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Tumor of Meninges

Meningeal Neoplasm


Presentation

  • The case is reported in view of its rarity, atypical presentation and need to distinguish from meningiomas which they can mimic radiologically.[ncbi.nlm.nih.gov]
  • She has presented at the annual meetings of United States and Canadian Academy of Pathology, American Society of Cytopathology, and American Society of Clinical Oncology, and has been a speaker at numerous educational courses.[books.google.com]
  • NEUROPATHOLOGY FOR MEDICAL STUDENTS Presented by William I.[web.archive.org]
  • Article / Publication Details First-Page Preview Abstract Three cases of melanotic neuroectodermal tumors of infancy are presented. Two were localized on the midline, involving the skull and extending subdurally.[karger.com]
  • More than 70% of meningiomas express somatostatin receptors which can be used with radiological imaging, especially when looking for local recurrence. [ 2, 9 ] Presentation Meningiomas present as a space-occupying lesion.[patient.info]
Increased Energy
  • According to the metabolic profiles, these tumors had increased energy demand, higher hypoxic conditions, increased membrane turnover and cell proliferation, and possibly increased resistance to apoptosis.[web.archive.org]
Collapse
  • An MR angiogram was performed on the previous case, with the following sequences: MRA through the level of the middle cerebral arteries, MRA through the level of the petrous segment of the internal carotid arteries, collapsed MRA, and MRA projection.[emedicine.com]
Hypothermia
  • Hypothalamic involvement may also cause changes in behavior (hypophagia, hyperphagia, placidity, sedation, low threshold for rage reactions) and autonomic function disorders (Horner's syndrome, disordered temperature regulation with hypothermia from posterior[dartmouth.edu]
Cafe-Au-Lait Spots
  • This would be in keeping with the fact that multiple neurofibromas are seen in von Recklinghausen's disease, a familial disorder also characterized by pigmented (cafe au lait) spots on the skin.[web.archive.org]
Contusion
  • Imaging showed a small left frontotemporal contusion along with a large right frontoparietal extra axial mass lesion suggestive of a meningioma. Patient improved significantly after craniotomy and tumour decompression.[ncbi.nlm.nih.gov]
Headache
  • Sphenoid Ridge Eye-bulging, decreased vision, paralysis of eye movement, seizures, memory difficulty, personality change, headache.[braininjury-explanation.com]
  • These types of posterior fossa meningiomas can cause headaches, seizures, and difficulty walking.[mountsinai.org]
  • Seek emergency care if you have: Sudden onset of seizures Sudden changes in your vision or memory Make an appointment to see your doctor if you have persistent signs and symptoms that concern you, such as headaches that worsen over time.[mayoclinic.com]
  • They may also cause headache, double vision and loss of pituitary function. Meningiomas that arise in the midline under the frontal lobe in the area called the olfactory groove typically cause headache, seizures and/or personality changes.[pacificneuroscienceinstitute.org]
  • A large meningioma tumor could eventually become cancerous, but even if it remains benign, it can create pressure on the brain, resulting in vision or hearing loss, headaches, seizures or other problems.[abcnews.go.com]
Papilledema
  • […] field testing (see the section on papilledema in Chapter 1 ).[dartmouth.edu]
  • […] associated with nausea, vomiting, light-headedness) Gait difficulties from weakness or ataxia Memory problems Incontinence Sensory abnormalities CNS symptoms are divided into the following 3 anatomic groups: Cerebral involvement: Headache, lethargy, papilledema[emedicine.medscape.com]
  • […] found that blindness occurred in only 3 (3%) and some degree of hearing loss was reported in 7 (8%). 11 Our literature review identified 11 additional cases of blindness from meningeal carcinomatosis 12-20 related to a variety of mechanisms, including papilledema[hematologyandoncology.net]
  • The signs and symptoms in patients harboring meningiomas are quite variable and depend on the location of the tumor within the intracranial cavity. 6, 9, 50 Symptoms referable to chronic increased intracranial pressure (such as papilledema and sixth cranial[doi.org]

Workup

  • If an emergency craniotomy is required, an extensive workup may not be possible. Common Types of Brain Tumors We treat several types of brain tumors at Goodman Campbell.[goodmancampbell.com]
  • If an emergency craniotomy is required, an extensive workup may not be possible.[tnbrainandspine.com]
  • […] cauda equina, or subependymal areas, which extend into the sulci of the cerebrum or folia of the cerebellum MRI of the spinal cord can show nerve-root thickening, cord enlargement, intraparenchymal and subarachnoid nodules, or epidural compression See Workup[emedicine.medscape.com]
  • Any adult who has a recent onset of seizures, particularly focal seizures, is considered a tumor suspect until adequate neurologic workup proves otherwise. Specific Tumor Types There are many types of tumors that develop intracranially.[dartmouth.edu]

Treatment

  • Treatment The decision of whether to, and how best to, treat a meningioma is based on multiple factors, including size and location of the tumor, symptoms, growth rate, and age of the patient (among others).[braininjury-explanation.com]
  • Because most meningiomas grow slowly, often without any significant signs and symptoms, they do not always require immediate treatment and may be monitored over time.[mayoclinic.com]
  • When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial.[web.archive.org]
  • The recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry 1957; 20 (1) 22-39 50 McWhirter R, Pennybacker J, et al. Radiation treatment of cerebral tumours.[doi.org]

Prognosis

  • More novel molecular targets are being researched. [ 18, 19 ] Prognosis Atypical and anaplastic types of meningiomas can rarely metastasise. Completely resected meningiomas usually have an excellent prognosis.[patient.info]
  • In adults, the age that a person is diagnosed with meningioma is one of the best ways to predict prognosis. In general, the younger the adult, the better the prognosis. Extent of tumor residual. Resection is surgery to remove a tumor.[cancer.net]
  • Prognosis A prognosis is an estimate of the likely progress of a disease after a diagnosis, based on an average patient group.[braintumour.ca]
  • What is the prognosis of meningiomas? For tumours treated by surgery, the prognosis (likely outcome of treatment) depends primarily on the extent of the surgical resection, which is largely determined by the location of the tumour.[uhs.nhs.uk]
  • Prognosis 5-year survival, 70%.[medical-dictionary.thefreedictionary.com]

Etiology

  • The etiology of meningioma is largely unknown, and exposure to high-dose ionizing radiation and coexistence with certain rare genetic conditions explain only a small fraction of the incidence of the disease.[doi.org]

Epidemiology

  • The epidemiology study results were heterogeneous, with sparse data on long‐term use ( 10 years).[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology The brain and spinal cord tissue are very delicate and are protected within the bony cavities of the skull (cranium) and vertebral column (spinal canal) respectively.[healthhype.com]
  • The authors review the pathophysiology, presentation, and treatment of this tumor, including new prognostic indicators in atypical and malignant meningiomas.[medlink.com]
  • Pathophysiology Meningiomas may occur intracranially or within the spinal canal. They are thought to arise from arachnoidal cap cells, which reside in the arachnoid layer covering the surface of the brain. See the images below.[emedicine.com]
  • Metabolomics is defined as “the quantitative measurement of the multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification” ( 9 ).[web.archive.org]

Prevention

  • Strength of the Evidence for a Cancer-Preventive Effect of the Absence of Excess Body Fatness, According to Cancer Site or Type.[doi.org]
  • Depending on the areas of the brain and/or spinal cord that are involved, radiation therapy may help shrink any remaining tumor and can also prevent it from spreading to the tissues around it.[columbianeurology.org]
  • "These findings should not prevent anyone from going to the dentist," says lead researcher and neurosurgeon Elizabeth B. Claus, MD, PhD, of Yale University School of Medicine and Boston's Brigham and Women's Hospital.[webmd.com]
  • Depending on the areas of the brain or spinal cord that are involved, radiation therapy may help shrink any remaining tumor and can also help prevent it from spreading to the tissues around it.[healthlibrary.uchospitals.edu]

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