Presentation
It is most commonly a genetic disorder present from birth, however some people start noticing symptoms in adulthood and do not possess a gene defect. [news-medical.net]
Abstract Abstract Trimethylamine (TMA) is a tertiary amine derived from the enterobacterial metabolism of precursors such as choline and phosphatidylcholine present in the diet. [ommbid.mhmedical.com]
[…] fish oil supplements Trimethylamine N-oxide is present in seafood (fish, cephalopods, crustaceans). [genome.gov]
Teased: Her workmates would give Ellie soap and perfume as presents in the office secret Santa as a joke ‘I was at my wits’ end,’ she told the Sunday Mirror. [dailymail.co.uk]
Interestingly, FMO3 is also responsible for the metabolism of other endogenous amines, such as tyramine, which are present in the brain. 30 It is conceivable that the disordered metabolism of these endogenous amines could cause or at least contribute [ncbi.nlm.nih.gov]
Entire Body System
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Disability
Abstract Trimethylaminuria, better known as fish odor syndrome, is a psychologically disabling condition in which a patient emits a foul odor, which resembles that of rotting fish. [ncbi.nlm.nih.gov]
Gastrointestinal
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Gagging
The above substitutions occur in homozygous form, while the E308G polymorphism (GGG to GAG) is shown here in heterozygous form. [academic.oup.com]
Psychiatrical
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Suggestibility
This suggests an original founder chromosome which accumulated the mutations, and ‘identity by state’ for the chromosomes carrying these mutations. [academic.oup.com]
At least one study [4] has suggested that the daily intake of charcoal and/or copper chlorophyllin may be of significant use in improving the quality of life of individuals suffering from TMAU, the success rates vary: 85% of people tested completely lost [chemeurope.com]
[…] sulfur and lecithin Taking low doses of antibiotics such as neomycin and metronidazole [12] in order to reduce the amount of bacteria in the gut Using slightly acidic detergent with a pH between 5.5 and 6.5 Additionally, at least one study [13] has suggested [en.wikipedia.org]
The condition is uncommon, but there has been recent research to suggest that the diagnosis may often be overlooked. [ncbi.nlm.nih.gov]
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Low Self-Esteem
The malodorous aspect can have serious and destructive effects on schooling, personal life, career and relationships, resulting in social isolation, low self-esteem, depression, paranoid behaviour, and suicide. [en.wikipedia.org]
Patients with FOS are often ridiculed and suffer from low self-esteem. [ncbi.nlm.nih.gov]
Anxiety, low self-esteem, clinical depression and addiction to drugs are also reported ( 5 ). First described in 1970 ( 6 ), TMAuria is proposed to be an autosomal recessive inborn error of metabolism ( 3, 7, 8 ). [academic.oup.com]
Urogenital
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Foul Smelling Urine
A second case of foul smelling urine in a boy caused by Aerococcus urinae. Pediatr Infect Dis J. 2013;32:1300-1. Treacy E; Johnson D. Pitt JJ; Danks DM (1995). [en.wikipedia.org]
Treatment
While there is no cure, many simple treatment options exist that may drastically improve the quality of life of these patients. This article will review the literature with an emphasis on the psychosocial impact and treatment options. [ncbi.nlm.nih.gov]
[ edit ] There is no known cure or treatment for the disorder. [en.wikipedia.org]
Treatment of both primary and secondary TMAU relies on restriction of dietary precursors of TMA, antibiotic-based reduction of gut flora, and odor chelators. Riboflavin may also benefit some patients. [oxfordmedicine.com]
Treatment Currently, there is no cure and treatment options are limited. [chemeurope.com]
Currently there is no specific treatment or cure for fish odour syndrome, but those affected can manage the condition using several recognized techniques. [news-medical.net]
Etiology
ETIOLOGY Most patients with FOS are eventually diagnosed with primary trimethylaminuria, which is caused by a deficiency in FMO3 that is inherited in an autosomal recessive fashion. 1 Under normal circumstances, dietary TMAO and other TMA precursors, [ncbi.nlm.nih.gov]