Lesions typically present during infancy or early childhood and are most commonly reported to persist and/or expand over time. Congenital presentations are rare, as are reports of spontaneous regression. [ncbi.nlm.nih.gov]

Case presentation Case 1 A 17-year-old male presented with a history of a gradually progressive, painless swelling of right lower eyelid of 6 years’ duration. [diagnosticpathology.biomedcentral.com]

• Prolonged Bleeding

  A female infant, born with a tufted angioma, developed a coagulopathy with prolonged bleeding time, with the risk of progression to Kasabach-Merritt phenomenon. [ncbi.nlm.nih.gov]

• Hunting

  Wassef M, Hunt SJ, Santa Cruz DJ, Barnhill RL. Vascular tumors and vascular malformations. In: Barnhill RL editor. Dermatopathology. 3 rd ed. New York: McGraw Hill; 2010; p. 805-6. 10. [e-ijd.org]

• Soft Tissue Mass

  At biopsy under local anesthesia, the mass appeared o be reddish and ill-defined with intermingling soft and firm areas. Piecemeal excision of the lesion was done and the excised tissue was submitted for histological examination. [diagnosticpathology.biomedcentral.com]

• Episodic Pain

  In the subsequent years, she experienced episodic pain at the same site, but no specific therapy was given. [nature.com]

• Eye Pain

  PATIENT: A 73-year-old man presented with right eye pain, redness, burning sensation, swelling, and double vision. [ncbi.nlm.nih.gov]

• Papule

  A 4-month-old girl developed coalescing, red-purple, firm plaques with irregular borders and superimposed papules in the left groin. The lesions were tender to palpation and they slowly expanded and became thicker over the next year. [ncbi.nlm.nih.gov]

• Localized Hyperhidrosis

  We found localized hyperhidrosis in two of our patients. Proliferation of eccrine glands near the tumour lobule was a consistent finding in the biopsy specimens from these four patients. [ncbi.nlm.nih.gov]

• Macula

  This lesion was seen at the age of 7 as a small, asymptomatic red wine macula, which grew progressively. At present it is slightly painful and presents papular areas. [elsevier.es]

• Epistaxis

  A 35-year-old woman visited our clinic because of frequent epistaxis. A mass was found in the left posterior nasal cavity, adjacent to the middle turbinate, and attached to the nasal septum. [ncbi.nlm.nih.gov]

• Suggestibility

  Cell marker studies suggest that the cell lobules of the angiomas consist of closely packed blood capillary endothelial and perithelial cells. [ncbi.nlm.nih.gov]

• Burning Sensation

  PATIENT: A 73-year-old man presented with right eye pain, redness, burning sensation, swelling, and double vision. [ncbi.nlm.nih.gov]

Effective treatments reported in the literature are scarce. We report a case of tufted angioma in a child, which had a successful outcome after treatment with the pulsed-dye laser both in terms of cosmesis and alleviation of pain and discomfort. [ncbi.nlm.nih.gov]

Variable response to propranolol treatment of kaposiform hemangioendothelioma, tufted angioma, and Kasabach-Merritt phenomenon. [scholars.northwestern.edu]

It has been associated with Kasabach-Merritt syndrome, a severe coagulopathy of poor prognosis. There have been very few published cases of oral tufted angiomas, and maxillary bone involvement has not been hitherto reported. [ncbi.nlm.nih.gov]

What is the Prognosis of Tufted Angioma? (Outcomes/Resolutions) The prognosis of Tufted Angiomas with adequate treatment is usually good. [dovemed.com]

Treatment and prognosis Various treatments are used, with varying degrees of success, in Kasabach-Merritt syndrome - systemic corticosteroids, radiation therapy, compression, embolization and/or pharmacotherapy (e.g. interferon, platelet aggregation inhibitors [radiopaedia.org]

Prognosis in patients with large or abdominal tumors is poor. Mortality is approximately 10% and is attributable to extensive local disease or Kasabach-Merritt phenomenon. [path.upmc.edu]

Its etiology and pathogenesis are uncertain. Tufted angioma typically occurs during infancy or early childhood and displays various clinical patterns. [ncbi.nlm.nih.gov]

Etiology Kasabach-Merritt syndrome is usually caused by kaposiform hemangioendothelioma or tufted angioma. Other vascular tumors may be responsible, such as infantile hemangioma. The radiographic features are specific to each vascular tumor. [radiopaedia.org]

The etiology of kaposiform hemangioendothelioma remains unknown. It is not associated with HHV8 infection or Kaposi sarcoma. Tumors often involve soft tissue of extremities as ill-defined, violaceous lesions and may encase normal structures. [path.upmc.edu]

(Etiology) The exact cause of Tufted Angioma formation is unknown. [dovemed.com]

Her main area of interest is cancer epidemiology, with a particular focus on melanoma and other skin cancers. Nagwa M. Elwan is Professor of Dermatology at the Faculty of Medicine, Tanta University, Egypt. [books.google.com]

[…] pattern Considered to be on the same neoplastic spectrum as kaposiform hemangioendothelioma ; some consider it to be the same entity Terminology Synonyms: Tufted angioma, Nakagawa’s angioblastoma, progressive capillary hemangioma, tufted hemangioma Epidemiology [pathologyoutlines.com]

Other clinical findings include increase in local sensitivity, and, more rarely, hyperhydrosis and hypertricosis.9 All clinical and epidemiological data pof the present patient agree to those in literature. [scielo.br]

Vascular markers (CD31 and CD34), vascular endothelial growth factor receptor-3 (VEGFR-3), and lymphatic markers (D2-40 and PROX1) on the neoplastic cells suggest they may be derived from the endothelial cells of lymphatic vessels. [3, 4] Epidemiology [emedicine.medscape.com]

We included a total of nine patients for whom we collected epidemiological data such as sex, age at onset and ethnicity; clinical data such as localisation, appearance, and clinical diagnosis; data on diagnostic testing, such as imaging studies, coagulation [analesdepediatria.org]

Tufted angiomas usually have a benign course, with only rare reports of aggressive behavior or local invasion. [1] However, tufted angiomas seldom self-involute. [2] Pathophysiology The pathogenesis of tufted angiomas is not well understood. [emedicine.medscape.com]

Familiarity with distinctive histologic features of tufted angioma should prevent these lesions from being misdiagnosed as either Kaposi's sarcoma or as angiosarcoma. [ncbi.nlm.nih.gov]

Also, post-operative follow-up care with regular screening and check-ups are advised, especially to monitor for any recurrences How can Tufted Angioma be Prevented? Current medical research has not established a method of preventing Tufted Angioma. [dovemed.com]

Consequently, we chose radical excision of the lesion to prevent, if the medical treatment was ineffective, the lesion from reaching critical areas. Various options exist for medical treatment. [elsevier.es]

One can also argue whether an early intervention with interferon for example, may prevent complications such as the Kasabach-Merritt syndrome, or the local aggressive infiltration of this tumor. [nature.com]

If a lesion responds to steroid, the dose should be reduced slowly to prevent recurrence. [synapse.koreamed.org]