Presentation
Results: Metabolic markers did not distinguish between early and late-stage cases but were associated with neuroinflammatory responses and the presentation of neurological disturbances. [ncbi.nlm.nih.gov]
VSG-seq is capable of reliably detecting variants present on 0.01% of parasites and quantifying a variant’s presence within the population, for variants present above 0.1% of the population ( Fig. 1B and fig. S1). [doi.org]
Entire Body System
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Intravenous Administration
Current drugs suffer from severe toxicities and require intramuscular or intravenous administrations. The situation is further aggravated due to the emergence of drug resistance. [ncbi.nlm.nih.gov]
However, the combination therapy is still only effective against T. b. gambiense, and still limited by the complex intravenous administration. [mdpi.com]
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Weight Gain
Body weight gain was reduced from day 7 onwards. SOREM episodes started in most cases early after infection, with an increase in number and duration after parasite neuroinvasion. [ncbi.nlm.nih.gov]
Neurologic
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Gait Ataxia
In particular, increased concentrations of 3-hydroxybutyrate and alanine and reduced concentrations of mannose and urea were discriminatory for the presentation of daytime somnolence and gait ataxia. [ncbi.nlm.nih.gov]
Workup
Microbiology
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Treponema Pallidum
Giacani L, Molini BJ, Kim EY, Godornes BC, Leader BT, et al. (2010) Antigenic Variation in Treponema pallidum: TprK Sequence Diversity Accumulates in Response to Immune Pressure during Experimental Syphilis. [doi.org]
Treatment
Treatment discontinuations were unrelated to treatment (n 2 [1%] in the fexinidazole group). [ncbi.nlm.nih.gov]
Prognosis
Reliable and validated biomarkers could represent a possible breakthrough in the management of this tumor type, by facilitating diagnosis, refining prognosis and providing guidance towards the choice of the most appropriate therapy In this thesis we approach [avhandlingar.se]
Prognosis African trypanosomiasis is fatal if not treated. [ 15 ] In early or stage 1 disease, most patients recover fully with treatment. [patient.info]
Etiology
Brigadeiro Trompowski, Rio de Janeiro 21941-590, Brazil Received: 6 February 2018 / Revised: 12 April 2018 / Accepted: 20 April 2018 / Published: 25 April 2018 Trypanosoma brucei, etiological agent of Sleeping Sickness in Africa, is the prototype of African [mdpi.com]
Life Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China. 2 Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China; State Key Laboratory of Veterinary Etiological [ncbi.nlm.nih.gov]
Trypanosoma brucei Protozoan parasites within the species Trypanosoma brucei are the etiological agent of human sleeping sickness and Nagana in animals. [sanger.ac.uk]
Epidemiology
Here, we have explored the feasibility of using commercially available LAMP kits, designed to detect the Trypanozoon group of trypanosomes, as a xenomonitoring tool to screen tsetse flies for trypanosomes to be used in future epidemiological surveys. [ncbi.nlm.nih.gov]
The second volume, Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, is devoted to the clinical aspects of drug resistance. [books.google.it]
Epidemiology and diagnosis of African trypanosomiasis using DNA probes. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 96, Issue., p. S141. [doi.org]
Prevention
Here we report that T. b. gambiense resists TLFs via a hydrophobic β-sheet of the T. b. gambiense-specific glycoprotein (TgsGP), which prevents APOL1 toxicity and induces stiffening of membranes upon interaction with lipids. [ncbi.nlm.nih.gov]
[…] ice crystal formation in one part of a tightly sealed metal tube to prevent crystallization in another part of the same volume. [leica-microsystems.com]