Edit concept Question Editor Create issue ticket

Ulcerative Colitis Flare

Exacerbation of Ulcerative Colitis


Presentation

  • The patient presented with a 10-day history of hematochezia, for which endoscopy was performed with gross findings indicative of ulcerative colitis flare.[insights.ovid.com]
  • A study in the future may be able to conclusively add procalcitonin to the list of routinely used markers for ulcerative colitis disease activity, Reinink concluded, but that question could not be answered in the present study.[mdmag.com]
  • Case presentation A fourteen-year-old boy with a history of poorly controlled ulcerative colitis presented with nonbilious emesis, hematochezia, and hematuria. Laboratory workup revealed disseminated intravascular coagulation.[bmcgastroenterol.biomedcentral.com]
  • Public Health Relevance Patients presenting with Inflammatory Bowel Disease (IBD) are commonly told to not drink alcohol as it has previously correlated with IBD flare periods.[grantome.com]
  • History A 27-year-old male, with history of ulcerative colitis (UC) presented to the emergency room with a 10-day history of malaise, joint pain, diffuse abdominal pain, nausea, vomiting and bloody diarrhea.[thoracic.org]
Developmental Delay
  • There is no evidence of any functional impairment or developmental delay. DISCUSSION This case with active UC during pregnancy and intolerant to first-line salicylate preparations demonstrates a serious challenge in therapeutic settings.[ncbi.nlm.nih.gov]
Constitutional Symptom
  • Clinically, the disease is characterized by bloody diarrhea, abdominal pain, and constitutional symptoms such as fever and weight loss. Treatment strategies vary based on disease activity and target various aspects of the inflammatory cascade.[clinicaltrials.gov]
Cutaneous Manifestation
  • Sweet’s syndrome, also known as acute febrile neutrophilic dermatosis, is a rare cutaneous manifestation of inflammatory bowel disease (IBD).[academic.oup.com]

Workup

  • Laboratory workup revealed disseminated intravascular coagulation. He was placed on triple antibiotics therapy. An infectious workup came back negative.[bmcgastroenterol.biomedcentral.com]
  • (See Workup .) The initial treatment for ulcerative colitis includes mesalamine, corticosteroids, anti-inflammatory agents, antidiarrheal agents, and rehydration (see Medication ).[emedicine.medscape.com]
Staphylococcus Aureus
  • Arai H, Hanai H, Furuta T, Sato Y, Yamada M, Kaneko E, Baba S, Sugimura H: A patient who survived total colonic type ulcerative colitis complicated by toxic megacolon, disseminated intravascular coagulation, methicillin-resistant Staphylococcus aureus[bmcgastroenterol.biomedcentral.com]

Treatment

  • Treatment strategies vary based on disease activity and target various aspects of the inflammatory cascade.[clinicaltrials.gov]
  • “What they don’t realize is that the treatment is just controlling their colitis. When they stop the treatment, many people will eventually flare.”[healthination.com]
  • The most effective treatment of Sweet’s syndrome is with systemic corticosteroids.[academic.oup.com]
  • Keep in mind that your healthcare team is there to work with you on your treatment as well as your overall well-being.[crohnsandcolitis.com]
  • Your doctor can assess the intensity of your symptoms to decide on the proper treatment.[wikihow.com]

Prognosis

  • Treatment and prognosis Total colectomy is curative of both the intestinal symptoms and of the potential risk of colorectal carcinoma.[radiopaedia.org]
  • The guidelines likewise note a specific distinction from previous recommendations on how physicians should decide on a treatment: doctors should now consider both the patient’s inflammatory activity and the prognosis.[uchicagomedicine.org]
  • The prognosis and life expectancy of colon cancer is less than that of ulcerative colitis. However, life expectancy and prognosis vary upon the extent of the colon cancer disease before surgery.[emedicinehealth.com]
  • Management in adults, children and young people Links: epidemiology of ulcerative colitis aetiology pathological features clinical features severity differential diagnosis investigations diagnosis of ulcerative colitis management complications/associations prognosis[gpnotebook.co.uk]
  • These may change the treatment options over the next ten years or so and improve the outlook (prognosis).[patient.info]

Etiology

Epidemiology

  • Ulcerative colitis Management in adults, children and young people Links: epidemiology of ulcerative colitis aetiology pathological features clinical features severity differential diagnosis investigations diagnosis of ulcerative colitis management complications[gpnotebook.co.uk]
  • […] patients with UC, physicians may be waiting too long to initiate biologic therapies; at the end of the first year following diagnosis, around 5% of patients with UC have received biologic therapy compared with 10–15% of patients with CD, according to epidemiologic[emjreviews.com]
  • Epidemiology United States statistics In the United States, about 1 million people are affected with ulcerative colitis (UC). [27, 28] The annual incidence is 10.4-12 cases per 100,000 people, and the prevalence rate is 35-100 cases per 100,000 people[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. . Accessed Jan. 20, 2018. Living with Crohn's and Colitis.[mayoclinic.org]
  • Bick RL: Disseminated intravascular coagulation: a review of etiology, pathophysiology, diagnosis, and management: guidelines for care. Clin Appl Thromb Hemost. 2002, 8: 1-31. 2.[bmcgastroenterol.biomedcentral.com]
  • Pathophysiology Ulcerative colitis (UC) is a diffuse, nonspecific inflammatory disease whose etiology is unknown. [10] The colonic mucosa proximal from the rectum is persistently affected, frequently involving erosions and/or ulcers, as well as involving[emedicine.medscape.com]

Prevention

  • Tips for reducing flares A large part of treating ulcerative colitis is preventing and controlling flares. Preventing flares involves a variety of steps and measures. Some of the most common steps to preventing flares are described below.[medicalnewstoday.com]
  • Part 3 Preventing Future Flare-Ups 1 Go for regular check-ups with your doctor. The best way to keep your ulcerative colitis in check is to see your doctor regularly to track your condition.[wikihow.com]
  • Overall, we expect this study to illuminate potential translational contributions to the treatment and/or prevention of an alcohol induced UC flare.[grantome.com]
  • DIC arises from an overwhelming of the haemostatic regulatory mechanisms leading to an excessive generation of thrombin and a failure of the normal inhibitory pathways to prevent systemic effects of the enzyme leading to DIC [ 1 ].[bmcgastroenterol.biomedcentral.com]
  • Can Probiotics Prevent Flares in Ulcerative Colitis? It’s a well-known fact that probiotics promote healthy bacteria in the gut and work to strengthen the immune system.[healthygut.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!