Zane is very cognitively impaired and very physically impaired—he can’t stand or walk, and he can’t sit without support. But the great thing about him is, he’s such a happy kid. He is interactive, he loves people, he’s very engaging. [thedailybeast.com]

Introduction Trisomy 18 was first described in 1960 by Edwards et al, who reported a newborn with multiple malformations and cognitive impairment(1). [scielo.br]