Presentation
This form accounts for ≤4% of all reported cases of tularemia 1, 2 but has been present in 67% of the cases of meningitis in patients ≤16 years of age. [journals.lww.com]
Snapshot A 40-year-old woman presents to the emergency room for acute-onset fever, nausea, vomiting, and diarrhea. She works as a veterinarian tech in rural Colorado. [medbullets.com]
Oropharyngeal: The oropharyngeal form can present with stomatitis or an exudative pharyngitis or tonsillitis. There may also be ulcers and cervical lymphadenopathy. It may present with cervical nodes resembling the "bull neck" of diphtheria. [visualdx.com]
Classified as 7 distinct forms, each of which presents as a different clinical syndrome. Diagnosis requires a high index of suspicion from the clinical presentation, although it can be confirmed only by serologic testing. [online.epocrates.com]
Entire Body System
- Fever
[…] specified arthropod-borne viral fevers A94Unspecified arthropod-borne viral fever A950Sylvatic yellow fever A951Urban yellow fever A959Yellow fever, unspecified A960Junin hemorrhagic fever A961Machupo hemorrhagic fever A962Lassa fever A968Other arenaviral [cms.gov]
517 CommunityAcquired Pneumonia Due to Nonfermenting GramNegative Bacilli 531 Miscellaneous Bacterial Causes of CommunityAcquired Pneumonia 541 Listeria 555 Q Fever 571 Acute Q Fever Treatment 585 Parainfluenza Viruses 602 Respiratory Syncytial Virus [books.google.es]
Rickettsia rickettsii and other spotted fever group rickettsiae (Rocky Mountain spotted fever and other spotted fevers). In: Mandell GL, Douglas RG, Bennett JE, Dolin R, eds. [aafp.org]
North Asian tick typhus, Siberian tick typhus, Astrakhan fever, African tick bite fever, Japanese spotted fever, Queensland tick typhus, Flinders Island spotted fever, Israeli tick typhus, Marseilles tick bite fever Influenza Typhoid fever Disseminated [emedicine.medscape.com]
- Malaise
PATIENT: A 21-year-old healthy man who had recently worked as a professional landscaper in the Albuquerque, New Mexico, metropolitan area developed fever, malaise, headache, and a stiff neck. [ncbi.nlm.nih.gov]
Most patients exhibit generalized symptoms including fever, chills, headache, malaise, anorexia, fatigue, cough, myalgias, chest discomfort, vomiting, sore throat, abdominal pain and diarrhea. [aafp.org]
Patients with this disease present with the following: Fever Chills Myalgias Malaise Weight loss Patients often have pneumonia. Diagnosis is difficult because ulcers and lymphadenopathy are usually absent. [emedicine.medscape.com]
Hepatic failure Renal failure Rhabdomyolysis Meningitis Endocarditis Osteomyelitis Sepsis Peritonitis Tick, deerfly, or mosquito bite Exposure to contaminated food or water Exposure to contaminated blood Abrupt onset of fever, chills, headache, and malaise [quizlet.com]
- Chills
Mild systemic symptoms may accompany the rash including fatigue, myalgias, arthralgias, headache, fever and chills. [aafp.org]
Early symptoms almost always include the abrupt onset of fever, chills, headache, muscle aches, joint pain, dry cough, and progressive weakness. [health.wyo.gov]
Chills Eye irritation ( conjunctivitis -- if the infection began in the eye) Fever Headache Joint stiffness Muscle pains Red spot on the skin, growing to become a sore (ulcer) Shortness of breath Sweating Weight loss Exams and Tests Blood culture for [sites.magellanhealth.com]
Typically, a patient has an abrupt onset of fever, headache, chills and rigors, myalgia (especially the low back), coryza, and sore throat. In 42% of patients, a pulse-temperature dissociation has been observed. [visualdx.com]
- Veterinarian
She works as a veterinarian tech in rural Colorado. She frequently treats exotic pets and wildlife refugees, involving injured rabbits and muskrats. On physical exam, she is severely febrile. [medbullets.com]
- High Fever
Snapshot A 40-year-old woman presents to the emergency room for acute-onset fever, nausea, vomiting, and diarrhea. She works as a veterinarian tech in rural Colorado. [medbullets.com]
Gastrointestinal
- Nausea
Snapshot A 40-year-old woman presents to the emergency room for acute-onset fever, nausea, vomiting, and diarrhea. She works as a veterinarian tech in rural Colorado. [medbullets.com]
Nausea, vomiting, and diarrhea may also occur. Francisella tularensis usually produces a marked reaction at the portal of entry. [visualdx.com]
[…] nodes Systemic febrile illness Fulminating sepsis Assessment-Oculoglandular Painful red eye Purulent exudates Swollen submandibular, preauricular, or cervical lymph nodes Photophobia Sore throat Cervical adenopathy Exudative pharyngitis Abdominal pain Nausea [quizlet.com]
[…] streptomycin No Interactions Found Interactions Found Serious - Use Alternative Significant - Monitor Closely All Interactions Sort By: Adverse Effects Frequency Not Defined Hypotension Neurotoxicity Drowsiness Headache Drug fever Paresthesia Skin rash Nausea [reference.medscape.com]
Manifestations of oropharyngeal tularemia include the following: Stomatitis and exudative pharyngitis or tonsillitis - The patient may occasionally develop a yellow-white pseudomembrane resembling diphtheria Abdominal pain (due to mesenteric lymphadenopathy), nausea [emedicine.medscape.com]
- Vomiting
Snapshot A 40-year-old woman presents to the emergency room for acute-onset fever, nausea, vomiting, and diarrhea. She works as a veterinarian tech in rural Colorado. [medbullets.com]
Most patients exhibit generalized symptoms including fever, chills, headache, malaise, anorexia, fatigue, cough, myalgias, chest discomfort, vomiting, sore throat, abdominal pain and diarrhea. [aafp.org]
Nausea, vomiting, and diarrhea may also occur. Francisella tularensis usually produces a marked reaction at the portal of entry. [visualdx.com]
[…] forms of tularemia: Abrupt onset of fever and chills - These symptoms typically last for several days, remit for a brief interval, and then recur Pulse-temperature disassociation [1] Headache Anorexia Malaise and fatigue or prostration Myalgias Cough Vomiting [emedicine.medscape.com]
Eyes
- Photophobia
[…] inoculation that don't heal Swollen regional lymph nodes Swollen localized lymph nodes Systemic febrile illness Fulminating sepsis Assessment-Oculoglandular Painful red eye Purulent exudates Swollen submandibular, preauricular, or cervical lymph nodes Photophobia [quizlet.com]
[…] conjunctivitis; some patients experience chemosis, periorbital edema, and small, nodular or ulcerative lesions of the palpebral conjunctivae Corneal ulceration Lymphadenopathy - Most commonly cervical, but preauricular and submandibular also observed Photophobia [emedicine.medscape.com]
Early symptoms include photophobia and increased lacrimation. Later, patients develop lid edema, painful conjunctivitis with scleral injection, chemosis and small yellowish conjunctival ulcers or papules. [aafp.org]
Neurologic
- Headache
Volume 1 covers the visual sensory system, the autonomic nervous system, the ocular motor system, the eyelid, facial pain and headache, and nonorganic disease. Volume 2 covers tumors, the phacomatoses, and vascular disease. [books.google.es]
Mild systemic symptoms may accompany the rash including fatigue, myalgias, arthralgias, headache, fever and chills. [aafp.org]
PATIENT: A 21-year-old healthy man who had recently worked as a professional landscaper in the Albuquerque, New Mexico, metropolitan area developed fever, malaise, headache, and a stiff neck. [ncbi.nlm.nih.gov]
- Confusion
Symptoms of tularemia are initially nonspecific and the disease can be confused with less pathogenic microbial infections. Serological assays for tularemia have been explored but the time to diagnosis following infection is clearly too long. [med.unr.edu]
In addition to the GI presentation of the typhoidal form, central nervous system symptoms such as confusion or coma may occur. [visualdx.com]
This presentation can cause clinicians confusion about potential etiologic agents for their patient's disease, and many of the patients have been assumed to have meningitis caused by Mycobacterium tuberculosis, Listeria monocytogenes or a virus. 4, 8, [journals.lww.com]
Less common symptoms include nausea, vomiting, abdominal pain, diarrhea, cough and confusion. A rash occurs in fewer than one half of patients with HME and fewer than one tenth of those with HGE. [aafp.org]
- Irritability
Overnight KH became increasingly irritable and lethargic and developed projectile emesis. A lumbar puncture was performed. [journals.lww.com]
Chills Eye irritation ( conjunctivitis -- if the infection began in the eye) Fever Headache Joint stiffness Muscle pains Red spot on the skin, growing to become a sore (ulcer) Shortness of breath Sweating Weight loss Exams and Tests Blood culture for [sites.magellanhealth.com]
- Neck Stiffness
Physical examination may reveal neck stiffness, regional adenopathy and secondary skin lesions smaller than the primary lesion and not associated with the site of the tick bite. [aafp.org]
- Focal Neurological Deficit
neurologic deficits; death may occur within 24 hours of disease onset; pathologic features include a purulent exudate in the subarachnoid space, and diffuse inflammation of neural and vascular structures. [fpnotebook.com]
Workup
Serum
- Hyponatremia
[…] weeks Doxycycline Chloramphenicol Rifampin Rocky Mountain spotted fever Rickettsia rickettsii Southeast Atlantic coast states and Midwest Fever, headache, myalgias, malaise, vomiting, rash Mild leukopenia, thrombocytopenia, elevated liver transaminases, hyponatremia [aafp.org]
Microbiology
- Francisella Tularensis
MAIN OUTCOME MEASURES: Francisella tularensis cerebrospinal fluid culture, antibiotic sensitivity, transmission source, and outcome. [ncbi.nlm.nih.gov]
Keywords : Ciprofloxacin, Francisella tularensis, Bacterial meningitis Mots clés : Ciprofloxacine, Francisella tularensis, Méningite bactérienne © 2011 Elsevier Masson SAS. All Rights Reserved. [em-consulte.com]
Tularemia is a zoonotic disease caused by the Gramnegative coccobacillus, Francisella tularensis. [journals.lww.com]
Treatment
Reference is easy thanks to a unique 3-part structure covering general aspects of treatment; reviews of every agent; and details of treatments of particular infections. [books.google.com]
Treatment The goal of treatment is to cure the infection with antibiotics. Streptomycin and tetracycline are commonly used to treat this infection. [sites.magellanhealth.com]
Prognosis
Prognosis following treatment is excellent. Ulceroglandular tularemia of the lower extremity from a tick bite; ulcer over the patella and ascending lymphadenopathy are evident Courtesy of Barry Farr, MD, MPH [online.epocrates.com]
[…] and other organs inhalation may result in pulmonary disease Associated conditions ulceroglandular tularemia (most common) typhoidal tularemia pulmonary tularemia may accompany both ulceroglandular (< 50% of cases) or typhoidal (80% of cases) tularemia Prognosis [medbullets.com]
Outlook (Prognosis) Tularemia is fatal in about 5% of untreated cases, and in less than 1% of treated cases. [sites.magellanhealth.com]
Etiology
If you suspect or have confirmation of the following specified “Diseases of Public Health Significance”, or their “etiologic agents”, as per Ontario Reg 135/18 and amendments under the Health Protection and Promotion Act, please report them to the local [wechu.org]
This presentation can cause clinicians confusion about potential etiologic agents for their patient's disease, and many of the patients have been assumed to have meningitis caused by Mycobacterium tuberculosis, Listeria monocytogenes or a virus. 4, 8, [journals.lww.com]
Epidemiology
164 Chapter 11 179 Intensive Care Unit Management of Pneumonia 193 Providing Palliative Care 213 Influenza and Pneumococcal Vaccines 221 Chapter 15 234 Treatment 249 Clinical Manifestations 263 Followup Chest Radiographs 277 Epidemiology of Pneumonia [books.google.es]
Developed for current and future healthcare professionals, the text offers vital coverage of antibiotics and other antimicrobial agents, epidemiology and public health, hospital-acquired infections, infection control, and the ways in which microorganisms [books.google.com]
Epidemiology of meningitis and encephalitis in infancts and children in the United States, 2011-2014. Pediatr Infect Dis J 2019 Jan;38(1):37-41 Hassan A, Mustapha GU, Lawal BB, et al. [cidrap.umn.edu]
Infectious Disease Epidemiology Unit Conducts surveillance for infectious diseases and investigates clusters and outbreaks Skip to Page Content Overview Meningitis is caused when the protective membranes surrounding a person’s spinal cord and brain become [health.wyo.gov]
Prevention
Food and Drug Administration approved the first vaccine for the prevention of Lyme disease. Two studies of the recombinant OspA (LYMErix) vaccine have shown it to be 76 to 92 percent effective at preventing symptomatic infections. [aafp.org]
Obtain specimens for laboratory testing, such as serum peak and trough levels for gentamicin sulfate or streptomycin to prevent toxicity. Obtain baseline renal and hearing tests to evaluate for possible changes related to drug therapy. [quizlet.com]
Steps to prevent tularemia include: Using insect repellent Wearing gloves when handling sick or dead animals Avoiding mowing over dead animals In the United States, naturally occurring infections have been reported from all states except Hawaii. [cdc.gov]
Yet the admission rates to hospital, length of stay, investigations, antimicrobial therapy and prevention strategies vary greatly from one geographic area to the next, and the scientific basis for many of our management strategies for pneumonia is weak [books.google.es]