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Undifferentiated Carcinoma of Liver and Intrahepatic Biliary Tract

Undifferentiated Carcinoma of Liver and IBT


Presentation

  • The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment.[books.google.de]
  • TY - JOUR T1 - A patient with undifferentiated carcinoma of gallbladder presenting with hemobilia.[unboundmedicine.com]
  • We describe an unusual presentation of HP in a 17-year-old female with a history acute idiopathic pancreatitis who presented with nausea followed by an episode of hematemesis.[acgcasereports.gi.org]
  • Case presentation The patient was a 61-year-old male who presented to our hospital with increased blood levels of hepatobiliary system enzymes detected during a health check-up. He had a past medical history of hypertension and appendectomy.[surgicalcasereports.springeropen.com]
  • Clinical Presentation and Management Patients often present with a mass, sudden onset of right upper quadrant pain, or bleeding due to rupture of the liver capsule.[lecturio.com]
Inflammation
  • Ultrasound -Irregular borders of gallbladder with echogenic gas and reverberation artifacts in gallbladder fossa -May or may not be in association with stones Cholecystitis Gangrenous Etiology Mucosal ischemia in addition to severe, acute or chronic inflammation[quizlet.com]
  • It is possible that chronic inflammation leads to squamous metaplasia which subsequently undergoes malignant transformation. In our case, none of the known predisposing factors were present.[joplink.net]
  • Such laboratory findings suggest obstruction of the bile ducts, rather than inflammation or infection of the liver parenchyma, as the primary cause of the jaundice. [12] Risk factors [ edit ] Although most people present without any known risk factors[en.wikipedia.org]
  • Most patients do not carry the documented risk factors, which include infections and inflammatory conditions, but cholangiocarcinoma typically forms in the setting of cholestasis and chronic inflammation.[cancerindex.org]
Pathologist
  • A specialist doctor (pathologist) works out the grade by looking at a sample of cells under the microscope. Bile duct cancer is also known as cholangiocarcinoma. There are different ways of staging the different types of bile duct cancer.[cancerresearchuk.org]

Workup

  • Make a comprehensive diagnostic workup with data from ancillary techniques and molecular findings whenever appropriate. Effectively grasp complex topics and streamline decision- making by using extensive tables, graphs, and flowcharts.[books.google.de]
Liver Biopsy
  • Biopsy, and Approach to Gastrointestinal Tract Biopsies.[books.google.de]
  • Acta Gastro-Enterologica Belgica. 2007; 70(1): 1-5 [Pubmed] 25 Approaches to liver biopsy techniques - Revisited Strassburg, C.P., Manns, M.P. Seminars in Liver Disease. 2006; 26(4): 318-327 [Pubmed] 26 The best in CytoJournal: 2005 Cohen, M.B.[cytojournal.com]
  • A 63-year-old man with extrahepatic portal vein thrombosis presented with biliary obstruction and hemobilia after a liver biopsy.[acgcasereports.gi.org]

Treatment

  • The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment.[books.google.de]
  • Other treatment options Other treatment options may include the following: Chemotherapy.[cigna.com]

Prognosis

  • Treatment and prognosis Surgical removal of the tumor by complete excision is often the treatment of choice. The overall prognosis is considered better than for other malignant tumors of the liver 8 .[radiopaedia.org]
  • Prognosis Undifferentiated carcinomas are postulated to have a poorer prognosis than HCC, although evidence from more cases is needed to support this hypothesis.[atlasgeneticsoncology.org]
  • On the other hand, undifferentiated carcinoma of the common bile duct grew in a polypoid pattern and could be discovered in an early stage, leading to favorable prognosis [ 3 ].[surgicalcasereports.springeropen.com]
  • Anatomic stage/prognosis groups Table. Distal bile duct tumor staging Table. Histologic grading Table.[emedicine.medscape.com]

Etiology

  • […] pathogen Complex mass containing septations and/or debris relating to pus, necrosis, or fluid; presence of gas with increased echogencity and posterior shadowing -Irregular, thick borders -Parenchymal echo pattern may be distorted Hepatic Candidiasis Etiology[quizlet.com]
  • Etiology Etiology is not well known. Epidemiology Undifferentiated carcinoma of the liver is very rare, accounting for less than 2% of all epithelial liver tumors .[atlasgeneticsoncology.org]
  • Etiology The exact cause of HCC is unknown, although several risk factors have been identified. The four major risk factors associated with HCC are: 1.[lecturio.com]
  • Not much is known about the etiology of this tumor.[joplink.net]
  • The etiological, clinical, pathological, and molecular features are needed to be future studied by multicentric efforts in recruiting more EBV-associated IHCC patients.[cancerindex.org]

Epidemiology

  • It is a welcome combination of epidemiology, aspects of basic science, pharmacology and radiation therapy that trainees will fine a nice change...should enjoy a wide readership...because of its appealing design and comprehensive approach to oncology.[books.google.de]
  • The epidemiology of pancreatic, gallbladder, and other biliarytract cancers.[docslide.com.br]
  • Epidemiology Undifferentiated carcinoma of the liver is very rare, accounting for less than 2% of all epithelial liver tumors . There is a male preponderance, but no data on its geographic distribution are available.[atlasgeneticsoncology.org]
  • Food-borne trematodiases in Southeast Asia epidemiology, pathology, clinical manifestation and control. Advances in Parasitology. 72. pp. 305–50. doi : 10.1016/S0065-308X(10)72011-X. ISBN 9780123815132. PMID 20624536.[en.wikipedia.org]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology Although there is a relationship between hormonal stimulation and the development of hepatic adenomas, the exact cause is not yet known.[lecturio.com]
  • […] dioxide which was used as a radiologic contrast medium, has been linked to the development of cholangiocarcinoma as late as 30–40 years after exposure; Thorotrast was banned in the United States in the 1950s due to its carcinogenicity. [35] [36] [37] Pathophysiology[en.wikipedia.org]

Prevention

  • Janssens, European Journal of Cancer Prevention * This volume provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests. *[books.google.de]
  • Precursor lesions Similar to many other cancer types, there are precursor lesions in the liver possible to diagnose and prevent from further developing into manifest cancer.[oncolex.org]
  • Efforts to identify and develop new agents for prevention and treatment of this deadly disease are urgent.[cancerindex.org]
  • However, an author would be permitted to write a sentence such as “NCI’s PDQ cancer information summary about breast cancer prevention states the risks succinctly: [include excerpt from the summary].”[siteman.wustl.edu]

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