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Tropical Pancreatitis

TCP


Presentation

  • Infected pseudocyst as a consequence of tropical pancreatitis presenting as psoas abscess is unusual. We report a 40-year-old man who presented with pain in the right lumbar region.[ncbi.nlm.nih.gov]
  • Some are well nourished or even overweight at presentation. Abdominal pain is the presenting feature of tropical chronic pancreatitis in up to 90% of cases.[diapedia.org]
  • We present a case of an 11 year old boy who was diagnosed as having tropical chronic pancreatitis. CASE REPORT An 11 year old boy presented with history of para-umbilical pain since 6 years.[bhj.org.in]
  • Recent reports indicate change in profile of CP in India with identification of novel risk factors; and delayed presentation as well as delayed onset of exocrine and endocrine insufficiency.[tropicalgastro.com]
Painter
  • Sharer N, Schwarz M, Malone G, Howarth A, Painter J, Super M, Braganza J: Mutations of the cystic fibrosis gene in patients with chronic pancreatitis. N Engl J Med 1998;339:645–652.[karger.com]
Gangrene
  • For the present however, this case report only shows that severe peripheral vessel disease causing gangrene can occur in diabetic subjects with TCP.[pancreas.imedpub.com]
Abdominal Pain
  • Abstract The name juvenile tropical pancreatitis syndrome (JTPS) is proposed for a disease which affects young people of both sexes in certain parts of the tropics and which is characterised by abdominal pain, diabetes, steatorrhoea, and pancreatic calcification[ncbi.nlm.nih.gov]
  • Tropical Pancreatitis Motior Rahman Tropical pancreatitis is a syndrome characterised by abdominal pain, diabetes mellitus and pancreatic calculi occurring in non alcoholic individuals in the tropics and subtropical regions.[orion-group.net]
  • There were similar episodes of such type of abdominal pain. Abdominal pain was mid epigastric, dull aching in nature, increased after taking meal and some times radiating to back.[ijstd.org]
  • It is characterised by non-alcoholic pancreatitis affecting young adults, presenting with progressive exocrine pancreatic deficiency, and (typically, but not invariably) with abdominal pain.[diapedia.org]
Regurgitation
  • It is postulated that regurgitation of the pancreatic juice leads to chronic inflammation, metaplasia of the biliary epithelium and, eventually, to gallbladder cancer.[pancreas.imedpub.com]
Parotid Swelling
  • None of them exhibited classical findings of parotid swelling or bluish discoloration of lips. Two patients however were malnourished clinically.[ijnm.in]
Neglect
  • Effect of NaF, NaF plus TCP, NaF plus CPP-ACP, and SDF Varnishes on Sound Dentin and Artificial Dentin Caries in vitro. ( 29339648 ) Wierichs RJ...Esteves-Oliveira M 2018 43 mutTCPdb: a comprehensive database for genomic variants of a tropical country neglected[malacards.org]
  • Materials and methods Data collection TCP is a neglected tropical disease, therefore limited information is available.[academic.oup.com]

Workup

  • Provides all the necessary tools to make a comprehensive diagnostic workup including data from ancillary techniques and molecular findings whenever appropriate.[books.google.es]
  • Workup of a patient with familial pancreatic cancer. Pancreas 1999 ; 18(3): 219–224. Crossref , Medline , Google Scholar 41 Ghaneh P , Costello E, Neoptolemos JP. Biology and management of pancreatic cancer. Gut 2007 ; 56(8): 1134–1152.[pubs.rsna.org]
Dyslipidemia
  • However, these patients with pancreatic diabetes resulting from TCP (as in our case) have macrovascular disease in the absence of obesity, hypertension and overt dyslipidemia.[pancreas.imedpub.com]

Treatment

  • Treatment may be frustrating, and may include pancreatic enzymes, duct manipulations at endoscopic retrograde cholangiopancreatography, octreotide, celiac axis blocks for pain control, or surgery via drainage and/or resection.[ncbi.nlm.nih.gov]
  • New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer. National Cancer Institute of the United States. National Cancer Institute of Canada. ‏[books.google.com]

Prognosis

  • In the last few decades, the prognosis has markedly improved as a result of better management of diabetes.[journals.lww.com]
  • The prognosis of TCP patients has improved in the last two to three decades because of the better understanding of the natural history of TCP but its aetio-pathogenesis continues to be elusive.[posterng.netkey.at]
  • The prognosis is good relative to other causes of chronic pancreatitis.[diapedia.org]
  • Treatment and prognosis The presence of necrosis implies a poorer prognosis with mortality rates reported up to 14% 3 , if sterile.[radiopaedia.org]
  • After diagnosis the patient prognosis is dismal with few surviving over 5 years. Treatment regimes are highly patient variable and often the patients are too sick to undergo surgical resection or chemotherapy.[mdpi.com]

Etiology

  • CONCLUSION: Malnutrition is not an etiological factor of TP and weight loss occurred as a result of low calorie intake after the onset of TP.[ncbi.nlm.nih.gov]
  • Etiology of this disease is still not clear. The authors examine various hypotheses of etiology of TP and advocate the concept wherein pancreatitis of different types may have common etiological factors, but in differing proportions.[citeseerx.ist.psu.edu]

Epidemiology

  • The cyanide hypothesis is consistent with the known epidemiologic and metabolic characteristics of these two contrasting forms of pancreatitis.[ncbi.nlm.nih.gov]
  • Search for more papers by this author First published: February 1992 Cited by: 15 ABSTRACT Tropical and alcoholic forms of chronic pancreatitis differ in their clinical, aetiological and epidemiological features.[onlinelibrary.wiley.com]
  • Others may - 388Kb Abstract Tropical and alcoholic forms of chronic pancreatitis differ in their clinical, aetiological and epidemiological features.[mdrf-eprints.in]
  • Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India, IN X close Abstract Tropical calcific pancreatitis (TCP) is a form of idiopathic chronic pancreatitis with distinct clinical and epidemiological[cmj.sljol.info]
  • The patients with tropical pancreatitis had unique clinical and epidemiological features different from that of alcoholic chronic pancreatitis. These patients typically had pain in childhood, diabetes in adolescence and death during prime of life.[omicsonline.org]
Sex distribution
Age distribution

Pathophysiology

  • His primary research is in the pathophysiology and clinical management of acute and chronic pancreatitis. He is Associate Editor of the journal Pancreatology and the World Journal of Surgery .[books.google.com]
  • Nearly 30 years ago, it was speculated that lysosomal enzymes might play a role in the pathophysiology of pancreatitis[ 62 ].[wjgnet.com]
  • […] biochemistry of nutrition 180 Nutritional disorders and their management 200 Clinical biochemistry of the gastrointestinal tract 214 Assessment of hepatic function and investigation of jaundice 231 Acute and chronic liver disease 250 Glucose metabolism and the pathophysiology[books.google.ro]

Prevention

  • Yet a better understanding of the pathogenesis of tropical chronic pancreatitis could further improve treatment options and offer an opportunity for prevention of this disorder, which leads to severe morbidity in a large proportion of affected patients[journals.lww.com]
  • Given that diabetes of subjects with TCP is similar to type 1 diabetes in that both are associated with a defect in pancreatic insulin secretion, it is likely that intensive insulin could prevent macrovascular disease in both these groups.[pancreas.imedpub.com]
  • INTERACTING FACTOR 4 and CRYPTOCHROME 1 to Regulate Thermomorphogenesis in Arabidopsis thaliana. ( 31078553 ) Zhou Y...Li J 2019 41 Genome-Wide Analysis of the TCP Gene Family in Switchgrass (Panicum virgatum L.). ( 31093492 ) Huo Y...Sun Z 2019 42 Caries-Preventive[malacards.org]
  • Conclusion 17 Indications for Surgery in Pancreatic Cancer 16 Choice of Surgical Procedures 6 Palliative Treatment of Gastric Outlet Obstruction in Advanced 7 Japanese 25 References 15 Adjuvant Intraoperative Radiation Therapy During 35 Conclusion 40 Prevention[books.google.ro]

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