Here we present three historic T. pallidum genomes (two from T. pallidum ssp. pallidum and one from T. pallidum ssp. pertenue) that have been reconstructed from skeletons recovered from the Convent of Santa Isabel in Mexico City, operational between the [ncbi.nlm.nih.gov]

• Epigastric Pain

  A 49-year-old man complaining of epigastric pain underwent endoscopy, during which thickened stomach folds below the fundus were observed. Microscopic examination of gastric tissue biopsy specimens revealed chronic active gastritis. [ncbi.nlm.nih.gov]

• Neglect

  Yaws is a neglected infectious disease that affects mostly children and adolescents living in poor, rural communities in humid, tropical areas of Africa, southeast Asia, and the Pacific Islands. [ncbi.nlm.nih.gov]

• Gastric Lesion

  Because of the nonspecific symptoms and signs of the disease, it is necessary to demonstrate Treponema pallidum in the gastric lesions to confirm the diagnosis. [ncbi.nlm.nih.gov]

Abstract Currently, the efficacy of syphilis treatment is measured with anti-lipid antibody tests. These can take months to indicate cure and, as a result, syphilis treatment trials require long periods of follow-up. [ncbi.nlm.nih.gov]

Its prognosis is poor and optimal therapy has not been determined. Tuberculous meningitis has a high mortality in those also infected with HIV, especially in the developing world, and better therapies are urgently needed. [ncbi.nlm.nih.gov]

[…] favorable prognosis for patients diagnosed with either primary or secondary syphilis 20% of untreated patients with tertiary syphilis die of the disease prognosis for tertiary syphilis depends on extent of scarring and tissue damage with adequate treatment [medbullets.com]

They were the first investigators to find the etiological agent of syphilis, described under the name of Spirochaeta pallida. [scielo.br]

The etiological agent of yaws, Treponema pallidum subspecies pertenue (T. pertenue), was discovered by Aldo Castellani in 1905 shortly after Schaudinn and Hoffmann discovered the etiological agent of syphilis, T. pallidum subspecies pallidum. [ncbi.nlm.nih.gov]

The spirochete Treponema pallidum (Tp), the etiologic agent of syphilis, causes a multistage sexually transmitted infection (STI). [certest.es]

Author information 1 Epidemiology of Highly Pathogenic Microorganisms, Germany; Primatology Department, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany; Department of Biology, McGill University, Montreal, Quebec, Canada. 2 Epidemiology [ncbi.nlm.nih.gov]

Useful For Suggests clinical disorders or settings where the test may be helpful Identification of Treponema pallidum in tissues Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test [mayomedicallaboratories.com]

Vascular inflammation is a complex and multifactorial pathophysiological process that plays a crucial role in the development and progression of disease (Clarke et al., 2010; Iwata et al., 2010; Yang et al., 2018; Zeng et al., 2018). [frontiersin.org]

The severity of the skeletal response in individual 133 together with the young age at death (6 months, +/- 3 months) supports a diagnosis of congenital yaws; however, the known pathophysiology of T. pallidum ssp. pertenue infections, namely that skeletal [journals.plos.org]

Author information 1 Department of Infection Control and Prevention, Aichi Medical University Hospital, Japan; Department of Molecular Epidemiology and Biomedical Sciences, Japan. 2 Department of Infection Control and Prevention, Aichi Medical University [ncbi.nlm.nih.gov]