Clinical Presentation Although patients with LD syndrome are born with distichiatic lashes, they typically present around the age of 4 or 5 years and not at birth. [entokey.com]

Lymphoedema may present after the age of ten years and may not be noticeable at the time of presentation of distichiasis. [aimu.us]

His younger sister presented with a similar phenotype. At birth she had normal black hair. A vascular nevus was present on the palm of the right hand and faded during childhood. [lymphedemapeople.com]

Wyatt JP, Anderson HF, Greer KE, Cordoro KM (2007) Acquired hypertrichosis lanuginosa as a presenting sign of metastatic prostate cancer with rapid resolution after treatment. J Am Acad Dermatol 56(2 Suppl):S45–47 PubMed Article Google Scholar 19. [link.springer.com]

[…] conjunctivitis, and photophobia.[11] Approximately 30% of individuals with LDS have unilateral or bilateral congenital ptosis.[12] Lower extremity lymphedema is bilateral, confined to the lower limbs without involvement of external genitalia, and typically presents [eyewiki.aao.org]

• Falling

  Like scalp hair, eyelashes sprout, grow for a while and eventually fall out. Latisse both extends the growth phase and increases the number of hairs that sprout. [medicaltalk.net]

• Turkish

  The single affected individual in the second family studied by Irrthum et al. (2003) was a 12-year-old girl, the offspring of unaffected first-cousin Turkish parents, who had previously been described in detail by Glade et al. (2001). [lymphedemapeople.com]

• Short Stature

  The contour of the sternum, the low-set ears, and the short stature are suggestive. [lymphedemapeople.com]

Treatment Treatment of mild cases is with lubricating ointment, epilation, and electrolysis. Severe cases require lamellar eyelid division and cryotherapy to the posterior lamella as discussed above. [eyewiki.aao.org]

Prognosis Prognosis is good if prompt treatment is initiated before permanent damage to the cornea. Recurrence of distichiatic cilia after surgical intervention may still take place. [aimu.us]

There are treatments however that can lesson the symptoms. [lymphedemapeople.com]

Wyatt JP, Anderson HF, Greer KE, Cordoro KM (2007) Acquired hypertrichosis lanuginosa as a presenting sign of metastatic prostate cancer with rapid resolution after treatment. J Am Acad Dermatol 56(2 Suppl):S45–47 PubMed Article Google Scholar 19. [link.springer.com]

Hirsutism: diagnosis and treatment. Arq Bras Endocrinol Metabol. 2014;58(2):97-107. https://doi.org/10.1590/0004-2730000002923 https://doi.org/10.1590/0004-27300000029.... [scielo.br]

Prognosis Prognosis is good if prompt treatment is initiated before permanent damage to the cornea. Recurrence of distichiatic cilia after surgical intervention may still take place. [aimu.us]

In this context, different genes are associated, the main inheritance pattern observed is autosomal dominant, and the prognosis is usually poor. [scielo.br]

Sharing information on coping, diagnosis, treatment and prognosis. Sponsored by Lymphedema People. http://health.groups.yahoo.com/group/childrenwithlymphedema/ Subscribe: childre[email protected] ...................... [lymphedemapeople.com]

[…] approximately 25 glands in the upper eyelid, and 20 in the lower eyelid.[2] Meibomian glands and eyelashes differentiate from a common pilosebaceous unit during the 2nd month of gestation.[2] The dual potentiality of the pilosebaceous unit explains the etiology [eyewiki.aao.org]

Sidney Fox remarked decades ago, owing to the rarity of distichiasis most papers studying the condition blend the discussion of trichiasis and distichiasis together, and consequently, robust or useful information is generally lacking in the literature.1 Etiology [entokey.com]

Etiologic and hereditary factors: a report of cases and review of the literature. Trans. Am. Ophthal. Soc. 55: 663-700, 1957. 9. Pico, G. : Congenital ectropion and distichiasis. [lymphedemapeople.com]

In other genetic diseases, such as the Bohring–Opitz syndrome and Rubinstein–Taybi syndrome, tumor predisposition has been observed in many case reports, but the risk cannot be established or fully dismissed because epidemiologic studies have not been [scielo.br]

Prevention References : Krachmer Jay H, Mannis Mark J, Holland Edward J. Cornea- Fundamentals, Diagnosis and Management Volume One Third Edition. Mosby Elsevier 2011. P 355- 356. Yanoff Myron, Sassani Joseph W. Ocular Pathology Seventh Edition. [aimu.us]