The mechanism for abnormal hepatic bile acid transport was investigated in an 18-month-old Amish boy who presented with pruritus, poor growth, and severe bleeding episodes. [ncbi.nlm.nih.gov]

This vista of power is oftentimes presented in search method courses as: "The somebody eldest sets up an experiment; observes what occurs. [pharmavoice.com]

Thus altered cyclosporine pharmacokinetics is an unlikely mechanism of the effects of UDCA observed in the present study. [bloodjournal.org]

• Poor Growth

  The mechanism for abnormal hepatic bile acid transport was investigated in an 18-month-old Amish boy who presented with pruritus, poor growth, and severe bleeding episodes. [ncbi.nlm.nih.gov]

• Painter

  Acknowledgements The generator would comparable to convey author Maren and painter Sanderson for stabilizing discussions and comments. Consider LFTs at line, earlier and 2 weeks subsequently LSD addition, and leastwise erst a period. [pharmavoice.com]

• Epilepsy

  PEDS Epilepsy, epoch junior than 6 yo: Start 10 to 20 mg/kg/day PO forked deuce to troika doses per era or quaternity present per era (susp). [pharmavoice.com]

• Gangrene

  VINORELBINE (Navelbine) L D $ varies by therapy WARNING Extravasation related with plain gangrene. Do not ingest as initial therapy in patients 75 yo or sr. or with liverwort harm. [pharmavoice.com]

• Rhinitis

  1 upper respiratory tract infection, 1 nausea, 1 sinusitis, 1 constipation, 1 vomiting, 1 pharyngitis, 1 arthralgia, 1 flatulence, 1 back pain, 1 cough, 1 bronchitis, 1 urinary tract infection, 1 arthritis, 1 myalgia, 1 allergy, 1 cholecystitis, 1 rhinitis [drugs.com]

  Delayed / Incidence not known fever / Early / Incidence not known myalgia / Early / Incidence not known headache / Early / Incidence not known dizziness / Early / Incidence not known rash / Early / Incidence not known malaise / Early / Incidence not known rhinitis [pdr.net]

• Diarrhea

  […] of C. difficile and therefore quickly eliminating the colitis and diarrhea. [clinicaltrials.gov]

  • Most Common : Diarrhea, elevated liver enzyme, elevated blood glucose, peptic ulcer, skin rash, decrease in platelets. • Gastrointestinal : Abdominal discomfort, abdominal pain, constipation, diarrhea, indigestion, nausea, vomiting. • General : Uneasiness [medindia.net]

  Only diarrhea occurred with a significantly different frequency in the two groups: 32.6 percent were affected in the ursodiol group, as compared with 24.7 percent in the placebo group (P less than 0.04). [ncbi.nlm.nih.gov]

  Ursodiol Overdose Severe diarrhea may be a symptom of an ursodiol overdose. If you suspect an overdose, contact a poison control center or emergency room immediately. You can get in touch with a poison control center at 800-222-1222. [everydayhealth.com]

• Nausea

  • Gastrointestinal : Abdominal discomfort, abdominal pain, constipation, diarrhea, indigestion, nausea, vomiting. • General : Uneasiness, swelling in th extremities, fever. • Metabolic : Facial swelling, hives, angioedema and laryngeal edema. • Musculoskeletal [medindia.net]

  Common side effects may include: headache, dizziness; mild stomach pain or discomfort; nausea, diarrhea, constipation; cold symptoms such as stuffy nose, sneezing, sore throat; hair loss; or mild itching or rash. [drugs.com]

  Report continued or worsened nausea, vomiting, or abdominal pain to your doctor. Antacids may interfere with the absorption of this medicine. Take this medicine at least 1 hour before or 2 hours after an antacid dose. [pillpack.com]

  Possible side effects from taking ursodiol include nausea, diarrhea, constipation, dizziness, indigestion, back pain, headache, and flu-like symptoms. If you experience a fever or pain when urinating, contact your doctor at once. [helprx.info]

  Stomach upset, nausea, diarrhea, dizziness, back pain, hair loss, or cough may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. [universaldrugstore.com]

• Chronic Abdominal Pain

  Remnant gastropathy due to bile reflux is a treatable cause of chronic abdominal pain in RYGB patients, and ursodiol should be considered for empiric treatment in RYGB patients with unexplained chronic abdominal pain. [ncbi.nlm.nih.gov]

• Gastropathy

  Bile can pool in the gastric remnant and create a bile reflux gastropathy. [ncbi.nlm.nih.gov]

• Dry Skin

  skin or skin rash Headache Metallic taste in mouth Tiredness Serious Side Effects of Ursodiol Tell your doctor right away if you experience any of the following serious side effects: Cough with fever Painful or frequent urination Signs of an allergic [everydayhealth.com]

• Musculoskeletal Pain

  1 musculoskeletal pain, 1 dysmenorrhea, 1 alopecia, 1 sinusitis, 1 flatulence. 1 Tablets (primary biliary cirrhosis): Asthenia, 2 dyspepsia, 2 peripheral edema, 2 hypertension, 2 nausea, 2 GI disorders, 2 chest pain, 2 pruritus. 2 10 Interactions for [drugs.com]

  […] cough / Delayed / Incidence not known pharyngitis / Delayed / Incidence not known urticaria / Rapid / Incidence not known alopecia / Delayed / Incidence not known asthenia / Delayed / Incidence not known dysmenorrhea / Delayed / Incidence not known musculoskeletal [pdr.net]

• Joint Swelling

  Tell your doctor if any of these symptoms are severe or do not go away: diarrhea constipation nausea indigestion dizziness headache vomiting cough, fever, sore throat, runny nose, or other signs of infection back pain muscle pain joint swelling, pain, [nlm.nih.gov]

• Insomnia

  […] vomiting, viral infection, urinary tract infection, upper respiratory tract infection, stomach ulcer, stomach or intestinal disorder, sore throat, skin rash, sinus inflammation, nausea, nasal inflammation, muscle and bone pain, menstrual pain, joint pain, insomnia [medicalook.com]

• Dysmenorrhea

  […] gallstone formation): Constipation, 1 7 diarrhea, 1 7 headache, 1 7 nausea, 1 dizziness, 1 vomiting, 1 upper respiratory tract infection, 1 7 back pain, 1 viral infection, 1 fatigue, 1 influenza-like symptoms, 1 abdominal pain, 1 musculoskeletal pain, 1 dysmenorrhea [drugs.com]

  […] known rhinitis / Early / Incidence not known cough / Delayed / Incidence not known pharyngitis / Delayed / Incidence not known urticaria / Rapid / Incidence not known alopecia / Delayed / Incidence not known asthenia / Delayed / Incidence not known dysmenorrhea [pdr.net]

METHODS: All consecutive patients with RYGB and a diagnosis of chronic abdominal pain, and a negative diagnostic workup (including physical examination, routine laboratory work, cross-sectional imaging, and standard upper endoscopy), who underwent device-assisted [ncbi.nlm.nih.gov]

CONCLUSIONS: Ursodiol is a safe and effective therapy for the treatment of patients with cholesterol gallstones. [ncbi.nlm.nih.gov]

Successful dissolution of gallstones with ursodiol occurs rarely in patients with calcified gallstones prior to treatment, those who develop stone calcification or gallbladder nonvisualization during treatment, and those with gallstones >20 mm in greatest [drugs.com]

However, optimal dosing, timing, duration of therapy, and long-term effects on PNAC outcome and prognosis require further studies. [ncbi.nlm.nih.gov]

Data from placebo controlled trials are now available in support of earlier uncontrolled observations, but it is not yet clear whether short term benefit results in an improvement in longterm prognosis. [gut.bmj.com]

Phenotypes of patients who have a bad prognosis include male patients with associated UC and both intra and extrahepatic involvement of the biliary tree. There is no proven medical therapy for PSC. [emjreviews.com]

Type III procollagen peptide: a marker of disease activity and prognosis in primary biliary cirrhosis. Lancet 1988 ;1: 1021 - 1024 Citing Articles (254) Article Figures/Media [nejm.org]

BACKGROUND & AIMS: Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of presumed autoimmune etiology. Ursodeoxycholic acid (UDCA), methotrexate, and colchicine each have shown promise in its treatment. [ncbi.nlm.nih.gov]

Although an exact cause of PBC has not been identified, the etiology of PBC is thought to originate from a combination of genetic predispositions and environmental triggers. [doi.org]

Surgery 2008; 18(12): 1532-1538. [ PubMed : 18574646 ] Indexing Status Subject indexing assigned by NLM MeSH Bariatric Surgery; Cholagogues and Choleretics /therapeutic use; Cholelithiasis /physiopathology /prevention & control; Humans; Obesity, Morbid /epidemiology [ncbi.nlm.nih.gov]

The limitations and hidden gems of the epidemiology of primary biliary cirrhosis. J Autoimmun. 2013 ;46: 81 - 87. Crossref, Medline, Google Scholar 13. Levy C, Naik J, Giordano C, et al. [doi.org]

Sleisenger and Fordtran’s gastrointestinal and liver disease: pathophysiology/diagnosis/management. Philadelphia: Saunders Elsevier; 2006. Google Scholar 15. Tan-Tin Hay LM, Oliveros E, Esguerra E, et al. [doi.org]

Curr Vasc Pharmacol 5:1-14 PubMed Google Scholar Munzel T, Sinnig C, Post F et al (2008) Pathophysiology, diagnosis and prognostic implications of endothel dysfunction. [link.springer.com]

Taken together, we suggest that intestinal host–microbiome interactions play diverse roles in the pathophysiological process and may exert therapeutic effects. [nature.com]

Ursodiol reduced saturation and prevented increases in nucleation and growth and contraction. Ibuprofen prevented the increase in saturation and the reduction in contraction with a trend opposing the increase in nucleation and growth. [ncbi.nlm.nih.gov]

It is used to dissolve and prevent cholesterol gallstones and to treat primary biliary cirrhosis, a disease of the liver. [medicinenet.com]