Presentation
At present, T. cruzi is partitioned into seven discrete typing units (DTUs), TcI-TcVI and Tcbat. [ncbi.nlm.nih.gov]
Entire Body System
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Pseudotumor
[…] of Trypanosoma cruzi is also described but appears to be less frequent in acquired immunodeficiency syndrome (AIDS) and transplant recipients, associated with necrotizing myocarditis and neurological symptoms related to the occurrence of necrotizing pseudotumoral [ncbi.nlm.nih.gov]
Cardiovascular
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Hypertension
The echocardiogram, which was normal preoperatively, showed dilated cardiac chambers, depressed left ventricular systolic function (ejection fraction 35%) and moderate pulmonary hypertension. [ncbi.nlm.nih.gov]
Workup
Opportunities exist to decrease heterogeneity of clinical workup and improve evaluation of persons who screen positive. [ncbi.nlm.nih.gov]
Serum
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CD4+ T Cells Decreased
CD4 T cells decreased with time in two patients and the lymphocyte proliferative response to T. cruzi was very low in all patients. These data suggest that T. cruzi infection may have a long silent course in immunosuppressed HIV patients. [ncbi.nlm.nih.gov]
Treatment
Benznidazole treatment reduced the frequency of CD4 CD8 T cells and decreased the ratio of CD4 CD8low/CD4 CD8high subpopulations. [ncbi.nlm.nih.gov]
Prognosis
Early diagnosis of the clinical reactivation of Chagas' disease in human immunodeficiency virus- and Trypanosoma cruzi-coinfected persons is fundamental for a good prognosis. [ncbi.nlm.nih.gov]
The prognosis depends upon the degree of heart variance. A variety of diagnostic methods have been used, but detection of antibodies to T. cruzi antigens remains the strongest method to diagnose infection. [ibl-international.com]
Etiology
The definitive confirmation of T. cruzi as the etiological agent was achieved by PCR suggesting that the NME by T. cruzi was due to a reactivation of Chagas' disease. [ncbi.nlm.nih.gov]
Epidemiology
This represents the first report of TcBat infection in humans; the epidemiological consequences of this finding are discussed herein. [ncbi.nlm.nih.gov]
Pathophysiology
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Chagas disease (American trypanosomiasis) is an acute and chronic infection caused by the protozoan hemoflagellate. [mayomedicallaboratories.com]
It is conceivable that neurogenic disturbances may be a contributory factor to the complications of the chronic phase of Chagas disease in at least 3 pathophysiological ways: A. [doi.org]
Complement in immune and inflammatory disorders: pathophysiological mechanisms. J. Immunol. 190, 3831–3838. doi: 10.4049/jimmunol.1203487 CrossRef Full Text Google Scholar Rimoldi, M. T., Sher, A., Heiny, S., Lituchy, A., Hammer, C. [frontiersin.org]
Prevention
We have previously proposed that local placental factors, such as the epithelial turnover of the trophoblast and the innate immune response initiated by Toll-like receptors (TLRs), might prevent parasite infection and congenital transmission. [ncbi.nlm.nih.gov]