IC presents in juxta-articular tissue in a tumour-like fashion is known as idiopathic tumoral calcinosis (ITC). Recurrent trauma and chronic pressure are thought to be the triggering factors. It usually presents in adolescents and adults. [ncbi.nlm.nih.gov]

• Fever of Unknown Origin

  Unexpected inflammatory activity of tumoral calcinosis periarticular to the shoulders and hips in a man with recurrent fever of unknown origin and dialysis-dependent kidney insufficiency was revealed by FDG PET/CT. [ncbi.nlm.nih.gov]

  Due to the general fatigue, anorexia, fever of unknown origin and inflammatory syndrome, and considering the endemic state of TB in our country and the protein rich ascites effluent with high lymphocyte count, tuberculosis peritonitis was suspected. [sjkdt.org]

• Intermittent Fever

  Two others experienced increased fatigue, inflammation-mediated anemia of chronic disease, and thrombocytosis; one also had intermittent fevers and a cutaneous inflammatory calcific reaction [ Ramnitz et al 2016 ]. [ncbi.nlm.nih.gov]

• Dental Abscess

  Prior to this episode he had chronic conjunctival irritation and abnormal dental roots shown on x-ray. Dental abscesses and spontaneous tooth loss started at 25 years of age. [bmcgenet.biomedcentral.com]

• Elbow Pain

  pain with a palpable nodule over the olecranon of several months duration. [orthobullets.com]

  On physical examination, the man was found to have firm, fixed, nontender nodules on the right elbow and bilateral metacarpal joints. Pain was elicited in the right elbow on passive range of motion. [consultant360.com]

• Joint Stiffness

  Orthopedic surgeons are often consulted for diagnosis of MASS syndrome, imaging showing periarticular calcification, or joint stiffness. [ncbi.nlm.nih.gov]

• Joint Swelling

  He had been suffering from multiple, migratory large joint swellings. All the swellings spontaneously subsided following suppuration of chalky white material and scar formation except over the gluteal region. [ijo.in]

A computed tomography (CT) scan was performed as part of his workup, and a posterior cervical neck mass was detected. CT-guided fine needle aspiration was performed with an immediate cytologic interpretation of tumoral calcinosis. [ncbi.nlm.nih.gov]

• Muscle Calcification

  Calcific myonecrosis (benign calcified mass in leg muscles). Calcific tendonitis. Calcinosis circumscripta (calcium deposits in the skin and tissue of the hands and feet). [my.clevelandclinic.org]

  Computed tomography (CT) scan showing calcifications in an adult with HFTC including shoulder and hip soft tissue calcifications (white arrows), aortic calcification (dashed arrow), papillary muscle calcification (black arrow), and submucosal gut calcifications [ncbi.nlm.nih.gov]

It can be considered an effective alternative treatment for tumoral calcinosis if surgical treatment is not feasible. [ncbi.nlm.nih.gov]

Nonoperative observation indications treatment of choice for non-symptomatic lesions Operative complete surgical excision indications treatment of choice for symptomatic lesions technique complete surgical excision is required to decrease the rate of [orthobullets.com]

In secondary cases, medical treatment in the mainstay. Treatment failure warrants parathyroidectomy, and surgical excision should be the last resort in these cases. [wjgnet.com]

[…] milky fluid Microscopic • Nodules have large areas of amorphous or granular calcium masses • May have interspersed calcopherites • Calcium crystals exhibit hydroxyapatite • Macrophage infiltration, osteoclast-like giant cells, inflammatory cells present PROGNOSIS [tumorsurgery.org]

This sub-typing is closely related to the prognosis and to the response to treatment. References 1. Maize J, Metcalf. Metabolic Diseases of the skin. In: Elder D (editor). [ijdvl.com]

Although the pathogenesis of the calcification process in tumoral calcinosis is still controversial, surgical removal remains the mainstay treatment with a satisfactory prognosis. References 1. Weiss, SW.; Goldblum, JR. [ccmbm.com]

Outlook / Prognosis What is the outlook for someone with tumoral calcinosis? Most people with tumoral calcinosis enjoy full, active lives. It’s rare for the condition to cause serious health problems. [my.clevelandclinic.org]

Infectious complications of these lesions are associated with poor prognosis. [4] Tumoral calcinosis is a rare inherited metabolic disorder characterized by massive calcium and phosphate deposits. [5] It is rare in dialyzed patients, [6] and its pathogenesis [sjkdt.org]

TERMINOLOGY Synonyms Lipid calcinosis Calcifying collagenolysis Tumoral lipocalcinosis Definitions Extraskeletal soft tissue calcification with granulomatous response ETIOLOGY/PATHOGENESIS Etiology Theories Inborn error of phosphorus metabolism Associated [basicmedicalkey.com]

In primary type, there is no associated disease (responsible etiology) and a secondary type that follows other disorders, particularly chronic renal failure. [cjhr.org]

TC is a disorder of obscure etiology with typical clinical, radiologic, cytologic and histopathologic features. [ncbi.nlm.nih.gov]

Epidemiology Demographics more common in females and African-Americans onset in childhood or early adolescence Anatomic location around joints, primarily the hip (trochanteric bursa is most common location) > shoulder Etiology Pathophysiology unknown [orthobullets.com]

Chondrocalcinosis Allowable Qualifiers English : BL blood CF cerebrospinal fluid CI chemically induced CL classification CO complications CN congenital DI diagnosis DG diagnostic imaging DH diet therapy DT drug therapy EC economics EM embryology EN enzymology EP epidemiology [decs.bvs.br]

Identification of this pathophysiology extends the etiologic spectrum of hyperphosphatemic tumoral calcinosis and suggests that immunomodulatory therapy may be an effective treatment. Authors Mary Scott Roberts, Peter D. [jci.org]

Epidemiology Demographics more common in females and African-Americans onset in childhood or early adolescence Anatomic location around joints, primarily the hip (trochanteric bursa is most common location) > shoulder Etiology Pathophysiology unknown [orthobullets.com]

The recent identification of a fusion of fibronectin and fibroblast growth factor receptor 1 (FGFR1) as a molecular driver in some tumours not only sheds light on the pathophysiology of TIO but also opens the door to a better understanding of the transcription [natureasia.com]

Tumoral calcinosis revisited: pathophysiology and treatment. Rheumatol Int. 2005; 25: 55-9. Martínez S, Vogler J, Harrelson J, Lyles K. Imaging of tumoral calcinosis: new observations. Radiology. 1990; 174: 215-22. [archivo.bc.una.py]

Tumoral calcinosis revisited: pathophysiology and treatment. Rheumatol Int. 2005; 25(1):55-9. 7. Kim HS, Suh JS, Kim YH, Park SH. Tumoral calcinosis of the hand: three unusual cases with painful swelling of small joints. [oapublishinglondon.com]

A concise review of the pertinent literature focusing on the diagnosis, treatment options, and preventive measures also is reported. This journal requires that authors assign a level of evidence to each article. [ncbi.nlm.nih.gov]

Determine whether calcitonin reduces or prevents tumor recurrence. III. Determine whether hyperphosphatemia abolishes the normal circadian pattern of serum phosphorus. IV. [clinicaltrials.gov]