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Trichofolliculoma


Presentation

  • The finding of cohesive, branching keratinized squamous cell clusters admixed with sebaceous cells may suggest a diagnosis of trichofolliculoma, as was seen in the present case.[ncbi.nlm.nih.gov]
  • In the present study, we revaluated the histopathological features of 40 TF lesions, focusing on their chronological changes.[ncbi.nlm.nih.gov]
  • Mostly, it presents as a papule or nodule, involving the skin of the face and scalp area. A central, dilated keratin plugged ostium with vellus hair(s) is often present.[ncbi.nlm.nih.gov]
  • It presented as an asymptomatic, 10 mm deep sinus and histology showed keratin-filled cysts or sinuses lined by stratified squamous epithelium.[ncbi.nlm.nih.gov]
  • A 6-year-old male presented with a protruding hair emerging from a temporally located nodule on his left upper eyelid 5mm above the eyelid margin since birth. The lesion was excised and sent to histopathology.[ncbi.nlm.nih.gov]
Vietnamese
  • Dutch English Estonian Finnish French German Greek Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Korean Latvian Lithuanian Malagasy Norwegian Persian Polish Portuguese Romanian Russian Serbian Slovak Slovenian Spanish Swedish Thai Turkish Vietnamese[dictionary.sensagent.com]
Turkish
  • Danish Dutch English Estonian Finnish French German Greek Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Korean Latvian Lithuanian Malagasy Norwegian Persian Polish Portuguese Romanian Russian Serbian Slovak Slovenian Spanish Swedish Thai Turkish[dictionary.sensagent.com]
Otalgia
  • We present a case of a 7-year old girl who presented with bloody otorrhea, aural fullness, and otalgia, in the irst pediatric report of trichofolliculoma of the external auditory canal.[semanticscholar.org]
Arthritis
  • Register or Login Full Menu Full Menu CME Diseases & Conditions Acne Actinic Keratosis Aesthetic Dermatology Atopic Dermatitis Autoimmune Diseases Contact Dermatitis Hair & Nails Melanoma Nonmelanoma Skin Cancer Pigmentation Disorders Psoriasis Psoriatic Arthritis[mdedge.com]
Normal Hair
  • In spite of the well known regressive changes of normal hair follicles during catagen and telogen, the possibility of corresponding changes in the trichofolliculoma has not yet been discussed in the literature.[ncbi.nlm.nih.gov]
  • The results of the present study indicate that while the secondary follicles in the TF exhibited the hair cycle, the normal hair cycle was out of control, and tertiary hair follicles randomly developed from the involuting secondary follicles.[ncbi.nlm.nih.gov]
  • Abstract The morphologic features of trichofolliculoma are variable, reminiscent of the anagen, catagen, and telogen phases of a normal hair follicle in its cycle.[ncbi.nlm.nih.gov]
  • Clinical images Images hosted on other servers: Gross description Solitary and nodular, may have multiple fine hairs protruding Microscopic (histologic) description Highly organoid hamartomatous lesions that recapitulate various phases of normal hair[pathologyoutlines.com]
  • This results in disorder of the normal-hair cycle. [ILLUSTRATION OMITTED] The clinical differential diagnosis for trichofolliculoma includes dermal nevus, basal cell carcinoma, and pilar sheath acanthoma.[thefreelibrary.com]
Hyperkeratosis
  • Hyperkeratosis, acantholysis, dyskeratosis, and suprabasilar clefts were also focally present.[ncbi.nlm.nih.gov]
  • Multiple Trichodiscomas Fanconi-like syndrome Giant Pigmented Hairy Nevus Hamartoma, Precalcaneal Congenital Fibrolipomatous Hereditary Leiomyomatosis and Renal Cell Cancer neurilemmomatosis PALMOPLANTAR CARCINOMA, MULTIPLE SELF-HEALING Palmoplantar Hyperkeratosis[rgd.mcw.edu]
  • Keywords Cutaneous horn, hyperkeratosis, trichofolliculoma, hamartoma, hair follicle References Bondeson J. Everard home, John hunter, and cutaneous horns: A historical review. Am J Dermatopathol. 2001;23:362-9. Sadeghi E, Johari HG, Deylami HN.[jpad.com.pk]
Cutaneous Manifestation
  • Multiple facial angiofibromas: a cutaneous manifestation of Birt-Hogg-Dube syndrome. J Am Acad Dermatol . 2005;53(Suppl):108-111. 2009 Lippincott Williams & Wilkins, Inc.[journals.lww.com]
  • Multiple facial angiofibromas: a cutaneous manifestation of Birt-Hogg-Dube syndrome. J Am Acad Dermatol. 2005;53(Suppl):108-111. 2009 Lippincott Williams & Wilkins, Inc.[journals.lww.com]
Facial Angiofibroma
  • Multiple facial angiofibromas: a cutaneous manifestation of Birt-Hogg-Dube syndrome. J Am Acad Dermatol . 2005;53(Suppl):108-111. 2009 Lippincott Williams & Wilkins, Inc.[journals.lww.com]
  • Multiple facial angiofibromas: a cutaneous manifestation of Birt-Hogg-Dube syndrome. J Am Acad Dermatol. 2005;53(Suppl):108-111. 2009 Lippincott Williams & Wilkins, Inc.[journals.lww.com]
Dermatitis
  • PDF PD F PDF Download Next Article: Dermatitis Herpetiformis Dermatopathology[mdedge.com]
Suggestibility
  • The finding of cohesive, branching keratinized squamous cell clusters admixed with sebaceous cells may suggest a diagnosis of trichofolliculoma, as was seen in the present case.[ncbi.nlm.nih.gov]
  • Although a combined tumor of trichofolliculoma with highly-graded desmoplasia, multiple trichogenic trichoblastomas, and perifollicular fibromas was suggested, calling it a pedunculated follicular hamartoma seemed more useful because the pathological[ncbi.nlm.nih.gov]
  • In the TF lesions, no features indicating the replacement of the regressing secondary hair follicles by any sebaceous elements were observed, thereby suggesting that FSCH is not a very-late-stage TF. 2017 Japanese Dermatological Association.[ncbi.nlm.nih.gov]
  • Findings in NLCS are reminiscent of fetal adipogenesis; pinocytosis and condensation of the plasma membrane and the many vascular elements in contact with adipocytes suggest a vascular origin of the adipose cells.[e-ijd.org]
Tingling
  • Surrounding stroma does not have a basophilic tingle (seen in BCC ). DDx: Trichoblastoma. Basal cell carcinoma. Pilar sheath acanthoma. Images www: Trichofolliculoma DermNet Trichofolliculoma. (WC) See also Dermatologic neoplasms.[librepathology.org]

Workup

  • Workup Histologic Findings Following surgical excision, these tumors are found to consist of a dilated primary follicle lined by infundibular, stratified squamous epithelium and opening to the skin surface. [6] Low-power view of trichofolliculoma with[emedicine.medscape.com]

Treatment

  • What is the treatment of trichofolliculoma? Trichofolliculoma is a benign follicular tumour that requires no treatment. Occasionally they may be excised for cosmetic reasons or if they occur in functionally sensitive areas.[dermnetnz.org]
  • The treatment of Sebaceous Trichofolliculoma may involve the following: In a majority of cases, removal of the tumor is not necessary, unless it causes bothersome signs and symptoms such as cosmetic issues The treatment is a complete surgical excision[dovemed.com]

Prognosis

  • The prognosis is excellent.[emedicine.medscape.com]
  • What is the Prognosis of Trichofolliculoma? (Outcomes/Resolutions) The prognosis for Trichofolliculoma is excellent with appropriate treatment, since it is a benign tumor.[dovemed.com]
  • What is the Prognosis of Sebaceous Trichofolliculoma? (Outcomes/Resolutions) The prognosis for Sebaceous Trichofolliculoma is excellent with appropriate treatment, since it is a benign tumor.[dovemed.com]

Etiology

  • TERMINOLOGY Definitions Hamartoma with prominent follicular differentiation ETIOLOGY/PATHOGENESIS Unknown Majority of cases are sporadic Likely represents a hamartoma rather than a true tumor CLINICAL ISSUES Epidemiology Incidence Rare Age Usually presents[basicmedicalkey.com]
  • Pathophysiology Although the precise etiology of trichofolliculoma is uncertain, these tumors are not associated with systemic disease or other skin disorders.[emedicine.medscape.com]
  • While the etiology is largely known, it is considered to be a hamartoma with follicular differentiation that results when the pluripotent skin cells cease to differentiate into the hair follicle.[thefreelibrary.com]

Epidemiology

  • TERMINOLOGY Definitions Hamartoma with prominent follicular differentiation ETIOLOGY/PATHOGENESIS Unknown Majority of cases are sporadic Likely represents a hamartoma rather than a true tumor CLINICAL ISSUES Epidemiology Incidence Rare Age Usually presents[basicmedicalkey.com]
  • Epidemiology Frequency Trichofolliculoma represents an uncommon clinical entity. Race In reported cases, trichofolliculomas demonstrate no definitive racial predilection.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • Case Overview trichofolliculoma Member Rated 0 Patient case no. 3133 Date added 30 June 2003 Patient details Age Elderly patient Localisation Head / face / forehead Description Primary Lesions Papule / skin color Pathophysiology tumors and proliferative[dermquest.com]
  • Pathophysiology Although the precise etiology of trichofolliculoma is uncertain, these tumors are not associated with systemic disease or other skin disorders.[emedicine.medscape.com]
  • Etiology Pathophysiology The etiology of trichofolliculoma remains unclear. Systemic Implications and Complications Trichofolliculomas are benign hamartomas.[dermatologyadvisor.com]

Prevention

  • An incomplete removal may result in its recurrence Cauterization (burning-off) of the nodule can be performed using a CO2 laser How can Trichofolliculoma be Prevented? Currently, there are no known methods to prevent Trichofolliculoma occurrence.[dovemed.com]
  • If laser treatment is attempted with deeper and multiple passes, recurrence can be prevented, but there is an increased risk of scarring. Electrosurgery can also be used, but hypopigmented scars may replace the lesions because of thermal effects.[dermatologyadvisor.com]

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