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Treponema Pallidum

T Palidum


Presentation

  • Presentation was not significantly altered by HIV status. CONCLUSIONS: Primary syphilis lesions are often painful and/or multiple in the absence of herpes coinfection, and may be clinically misdiagnosed.[ncbi.nlm.nih.gov]
Fishing
  • In two cases with oral involvement, FISH was able to differentiate T. pallidum from oral treponemes and showed infection of the oral mucosa and tonsils, respectively.[ncbi.nlm.nih.gov]
Epigastric Pain
  • A 49-year-old man complaining of epigastric pain underwent endoscopy, during which thickened stomach folds below the fundus were observed. Microscopic examination of gastric tissue biopsy specimens revealed chronic active gastritis.[ncbi.nlm.nih.gov]
Rectal Mass
  • The rectal mass and symptoms resolved following penicillin therapy. This case and a review of previously reported cases of anorectal syphilis emphasize the significance of these often neglected and misdiagnosed lesions of syphilis.[ncbi.nlm.nih.gov]
Cutaneous Manifestation
  • With the use of immunofluorescence and immunoperoxidase methods we have succeeded in identifying T. pallidum in the gastric wall of a patient who initially had cutaneous manifestations of secondary syphilis and gastric symptoms.[ncbi.nlm.nih.gov]

Treatment

  • Abstract Currently, the efficacy of syphilis treatment is measured with anti-lipid antibody tests. These can take months to indicate cure and, as a result, syphilis treatment trials require long periods of follow-up.[ncbi.nlm.nih.gov]

Prognosis

  • Its prognosis is poor and optimal therapy has not been determined. Tuberculous meningitis has a high mortality in those also infected with HIV, especially in the developing world, and better therapies are urgently needed.[ncbi.nlm.nih.gov]
  • […] favorable prognosis for patients diagnosed with either primary or secondary syphilis 20% of untreated patients with tertiary syphilis die of the disease prognosis for tertiary syphilis depends on extent of scarring and tissue damage with adequate treatment[step1.medbullets.com]

Etiology

  • The etiological agent of yaws, Treponema pallidum subspecies pertenue (T. pertenue), was discovered by Aldo Castellani in 1905 shortly after Schaudinn and Hoffmann discovered the etiological agent of syphilis, T. pallidum subspecies pallidum.[ncbi.nlm.nih.gov]
  • They were the first investigators to find the etiological agent of syphilis, described under the name of Spirochaeta pallida.[scielo.br]

Epidemiology

  • Author information 1 Epidemiology of Highly Pathogenic Microorganisms, Germany; Primatology Department, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany; Department of Biology, McGill University, Montreal, Quebec, Canada. 2 Epidemiology[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Useful For Suggests clinical disorders or settings where the test may be helpful Identification of Treponema pallidum in tissues Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test[mayocliniclabs.com]
  • The severity of the skeletal response in individual 133 together with the young age at death (6 months, /- 3 months) supports a diagnosis of congenital yaws; however, the known pathophysiology of T . pallidum ssp. pertenue infections, namely that skeletal[journals.plos.org]

Prevention

  • Author information 1 Department of Infection Control and Prevention, Aichi Medical University Hospital, Japan; Department of Molecular Epidemiology and Biomedical Sciences, Japan. 2 Department of Infection Control and Prevention, Aichi Medical University[ncbi.nlm.nih.gov]

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