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Trichinella Spiralis


Presentation

  • This report presents an extensive characterization of the outbreak using the documents of the epidemiological investigation and the medical charts of the hospitalized patients.[ncbi.nlm.nih.gov]
  • In the present study we investigated whether MBL binds to the parasitic nematode Trichinella spiralis (T. spiralis).[ncbi.nlm.nih.gov]
  • An uncommon presentation of Trichinella spiralis with squamous cell carcinoma of the larynx is reported. The possible carcinogenic potential of trichinosis and its management are discussed.[ncbi.nlm.nih.gov]
  • Patients presented similar clinical symptoms. Mother's sera showed differences in the presence and titres of Igs, IgE, IgG1 and IgG4 against NBL surface.[ncbi.nlm.nih.gov]
  • Histological analysis pointed at a ductal invasive carcinoma with numerous parasites of Trichinella spiralis present within both the muscle and the tumor tissue.[ncbi.nlm.nih.gov]
Chronic Infection
  • Abstract Evidence from experimental studies indicates that during chronic infections with certain helminth species a regulatory network is induced that can down-modulate not only parasite-induced inflammation but also reduce other immunopathologies such[ncbi.nlm.nih.gov]
  • The muscle larval stage of this parasite establishes a chronic infection in skeletal muscle cells of humans who acquire trichinellosis.[ncbi.nlm.nih.gov]
Suggestibility
  • Collective data suggest that helminth infections affect immune responses to some vaccines.[ncbi.nlm.nih.gov]
  • A recombinant MCD-1 protein expressed as a GST-fusion protein in Escherichia coli failed to inhibit papain in vitro suggesting that the T. spiralis protein is a new member of the non-inhibitory cystatin-related proteins.[ncbi.nlm.nih.gov]
  • Specific Igs observed in newborns would be a suggestion of transplacental passage of this Igs and/or their production by the fetus. Specific Igs found in infants sera suggests that newborn larvae transplacental passage is possible.[ncbi.nlm.nih.gov]
  • Results of the study suggest that T. spiralis, typically transmitted in the peridomestic rat-pig-human cycle in the US, was not maintained in scavenging mammals in the absence of infected pigs. Published 2009.[ncbi.nlm.nih.gov]
  • CONCLUSION: The results show that gp45 inhibits PMN in different functions, suggesting an anti-inflammatory action. Copyright 2000 S. Karger AG, Basel[ncbi.nlm.nih.gov]

Workup

Toxocara Canis
  • The presence of antistriational antibodies (aStrAbs) was determined in the following groups of patients: group 1--66 patients with toxocariasis and the presence of anti-Toxocara antibodies, group 2--22 patients suspected of Toxocara canis infection without[ncbi.nlm.nih.gov]
Capillaria Philippinensis
  • Abstract Intestinal capillariasis is an emerging helminthic zoonosis caused by Capillaria philippinensis and is frequently fatal if not diagnosed correctly.[ncbi.nlm.nih.gov]
Plasmodium Falciparum

Treatment

  • For the combined-treatment group, the area under the plasma concentration-time curve between 0 and 6 h was higher than that for the albendazole group.[ncbi.nlm.nih.gov]
  • Abstract Trichinellosis is a widespread zoonoses for which no effective drug treatment is available at this time.[ncbi.nlm.nih.gov]
  • Treatment was started on day 7 post-infection and continued for 120 days. After completion of treatment, the mice were sacrificed and the larvae were extracted from muscles by HCl-pepsin digestion.[ncbi.nlm.nih.gov]
  • Abstract Trichinella spiralis larvae infective for laboratory mice were collected from muscle biopsies performed at different times (from 1 day to 16 months) following the end of treatment, indicating the failure of mebendazole to kill Trichinella parasites[ncbi.nlm.nih.gov]
  • These treatments to inhibit tumor growth were dose-dependent (p[ncbi.nlm.nih.gov]

Prognosis

  • […] weeks after cyst-containing meat Myalgia, Swelling & Weakness Disease may be self limitied Systemic: Fever; Periorbital edema Skin: Maculopapular rash; Splinter hemorrhages Cardiac: Congestive failure; Arrhythmias Encephalitis: Normal spinal fluid Poor prognosis[web.archive.org]
  • Prognosis for severe cases including cardiac or cerebral complications is not good. Despite therapy, lethality in cases with high infection intensity was up to 5%.[doi.org]

Etiology

  • This species is also the most important etiological agent to cause disease in humans ( 125 ).[doi.org]

Epidemiology

  • Abstract Many epidemiological data support the postulate that infection with helminths might provide some protection against allergic and autoimmune diseases.[ncbi.nlm.nih.gov]
  • This report presents an extensive characterization of the outbreak using the documents of the epidemiological investigation and the medical charts of the hospitalized patients.[ncbi.nlm.nih.gov]
  • RESULTS: An epidemiological investigation showed that the disease was linked to the consumption of infected pork and/or smoked pork products and affected the household members of four families.[ncbi.nlm.nih.gov]
  • For epidemiological studies, it is extremely important to identify each taxon since they have different distribution areas and host ranges.[ncbi.nlm.nih.gov]
  • KEYWORDS: Epidemiology; Free-range pigs; Parasite; Trichinella spiralis; Zoonosis[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Prevention

  • Molting and ecdysis in vitro required entry of the parasite into cells; conditions that prevented entry into cells also prevented ecdysis.[ncbi.nlm.nih.gov]
  • The finding of parasites in the tumor tissue witnesses in favor of infestation, and the parasite morphology preserved in the tumor shows at the protective effects of the cysts, i.e. preventing parasite necrosis.[ncbi.nlm.nih.gov]
  • ., 1991) to prevent human TS from impairing its translation.[ncbi.nlm.nih.gov]
  • Vaccination of swine could be an alternative to prevent the risk of human contamination. In order to develop an efficient and safe inactivate vaccine, the choice of the adjuvant is an important issue.[ncbi.nlm.nih.gov]
  • Therefore, this mAb is a protective antibody that has potential as a preventive and therapeutic agent for T. spiralis infection.[ncbi.nlm.nih.gov]

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