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Treponema Denticola


Presentation

  • CONCLUSIONS: In the present study, pregnant women with periodontal disease presented an association in the placental tissue between the presence of T. denticola and P. gingivalis and hypertensive disorders.[ncbi.nlm.nih.gov]
  • Other species, including S. oralis, Eikenella corrodens, S. intermedius and F. nucleatum ssp. vincentii, were associated with disease when P. gingivalis and T. forsythia were present in low proportions.[ncbi.nlm.nih.gov]
  • Based on the data presented here, we hypothesize that the primary function of FHL-1 binding by T. denticola might be to facilitate adherence to FHL-1 present on anchorage-dependent cells and in the extracellular matrix.[ncbi.nlm.nih.gov]
  • T. denticola was present at significantly elevated levels in plaque samples collected from deep-pocket sites of patients with severe periodontitis relative to the healthy controls and a group with moderate disease.[ncbi.nlm.nih.gov]
  • Our present data suggest that these three bacteria could have significant roles in the carcinogenic process of many cases of esophageal cancer by causing inflammation and by promoting the carcinogenic process, and that eradication of these three bacteria[ncbi.nlm.nih.gov]
Fishing
  • The use of the FISH technique suggested that these periodontopathic micro-organisms might be metabolically active within the wall of arteries, under the atherosclerotic lesion.[ncbi.nlm.nih.gov]
  • Molecular detection of Treponema denticola and Porphyromonas gingivalis in carotid and aortic atheromatous plaques by FISH: report of two cases. J Med Microbiol 54(Pt 1): 93 - 96.[doi.org]
  • Sambri V , Moter A , Servidio D , Marangoni A , Montebugnoli L , Foschi F , Prati C , Bartolomeo R , Di, Cevenini R (2005) Case report molecular detection of Treponema denticola and Porphyromonas gingivalis in carotid and aortic atheromatous plaques by FISH[nature.com]
Chronic Infection
  • These results suggest that T. denticola can evade host defense mechanisms by modulating production of IL-8 and MCP-1, and that this play a role in the development of chronic infections such as periodontitis.[ncbi.nlm.nih.gov]
  • Periodontal disease as a specific, albeit chronic, infection: diagnosis and treatment. Clin Microbiol Rev 14: 727 - 752. Google Scholar Crossref Medline ISI Lux, R, Miller, JN, Park, NH, Shi, W ( 2001 ).[doi.org]
Rigor
  • Addition of routine plasmid-based fluorescence labeling to the Treponema toolset will enable more-rigorous and -detailed studies of the behavior of this organism. Copyright 2015, American Society for Microbiology. All Rights Reserved.[ncbi.nlm.nih.gov]
Aspiration
  • STUDY DESIGN: Microbial samples were collected by aspiration from 32 cases diagnosed as acute periradicular abscess. DNA was extracted from the samples by using a QIAamp DNA mini-kit and analyzed with real-time PCR.[ncbi.nlm.nih.gov]
  • The fibroblast medium was aspirated and was replaced by the P. micros suspension. After a 24-h incubation (37 C, 5% CO 2 ), the culture medium supernatants were collected and were stored at 20 C until used.[tandfonline.com]
Gagging
  • TGC 1 3 Gly ACC GCC 1 CCC TCC 1 2 Pro AGG GGG 1 CGG 1 TGG 1 3 Thr AGT GGT 1 CGT 1 TGT 1 3 Val AAC GAC 1 CAC TAC 1 2 Six Box tRNA Sets Isotype tRNA Count by Anticodon Total Ser AGA GGA 1 CGA TGA 1 ACT GCT 2 Arg ACG GCG 1 CCG TCG 1 CCT 1 TCT 1 4 Leu AAG GAG[lowelab.ucsc.edu]
  • .: #20218] INSDC Sequence TPA: Treponema denticola ATCC 35405 tRNA-Leu-GAG-1-1 gene LK018916 83 243275 * [Ref.: #20218] INSDC Sequence TPA: Treponema denticola ATCC 35405 tRNA-Leu-TAA-1-1 gene LK018917 87 243275 * [Ref.: #20218] INSDC Sequence TPA: Treponema[bacdive.dsmz.de]
Skin Lesion
  • Treponema denticola is part of the human oral microbiota and is associated with periodontitis while T. pedis has been isolated from skin lesions in animals, e.g., digital dermatitis in cattle and necrotic ulcers in pigs.[ncbi.nlm.nih.gov]
Fracture
  • Calculus was removed in as large pieces as possible by the use of a sickle or a push scaler placed underneath the apical or facial border of the calculus and fracturing it from the tooth surface in a single stroke.[ncbi.nlm.nih.gov]
Suggestibility
  • It has been suggested that some bacteria mask their surfaces with serum proteins.[ncbi.nlm.nih.gov]
  • The chymotrypsin-like protease, dentilisin (PrtP), has been suggested to be an important virulence factor of T. denticola.[ncbi.nlm.nih.gov]
  • This data suggested that the antigenic variability found in to the MSP molecule, may be an important factor involved in immune evasion by T. denticola.[ncbi.nlm.nih.gov]
  • These results suggest that inappropriate expression of FlaB2 and FlaB3 caused the unusual elongation of flagella that resulted in decreased motility.[ncbi.nlm.nih.gov]
  • Recent studies suggest that the tip-oriented adhesion of Treponema denticola is a consequence of polar clustering of its adhesins on contact with the substratum and is compatible with viability.[ncbi.nlm.nih.gov]

Treatment

  • Additionally, F. alocis and T. forsythia were detected more frequently in teeth with necrotic pulp than in teeth with failing endodontic treatment.[ncbi.nlm.nih.gov]
  • MATERIAL AND METHODS: The study was conducted on 25 alcoholics from the Department of Alcohol Addiction Closed Treatment and 25 non-alcoholic patients from the Department of Periodontology, Wroclaw Medical University.[ncbi.nlm.nih.gov]
  • Treatment involves extensive antibiotic treatment and complex surgery. See also Oral microbiology Periodontitis References nl:Treponema denticola[wikidoc.org]
  • Heat treatment of the serum to inactivate complement confirmed that killing was mediated by complement. These results indicate that the FH-FhbB interaction is required for serum resistance whereas dentilisin is not.[ncbi.nlm.nih.gov]
  • However, qualitative analysis is insufficient for the clinical evaluation of periodontal treatments, and quantification of T. denticola populations is essential for monitoring therapeutic efficacy.[ncbi.nlm.nih.gov]

Prognosis

  • However, it is clear that the prognosis for periodontal health after dental treatment is much better for patients whose blood sugar levels are well controlled.[herenciageneticayenfermedad.blogspot.com]
  • Elevated levels of MMP-9 have been associated with poor prognosis and metastasis in tongue, oesophageal, gastric, pancreatic, and colorectal cancers ( Zeng et al, 2013 ; Aparna et al, 2015 ; Jakubowska et al, 2016 ).[nature.com]

Etiology

  • The high prevalence of P gingivalis, T denticola, and T forsythia in the samples examined suggests that these bacteria are related to the etiology of symptomatic periradicular diseases.[ncbi.nlm.nih.gov]
  • Abstract The oral anaerobic spirochete, Treponema denticola, has been implicated in the etiology of human periodontal diseases; however, the molecular basis for the virulence of these organisms is still unclear.[ncbi.nlm.nih.gov]
  • Abstract There is compelling evidence that treponemes are involved in the etiology of several chronic diseases, including chronic periodontitis as well as other forms of periodontal disease.[ncbi.nlm.nih.gov]
  • Porphyromonas gingivalis, an important etiological agent of periodontal disease, is frequently found associated with Treponema denticola, an anaerobic spirochete, in pathogenic biofilms.[ncbi.nlm.nih.gov]
  • The spirochete Treponema denticola is a major etiological agent of periodontitis and can invade oral tissues.[ncbi.nlm.nih.gov]

Epidemiology

  • Our methodology and results establish a genetic framework for the discrimination and phylogenetic analysis of T. denticola isolates, which will greatly assist future biological and epidemiological investigations involving this putative 'periodontopathogen[ncbi.nlm.nih.gov]
  • Recent epidemiological studies have revealed a significant association between periodontitis and oral cancer.[cancerres.aacrjournals.org]
  • Molecular epidemiology of oral treponemes associated with periodontal disease. J Clin Microbiol 36: 1399 -1403. Google Scholar Medline ISI Nilius AM, Spencer SC, Simonson LG ( 1993 ).[journals.sagepub.com]
  • Novel epidemiological studies have linked periodontal pathogens to pancreatic and oral cancers ( Ahn et al, 2012a ; Michaud, 2013 ). Also, it has been reported that Fn can promote colorectal carcinogenesis ( Rubinstein et al, 2013 ).[nature.com]
Sex distribution
Age distribution

Prevention

  • While the majority of people will not require the preventative treatment being proposed, those at high risk of oral infections would make the ideal candidates for this new inhibitor and preventing the cooperation of bacteria could mean vastly reduced[smileaustin.com]
  • TDE0471 protects T.denticola from serum killing by preventing the deposition of membrane attack complexes on the bacterial cell surface.[ncbi.nlm.nih.gov]
  • Moreover, in vivo, saliva inhibits dentilisin, thus preventing LL-37 restriction and ensuring its bactericidal and immunoregulatory activities.[ncbi.nlm.nih.gov]
  • In contrast, Msp-induced inhibition of collagen binding was reversed by beta1 integrin affinity-activating antibodies and by latrunculin B, which prevented subcortical actin assembly.[ncbi.nlm.nih.gov]
  • While a specific inhibitor of the ERK MAP kinase pathway prevented the T. denticola stimulation of cell proliferation, inhibitor of p38 increased the cell numbers in T. denticola-treated cultures.[ncbi.nlm.nih.gov]

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