Presentation
The mechanism for abnormal hepatic bile acid transport was investigated in an 18-month-old Amish boy who presented with pruritus, poor growth, and severe bleeding episodes. [ncbi.nlm.nih.gov]
Claim your free Ursodiol discount Click the "Get free coupon" button to receive your free Ursodiol discount Print, email or text message your coupon Present your coupon the next time you fill your prescription Ursodiol Information: What How Precautions [helprx.info]
This vista of power is oftentimes presented in search method courses as: "The somebody eldest sets up an experiment; observes what occurs. [pharmavoice.com]
Entire Body System
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Collapse
If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Symptoms of overdose may include the following: diarrhea Keep all appointments with your doctor and the laboratory. [nlm.nih.gov]
If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Drgotherinfo Keep all appointments with your doctor and the laboratory. [cancercarewny.com]
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Poor Growth
The mechanism for abnormal hepatic bile acid transport was investigated in an 18-month-old Amish boy who presented with pruritus, poor growth, and severe bleeding episodes. [ncbi.nlm.nih.gov]
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Noncompliance
In patients with gallstones, all of the symptomatic patients were noncompliant, whereas none of the compliant patients developed symptoms. Medication side-effects occurred in 17 of 69 patients (25%). [ncbi.nlm.nih.gov]
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Painter
Acknowledgements The generator would comparable to convey author Maren and painter Sanderson for stabilizing discussions and comments. Consider LFTs at line, earlier and 2 weeks subsequently LSD addition, and leastwise erst a period. [pharmavoice.com]
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Gangrene
VINORELBINE (Navelbine) L D varies by therapy WARNING Extravasation related with plain gangrene. Do not ingest as initial therapy in patients 75 yo or sr. or with liverwort harm. [pharmavoice.com]
Respiratoric
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Rhinitis
1 upper respiratory tract infection, 1 nausea, 1 sinusitis, 1 constipation, 1 vomiting, 1 pharyngitis, 1 arthralgia, 1 flatulence, 1 back pain, 1 cough, 1 bronchitis, 1 urinary tract infection, 1 arthritis, 1 myalgia, 1 allergy, 1 cholecystitis, 1 rhinitis [drugs.com]
Delayed / Incidence not known fever / Early / Incidence not known myalgia / Early / Incidence not known headache / Early / Incidence not known dizziness / Early / Incidence not known rash / Early / Incidence not known malaise / Early / Incidence not known rhinitis [pdr.net]
Gastrointestinal
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Diarrhea
[…] of C. difficile and therefore quickly eliminating the colitis and diarrhea. [clinicaltrials.gov]
• Most Common : Diarrhea, elevated liver enzyme, elevated blood glucose, peptic ulcer, skin rash, decrease in platelets. • Gastrointestinal : Abdominal discomfort, abdominal pain, constipation, diarrhea, indigestion, nausea, vomiting. • General : Uneasiness [medindia.net]
Only diarrhea occurred with a significantly different frequency in the two groups: 32.6 percent were affected in the ursodiol group, as compared with 24.7 percent in the placebo group (P less than 0.04). [ncbi.nlm.nih.gov]
Symptoms of overdose may include the following: diarrhea Keep all appointments with your doctor and the laboratory. Your doctor will order blood tests to check your liver function every few months while you take ursodiol. [nlm.nih.gov]
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Nausea
Report continued or worsened nausea, vomiting, or abdominal pain to your doctor. Antacids may interfere with the absorption of this medicine. Take this medicine at least 1 hour before or 2 hours after an antacid dose. [pillpack.com]
• Gastrointestinal : Abdominal discomfort, abdominal pain, constipation, diarrhea, indigestion, nausea, vomiting. • General : Uneasiness, swelling in th extremities, fever. • Metabolic : Facial swelling, hives, angioedema and laryngeal edema. • Musculoskeletal [medindia.net]
Capsules (prevention of gallstone formation): Constipation, 1 7 diarrhea, 1 7 headache, 1 7 nausea, 1 dizziness, 1 vomiting, 1 upper respiratory tract infection, 1 7 back pain, 1 viral infection, 1 fatigue, 1 influenza-like symptoms, 1 abdominal pain, [drugs.com]
Stomach upset, nausea, diarrhea, dizziness, back pain, hair loss, or cough may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. [universaldrugstore.com]
Possible side effects from taking ursodiol include nausea, diarrhea, constipation, dizziness, indigestion, back pain, headache, and flu-like symptoms. If you experience a fever or pain when urinating, contact your doctor at once. [helprx.info]
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Chronic Abdominal Pain
Remnant gastropathy due to bile reflux is a treatable cause of chronic abdominal pain in RYGB patients, and ursodiol should be considered for empiric treatment in RYGB patients with unexplained chronic abdominal pain. [ncbi.nlm.nih.gov]
Cardiovascular
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Chest Pain
pain, bronchitis, back pain, arthritis, allergy, and abdominal pain. [medicalook.com]
1 influenza-like symptoms, 1 abdominal pain, 1 musculoskeletal pain, 1 dysmenorrhea, 1 alopecia, 1 sinusitis, 1 flatulence. 1 Tablets (primary biliary cirrhosis): Asthenia, 2 dyspepsia, 2 peripheral edema, 2 hypertension, 2 nausea, 2 GI disorders, 2 chest [drugs.com]
pain (unspecified) / Early / Incidence not known hypertension / Early / Incidence not known diabetes mellitus / Delayed / Incidence not known peripheral edema / Delayed / Incidence not known Mild dyspepsia / Early / 10.0-10.0 nausea / Early / 8.3-8.3 [pdr.net]
Musculoskeletal
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Musculoskeletal Pain
pain, 1 dysmenorrhea, 1 alopecia, 1 sinusitis, 1 flatulence. 1 Tablets (primary biliary cirrhosis): Asthenia, 2 dyspepsia, 2 peripheral edema, 2 hypertension, 2 nausea, 2 GI disorders, 2 chest pain, 2 pruritus. 2 10 Interactions for Ursodiol Specific [drugs.com]
pain / Early / Incidence not known infection / Delayed / Incidence not known DRUG INTERACTIONS Aluminum Hydroxide: (Moderate) Aluminum hydroxide based antacids have been shown to adsorb bile acids in vitro and are expected to interfere with the efficacy [pdr.net]
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Joint Swelling
Tell your doctor if any of these symptoms are severe or do not go away: diarrhea constipation nausea indigestion dizziness headache vomiting cough, fever, sore throat, runny nose, or other signs of infection back pain muscle pain joint swelling, pain, [nlm.nih.gov]
Urogenital
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Dysmenorrhea
[…] gallstone formation): Constipation, 1 7 diarrhea, 1 7 headache, 1 7 nausea, 1 dizziness, 1 vomiting, 1 upper respiratory tract infection, 1 7 back pain, 1 viral infection, 1 fatigue, 1 influenza-like symptoms, 1 abdominal pain, 1 musculoskeletal pain, 1 dysmenorrhea [drugs.com]
[…] known rhinitis / Early / Incidence not known cough / Delayed / Incidence not known pharyngitis / Delayed / Incidence not known urticaria / Rapid / Incidence not known alopecia / Delayed / Incidence not known asthenia / Delayed / Incidence not known dysmenorrhea [pdr.net]
Workup
METHODS: All consecutive patients with RYGB and a diagnosis of chronic abdominal pain, and a negative diagnostic workup (including physical examination, routine laboratory work, cross-sectional imaging, and standard upper endoscopy), who underwent device-assisted [ncbi.nlm.nih.gov]
Treatment
CONCLUSIONS: Ursodiol is a safe and effective therapy for the treatment of patients with cholesterol gallstones. [ncbi.nlm.nih.gov]
Successful dissolution of gallstones with ursodiol occurs rarely in patients with calcified gallstones prior to treatment, those who develop stone calcification or gallbladder nonvisualization during treatment, and those with gallstones 20 mm in greatest [drugs.com]
Prognosis
However, optimal dosing, timing, duration of therapy, and long-term effects on PNAC outcome and prognosis require further studies. [ncbi.nlm.nih.gov]
Type III procollagen peptide: a marker of disease activity and prognosis in primary biliary cirrhosis. Lancet 1988 ;1: 1021 - 1024 Citing Articles (254) Article Figures/Media [nejm.org]
Moreover, PT and aPTT could reflect the degree of hepatic dysfunction, directly associated with the prognosis of hepatic VOD. [nature.com]
Data from placebo controlled trials are now available in support of earlier uncontrolled observations, but it is not yet clear whether short term benefit results in an improvement in longterm prognosis. [gut.bmj.com]
Etiology
BACKGROUND & AIMS: Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of presumed autoimmune etiology. Ursodeoxycholic acid (UDCA), methotrexate, and colchicine each have shown promise in its treatment. [ncbi.nlm.nih.gov]
Although an exact cause of PBC has not been identified, the etiology of PBC is thought to originate from a combination of genetic predispositions and environmental triggers. [doi.org]
Epidemiology
Surgery 2008; 18(12): 1532-1538. [ PubMed : 18574646 ] Indexing Status Subject indexing assigned by NLM MeSH Bariatric Surgery; Cholagogues and Choleretics /therapeutic use; Cholelithiasis /physiopathology /prevention & control; Humans; Obesity, Morbid /epidemiology [ncbi.nlm.nih.gov]
The limitations and hidden gems of the epidemiology of primary biliary cirrhosis. J Autoimmun. 2013 ;46: 81 - 87. Crossref, Medline, Google Scholar 13. Levy C, Naik J, Giordano C, et al. [doi.org]
Pathophysiology
Sleisenger and Fordtran’s gastrointestinal and liver disease: pathophysiology/diagnosis/management. Philadelphia: Saunders Elsevier; 2006. Google Scholar 15. Tan-Tin Hay LM, Oliveros E, Esguerra E, et al. [doi.org]
Curr Vasc Pharmacol 5:1-14 PubMed Google Scholar Munzel T, Sinnig C, Post F et al (2008) Pathophysiology, diagnosis and prognostic implications of endothel dysfunction. [link.springer.com]
Prevention
Ursodiol reduced saturation and prevented increases in nucleation and growth and contraction. Ibuprofen prevented the increase in saturation and the reduction in contraction with a trend opposing the increase in nucleation and growth. [ncbi.nlm.nih.gov]
It is used to dissolve and prevent cholesterol gallstones and to treat primary biliary cirrhosis, a disease of the liver. [medicinenet.com]
It is usually taken two or three times a day with or without food to treat gallstones and two times a day to prevent gallstones in people who are losing weight quickly. [nlm.nih.gov]