview.com]