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Trypanosoma Brucei


Presentation

  • Results: Metabolic markers did not distinguish between early and late-stage cases but were associated with neuroinflammatory responses and the presentation of neurological disturbances.[ncbi.nlm.nih.gov]
  • Blue-native gel electrophoresis revealed that TbTim62 is present primarily in 150-kDa and also in 1100-kDa protein complexes, whereas TbTim17 is present in multiple complexes within the range of 300 to 1100 kDa.[ncbi.nlm.nih.gov]
  • Cytokine concentrations were analyzed in relation to disease progression, clinical presentation and severity of neurological responses.[ncbi.nlm.nih.gov]
  • We present characteristic clinical and microbiologic features of a fatal case of African Sleeping Sickness in an HIV-infected individual.[ncbi.nlm.nih.gov]
  • Six days after the initial presentation of this infection she developed evidence of tropical pyomyositis (TP). These diseases, both of which are rare in Europids, were satisfactorily treated.[ncbi.nlm.nih.gov]
Intravenous Administration
  • Current drugs suffer from severe toxicities and require intramuscular or intravenous administrations. The situation is further aggravated due to the emergence of drug resistance.[ncbi.nlm.nih.gov]
  • However, the combination therapy is still only effective against T. b. gambiense , and still limited by the complex intravenous administration.[mdpi.com]
Gait Ataxia
  • In particular, increased concentrations of 3-hydroxybutyrate and alanine and reduced concentrations of mannose and urea were discriminatory for the presentation of daytime somnolence and gait ataxia.[ncbi.nlm.nih.gov]

Workup

Treponema Pallidum
  • Giacani L, Molini BJ, Kim EY, Godornes BC, Leader BT, et al. (2010) Antigenic Variation in Treponema pallidum: TprK Sequence Diversity Accumulates in Response to Immune Pressure during Experimental Syphilis.[doi.org]

Treatment

  • Treatment discontinuations were unrelated to treatment (n 2 [1%] in the fexinidazole group).[ncbi.nlm.nih.gov]
  • Human African trypanosomiasis a fatal disease for which no vaccines exist and treatment regimens are difficult. Here, we evaluate a Trypanosoma brucei protein kinase, AEK1, as a potential drug target.[ncbi.nlm.nih.gov]
  • The compound is currently awaiting phase III clinical trials and could lead to a novel oral therapeutic for the treatment of HAT. However, the mode of action of AN5568 in T. brucei is unknown.[ncbi.nlm.nih.gov]
  • As the few drugs available for treatment of the diseases have limited efficacy and produce adverse reactions, new and better tolerated therapies are required.[ncbi.nlm.nih.gov]
  • Follow up evaluation of these plant extracts is likely to yield new antitrypanosomal drug-leads or alternate medicines for treatment of HAT.[ncbi.nlm.nih.gov]

Prognosis

  • Reliable and validated biomarkers could represent a possible breakthrough in the management of this tumor type, by facilitating diagnosis, refining prognosis and providing guidance towards the choice of the most appropriate therapy In this thesis we approach[avhandlingar.se]
  • Prognosis African trypanosomiasis is fatal if not treated. [ 15 ] In early or stage 1 disease, most patients recover fully with treatment.[patient.info]

Etiology

  • Brigadeiro Trompowski, Rio de Janeiro 21941-590, Brazil Received: 6 February 2018 / Revised: 12 April 2018 / Accepted: 20 April 2018 / Published: 25 April 2018 Trypanosoma brucei , etiological agent of Sleeping Sickness in Africa, is the prototype of[mdpi.com]
  • Life Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China. 2 Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China; State Key Laboratory of Veterinary Etiological[ncbi.nlm.nih.gov]
  • Trypanosoma brucei Protozoan parasites within the species Trypanosoma brucei are the etiological agent of human sleeping sickness and Nagana in animals.[sanger.ac.uk]
  • Clinical signs have their intensity associated with the etiological agent T. b. rhodesiense or T. b. gambiense [ 1 , 3 , 6 ].[mdpi.com]

Epidemiology

  • Here, we have explored the feasibility of using commercially available LAMP kits, designed to detect the Trypanozoon group of trypanosomes, as a xenomonitoring tool to screen tsetse flies for trypanosomes to be used in future epidemiological surveys.[ncbi.nlm.nih.gov]
  • Potential genetic recombination of this gene between Tbr and non-human infective Tbb strains has significant epidemiological consequences for Human African Trypanosomiasis outbreaks.[ncbi.nlm.nih.gov]
  • Author information 1 Department of Cell Biology, School of Medicine, Yale University, 333 Cedar Street, New Haven, CT 06520, USA. 2 Department of Epidemiology of Microbial Diseases, Yale School of Public Health, 60 College Street, New Haven, CT 06520,[ncbi.nlm.nih.gov]
  • The second volume, Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, is devoted to the clinical aspects of drug resistance.[books.google.it]
  • Epidemiology and diagnosis of African trypanosomiasis using DNA probes . Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 96, Issue. , p. S141.[doi.org]
Sex distribution
Age distribution

Prevention

  • Here we report that T. b. gambiense resists TLFs via a hydrophobic β-sheet of the T. b. gambiense-specific glycoprotein (TgsGP), which prevents APOL1 toxicity and induces stiffening of membranes upon interaction with lipids.[ncbi.nlm.nih.gov]
  • A new class of steroidal therapeutics based on phylogenetic-guided design of covalent inhibitors that target parasite-specific enzymes of ergosterol biosynthesis is shown to prevent growth of the protozoan-Trypanosoma brucei, responsible for sleeping[ncbi.nlm.nih.gov]
  • Furthermore, neither high concentrations of transferrin nor knock-out of cytosolic lipid peroxidases prevented TLF-1 lysis. Instead, purified ApoL1 was sufficient to induce lysis, and ApoL1 lysis was inhibited by the antioxidant DPPD.[ncbi.nlm.nih.gov]
  • […] ice crystal formation in one part of a tightly sealed metal tube to prevent crystallization in another part of the same volume.[leica-microsystems.com]

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