Presentation
Tuberculosis of pubic symphysis presenting with hypogastric mass. [jpgmonline.com]
Definitive diagnosis of tuberculosis is made after demonstration of M. tuberculosis by microbiological, cytopathological or histopathological methods (as done in present case). [ispub.com]
In our case, the clinical presentation directed us towards adnexal malignancy. [abdominalsurg.org]
The urine and seminal fluid of 2 patients presenting with hemospermia and of 1 patient presenting irritative voiding symptoms with abnormal DRE were sent for an AFB smear, mycobacterial culture, and PCR. [urotoday.com]
Majority of cases presented late in our set up which causes delay in management, increases number of complications and atypical presentations. [pjms.com.pk]
Entire Body System
- Pain
When no disease occurs pain in the pelvic bones: The main causes of pain in the pelvic bones: 1. [md-tips.com]
Bone tuberculosis. pain in pelvic bone I have bone tb. i m takin myrin P forte since 1 month. i had severe pain in left pelvic bone and the pain was radiating in left leg. now after 1 month of treatment my pain is almost 25% left. i m taking panadol pain [practo.com]
Read Full » I get lower back pain on and off. What to do? Query: Hi doctor, I have been suffering from lower back pain, which radiates to my buttock and thigh muscles. The pain is not constant. It comes and goes. What shall I do? Read Full » Dr. [icliniq.com]
Q: I was suffering from pain in my hip joint since last year, which was wrongly taken as a normal rheumatic pain by my doctor, who advised treatment under a physiotherapist. The pain continued and spread to the other hip also making me immobile. [doctor.ndtv.com]
There was a significant reduction in pain scores after treatment. Conclusion: Genital tuberculosis contributes to one-third cases of chronic pelvic pain. [ijmyco.org]
- Fever
Infection of the kidneys may manifest as pyelonephritis (eg, fever, back pain, pyuria) without the usual urinary pathogens on routine culture (sterile pyuria). [merckmanuals.com]
Fever Non-productive cough Breathing difficulty Pain on deep breathing Decreased air entry in the chest over where the fluid has accumulated Hypoxia Tachypnea Tuberculosis of the Nervous System Fever Headache, nausea, vomiting Altered Mental Status Convulsions [medindia.net]
There are problems when trying to differentiate certain diseases for example; TB with brucellosis (undulant fever). [allthingsaafs.com]
May be symptoms such as fever, chills, night sweats and weight loss, but they are less common. [md-tips.com]
Pleural tuberculosis often is an acute illness with cough, pleuritic chest pain, fever, or dyspnea. [aafp.org]
- Weight Loss
May be symptoms such as fever, chills, night sweats and weight loss, but they are less common. [md-tips.com]
Symptoms vary by site but generally include fever, malaise, and weight loss. Diagnosis is most often by sputum smear and culture and, increasingly, by rapid molecular-based diagnostic tests. [merckmanuals.com]
J Postgrad Med 2001;47:54 A 28-year-old male patient presented with a swelling in the hypogastrium since one and a half months associated with a history of chronic cough, anorexia and weight loss. [jpgmonline.com]
The symptoms of extra pulmonary tuberculosis are more varied, but fever and weight loss are present in the majority of cases. [medindia.net]
- Collapse
Stage of advanced arthritis: Collapse subluxation or dislocation migration of bone deformity of joint 88. 4. [slideshare.net]
Untreated, the vertebrae may collapse, possibly impinging on the spinal cord. Symptoms include progressive or constant pain in involved bones and chronic or subacute arthritis (usually monoarticular). [merckmanuals.com]
Infection of the vertebral column (spine) by TB can cause collapse and fracture of the bones and/or abscess formation, which may lead to compression of the spinal cord, with drastic consequences. [medindia.net]
Discussion Tuberculosis spondylitis preferentially affects the anterior structures of the vertebral column in more than 90% of patients with lumbosacral tuberculosis. 13 Collapse and major vertebral body loss causes spinal instability and kyphosis. [healio.com]
In some cases, the femoral head and neck are grossly destroyed, collapsed and small in size contained in an enlarged acetabulum-mortar and pestle appearance. All the movements of the hip are grossly restricted. [boneandspine.com]
- Fatigue
- For acute leukemia characterized by: General weakness, fatiguability, the undefined the pain in the bones, inconstant subfebrile, the increase in peripheral lymph nodes, spleen. [md-tips.com]
Symptoms may be mild, with fatigue, abdominal pain, and tenderness, or severe enough to mimic acute abdomen. Pericardial infection may develop from foci in mediastinal lymph nodes or from pleural TB. [merckmanuals.com]
The symptoms of active pulmonary tuberculosis include: Fever, which is usually persistent and low grade, but may also sometimes be high grade and spiking Prolonged cough for three weeks or more Coughing of blood Loss of weight Loss of appetite Fatigue [medindia.net]
The results are muscle fatigue and low back pain. [healio.com]
A history of poor general health persisting over months or years and associated with weight loss, undue fatigue, low-grade fever, or vague lower abdominal discomfort is often elicited in patients with genital TB. [glowm.com]
Respiratoric
- Aspiration
CT guided needle aspiration of pus showed presence of acid fast bacilli. Fluid adenosine deaminase level was 284 U/L (normal of 0.1-22 U/L). Patient was started on antituberculous drugs and he showed good response. [jpgmonline.com]
Cytological Diagnosis of Vertebral Tuberculosis with Fine-Needle Aspiration Biopsy. Radiology of skeletal tuberculosis. Original Text by Clifford R. Wheeless, III, MD. [wheelessonline.com]
Thus, supporting the use of endometrial tissue biopsy, ovarian tissue biopsy, endometrial aspirations, pelvic aspirated fluids and fluid samples from the pouch of Douglas (POD), therefore endorses the study by Bhanu et al on the importance of multiple [journals.plos.org]
Differential diagnosis – Juvenile rheumatoid arthritis Villonodular synovitis Osteochondritis dissecans Hemophilia Biopsy of the synovial membrane and aspiration of thejoint fluid followed by smear & culture can confirm thediagnosis 112. [slideshare.net]
Treatment of septic arthritis should include prompt removal of purulent synovial fluid and needle aspiration. [omicsonline.org]
Gastrointestinal
- Nausea
Involvement of the meninges or the brain itself may cause many symptoms and signs, including headache, nausea, vomiting, stiff neck, confusion, delirium, seizures etc. [medindia.net]
Symptoms are low-grade fever, unremitting headache, nausea, and drowsiness, which may progress to stupor and coma. Kernig and Brudzinski signs may be positive. [merckmanuals.com]
Later observed loss of appetite, nausea, pain in the abdomen, may be persistent diarrhea. Sometimes in the forefront of the symptoms of nephrolithiasis. [md-tips.com]
Patients should be questioned regarding the presence or absence of symptoms such as nausea, vomiting, dark urine, abdominal pain, anorexia, rash, tingling in the hands and feet, etc. [antimicrobe.org]
Musculoskeletal
- Osteoporosis
An example of this is osteoporosis; this condition leaves the inners of bones a lot more porous than normal bones. [allthingsaafs.com]
From well-woman exams to family planning to osteoporosis care, we’re here for all the women of Taos and northern New Mexico, at all stages of life and health. [taoswomenshealth.org]
Radiography – Plain radiograph usually normal Displacement of fat planes (effusion) Soft tissue swelling and deossification Radiologically significant osteoporosis appears 12 to 18weeks after onset of symptoms (c/w pyogenic arthritis) Clinical - [slideshare.net]
A triad of radiologic abnormalities ( Phemister's triad ) include: peri-articular osteoporosis peripherally located osseous erosion gradual diminution of the joint space By radiological features, tubercular arthropathy can be divided into early and late [radiopaedia.org]
There is osteoporosis of the involved bones. This occurs due to increased circulation of the bone following inflammation. A slight decrease in the joint space may be visible due to cartilage destruction. [boneandspine.com]
- Hip Pain
A 64 years old man who presented in November 2004 complaining of right groin and hip pain related to activity. [hipandpelvis.or.kr]
Recently, I developed pain in the right thigh joint, but able to walk normally. In some positions, it is painful. I have got my MRI study of the hip joint. The report is enclosed here... Read Full » Dr. [icliniq.com]
The patient usually presents with pain and limping and deformity around the hip. Pain may be referred to medial aspect of the knee. The severity of the pain is maximum at the end of the day. The limp is the earliest and commonest symptom. [boneandspine.com]
- Muscle Spasm
There would be muscle spasm in lower abdominals and adductors of the hip and disproportionate wasting of muscles of the affected limb. [boneandspine.com]
Other local features may be muscle spasms and discharging sinuses. There may be additional features referable to the primary site of involvement, such as the lungs, but these may be minor or even absent. [ijp-online.com]
- Muscle Cramp
Deficiency of thiamine, or vitamin B1, is accompanied, along with the other symptoms, a sense of stinging and tingling in the feet and calves and muscle cramps in the legs. [md-tips.com]
Neurologic
- Headache
Involvement of the meninges or the brain itself may cause many symptoms and signs, including headache, nausea, vomiting, stiff neck, confusion, delirium, seizures etc. [medindia.net]
Symptoms are low-grade fever, unremitting headache, nausea, and drowsiness, which may progress to stupor and coma. Kernig and Brudzinski signs may be positive. [merckmanuals.com]
In the early stages of a note uncertain bone pain, muscle weakness, fatigue, headache. Later observed loss of appetite, nausea, pain in the abdomen, may be persistent diarrhea. Sometimes in the forefront of the symptoms of nephrolithiasis. [md-tips.com]
[…] weeks by protracted headache, meningismus, vomiting, confusion, and focal neurologic findings. [aafp.org]
Patients may present with a headache that is either intermittent or persistent for 2-3 weeks. If not detected and treated coma may develop. [ourmed.org]
- Seizure
Involvement of the meninges or the brain itself may cause many symptoms and signs, including headache, nausea, vomiting, stiff neck, confusion, delirium, seizures etc. [medindia.net]
Tuberculomas Patients with tuberculoma are usually asymptomatic but may present with headache, seizures (focal or generalized) or focal neurologic signs, depending upon the location of the lesion(s) Footnote 20. [canada.ca]
Cerebral edema causes impairment of consciousness, seizures, and raised intracranial pressure, whereas tuberculomas can manifest as space-occupying lesions. 30 An initial phase of malaise, headache, fever, or personality change is followed in two to three [aafp.org]
Patients may present with seizures or other focal neurologic symptoms without evidence of systemic illness or meningeal inflammation. [antimicrobe.org]
In patients at risk for peripheral neuropathy, concomitant pyridoxine administration is recommended, and it is also recommended in patients with seizure disorders and in pregnant women. RIFAMPIN. [glowm.com]
- Dizziness
He is unable to walk, move and feel dizzy. We consulted many doctors, some said he is having bone tuberculosis and he got treated for that. After treatment, it got cured. But, with changing weather it gets revoked and the pain will be more acute. [icliniq.com]
[…] manifestations of Paget's disease of the disease are the following: - pain in the affected pelvic bones; - bone deformation (the lower extremities, spine); - secondary osteoarthritis; - fractures; - neurological disorders (compression neuropathy, hearing loss, dizziness [md-tips.com]
Not approved by FDA for TB treatment Should not be used in children Avoid: antacids, iron, zinc, sucralfate Gatifloxacin 400 mg/day GI upset Drug interactions Dizziness Headaches Hypersensitivity Restlessness Drug interactions Not approved by FDA for [antimicrobe.org]
- Paresis
Paresis of cranial nerves, especially ocular nerves, is a frequent finding. Approximately three fourths of cases have evidence of concomitant extrameningeal tuberculosis, and 50% have abnormalities on chest X-ray. [antimicrobe.org]
Workup
Following patient history, laboratory and clinical workup we did not suspect pelvic tuberculosis and the diagnosis was made following intraoperative exclusion of malignancy. [abdominalsurg.org]
(See Workup.) The usual treatment regimen for TB cases from fully susceptible M tuberculosis isolates consists of 6 months of multidrug therapy. [emedicine.medscape.com]
Routine laboratory workup revealed that the erythrocyte sedimentation rate was 56 mm in the first hour. Hemoglobin level was 9.8 g/dL. The full blood count showed normocytic normochromic anemia, and a normal total and differential white cell count. [bone.imedpub.com]
Apart from routine examinations, laparoscopy and hysteroscopy were performed at infertility workup as and when needed. [journals.plos.org]
Female genital TB is typically understood as a disease of young women, with 80% to 90% of cases diagnosed in patients 20–40 years old, often during workup for infertility. 5 More recent reports from Sweden and Scotland suggest a trend toward presentation [glowm.com]
Skin Test
- Skin Test Positive
In addition, men are more likely than women to have a positive tuberculin skin test result. The reason for these differences may be social, rather than biologic, in nature. [emedicine.medscape.com]
Treatment
ATT treatment: The first line of treatment is to put a woman on anti-tuberculosis treatment. ‘It is imperative for the patient to undergo the full course of treatment to avert infertility and eventually conceive naturally,’ says Dr Sinha. [thehealthsite.com]
If response is slow or inadequate, treatment may be prolonged on a case-by-case basis. Treatment in HIV-positive individuals The treatment regimens as outlined above are also effective in the presence of HIV infection. [ijp-online.com]
The final section focuses on tuberculosis of the spine, including imaging for the disease, differential diagnosis, operative treatment, and surgical anatomy. [books.google.de]
A: Treatment of TB of the hip joint can lead to a normal pain free joint only if the treatment is started before there has been much destruction of the joint. [doctor.ndtv.com]
His repeated radiography of HIP region after treatment completion revealed was close to earlier. (Fig:2). Figure 2 Figure 2: X- Ray HIP AP view after treatment completion. [ispub.com]
Prognosis
[…] acetabuli may be caused by rheumatoid arthritis, Paget's disease, or osteomalacia. [2] In addition, protrusio acetabuli may be present bilaterally in Paget's disease, Marfan syndrome, [3] rheumatoid arthritis, ankylosing spondylitis, and osteomalacia ; Prognosis [en.wikipedia.org]
[…] para-articular abscess, tenosynovitis, bursitis, skin ulceration or sinus tract formation): sinus tracts appear linear T2 hyperintensity with marginal ‘tram-track enhancement’ para-articular abscesses have thin, smooth and enhancing wall Treatment and prognosis [radiopaedia.org]
Approach Synovitis Analgesics Antitubercular chemotherapy Traction, rest and mobilization Surgical interventions usually are not required Early arthritis Treatment similar to stage Synovectomy and joint debridement – to reduce the disease tissue load The prognosis [boneandspine.com]
If the cancer is localized (has not spread), the prognosis is usually good. According to the University of Rochester Medical Centre, United Kingdom, for all bone cancers combined, the 5-year survival rate is around 70 percent. [medicalnewstoday.com]
Pott's paraplegia in patients with severely deformed dorsal or dorsolumbar spines: Treatment and prognosis. [ijp-online.com]
Etiology
Conclusion Idiopathic CPP should be evaluated laparoscopically and genital TB should be considered as an important differential diagnosis in the etiology. [ijmyco.org]
Any factor which modifies the state of local resistance and resultant activation of dormant tubercle bacilli, microtrauma has been proposed as a mechanism, however no case could it be established that trauma was an etiological factor. [radiopaedia.org]
CT provides detailed analysis of the joint line and adjacent bone and visualization of microcalcifications within abscesses highly suggestive of tuberculous etiology [ 12 ]. [em-consulte.com]
Genital tuberculosis is one of the major etiologic factors of female tubal infertility, especially on the Indian subcontinent. [laparoscopyhospital.com]
His bone pain that did not respond to simple analgesics may have been of infective or neoplastic etiology. There are no specific radiographic features of tubercles osteomyelitis. [bone.imedpub.com]
Epidemiology
The first section covers general considerations in osteo-articular tuberculosis, including epidemiology and prevalence, pathology and pathogenesis, diagnosis and investigations, and anti-tubercular drugs. [books.google.de]
The epidemiology of Langerhans cell histiocytosis in Denmark, 1975–1989. Med Pediatr Oncol 1993; 21 : 387–388. 6 Nicholson HS, Egeler RM, Nesbit ME. The epidemiology of Langerhans cell histiocytosis. [nature.com]
(See Epidemiology and Treatment.) Historical background TB is an ancient disease. [emedicine.medscape.com]
Chapter 7 - Nonrespiratory Tuberculosis Dina Fisher, MSc, MD, FRCPC Kevin Elwood, MD Table of Contents Key Messages/Points 1.1 Epidemiology 1.2 Diagnosis 1.3 Treatment Definition Epidemiology Diagnostic Considerations Clinical Presentations 5.1 Peripheral [canada.ca]
Epidemiology Information concerning the epidemiology of septic arthritis is limited due to several factors. [omicsonline.org]
Pathophysiology
Read Detailed Anatomy of Hip Joint Pathophysiology of Tuberculosis of Hip Tuberculosis of hip, like other osteoarticular tuberculosis, is secondary to primary pathology in lungs, lymph nodes or any of the viscera. [boneandspine.com]
CPP is a multifactorial entity, with a poorly understood etiology and complex pathophysiology. As a result, there is a lack of evidence-based diagnosis and management options for CPP. [ijmyco.org]
Pathophysiology Infection with M tuberculosis results most commonly through exposure of the lungs or mucous membranes to infected aerosols. [emedicine.medscape.com]
Pathophysiology M. tuberculosis infection occurs through inhalation of aerosolized bacteria, ingestion or direct inoculation from infected individuals. [omicsonline.org]
Improved understanding of the complex pathophysiology will be required to expedite the identification of suitable biomarkers of protective immunity, and hopefully, the development of a vaccine that outperforms the natural pathogen in stimulating protective [antimicrobe.org]
Prevention
Centers for Disease Control and Prevention. (2014 February 7, Updated.) Treatment for Latent TB Infection. Available online at http://www.cdc.gov/tb/topic/treatment/ltbi.htm. Accessed January 2016. Centers for Disease Control and Prevention. [labtestsonline.it]
Ways to prevent it While genital tuberculosis is a matter of concern mainly for women in reproductive age, prevention for the same starts with treating the infection early. [thehealthsite.com]
- Protection of Health Care Personel: - historically transmission rate has been high; - in the past, when strict prevention measures were not manditory, there have been some reports of nearly half of health care students becoming PPD positive after [wheelessonline.com]
Kill persisting bacilli : To effect cure and prevent relapse. This depends on sterilizing capacity of the drug. Prevent emergence of resistance : So that the bacilli remain susceptible to the drugs. [doctoralerts.com]