Presentation
Tubercular meningitis presents with fever, headache, neck stiffness & cranial nerve palsy. Tuberculoma may present with headache, seizure and focal deficit. [ncbi.nlm.nih.gov]
Mode of presentation 3. Symptom analyses 4. [scribd.com]
[…] meningitis, unspecified convert 013.00 to ICD-10-CM 013.01 Tuberculous meningitis, bacteriological or histological examination not done convert 013.01 to ICD-10-CM 013.02 Tuberculous meningitis, bacteriological or histological examination unknown (at present [icd9data.com]
Results: In the present study, the most common CNS presentation was Tuberculous Meningitis followed by Tuberculoma. Common age group being between 15-19 yrs. [journalijar.com]
Entire Body System
- Fever
Tubercular meningitis presents with fever, headache, neck stiffness & cranial nerve palsy. Tuberculoma may present with headache, seizure and focal deficit. [ncbi.nlm.nih.gov]
Figure 1 A 28-year-old woman with a 10-year history of systemic lupus erythematosus presented with fever, back pain, and bilateral paresthesias and weakness of the legs of 10 days' duration. [nejm.org]
Patients and methods: A 74 year-old female was admitted in our clinic for investigation of fever, multiple bilateral pulmonary infiltrates and nodular cavitation in the left upper lobe. [jtd.amegroups.com]
- Weight Loss
A child or young person with active tuberculosis usually suffers from one or more of the following symptoms: loss of energy, poor appetite, loss of weight, and fever. [medical-dictionary.thefreedictionary.com]
Fever, night sweats, anorexia, weight loss and weakness are common, respiratory or other organ-specific symptoms less so. [canada.ca]
[…] were present in ∼60% to 75% of our cases, whereas cough, weight loss, and night sweats, which are commonly associated with pulmonary TB, were present in ∼25% of our patients. [pediatrics.aappublications.org]
In comparison to TNF −/− mice, MT-TNF −/− mice were similarly highly susceptible and rapidly succumbed to infection with >20% body weight loss (Figures 1 A,B). Table 1. [journal.frontiersin.org]
Cause Weight Loss[/url] Lose Weight Without Exercise Or Diet Meme Tacos Vs Bfads Anorexia Nervosa Symptoms Article 1 Of The Constitution Nissan 350z Specs 2003 Inicios De Varicela En Bebes De Dos Meses Alergia Al Frio Sintomas De Appendicitis Imitrex [movidasgordas.com]
- Sepsis
[…] by Mycobacterium tuberculosis, which may affect almost any tissue or organ of the body, with the most common seat of the disease being the lungs; the anatomic lesion is the tubercle, which can undergo caseation necrosis; general symptoms are those of sepsis [medical-dictionary.thefreedictionary.com]
No Prescription | Amoxicillin Tablets Buy Latisse http://millennialsberkarya.com/forums/topic/buy-leukeran-without-prescription-leukeran-cheap-leukeran/ Depression And Anxiety Medications With No Weight Gain Blood Pressure Chart By Age Webmd Disease Sepsis [movidasgordas.com]
Musculoskeletal
- Muscle Weakness
[…] disorder causing impaired muscle relaxation and variable degrees of permanent muscle weakness, abnormal currents linked to the chloride channel gene (CLCN1) encoding the chloride channel on skeletal muscle membrane. [zdoc.site]
Neurologic
- Convulsions
Ethnicity and stage of disease, headache, convulsions, motor function, brainstem dysfunction, and cerebral infarctions are all factors independently associated with poor outcome ( 1 ). [ispn.guide]
The characteristic features of this entity are the development of a diffuse cerebral disorder in the form of convulsions, stupor and coma without signs of meningeal irritation or focal neurological deficit. [omicsonline.org]
Suspected TBM CSF samples ( n = 240) Patients with clinical signs and symptoms of meningitis including one or more of the following presentations like headache, irritability, vomiting, fever, neck stiffness, convulsions, focal deficits, altered consciousness [ijmyco.org]
The female was diagnosed as having frontal non-convulsive status epilepticus. After 5 weeks of therapy with ethosuximide, the ictal electroencephalographic activity disappeared. [zdoc.site]
- Neurologic Manifestation
Neurological manifestations of TB-IRIS: a report of 4 children. Eur J Paediatr Neurol. 2012;16:676–82. View Article PubMed Google Scholar Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M. [jneuroinflammation.biomedcentral.com]
- Cranial Neuropathy
Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. [fpnotebook.com]
All presented bilateral deafness and multiple cranial neuropathies, variably associated with skeletal, cardiac and gastro-intestinal malformations. [zdoc.site]
- Personality Change
Fever was reported in 91%, vomiting in 87%, personality change in 63%, seizures in 62%, nuchal rigidity in 59%, and headaches in 58%. Table 2. Duration of Symptoms Before Admission Table 3. [pediatrics.aappublications.org]
The clinical course is characterized by a prodromal headache, malaise, fever and personality changes, followed by meningismus, cranial nerve palsies and confusion, which, if left untreated, can lead to seizures, coma and death within weeks Footnote 161 [canada.ca]
- Paresthesia
Figure 1 A 28-year-old woman with a 10-year history of systemic lupus erythematosus presented with fever, back pain, and bilateral paresthesias and weakness of the legs of 10 days' duration. [nejm.org]
The proband presented with an adult onset spastic paraparesis and diffuse paresthesias where neurophysiological and nerve biopsy morphological studies revealed an axonal neuropathy. [zdoc.site]
Workup
Clinical and instrumental workup of two symptomatic carriers in two generations has been carried out, together with genetic analysis of probands and of nine asymptomatic family members. [zdoc.site]
Cytology
- Cerebrospinal Fluid Abnormality
We tried to find a common metabolic abnormality, related with AHC. We did not find significant abnormalities in basic metabolic screening, at different ages. Neurotransmitters in cerebrospinal fluid (n = 26) were normal in all of the patients. [zdoc.site]
Treatment
For the treatment of CNS-TB, knowledge of the penetration across the blood-brain barrier of the various antituberculosis agents used in TB treatment is important. [ncbi.nlm.nih.gov]
Update on Tuberculosis of the Central Nervous System: Pathogenesis, Diagnosis, and Treatment. [kclpure.kcl.ac.uk]
Prognosis
Aseptic meningitis had a good prognosis compared to Obstructive Hydrocephalus which had a bad prognosis. [journalijar.com]
抄録 In spite of recent advances in diagnosis and chemotherapy of tuberculosis, prognosis of tuberculosis of the central nervous system (CNS) is still poor. [jstage.jst.go.jp]
The prognosis of tuberculous meningitis (TBM) correlates most closely with the clinical stage of illness at the time treatment is started. [ncbi.nlm.nih.gov]
Prospective Studies Transcriptome Tuberculosis, Meningeal Central Nervous System Neutrophils Humans Tuberculosis, Meningeal HIV Infections Caspase 1 Lymphocyte Count Prognosis Antiretroviral Therapy, Highly Active Prospective Studies Adult Middle Aged [spiral.imperial.ac.uk]
Etiology
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]
^ a b "Tuberculous Meningitis: Background, Pathophysiology, Etiology". 2018-05-23. ^ "Tuberculous Meningitis -- Medical Definition". www.medilexicon.com. Retrieved 2015-06-02. ^ Harman, Robin J.; Mason, Pamela (2002-01-01). [en.wikipedia.org]
Earlier data show that the most prevalent etiology in ABI is traumatic and that greater clinical impairments are reported for patients with non-traumatic etiologies. [zdoc.site]
[…] conventional spin echo (SE) sequences for imaging abnormal meninges, which appear hyperintense on precontrast T1W MT images and show further enhancement on postcontrast T1W MT images. [10] In addition, MT ratio (MTR) quantification helps in predicting the etiology [ijri.org]
If that assessment is non-diagnostic, a surgical biopsy should be performed for definitive diagnosis and to assess for etiologies other than tuberculosis osteomyelitis. [canada.ca]
Epidemiology
Epidemiology same as with adults: Inasmuch as children acquire infection with Mycobacterium tuberculosis from adults in their environment, the epidemiology of childhood TB follows that in adults. [ispn.guide]
Record : found Abstract : found Article : not found Global epidemiology of tuberculosis. Morbidity and mortality of a worldwide epidemic. [scienceopen.com]
We put forth this review to highlight the current understanding of the neuropathogenesis of M. tuberculosis, to discuss certain epidemiological, clinical, diagnostic, and therapeutic aspects of CNS tuberculosis, and also to underscore the many unmet needs [experts.umn.edu]
OBJECTIVES: To describe the epidemiology and factors associated with pediatric central nervous system (CNS) tuberculosis (TB) in California from 1993 to 2011. [ncbi.nlm.nih.gov]
Our epidemiologic data showed that 141 (66%) of the patients had a family history of TB, and 64 (30%) had a Mantoux skin test result of >10 mm of induration. [pediatrics.aappublications.org]
Pathophysiology
Central Nervous System Tuberculosis: Pathophysiology and Imaging Findings. Neuroimaging Clinics of North America, 22 (4), 677-705. [experts.umich.edu]
[ edit ] The pathophysiology of tuberculous meningitis has bacilli root itself to the brain parenchyma, which causes the formation of small subpial focus. [en.wikipedia.org]
Miliary tubercles are [Figure 4]. [10] In vivo MRS is a powerful technique that can provide biochemical information of the pathophysiological process of the tissue under investigation. [ijri.org]
Sporadic hemiplegic migraine (SHM) is a disorder, in which some patients may have their pathophysiology identical to FHM, but others, possibly the majority, may have different pathophysiology, probably related to the mechanisms of typical migraine with [zdoc.site]
Pathophysiology and prognosis in Vietnamese adults with tuberculous meningitis. J Infect Dis. 2003;188:1105–15. [jneuroinflammation.biomedcentral.com]
Prevention
Understanding how these microbial factors affect CNS disease would be essential to developing such preventive strategies. [ncbi.nlm.nih.gov]
Centers for Disease Control and Prevention (CDC) (2002 August 13, Reviewed). Frequently Asked Questions, Questions and Answers about TB. National Center for HIV, STD and TB Prevention Division of Tuberculosis Elimination [On-line information]. [labtestsonline.it]
Imaging plays an important role in the early diagnosis of CNS tuberculosis and may prevent unnecessary morbidity and mortality. [experts.umich.edu]