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Ulna Metaphyseal Dysplasia Syndrome

Rosenberg-Lohr Syndrome


Presentation

  • Patients usually present bony swelling of the wrists with or without pain (knees and ankles may also be affected).[malacards.org]
  • Practical tables provide a quick reference to essential information, including normal developmental anatomic milestones, developmental anomalies, common presentations and symptoms of diseases, and much more. 400 new and replacement images are added to[books.google.com]
  • The Irapa and the Iraqi types of SEMD superficially resemble the condition present in our patient.[czytelniamedyczna.pl]
  • Some patients present deformities of larynx and upper airways (laryngo and tracheomalacia). They can develop severe respiratory insufficiency.[gait.aidi.udel.edu]
  • Most patients present with mild genu valgum. The elbows are unable to extend fully. There may be widening of the lower femora and clavicles. Bones can sometimes be fragile, but fracturing is usually not common.[en.wikipedia.org]
Short Stature
  • Other variably associated features include platyspondyly, skeletal development delay, short stature and coxa valga.Visit the Orphanet disease page for more resources.[malacards.org]
  • Features include: Disproportionately short stature (short limbs or short trunk).[patient.info]
  • Hypothyroiditis. [109] Lymphatic: Lymphadenopathy. [109] Idiopathic thrombocytopenic purpura (ITP), symptoms of systemic lupus erythematosis (SLE) and other autoimmune diseases. [109] Joints bones muscles cartilage: Short stature.[autoinflammatory-search.org]
  • Their physical examination showed short stature, genu valgum, short and stubby fingers, and a flat nasal bridge ( Figure 1 ). In the 13 year old, CDVA was 20/200 in the right eye and 20/400 in the left eye.[healio.com]
  • Short stature syndrome, Brussels type 0 *Growth Disorders/congenital *Osteochondrodysplasias Face/abnormalities. Leri- Weil syndrome 0 *Growth Disorders *Osteochondrodysplasias.[reference.md]
Pain
  • Patients usually present bony swelling of the wrists with or without pain (knees and ankles may also be affected).[malacards.org]
  • Syndrome Synonyms METAPHYSEAL CHONDRODYSPLASIA, ROSENBERG TYPE Classification bone, developmental, genetic Phenotypes Abnormality of the vertebral column ; Autosomal dominant inheritance ; Coxa valga ; Delayed skeletal maturation ; Hypercalcemia ; Wrist pain[mousephenotype.org]
  • Symptoms - Ulna metaphyseal dysplasia syndrome Wrist pain Thickened wrists Irregular metaphyses Thickened dorsum sellae Wedged vertebrae Causes - Ulna metaphyseal dysplasia syndrome Not supplied.[checkorphan.org]
  • Some types of acquired hypermobility can, however, be disadvantageous, an example being tabes dorsalis with its flaccid joints and perhaps pain as well.[books.google.com]
Collapse
  • The SLAC wrist: scapholunate advanced collapse pattern of degenerative Arthritis. J Hand Surg [Am] 1984: 9-A:358-65. ‏ الصفحة 308 - Arnett FC, Edworthy SM, Bloch DA. McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS.[books.google.com]
  • These infants may exhibit apnea or vasomotor collapse similar to spinal shock. Imaging survey in suspected abuse Radiographic skeletal survey is necessary in all children less than 2 years old suspected of abuse.[radiologyassistant.nl]
Developmental Delay
  • One case of fatal encephalitis. [109] Some cases with spasticity, cognitive delay or deficits, and/or developmental delay, and cerebral calcifications (late-onset). [109] [110] Auditory: Normal hearing. Recurrent or frequent otitis media.[autoinflammatory-search.org]
  • The clinical features include global developmental delay, facial dysmorphism, narrow chest, prominent abdomen, and short stature due to limbs shorting.[mjdrdypu.org]
Fever
  • Still’s disease is an inflammatory condition characterized by high fevers, rash, sore throat, and joint pain. As it progresses, adult-onset Still’s disease may lead to chronic arthritis and other complications.[checkrare.com]
Fracture
  • Coverage of each body region includes normal developmental anatomy, fractures, deformities, dislocations, infections, hematologic disorders, and more.[books.google.com]
  • Bucket handle fracture in proximal tibia. The metaphyseal fracture fragment is seen as a disk or bucket handle. Bucket handle fractures These fractures are essentially the same as corner fractures.[radiologyassistant.nl]
  • 222 Fracture, Middle Phalanx 224 Fracture, Nasal 226 Fracture, Olecranon 228 Fracture, Orbital 230 Fracture, Patella 234 Fracture, Pelvic 236 Fracture, Posterior Malleolus 238 Fracture, Proximal Phalanx 240 Fracture, Proximal Tibia 242 Fracture, Radial[euro-libris.ro]
  • Introduction Epidemiology incidence common - forearm fractures in total account for approximately 40% of all pediatric long bone fractures distal radius (and ulna) is the most common site of pediatric forearm fractures. male female (male 2-3 times more[orthobullets.com]
  • Bones can sometimes be fragile, but fracturing is usually not common. Patients may present with dental caries, mandibular prognathism, spinal alignment, and disproportionate limb lengthening.[en.wikipedia.org]
Skeletal Dysplasia
  • The 4 most common skeletal dysplasias are thanatophoric dysplasia, achondroplasia, osteogenesis imperfecta, and achondrogenesis. Thanatophoric dysplasia and achondrogenesis account for 62% of all lethal skeletal dysplasias.[patient.info]
  • Manjiri Dighe et.al Fetal Skeletal Dysplasia: An Approach to Diagnosis with Illustrative Cases, RG, Volume 28, Number 4, 1061-773. Parilla et al. Antenatal Detection of Skeletal Dysplasias J Ultrasound Med 22:255–258, 2003. By Dr Sachin 2.[slideshare.net]
  • Medicine, 51: 41-58; 1972 Wynne-Davis/Hall/Apley Atlas of skeletal dysplasias. 258-273, 1985[gait.aidi.udel.edu]
  • .: Gamut Index of Skeletal Dysplasias. 3rg Ed 2001, Springer Verlag, LondonBerlin. 2. Maroteaux P.: Les maladies osseuses de l enfant. 3-e Ed 1995, Flammarion Paris. 3.[czytelniamedyczna.pl]
  • FMD is characterized by a generalized skeletal dysplasia, deafness and urogenital defects.[genome.jp]
Platyspondyly
  • Other variably associated features include platyspondyly, skeletal development delay, short stature and coxa valga.Visit the Orphanet disease page for more resources.[malacards.org]
  • Spine and Pelvis Platyspondyly 9.[slideshare.net]
  • Spinal defects: platyspondyly, irregularities in the vertebral endplates. [109] Cartilage is affected (ears and nose too). [108] Some with concurrent Juvenile Rheumatoid Arthritis (JRA).[autoinflammatory-search.org]
  • Radiographic findings are widening, scalloping, and irregularity of the metaphysis of long tubular bones, shortness of the femoral neck, progressive coxa vara, severe and diffuse platyspondyly of vertebral bodies, delay in ossification of carpal bones[mjdrdypu.org]
  • They differ in that the Irapa type shows generalised platyspondyly and coxa vara – features which are absent in our patient (4), while the Iraqi type resembles at early age achondroplasia (5).[czytelniamedyczna.pl]
Coxa Valga
  • Name Ulna Metaphyseal Dysplasia Syndrome Synonyms METAPHYSEAL CHONDRODYSPLASIA, ROSENBERG TYPE Classification bone, developmental, genetic Phenotypes Abnormality of the vertebral column ; Autosomal dominant inheritance ; Coxa valga ; Delayed skeletal[mousephenotype.org]
  • Delayed femoral head appearing, coxa valga or, on the contrary, coxa vara are common findings. Valgus deformity of the knees, associated to flexion contracture, is another common finding.[gait.aidi.udel.edu]
  • The acetabulae and proximal ends of the femora were horizontal and coxa valga was present. 3. The twelfth thoracic vertebral body was hypoplastic and posteriorly displaced. The other vertebral bodies were oval and large calcaneal spurs were present.[czytelniamedyczna.pl]
  • The radiographic features are characteristic with congenital platyspondyly with coronal clefts, metaphyseal changes involving limbs bone, limb shortening, and coxa valga. [6] Mitochondria-associated granulocyte macrophage colony stimulating factor-signaling[mjdrdypu.org]
  • Radiologic abnormalities noted included malformations of the cervical spine, pelvic abnormalities, bilateral coxa valga, genu valgum, small fibulae, pes equinovarus, and supernumerary carpal bones.[genome.jp]
Arthritis
  • Wilder RL, Hunder GG: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. ‏[books.google.com]
  • Spinal defects: platyspondyly, irregularities in the vertebral endplates. [109] Cartilage is affected (ears and nose too). [108] Some with concurrent Juvenile Rheumatoid Arthritis (JRA).[autoinflammatory-search.org]
  • As it progresses, adult-onset Still’s disease may lead to chronic arthritis and other complications. Still’s disease was named after an English doctor named George Still, who described the condition in … Previous 1 2 Next Last[checkrare.com]
  • […] in Sports 514 Rotator Cuff Tears 516 Scapholunate Dissociation 518 Sciatica 520 Scoliosis 522 SCUBA Diving Injuries: DCS and AGE 524 Seizures and Epilepsy 526 Septic Arthritis and Bursitis 528 Sesamoid Dysfunction 530 Sever Disease/Calcaneal Apophysitis[euro-libris.ro]

Workup

  • On chest X-ray obtained as part of apnea, workup showed metaphyseal widening and dysplasia. Baby was re-evaluated, and there was no obvious dysmorphism.[mjdrdypu.org]
  • Probably needs a metabolic workup to r/o rickets. Also get x rays of the remaining joints of upper extremity. Regards, Sanjeev Sabharwal Pediatric Orthopedics E-mail: sabharsa@umdnj.edu FROM: K I.[orthopaedicsone.com]
Delayed Bone Age
  • Radiographic at the age of 3 1/2 months revealed distinctive skeletal changes, notably delayed bone age and metaphyses of the tubular bones which were cupped, with pointed edges.[czytelniamedyczna.pl]

Treatment

  • Treatment - Ulna metaphyseal dysplasia syndrome Not supplied. Resources - Ulna metaphyseal dysplasia syndrome Not supplied.[checkorphan.org]
  • TREATMENT: Literature data are not enough to evaluate the orthopaedic treatment of this disease. Prevention and treatment of contractures, dislocations as well as spinal and foot deformities should be the goal of the orthopedist.[gait.aidi.udel.edu]
  • Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions .[patient.info]
  • The two, however, are clinically, radiographically, and genetically distinct from one another. [4] Treatment [ edit ] People with Pyle disease are often asymptomatic. Dental anomalies may require orthodontic interventions.[en.wikipedia.org]
  • Given the rarity of these diseases, the treatments outlined in the abstracts are not always evidence based. The information in the abstracts isnot intended to replace existing local, regional or country specific recommendations and guidelines.[orpha.net]

Prognosis

  • Prognosis - Ulna metaphyseal dysplasia syndrome Not supplied. Treatment - Ulna metaphyseal dysplasia syndrome Not supplied. Resources - Ulna metaphyseal dysplasia syndrome Not supplied.[checkorphan.org]
  • Prognosis Prognosis depends on the precise nature of the specific osteochondrodysplasia. Among infants with skeletal dysplasias detected at birth, approximately 13% are stillborn and 44% die during the perinatal period.[patient.info]
  • PMID 9584003 Hirschsprung's disease in cartilage-hair hypoplasia has poor prognosis. Mäkitie O, Heikkinen M, Kaitila I, Rintala R Journal of pediatric surgery. 2002 ; 37 (11) : 1585-1588. PMID 12407544 DWARFISM IN THE AMISH. II.[atlasgeneticsoncology.org]
  • Prognosis In many cases, patients with metaphyseal dysplasia may be symptomless and very healthy.[encyclopedia.com]
  • Long known as the source to consult for guidance on diagnosis, prognosis, plan management, and genetic counseling, this easy-to-use reference focuses on the patterns of human defects caused by inborn errors in morphogenesis as opposed to defects caused[geneeskundeboek.nl]

Etiology

  • They are organised into groups, and further divided into clinical, etiological or histopathological sub-types.[orpha.net]
  • Each chapter includes a description of the specific abnormality - including occasional associated abnormalities - natural history, etiology, and references.[geneeskundeboek.nl]
  • Abundant periosteal bone formation in a case of Caffey's disease Caffey's disease This is a rare disease of unknown etiology. These children have extreme periosteal reactions.[radiologyassistant.nl]

Epidemiology

  • […] dystrophy Synonym(s): (no synonyms) Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities - Epidemiological[csbg.cnb.csic.es]
  • Epidemiology Incidence is in the region of 1/4,000 births. [ 1 ] Lethal skeletal dysplasias are estimated to occur in 0.95 per 10,000 deliveries.[patient.info]
  • Introduction Epidemiology incidence common - forearm fractures in total account for approximately 40% of all pediatric long bone fractures distal radius (and ulna) is the most common site of pediatric forearm fractures. male female (male 2-3 times more[orthobullets.com]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology of Pyle metaphyseal dysplasia is a defect in metaphyseal remodeling which leads to metaphyseal widening of the long tubular bones with associated cortical thinning and osteoporosis.[mjdrdypu.org]
  • . male female (male 2-3 times more common than female) demographics most common during metaphyseal growth spurt peak incidence occurring from: 10-12 years of age in girls 12-14 years of age in boys most common fracture in children under 16 years old Pathophysiology[orthobullets.com]

Prevention

  • Prevention - Ulna metaphyseal dysplasia syndrome Not supplied. Diagnosis - Ulna metaphyseal dysplasia syndrome The signs and symptom information on this page attempts to provide a list of some possible signs and symptoms of Rosenberg-Lohr syndrome.[checkorphan.org]
  • Prevention and treatment of contractures, dislocations as well as spinal and foot deformities should be the goal of the orthopedist. CASE HISTORY: O.A. female. DOB 2-6-91. Product of a normal gestation. Two healthy half-sisters.[gait.aidi.udel.edu]
  • Genetics, Genetic Counseling, and Prevention 5. Minor Anomalies as Clues to More Serious Problems and Toward the Recognition of Malformation Syndromes 6.[geneeskundeboek.nl]

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