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Treprostinil


Presentation

  • The authors present a 30-year-old gravid women with symptoms of PH at 23 weeks gestation.[ncbi.nlm.nih.gov]
Infusion Site Pain
  • Infusion site pain is not dose dependent.[ncbi.nlm.nih.gov]
  • Common side effects of treprostinil therapy include headache, flushing, jaw pain, diarrhea, and for subcutaneous administration, infusion site pain or reaction.[doi.org]
Raynaud Phenomenon
  • Treprostinil diethanolamine may provide a new therapeutic option for Raynaud's phenomenon and the peripheral vascular disease of scleroderma. TRIAL REGISTRATION: ClinicalTrials.gov NCT00848939 .[ncbi.nlm.nih.gov]
  • But an analysis of data collected from that Phase 2 study and post-treatment follow-up showed an improvement in Raynaud’s phenomenon, another condition associated with scleroderma.[sclerodermanews.com]
  • U.S. provisional application No. 61/354,949 filed Jun. 15, 2010 discloses the use of orally administered treprostinil for treatment of Raynaud’s phenomenon, systemic sclerosis and digital ischemic lesions.[newdrugapprovals.org]
  • […] inhibitors excl. heparin B01A — ANTITHROMBOTIC AGENTS B01 — ANTITHROMBOTIC AGENTS B — BLOOD AND BLOOD FORMING ORGANS AHFS Codes 48:48.00 — Vasodilating Agents FDA label MSDS Clinical Trials Phase Status Purpose Conditions Count 0 Recruiting Treatment Raynaud's[drugbank.ca]
Ulcer
  • Abstract Diabetic foot ulcers are one of the most common and serious complications of diabetes mellitus. Few drugs are effective in enhancing the healing of microvascular skin ulcers.[ncbi.nlm.nih.gov]
  • Its primary outcome ws change in “net ulcer burden,” defined as new, active, or “indeterminate” digital ulcers that develop in treated patients at 20 weeks compared to study start and placebo.[sclerodermanews.com]
Skin Ulcer
  • Few drugs are effective in enhancing the healing of microvascular skin ulcers.[ncbi.nlm.nih.gov]
Confusion
  • […] increased thirst irregular heartbeat muscle pain or cramps nausea or vomiting pain in the jaw, arms, or legs unusual tiredness or weakness Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose Blurred vision confusion[drugs.com]
Cesarean Section
  • Treatment comprised of oxygen therapy, enoxaparin, and intravenous treprostinil from gestational week 25, following a successful elective cesarean section at 33 weeks gestation with favorable outcome.[ncbi.nlm.nih.gov]

Workup

Staphylococcus Aureus
  • RESULTS: After a total follow-up of 64,453 treatment days, we found 12 episodes of bacteremia: Staphylococcus aureus (5 episodes), non-fermenting gram-negative bacilli (4 episodes), other gram-positive cocci (2 episodes), and Enterobacter cloacae (one[ncbi.nlm.nih.gov]
  • The three most common organisms isolated in BSIs among patients on IV epoprostenol were coagulase-negative Staphylococcus (28), Micrococcus sp. (18), and Staphylococcus aureus (12).[cdc.gov]

Treatment

  • Treprostinil may offer a second effective treatment approach to individuals with MAP or "rescue therapy" to those in whom eculizumab treatment has failed to maintain suppression of disease activity.[ncbi.nlm.nih.gov]

Prognosis

  • […] has been shown in a large multicenter randomized controlled trial to improve exercise capacity, clinical state, functional class, pulmonary hemodynamics, and quality of life in patients with pulmonary arterial hypertension, an uncommon disease of poor prognosis[ncbi.nlm.nih.gov]
  • […] among the population infected with the human immunodeficiency virus (HIV) is estimated to be 0.5%, much higher than in the general population, 1,2 and it does not appear to be related to the stage of the disease or the degree of immunodepression. 3 The prognosis[revespcardiol.org]

Etiology

  • Etiology of pulmonary hypertension was most frequently PAH (51%) or secondary to lung disease (35%). Median follow-up was 20.3 months (interquartile range 14.2-33.2). Most patients (91%) had titrated iTRE dose to 12 breaths (72 μg) four times daily.[ncbi.nlm.nih.gov]
  • A structured diagnostic approach enables you to determine underlying etiology, then guides you to appropriate pharmacologic and non-pharmacologic therapeutic options, based upon their potential risks and benefits.[books.google.ro]
  • Neither baseline demographic covariates nor disease etiology showed significant interaction with the change in exercise capacity.[atsjournals.org]
  • The primary study that established efficacy (FREEDOM-M) included predominately patients with WHO functional class II-III symptoms and etiologies of idiopathic or heritable PAH (75%) or PAH associated with connective tissue disease (19%).[prnewswire.com]

Epidemiology

  • Articles include: Epidemiology of Pulmonary Arterial Hypertension, Pathology of Pulmonary Hypertension, Genetics of Pulmonary Arterial Hypertension, Diagnosis of Pulmonary Arterial Hypertension, Pulmonary Hypertension Owing to Left Heart Disease, Pulmonary[books.google.ro]
  • An epidemiological study of pulmonary arterial hypertension. Eur Respir J . 2007;30(1):104-109. 6 Kirson, KY, Birnbaum HG, Ivanova JI, et al.[insmed.com]
  • ., An epidemiological study of pulmonary arterial hypertension, Eur Respir J, 2007;30:104 óÔé¼ÔÇ 9.[radcliffecardiology.com]
  • An epidemiological study of pulmonary arterial hypertension. Eur Respir J. 2007;30(1):104-109. 26. Huertas A, Phan C, Bordenave J, et al.[orenitram.com]
  • An epidemiological study of pulmonary arterial hypertension. Eur Respir J. 2007; 30 :104–9. [ PubMed ] [ Google Scholar ] Phares KR, Weiser WE, Miller SP, et al.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • This new edition incorporates the latest clinical, pathophysiological and pathological research on pulmonary circulatory disorders.[books.google.ro]
  • These drugs include macitentan, riociguat, and treprostinil; all 3 target different pathophysiologic pathways and will be reviewed in this article.[phaonlineuniv.org]
  • The right ventricle in health and disease: insights into physiology, pathophysiology and diagnostic management . Cardiology 2012 ; 121 : 263 – 273 . 5. Humbert , M , Sitbon , O , Chaouat , A , et al .[cambridge.org]
  • PubMed View Article Google Scholar Garrett-Bakelman F, DeSancho M, Magro C: C5b-9 is a potential effector in the pathophysiology of Degos disease; a case report of treatment with eculizumab (abstract).[ojrd.biomedcentral.com]

Prevention

  • Prostacyclin (prostaglandin I 2 , PGI 2 ) overproduction in FVB/N mice prevents the formation of carcinogen and tobacco smoke-induced adenomas, and administration of the oral prostacyclin analogue iloprost to wild-type mice also prevented carcinogen-induced[ncbi.nlm.nih.gov]
  • Once safety is documented future studies will address its ability to ameliorate or prevent reperfusion mediated dysfunction of the liver graft and thereby reduce morbidity, leading to shorter hospital stays as compared to historical controls.[clinicaltrials.gov]
  • Treprostinil is very similar to prostacyclin, a natural substance in the body that widens blood vessels and prevents blood clotting.[ema.europa.eu]
  • The Maryland-based group has clung to the belief that its patient support services will allow it to prevail over cheaper competitors, along with settlements that prevent generics from being used in United’s newer delivery devices.[evaluate.com]

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