The mechanism for abnormal hepatic bile acid transport was investigated in an 18-month-old Amish boy who presented with pruritus, poor growth, and severe bleeding episodes. [ncbi.nlm.nih.gov]

This vista of power is oftentimes presented in search method courses as: "The somebody eldest sets up an experiment; observes what occurs. [pharmavoice.com]

Thus altered cyclosporine pharmacokinetics is an unlikely mechanism of the effects of UDCA observed in the present study. [bloodjournal.org]

• Poor Growth

  The mechanism for abnormal hepatic bile acid transport was investigated in an 18-month-old Amish boy who presented with pruritus, poor growth, and severe bleeding episodes. [ncbi.nlm.nih.gov]

• Diarrhea

  […] of their effectiveness in suppressing the growth of C. difficile and therefore quickly eliminating the colitis and diarrhea. [clinicaltrials.gov]

  • Most Common : Diarrhea, elevated liver enzyme, elevated blood glucose, peptic ulcer, skin rash, decrease in platelets. • Gastrointestinal : Abdominal discomfort, abdominal pain, constipation, diarrhea, indigestion, nausea, vomiting. • General : Uneasiness [medindia.net]

  Symptoms of overdose may include: severe diarrhea. Do not share this medication with others. [webmd.com]

  Symptoms of overdose may include the following: diarrhea Keep all appointments with your doctor and the laboratory. Your doctor will order blood tests to check your liver function every few months while you take ursodiol. [medlineplus.gov]

  Only diarrhea occurred with a significantly different frequency in the two groups: 32.6 percent were affected in the ursodiol group, as compared with 24.7 percent in the placebo group (P less than 0.04). [ncbi.nlm.nih.gov]

• Nausea

  Common side effects of ursodiol may include: upset stomach, nausea, vomiting; diarrhea, constipation; cough, sore throat; painful urination; hair loss; or back pain. This is not a complete list of side effects and others may occur. [drugs.com]

  Check with your doctor immediately if severe abdominal or stomach pain, especially toward the upper right side, or severe nausea and vomiting occur. [mayoclinic.org]

  • Gastrointestinal : Abdominal discomfort, abdominal pain, constipation, diarrhea, indigestion, nausea, vomiting. • General : Uneasiness, swelling in th extremities, fever. • Metabolic : Facial swelling, hives, angioedema and laryngeal edema. • Musculoskeletal [medindia.net]

  Report continued or worsened nausea, vomiting, or abdominal pain to your doctor. Antacids may interfere with the absorption of this medicine. Take this medicine at least 1 hour before or 2 hours after an antacid dose. [pillpack.com]

  Possible side effects from taking ursodiol include nausea, diarrhea, constipation, dizziness, indigestion, back pain, headache, and flu-like symptoms. If you experience a fever or pain when urinating, contact your doctor at once. [helprx.info]

• Joint Swelling

  Tell your doctor if any of these symptoms are severe or do not go away: diarrhea constipation nausea indigestion dizziness headache vomiting cough, fever, sore throat, runny nose, or other signs of infection back pain muscle pain joint swelling, pain, [medlineplus.gov]

• Fear

  Patient declined drug provocation test due to fear of reaction. As such, the diagnosis of an IgE-mediated reaction to ursodiol was made based on detailed clinical history. [aacijournal.biomedcentral.com]

• Bladder Pain

  Check with your doctor immediately if any of the following side effects occur: More common Bladder pain bloody or cloudy urine difficult, burning, or painful urination dizziness fast heartbeat frequent urge to urinate indigestion lower back or side pain [mayoclinic.org]

METHODS: All consecutive patients with RYGB and a diagnosis of chronic abdominal pain, and a negative diagnostic workup (including physical examination, routine laboratory work, cross-sectional imaging, and standard upper endoscopy), who underwent device-assisted [ncbi.nlm.nih.gov]

CONCLUSIONS: Ursodiol is a safe and effective therapy for the treatment of patients with cholesterol gallstones. [ncbi.nlm.nih.gov]

If partial stone dissolution is not observed after 12 months of treatment, the likelihood of treatment is significantly reduced. [drugs.com]

However, optimal dosing, timing, duration of therapy, and long-term effects on PNAC outcome and prognosis require further studies. [ncbi.nlm.nih.gov]

Data from placebo controlled trials are now available in support of earlier uncontrolled observations, but it is not yet clear whether short term benefit results in an improvement in longterm prognosis. [gut.bmj.com]

Phenotypes of patients who have a bad prognosis include male patients with associated UC and both intra and extrahepatic involvement of the biliary tree. There is no proven medical therapy for PSC. [emjreviews.com]

Type III procollagen peptide: a marker of disease activity and prognosis in primary biliary cirrhosis. Lancet 1988 ;1: 1021 - 1024 Citing Articles (254) Article Figures/Media [nejm.org]

BACKGROUND & AIMS: Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of presumed autoimmune etiology. Ursodeoxycholic acid (UDCA), methotrexate, and colchicine each have shown promise in its treatment. [ncbi.nlm.nih.gov]

Although an exact cause of PBC has not been identified, the etiology of PBC is thought to originate from a combination of genetic predispositions and environmental triggers. [doi.org]

Surgery 2008; 18(12): 1532-1538. [ PubMed : 18574646 ] Indexing Status Subject indexing assigned by NLM MeSH Bariatric Surgery; Cholagogues and Choleretics /therapeutic use; Cholelithiasis /physiopathology /prevention & control; Humans; Obesity, Morbid /epidemiology [ncbi.nlm.nih.gov]

The limitations and hidden gems of the epidemiology of primary biliary cirrhosis. J Autoimmun. 2013 ;46: 81 - 87. Crossref, Medline, Google Scholar 13. Levy C, Naik J, Giordano C, et al. [doi.org]

Sleisenger and Fordtran’s gastrointestinal and liver disease: pathophysiology/diagnosis/management. Philadelphia: Saunders Elsevier; 2006. Google Scholar 15. Tan-Tin Hay LM, Oliveros E, Esguerra E, et al. [doi.org]

Curr Vasc Pharmacol 5:1-14 PubMed Google Scholar Munzel T, Sinnig C, Post F et al (2008) Pathophysiology, diagnosis and prognostic implications of endothel dysfunction. [link.springer.com]

Taken together, we suggest that intestinal host–microbiome interactions play diverse roles in the pathophysiological process and may exert therapeutic effects. [nature.com]

Ursodiol reduced saturation and prevented increases in nucleation and growth and contraction. Ibuprofen prevented the increase in saturation and the reduction in contraction with a trend opposing the increase in nucleation and growth. [ncbi.nlm.nih.gov]

In vitro findings have established that ursodeoxycholic acid is a surrogate for deoxycholic acid in preventing the growth of C. difficile, and interrupting recurrence. [clinicaltrials.gov]

Ursodiol capsules are used to dissolve small gallstones that cannot be removed with surgery, or to prevent gallstones that may occur during rapid weight loss. Ursodiol will not dissolve calcified gallstones. [drugs.com]

It is used to dissolve and prevent cholesterol gallstones and to treat primary biliary cirrhosis, a disease of the liver. [medicinenet.com]