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Trisomy

Chromosomal Trisomies


Presentation

  • However, the relatively small number of patients in the present study, and specifically the low numbers who received bortezomib-based therapies, precludes this analysis.[bloodjournal.org]
  • During a rigorous week long session at Figure 8 studios with experimental and dimensional production extraordinaire Ben Greenberg (Uniform/The Men), Skum solely committed all the instrumentation present on Human Traffic Jam.[ticketfly.com]
  • On the second-trimester, malformations (essentially cardiac and digestive) are present in 60% of the cases, and can be associated with minor morphological signs.[orpha.net]
  • However, the risk of birth defects is higher when certain factors are present.[acog.org]
Multiple Congenital Anomalies
  • Multiple congenital anomaly caused by an extra autosome. Lancet, 1, 790-3. PMID: 14430807 Huang T, Meschino WS, Rashid S, Dennis A, Mak-Tam E & Cuckle H. (2018).[embryology.med.unsw.edu.au]

Treatment

  • The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.[orpha.net]
  • Management options and parental voice in the treatment of trisomy 13 and 18. J Perinatol,,. PMID: 29977011 DOI. Alberman E, Mutton D & Morris JK. (2012).[embryology.med.unsw.edu.au]
  • The findings herein may also impact treatment decisions.[bloodjournal.org]

Prognosis

  • Prognosis Median life expectancy is now above the age of 55 years. The documents contained in this web site are presented for information purposes only.[orpha.net]
  • In conclusion, we have further refined the category of high-risk MM, identifying a group of patients with poor prognosis and removing some of the heterogeneity of the current stratification.[bloodjournal.org]

Etiology

  • Etiology In 95% of the cases, trisomy 21 is free'': the extra chromosome is due to an accidental non-disjunction during meiosis. 2-3% of those cases are in a mosaic state.[orpha.net]

Epidemiology

  • Cytological and epidemiological findings in trisomies 13, 18, and 21: England and Wales 2004-2009. Am. J. Med. Genet. A, 158A, 1145-50. PMID: 22495937 DOI.[embryology.med.unsw.edu.au]
Sex distribution
Age distribution

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