DESIGN: A randomized, double-blind, controlled, 2-arm study of 48 patients with the neurologic presentation of Wilson disease. [ncbi.nlm.nih.gov]

The branched isomer tris(2-aminoethyl)amine and piperazine derivatives may also be present in commercial samples of TETA. [dbpedia.org]

• Swelling

  Tell your doctor about the allergy and what signs you had, like rash; hives ; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. [drugs.com]

  Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. [mskcc.org]

  Get emergency medical help if you have any of these signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat. [uofmhealth.org]

• Asymptomatic

  Hypothesis: The investigators postulate that patients with Wilson disease who are asymptomatic or who have been effectively treated for their symptoms and are in a maintenance phase therapy can be safely and effectively treated with a single daily dosage [clinicaltrials.gov]

  Drug adherence is more problematic for asymptomatic or stable conditions such as hypertension or maintenance therapy for WD [ 13, 14 ]. [link.springer.com]

  About 50% of patients presented with hepatic symptoms, about 20% neurologic symptoms, about 15% with combined hepatic/neurologic symptoms and the remainder, ~10%, were asymptomatic. 9 of 326 with DPA and 3 of 141 with trientine underwent liver transplantation [gutsandgrowth.wordpress.com]

  While zinc is indicated for maintenance therapy for WD or initial treatment of asymptomatic WD patients, zinc was used for first line treatment of some patients with neurological WD [ 10 ]. [bmcpharmacoltoxicol.biomedcentral.com]

  Sun Young Ahn and Soo Young Park, A Diagnostic Approach to Abnormal Liver Function Tests in Asymptomatic Patients, Korean Journal of Medicine, 82, 2, (134), (2012). [doi.org]

• Movement Disorder

  Pettarusp Wadia– Movement Disorders & Neurology; Dr. Atul Ursekar– Ophthalmology; Dr. Fazal Nabi – Pediatrics; Dr. Amit Desai – Psychiatry; Suvarna Sawant – Dietitian; Dr. Ria Mansukhani – Physical and Rehabilitation Therapy; Dr. [inspire.com]

  Pfeiffer, Wilson's disease, Hyperkinetic Movement Disorders, 10.1016/B978-0-444-52014-2.00049-5, (681-709), (2011). [doi.org]

• Pathologist

  Tissue pathways for urological pathology The target primary users of the tissue pathway are trainee and consultant cellular pathologists. These recommendations will also be of value to trainee/qualified biomedical scientists involved in... [evidence.nhs.uk]

• Nausea

  The adverse effects of trientine include nausea, arthralgia and rashes. Neurological symptoms may get worse at the start of treatment. Trientine can reduce serum iron so some patients may develop anaemia. [nps.org.au]

  SIDE EFFECTS : Trientine may cause nausea and skin rashes; duodenitis and colitis have also been reported. [sgpharma.com]

  or tongue changes in vision dizzy with headache unusual bleeding or bruising unusually weak or tired Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): nausea [fairview.org]

  Feeling sick (nausea) Stick to simple foods. This should settle as your body adjusts Skin rash If this becomes severe or troublesome, let your doctor know Speak with your doctor if you experience stomach pain or diarrhoea that doesn't go away. [patient.info]

  The most common side effects are nausea and abdominal or stomach pain or discomfort. [news-medical.net]

• Vomiting

  Diseases and Disorders section features more than 300 new figures and tables, as well as 20 new topics including: cyclic vomiting syndrome, traveler’s diarrhea, chronic pruritus, post-herpetic neuralgia, enteropathic arthritis, and hoarding disorder. [books.google.ro]

• Skin Rash

  Call your doctor if you have a fever or a skin rash while taking this medicine. You may need to take your temperature every night for the first month of treatment with trientine. While using trientine, you may need frequent blood and urine tests. [uofmhealth.org]

  Call your doctor at once if you have: fever or skin rash ; problems with speech, balance, walking, lifting, chewing, or swallowing; muscle pain or stiffness; muscle weakness, drooping eyelids, double vision; or symptoms of lupus (an autoimmune disorder [emedicinehealth.com]

  For the first month of treatment, take your temperature every night, and report any symptom such as fever or skin rash to your doctor. Do not take mineral supplements because they may block the absorption of SYPRINE. [syprine.com]

• Dermatitis

  Adverse Reactions: Iron deficiency, systemic lupus erythematosus, dystonia, muscular spasm, myasthenia gravis, contact dermatitis. Pricing for SYPRINE 250mg capsule ( Qty : 30) Appx. price $1936 [empr.com]

  Hazardous Substances Data Bank: TRIETHYLENETETRAMINE Toxicity Information Search TOXNET Chemical Information Search ChemIDplus Related Information in HazMap Diseases Occupational diseases associated with exposure to this agent: Asthma, occupational Contact dermatitis [hazmap.nlm.nih.gov]

  Because of the potential for contact dermatitis, any site of exposure to the capsule contents should be washed with water promptly. [sgpharma.com]

  However, there have been reports of asthma, bronchitis and dermatitis occurring after prolonged environmental exposure in workers who use trientine hydrochloride as a hardener of epoxy resins. [druginformation.com]

• Eruptions

  Monitor for symptoms of fever or skin eruption; take body temperature nightly during 1 st month of treatment. Any site of exposure to capsule contents must be washed with water. [empr.com]

  For the first month of treatment, the patient should have his temperature taken nightly, and he should be asked to report any symptom such as fever or skin eruption. [sgpharma.com]

  Frequency Not Defined Dystonia Iron deficiency Rash; thickening and fissuring of skin Muscular spasm Myasthenia gravis SLE Abdominal pain Gastritis Aphthoid ulcer Anorexia Colitis Heartburn Loss of taste Aplastic anemia Sideroblastic anemia Lupus like eruption [reference.medscape.com]

Long-term treatment with triethylene tetramine dihydrochloride, (trientine, TETA) was evaluated in 19 patients with Wilson's disease (WD). Two were given the drug as first choice and 17 after treatment with penicillamine. [ncbi.nlm.nih.gov]

Anticopper Agents in Children with Wilsons disease 122 Alternative Therapy for the Pediatric Patient 123 Teratogenicity of Anticopper Therapy 124 Alternative Therapy for the Pregnant PatientTrientine 125 Chapter 10 RISK FACTORS DURING MAINTENANCE THERAPY AND PROGNOSIS [books.google.com]

Philippe Ichai and Didier Samuel, Etiology and prognosis of fulminant hepatitis in adults, Liver Transplantation, 14, S2, (S67-S79), (2008). Robert J. [doi.org]

The histologic changes were suggestive of active colitis, but were etiologically non-specific. Given her history, the colonic changes were consistent with a drug induced mucosal injury. She was started on prednisone for the colitis. [bmcpharmacoltoxicol.biomedcentral.com]

Philippe Ichai and Didier Samuel, Etiology and prognosis of fulminant hepatitis in adults, Liver Transplantation, 14, S2, (S67-S79), (2008). Robert J. [doi.org]

Search California Search this site: Home Air Air Toxics Hot Spots Hot Spots risk assessments and guidelines Climate Change Changes in global weather patterns Criteria Pollutants Health-based recommendations for California's ambient air quality standards Epidemiological [oehha.ca.gov]

Epidemiology Wilson’s disease affects about 0.6 in 10,000 people in the EU. · Indication Wilson's disease - second-line to penicillamine in adults and children aged 5 years and older Methods of administration/route Oral Trial or other data 01. [sps.nhs.uk]

Jing Liu, Jing Luan, Xiaoyan Zhou, Yazhou Cui and Jinxiang Han, Epidemiology, diagnosis, and treatment of Wilson's disease, Intractable & Rare Diseases Research, 6, 4, (249), (2017). [doi.org]

AIMS: There is mounting evidence that the transition metal copper may play an important role in the pathophysiology of Alzheimer's disease (AD). [ncbi.nlm.nih.gov]

Briefly noted: “Molecular pathophysiology of portal hypertension” Hepatology 2015; 61: 1406-15. Terrific review with excellent figures. “Ezetimibe for the treatment of Nonacloholic Steatohepatitis” (MOZART trial) Hepatology 2015; 61: 1239-50. [gutsandgrowth.wordpress.com]

Patients and the cardiovascular field have identified a "critical need" for clinical studies of drug therapies that target HCM pathophysiological mechanisms. [clinicaltrials.gov]

The pathophysiological mechanism for the development of colitis is unknown. [bmcpharmacoltoxicol.biomedcentral.com]

Schilsky, Wilson disease: pathophysiology, diagnosis, treatment, and screening, Clinics in Liver Disease, 10.1016/j.cld.2004.06.005, 8, 4, (787-805), (2004). P. [doi.org]

In this model, trientine prevented the development of many diabetes-specific features similarly to RAS blockade. [ncbi.nlm.nih.gov]

The degradation of the trientine in the pharmaceutical dosage forms of the invention is substantially prevented even at ambient (i.e. room) temperatures (20-25°C). [google.com]

This security monitor is set up to prevent malicious bots and malware from accessing the site. [askapatient.com]

The aim of treatment is to remove the toxic levels of copper from your body, and then to prevent copper from re-accumulating. [patient.info]