Thus altered cyclosporine pharmacokinetics is an unlikely mechanism of the effects of UDCA observed in the present study. [bloodjournal.org]

This vista of power is oftentimes presented in search method courses as: "The somebody eldest sets up an experiment; observes what occurs. [pharmavoice.com]

The aims of the present study were to determine the short-term natural history of these gallstones and the efficacy of ursodiol for their dissolution. [ncbi.nlm.nih.gov]

Northfield TC, et al: Presented at the June 1988 Falk Meeting, Freiburg, West Germany. Google Scholar 3. [link.springer.com]

• Weight Loss

  CONCLUSION: A daily dose of 600 mg ursodiol is effective prophylaxis for gallstone formation following GBP-induced rapid weight loss. [ncbi.nlm.nih.gov]

  Ong Other First Online: 24 June 2008 Abstract Background Rapid weight loss increases risk for gallstone formation. Prophylactic cholecystectomy is difficult. [doi.org]

  Rapid weight loss can produce gallstones in a significant percentage of people, which may lead to complications, severely painful symptoms, and eventually require surgery. [buy-ursodeoxycholic-acid.kiwidrug.com]

• Swelling

  Biliary tract disorder This medicine is not recommended for use in patients having a swelling, obstruction, deformation, or fistula of the bile tract. [practo.com]

  However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction,rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. [universaldrugstore.com]

  • General : Uneasiness, swelling in th extremities, fever. • Metabolic : Facial swelling, hives, angioedema and laryngeal edema. • Musculoskeletal : Muscle pain. • Central Nervous system : Dizziness, headache. • Respiratory : Cough. • Skin : Hair loss [medindia.net]

  Biliary tract problems or Pancreatitis (swelling or inflammation of the pancreas)—These conditions may make it necessary to have surgery since treatment with ursodiol would take too long. [mayoclinic.org]

  If you have any of these health problems: Abnormal opening in the biliary and GI (gastrointestinal) tracts, pancreatitis, or swelling of the gallbladder ( cholecystitis ). [drugs.com]

• Ascites

  Klerida Answered by Recent questions on Ascites Get personalised answers from verified doctor in minutes across 80+ specialties [healthcaremagic.com]

  Treatment failure was defined as a doubling of bilirubin levels to more than 70 mumol per liter or the occurrence of a severe complication (ascites or variceal bleeding) or an adverse reaction. [ncbi.nlm.nih.gov]

  Compare the effects of these regimens on the development of ascites, encephalopathy, varices (or bleeding from pre-existing varices), histologic liver changes, transplantation, and survival. III. Compare the toxicity and safety of each regimen. [clinicaltrials.gov]

  The primary outcome was the time to treatment failure, defined as death; liver transplantation; histologic progression by two stages (of four) or progression to cirrhosis; the development of varices, ascites, or encephalopathy; sustained quadrupling of [pubmed.ncbi.nlm.nih.gov]

• Cough

  Common side effects of ursodiol may include: upset stomach, nausea, vomiting; diarrhea, constipation; cough, sore throat; painful urination; hair loss; or back pain. This is not a complete list of side effects and others may occur. [drugs.com]

  Your pharmacist may be able to advise you on managing side effects. constipation cough dizziness headache rapid or pounding heartbeat stomach pain sun sensitivity Although most of the side effects listed below don't happen very often, they could lead [medbroadcast.com]

  Ursodiol Side Effects Common Side Effects of Ursodiol Tell your doctor if any of the following side effects become severe or don't go away: Diarrhea or constipation Upset stomach, indigestion, or vomiting Dizziness Cough or sore throat Runny nose Back [everydayhealth.com]

  Stomach upset, nausea, diarrhea, dizziness, back pain, hair loss, or cough may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. [universaldrugstore.com]

• Sore Throat

  throat, mouth sores, skin sores, trouble swallowing. [drugs.com]

  Many people using Ursodiol 300mg do not have serious side effects.weakness, swelling of the ankles/feet, increased thirst/urination, signs of infection (e.g., fever, persistent sore throat), easy bleeding/bruising. [universaldrugstore.com]

• Pharyngitis

  First-line: Single medicate of rocephin 250 mg IM + zithromax 1 g PO unique medicate (preferred) or Vibramycin cardinal mg PO deuce multiplication per time for 7 years Second-line: cefixime cardinal mg PO (not for pharyngeal) + zithromax (preferred)/doxycycline [pharmavoice.com]

  Incidence not known headache / Early / Incidence not known dizziness / Early / Incidence not known rash / Early / Incidence not known malaise / Early / Incidence not known rhinitis / Early / Incidence not known cough / Delayed / Incidence not known pharyngitis [pdr.net]

  […] efficacy cannot be ruled out. 1 Common Adverse Effects Capsules (gallstone dissolution): Abdominal pain, 1 diarrhea, 1 4 5 6 viral infection, 1 headache, 1 dyspepsia, 1 upper respiratory tract infection, 1 nausea, 1 sinusitis, 1 constipation, 1 vomiting, 1 pharyngitis [drugs.com]

• Persistent Cough

  For ursodiol, the following are the observed side effects: Minor: diarrhea nausea vomiting gas metallic taste constipation rash headache muscle aches Major: severe itching severe muscle or joint pain persistent cough A physician’s comment… Gastroenterologists [gicare.com]

• Diarrhea

  Diarrhea Any incidence of diarrhea while taking this medicine should be reported to the doctor immediately. You may require a dose adjustment if this side effect is severe and persistent. [practo.com]

  […] of their effectiveness in suppressing the growth of C. difficile and therefore quickly eliminating the colitis and diarrhea. [clinicaltrials.gov]

  • Most Common : Diarrhea, elevated liver enzyme, elevated blood glucose, peptic ulcer, skin rash, decrease in platelets. • Gastrointestinal : Abdominal discomfort, abdominal pain, constipation, diarrhea, indigestion, nausea, vomiting. • General : Uneasiness [medindia.net]

  Only diarrhea occurred with a significantly different frequency in the two groups: 32.6 percent were affected in the ursodiol group, as compared with 24.7 percent in the placebo group (P less than 0.04). [ncbi.nlm.nih.gov]

  Symptoms of an overdose include vomiting, diarrhea, sore throat, fever, chills, and other signs of infection. Pediatric Use The safety and efficacy of this drug in pediatric patients have not been established. [giforkids.com]

• Nausea

  Report continued or worsened nausea, vomiting, or abdominal pain to your doctor. Antacids may interfere with the absorption of this medicine. Take this medicine at least 1 hour before or 2 hours after an antacid dose. [pillpack.com]

  Common side effects of ursodiol may include: upset stomach, nausea, vomiting; diarrhea, constipation; cough, sore throat; painful urination; hair loss; or back pain. This is not a complete list of side effects and others may occur. [drugs.com]

  Check with your doctor immediately if severe abdominal or stomach pain, especially toward the upper right side, or severe nausea and vomiting occur. [mayoclinic.org]

  Stomach upset, nausea, diarrhea, dizziness, back pain, hair loss, or cough may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. [universaldrugstore.com]

• Constipation

  Laxatives are drugs or medicinal preparations that are used for the treatment of constipation. [homework.study.com]

  […] experiencing rapid weight loss Treatment of primary biliary cirrhosis (tablets only) Unlabeled uses: Cholestasis-associated pruritus, primary sclerosing cholangitis Adverse effects fever, chills, body aches, flu symptoms; stomach pain, nausea, diarrhea, constipation [rnpedia.com]

  Since one of the side effects is diarrhea, it occasionally is even used to treat difficult constipation. How do I take it? Follow your physician’s instructions carefully. You may take it on an empty stomach or with food to prevent stomach upset. [gicare.com]

  • Gastrointestinal : Abdominal discomfort, abdominal pain, constipation, diarrhea, indigestion, nausea, vomiting. • General : Uneasiness, swelling in th extremities, fever. • Metabolic : Facial swelling, hives, angioedema and laryngeal edema. • Musculoskeletal [medindia.net]

  Side Effects The most common side effects include: constipation, gas, indigestion or nausea. [giforkids.com]

• Vomiting

  • Gastrointestinal : Abdominal discomfort, abdominal pain, constipation, diarrhea, indigestion, nausea, vomiting. • General : Uneasiness, swelling in th extremities, fever. • Metabolic : Facial swelling, hives, angioedema and laryngeal edema. • Musculoskeletal [medindia.net]

  Symptoms of an overdose include vomiting, diarrhea, sore throat, fever, chills, and other signs of infection. Pediatric Use The safety and efficacy of this drug in pediatric patients have not been established. [giforkids.com]

  Then, almost twelve years later, the symptoms reappeared and I was taken to emergency room with unbearable pain and constant vomiting. This time the doctors were more precise and diagnosed me with primary biliary cirrhosis. [mexicanpharmacyprices.com]

  Check with your doctor immediately if severe abdominal or stomach pain, especially toward the upper right side, or severe nausea and vomiting occur. [mayoclinic.org]

  Side effects Major & minor side effects for Ursodeoxycholic Acid Diarrhea Indigestion Headache Nausea or Vomiting Back pain Bloody and cloudy urine Black or tarry stools Unusual bleeding or bruising Frequent and/or painful urination Fever and cough Hair [practo.com]

• Dyspepsia

  […] respiratory tract infection, 1 7 back pain, 1 viral infection, 1 fatigue, 1 influenza-like symptoms, 1 abdominal pain, 1 musculoskeletal pain, 1 dysmenorrhea, 1 alopecia, 1 sinusitis, 1 flatulence. 1 Tablets (primary biliary cirrhosis): Asthenia, 2 dyspepsia [drugs.com]

  […] mg/kg PO qDay Interactions Interaction Checker Enter a drug name and ursodiol No Interactions Found Interactions Found Serious - Use Alternative Significant - Monitor Closely All Interactions Sort By: Adverse Effects >10% Headache Dizziness Diarrhea Dyspepsia [reference.medscape.com]

  […] known hyperglycemia / Delayed / Incidence not known chest pain (unspecified) / Early / Incidence not known hypertension / Early / Incidence not known diabetes mellitus / Delayed / Incidence not known peripheral edema / Delayed / Incidence not known Mild dyspepsia [pdr.net]

• Metallic Taste

  taste in mouth Tiredness Serious Side Effects of Ursodiol Tell your doctor right away if you experience any of the following serious side effects: Cough with fever Painful or frequent urination Signs of an allergic reaction (may include hives, rash, [everydayhealth.com]

  For ursodiol, the following are the observed side effects: Minor: diarrhea nausea vomiting gas metallic taste constipation rash headache muscle aches Major: severe itching severe muscle or joint pain persistent cough A physician’s comment… Gastroenterologists [gicare.com]

• Lip Swelling

  The nurse in my GP practice was telling me that she loved apples and now she cannot eat them as it makes her lips swell and tongue itch. [healthunlocked.com]

• Myalgia

  1.0 flatulence / Early / Incidence not known anorexia / Delayed / Incidence not known diarrhea / Early / Incidence not known abdominal pain / Early / Incidence not known arthralgia / Delayed / Incidence not known fever / Early / Incidence not known myalgia [pdr.net]

  […] viral infection, 1 headache, 1 dyspepsia, 1 upper respiratory tract infection, 1 nausea, 1 sinusitis, 1 constipation, 1 vomiting, 1 pharyngitis, 1 arthralgia, 1 flatulence, 1 back pain, 1 cough, 1 bronchitis, 1 urinary tract infection, 1 arthritis, 1 myalgia [drugs.com]

• Arthralgia

  10.0-10.0 nausea / Early / 8.3-8.3 pruritus / Rapid / 5.0-5.0 vomiting / Early / 0-1.0 flatulence / Early / Incidence not known anorexia / Delayed / Incidence not known diarrhea / Early / Incidence not known abdominal pain / Early / Incidence not known arthralgia [pdr.net]

  […] ruled out. 1 Common Adverse Effects Capsules (gallstone dissolution): Abdominal pain, 1 diarrhea, 1 4 5 6 viral infection, 1 headache, 1 dyspepsia, 1 upper respiratory tract infection, 1 nausea, 1 sinusitis, 1 constipation, 1 vomiting, 1 pharyngitis, 1 arthralgia [drugs.com]

• Pruritus

  The mechanism for abnormal hepatic bile acid transport was investigated in an 18-month-old Amish boy who presented with pruritus, poor growth, and severe bleeding episodes. [ncbi.nlm.nih.gov]

  Ursodiol is generally well tolerated and shown to improve pruritus in patients with PBC [6]. Paradoxically, exacerbation of pruritus after ursodiol administration has also been reported [4]. [aacijournal.biomedcentral.com]

  Authors' conclusions This systematic review did not demonstrate any significant benefits of ursodeoxycholic acid on all‐cause mortality, all‐cause mortality or liver transplantation, pruritus, or fatigue in patients with primary biliary cirrhosis. [doi.org]

  Assessment of Quality of Life and Pruritus A 10‐point numeric rating scale (NRS) was applied for assessment of pruritus intensity (0 points, no pruritus; 10 points, the most intense pruritus they can imagine). 16 HRQoL was assessed with both generic [aasldpubs.onlinelibrary.wiley.com]

• Skin Rash

  Contact your doctor as soon as possible, if you notice any of the following: Severe right-sided upper abdominal pain during the treatment of primary biliary cirrhosis Skin rash Inform your doctor if you notice any other unusual symptoms. [singhealth.com.sg]

  swelling in th extremities, fever. • Metabolic : Facial swelling, hives, angioedema and laryngeal edema. • Musculoskeletal : Muscle pain. • Central Nervous system : Dizziness, headache. • Respiratory : Cough. • Skin : Hair loss, itching, rash. [medindia.net]

  Contact your doctor immediately if you experience: Allergic reaction like skin rash, itching or hives, swelling of the face, lips or tongue Trouble breathing Diarrhea Feeling sick Fever, shivering/chills, rash Muscle and bone pain Kidney problems (changes [giforkids.com]

  Symptoms to watch for, which may be indicative of a reaction, include skin rashes, hives, swelling of the face or limbs, trouble breathing, and trouble swallowing. Always use Ursodil (Ursodiol) as you have been prescribed by your doctor. [unitedpharmacies-uk.md]

  One found comparable mild to moderate side effects between UCDA and placebo; the other reported that several patients dropped out because of vomiting or skin rashes, but that numbers were similar between treatment groups. [ncbi.nlm.nih.gov]

• Urticaria

  Incidence not known dizziness / Early / Incidence not known rash / Early / Incidence not known malaise / Early / Incidence not known rhinitis / Early / Incidence not known cough / Delayed / Incidence not known pharyngitis / Delayed / Incidence not known urticaria [pdr.net]

  – nettle rash (urticaria) Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. [drugs.com]

  Tell your doctor if you notice any of the following: Diarrhoea Itching/pruritus Urticaria (nettle rash) Allergic reactions Nausea/vomiting Sleep disturbance Pain in the stomach area or in the upper right part of the belly, under the ribs. [mydr.com.au]

• Dry Skin

  skin or skin rash Headache Metallic taste in mouth Tiredness Serious Side Effects of Ursodiol Tell your doctor right away if you experience any of the following serious side effects: Cough with fever Painful or frequent urination Signs of an allergic [everydayhealth.com]

• Erythema

  Pooling of bile with gastric erythema was noted in 22/28 patients. All 22 patients with endoscopic erythema had pathology consistent with bile reflux chemical gastropathy. [ncbi.nlm.nih.gov]

• Facial Swelling

  • General : Uneasiness, swelling in th extremities, fever. • Metabolic : Facial swelling, hives, angioedema and laryngeal edema. • Musculoskeletal : Muscle pain. • Central Nervous system : Dizziness, headache. • Respiratory : Cough. • Skin : Hair loss [medindia.net]

• Encephalopathy

  The end points in the assessment of efficacy were as follows: progression of disease, as defined by the presence of hyperbilirubinemia, variceal bleeding, ascites, or encephalopathy; liver transplantation or a referral for that procedure; and liver transplantation [ncbi.nlm.nih.gov]

  Compare the effects of these regimens on the development of ascites, encephalopathy, varices (or bleeding from pre-existing varices), histologic liver changes, transplantation, and survival. III. Compare the toxicity and safety of each regimen. [clinicaltrials.gov]

  The primary outcome was the time to treatment failure, defined as death; liver transplantation; histologic progression by two stages (of four) or progression to cirrhosis; the development of varices, ascites, or encephalopathy; sustained quadrupling of [pubmed.ncbi.nlm.nih.gov]

  Accumulation of fluids in the abdominal cavity (ascites) Veins that enlarge and bleed (bleeding varices) Brain disease due to liver failure (hepatic encephalopathy) Liver damage Liver problems Biliary tract problems pancreatitis Avoid taking this medication [giforkids.com]

  Precautions If you have a history of portosystemic encephalopathy, ascites or variceal bleeding, it is necessary to tell your doctor prior to commencing treatment with this drug. [unitedpharmacies-uk.md]

METHODS: All consecutive patients with RYGB and a diagnosis of chronic abdominal pain, and a negative diagnostic workup (including physical examination, routine laboratory work, cross-sectional imaging, and standard upper endoscopy), who underwent device-assisted [ncbi.nlm.nih.gov]

• Hepatocellular Carcinoma

  Chun-ting WANG, Mei MENG, Ji-cheng ZHANG, Chang-jun JIN, Jin-jiao JIANG, Hong-sheng REN, Jun-mei JIANG, Cheng-yong QIN and Dong-qing YU, Growth inhibition and gene induction in human hepatocellular carcinoma cell exposed to sodium 4-phenylbutanoate, Chinese [doi.org]

  Google Scholar Hippo Y, Watanabe K, Watanabe A et al (2004) Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage of hepatocellular carcinoma. [link.springer.com]

  Metabolomic analysis of human cirrhosis, hepatocellular carcinoma, non-alcoholic fatty liver disease and non-alcoholic steatohepatitis diseases. Gastroenterol Hepatol Bed Bench 9, 158–173 (2016). 22. Arteel, G. E. [nature.com]

CONCLUSIONS: Ursodiol is a safe and effective therapy for the treatment of patients with cholesterol gallstones. [ncbi.nlm.nih.gov]

The success-rate of the combined treatments is roughly 45%. For the treatment of primary biliary cirrhosis (PBC). NOTE: Ursodiol is designated an orphan drug by the FDA for this indication. [pdr.net]

Treatment with ursodiol reduced the high levels of hydroxymethylglutaryl coenzyme A reductase in gallstone patients treated for approximately one year. Such treatment did not appear to inhibit endogenous synthesis of bile acids. [link.springer.com]

However, optimal dosing, timing, duration of therapy, and long-term effects on PNAC outcome and prognosis require further studies. [ncbi.nlm.nih.gov]

Data from placebo controlled trials are now available in support of earlier uncontrolled observations, but it is not yet clear whether short term benefit results in an improvement in longterm prognosis. [gut.bmj.com]

Phenotypes of patients who have a bad prognosis include male patients with associated UC and both intra and extrahepatic involvement of the biliary tree. There is no proven medical therapy for PSC. [emjreviews.com]

Type III procollagen peptide: a marker of disease activity and prognosis in primary biliary cirrhosis. Lancet 1988 ;1: 1021 - 1024 Citing Articles (254) Article Figures/Media [nejm.org]

BACKGROUND & AIMS: Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of presumed autoimmune etiology. Ursodeoxycholic acid (UDCA), methotrexate, and colchicine each have shown promise in its treatment. [ncbi.nlm.nih.gov]

Although an exact cause of PBC has not been identified, the etiology of PBC is thought to originate from a combination of genetic predispositions and environmental triggers. [doi.org]

Surgery 2008; 18(12): 1532-1538. [ PubMed : 18574646 ] Indexing Status Subject indexing assigned by NLM MeSH Bariatric Surgery; Cholagogues and Choleretics /therapeutic use; Cholelithiasis /physiopathology /prevention & control; Humans; Obesity, Morbid /epidemiology [ncbi.nlm.nih.gov]

The limitations and hidden gems of the epidemiology of primary biliary cirrhosis. J Autoimmun. 2013 ;46: 81 - 87. Crossref, Medline, Google Scholar 13. Levy C, Naik J, Giordano C, et al. [doi.org]

Sleisenger and Fordtran’s gastrointestinal and liver disease: pathophysiology/diagnosis/management. Philadelphia: Saunders Elsevier; 2006. Google Scholar 15. Tan-Tin Hay LM, Oliveros E, Esguerra E, et al. [doi.org]

Curr Vasc Pharmacol 5:1-14 PubMed Google Scholar Munzel T, Sinnig C, Post F et al (2008) Pathophysiology, diagnosis and prognostic implications of endothel dysfunction. [link.springer.com]

Ursodiol reduced saturation and prevented increases in nucleation and growth and contraction. Ibuprofen prevented the increase in saturation and the reduction in contraction with a trend opposing the increase in nucleation and growth. [ncbi.nlm.nih.gov]

The trials reported tha UDCA for three to six months effectively prevents the formation of gallstones up to 24 months after bariatric surgery. [bariatricnews.net]

Several small trials have shown that ursodeoxycholic acid (UDCA) may prevent gallstone formation after bariatric surgery. [doi.org]