Presentation
A new external radiotherapy system has been developed for head and neck cancer and a case with T2 oral floor carcinoma treated with this system is presented in this report. [ncbi.nlm.nih.gov]
Specific MR cancer protocols are presented in Appendix B. [radiologykey.com]
Numbers show each treatment plan (i.e. ‘1’ for a conventional parallel-opposed plan and ‘2’ for the present RTRT 4-beam plan). Figure 3. Dose–volume histogram (DVH). [academic.oup.com]
Initial presentation was of an inflammatory condition, which subsequently presented as a nonspecific, small nodular growth. The characteristic histopathological features helped in achieving an accurate diagnosis for proper treatment. 1. [jomfp.in]
Gastrointestinal
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Dysphagia
Dysphagia can lead to malnutrition and food going down the wrong way, leading to choking, lung infections, or aspiration pneumonia. [medicalnewstoday.com]
Mouth & Throat Cancer Symptom Dysphagia Dysphagia has many causes. First, there may be physical (anatomical) obstruction to the passage of food. [emedicinehealth.com]
Treatment may lead to pain, xerostomia, infections, poor wound healing, dysphagia, fistula formation, trismus, potential disfigurement and fatigue. Buccal mucosa cancer The tumour is usually at the level of the occlusal plane or below it. [patient.info]
He presented with severe dysphagia (trouble swallowing) and on examination was found to have a very small airway. He underwent an emergency tracheotomy (breathing hole placed in the neck) under local anesthesia no IV sedation or analgesia was given. [entusa.com]
Jaw & Teeth
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Poor Oral Hygiene
Poor oral hygiene – not brushing or getting cleanings regularly Poor hydration Male gender Age 50 years A careful inspection of your mouth should be done by a skilled otolaryngologist, like Dr. Bailey, or your dentist. [drseanbaileystlent.com]
The addition of poor oral hygiene and poor dentition can increase the risk 8-fold. Some people seem to be more vulnerable than others to the effect of these irritants. [emedicine.medscape.com]
Risk factors may include: Tobacco use Regular and heavy alcohol consumption Advancing age Sun exposure Poor diet Poor oral hygiene Gum disease Habitual chewing of the lips or cheeks Irritants, such as breathing in smoky, or constantly polluted, atmospheres [betterhealth.vic.gov.au]
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Lesion of the Tongue
Q: I have a premalignant lesion on the tongue will this spread to other parts of my mouth or body? A: Oral premalignant lesions do not typically spread as would a cancer or an infection. However, these lesions can transform into a cancer over time. [maaom.memberclicks.net]
Lesions of the tongue may occur in different frequencies, depending on the specific location of the tongue examined. The tongue can be divided into three zones; the anterior dorsal (top front), posterior dorsal (top back) and ventral (underside). [oralhealthgroup.com]
Anna Age 45 Stage IV Base of Tongue Cancer Non-smoker ANNA from Pennsylvania Symptoms: Painful lesion on lateral tongue. Radiation and chemo gave me nine years cancer free. [sixstepscreening.org]
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Halitosis
Bad breath (a.k.a. halitosis), bleeding and referred pain to the ear are typically signs of oral cancer that has already spread to the surrounding tissue and structures of the head and neck. [drseanbaileystlent.com]
Referred pain to the ear (through the lingual nerve), halitosis, evidence of regional lymph node involvement, and bleeding are signs of advanced disease. [emedicine.medscape.com]
Face, Head & Neck
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Neck Mass
mass due to metastatic lymphadenopathy May have discomfort or pain under the mobile tongue, difficulty with protraction or swallowing, speech impairment Grading Grade 1: Well differentiated Grade 2: Moderately differentiated Grade 3: Poorly differentiated [pathologyoutlines.com]
If the tumor has grown with relatively few symptoms or if the patient has neglected its initial signs, the patient may first present with a neck mass, by which time the tumor has metastasized. [emedicine.medscape.com]
Patients with tonsillar carcinomas may present with a neck mass, usually in the jugulodigastric region. Even if the neck mass is not evident on casual inspection, careful palpation may reveal cervical lymphadenopathy. [patient.info]
Neurologic
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Neglect
If the tumor has grown with relatively few symptoms or if the patient has neglected its initial signs, the patient may first present with a neck mass, by which time the tumor has metastasized. [emedicine.medscape.com]
Treatment
This was probably due to the short treatment period of our regimen. There is accumulating evidence that suggests overall treatment time is a definite prognostic factor. [academic.oup.com]
External radiotherapy can be an option as a curative treatment for early stage carcinoma of the floor of the mouth provided that patient set-up is rigid and reproducible. [ncbi.nlm.nih.gov]
Following primary treatment of cancer with surgery or radiation therapy, consolidation chemotherapy has a particular role in the completion of advanced cancer treatment. [emedicine.medscape.com]
Coughing and breathlessness from lung involvement may require specific treatment. [myvmc.com]
Prognosis
Expression of MMP-1, MMP-2, and MMP-9 was reported higher in cells of BSCC than in cells of SCC, suggesting an aggressive behavior. [8] In conclusion, BSSCs have been reported to have poorer prognosis as compared to SCCs. [jomfp.in]
The most important factors that determine the treatment and prognosis include tumor size, penetration depth, and evidence of regional lymph node involvement. [emedicine.medscape.com]
Buccal mucosa cancers have a better prognosis than tongue or hard palate cancers. [health.am]
The prognosis for patients with oral cancer depends upon the stage of the disease at the time of diagnosis. [headneckandthyroid.com]
Etiology
Of note, the role of human papillomavirus (HPV) as an etiological factor for squamous cell carcinoma is strongest oral cavity (compared to other regions in the head and neck), with HPV DNA isolated from up to 50% of cases, and thought responsible for [radiopaedia.org]
Etiology Tobacco and alcohol have additive effects on oral cancer. Tobacco includes smokeless tobacco derivatives, such as snuff and betel nut. [emedicine.medscape.com]
Low etiologic fraction for high-risk human papillomavirus in oral cavity squamous cell carcinomas. Oral Oncol 2013; 49 :1-8; PMID:22841678; [ PubMed ] [ CrossRef ] [ Google Scholar ] 53. [ncbi.nlm.nih.gov]
They virtually never present with cervical adenopathy of uncertain etiology. These presenting circumstances make oral cavity cancer a consideration in many, predominantly adult, patients who seek care for oral cavity problems. [radiologykey.com]
The etiologic role of these factors is not well understood, and methods for modifying them need to be developed. [aafp.org]
Epidemiology
[…] the lower alveolar ridge to the undersurface of the tongue Posterior boundary is base of anterior pillar of tonsil Divided into two sides by the submaxillary and sublingual salivary glands SCC of floor of mouth is categorized under SCC of oral cavity Epidemiology [pathologyoutlines.com]
As they share epidemiology, pathology and general principles with other squamous cell carcinomas of the upper aerodigestive tract, those topics are covered there. Below are a few general comments specific to the oral cavity. [radiopaedia.org]
Oral Oncol 34:284–291. 7- Ho T, Wei Q, Sturgis EM (2007) Epidemiology of carcinogen metabolism genes and risk of squamous cell carcinoma of the head and neck. [otorrinocontiplanes.com]
"Epidemiology of oral cancer in Arab countries". Saudi Medical Journal. 37 (3): 249–55. doi : 10.15537/smj.2016.3.11388. PMC 4800887. [en.wikipedia.org]
Head and neck cancer: changing epidemiology and public health implications. Oncology 2010; 24 :915-9, 24; PMID:21138172 [ PubMed ] [ Google Scholar ] 5. [ncbi.nlm.nih.gov]
Pathophysiology
[…] mouth is categorized under SCC of oral cavity Epidemiology Age: fifth - sixth decade; 85 - 95% are males 5% of all cancers in United States and 50% in India Sites In decreasing order of frequency: anterior, lateral or posterior part of floor of mouth Pathophysiology [pathologyoutlines.com]
Pathophysiology The head and neck region has rich vascularity, which is an advantage for treating cancer in this region. In addition, this vascularity increases the metastasis. [emedicine.medscape.com]
Pathophysiology [ edit ] Oral squamous cell carcinoma is the end product of an unregulated proliferation of mucous basal cells. [en.wikipedia.org]
Prevention
If teeth are present, bite blocks are inserted to prevent premature pedicle division. [emedicine.medscape.com]
Prevention Although the role of secondary prevention is controversial, primary prevention through avoiding or limiting tobacco and alcohol use is strongly recommended. [aafp.org]
Britain's National Health Service (NHS) runs a fracture prevention program, but this is aimed at preventing secondary fractures only. [cnbc.com]
These cancers are very treatable if caught early, and are easily preventable. The most common causes of head and neck cancer are tobacco and alcohol use. [my.clevelandclinic.org]
No one is exempt from developing this condition but it can be prevented or, at least in its earliest form, eradicated before it develops into oral cancer. [colgate.com]