Presentation
VV infection of APCs perturbs MHC class II-mediated Ag presentation. [ncbi.nlm.nih.gov]
Seminar - Vaccinia virus presents! [sydney.edu.au]
Entire Body System
- Fever
In humans, VACV infection is characterized by skin lesions, primarily on the hands, and accompanied by systemic symptoms such as fever, myalgia, headache, and lymphadenopathy. [ncbi.nlm.nih.gov]
[…] et sujet Nakano, James H; Bingham, Patricia G; World Health Organization (Geneva, Switzerland : World Health OrganizationWorld Health OrganizationWorld Health Organization, 1973) Stuart, G; World Health Organization; WHO Expert Committee on Yellow Fever [apps.who.int]
The initial clinical signs of the infection are focal red skin areas, fever, and general symptoms similar to those of a cold. [quiplabs.com]
Case-patients 2–5 began having fever and skin lesions almost simultaneously and were seen as outpatients at community clinics during March 7–9. [wwwnc.cdc.gov]
By day 12, she was treated at a university-based emergency department for fever, left axillary lymphadenopathy, malaise, pain, and worsening edema of her finger. [infectiousdiseaseadvisor.com]
- Fatigue
The vaccination is accompanied by fever, rash, lymphadenopathy, fatigue, myalgia and headaches in some patients Footnote 4, Footnote 5. [canada.ca]
Skin
- Pustular Rash
Serious complications such as ocular vaccinia, myopericarditis, eczema vaccinatum (a papular, vesicular and pustular rash that is very infectious, 38 cases per million doses), progressive vaccinia (progressive necrosis at the vaccination site, 3 cases [canada.ca]
Psychiatrical
- Suggestibility
Our data suggest that the expression of NCRs NKp30, NKp44, NKp46 and cytokines by NK cells are important in the innate response against VACV. Copyright © 2014 Elsevier B.V. All rights reserved. [ncbi.nlm.nih.gov]
Treatment
Stittelaar and colleagues compared the levels of effectiveness of postexposure smallpox vaccination (Elstree-RIVM) and antiviral treatment with cidofovir or an acyclic nucleoside phosphonate analogue 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidine [ncbi.nlm.nih.gov]
Four days post-treatment, tumor infiltrating Treg counts were reduced, and active caspase 3 staining was increased, suggesting that infection lead to Treg death. [jitc.bmj.com]
(PEG-IFN) or ribavirin that cannot be discontinued within 14 days prior to any JX 594 dose Inability to suspend treatment with anti-hypertensive medication for 48 hours prior to and 48 hours after all JX-594 treatments. [clinicaltrials.gov]
Prognosis
[…] administered orally and topically, (in this case ST-246); CMX001, a lipid conjugate of cidofovir and granulocyte colony-stimulating factor for the exiguous normal white blood cells;supportive care; skin graft Medication Imiquimod, and thiosemicarbazone Prognosis [en.wikipedia.org]
Etiology
Conclusions Epidemiologic and molecular data implicated VACV as the etiology of this outbreak, the source of which was rabbit skins inoculated with smallpox vaccine. [wwwnc.cdc.gov]
Identification of vaccinia as the etiologic agent illustrates the power of using multiple new tools for identifying pathogens in patients with a disease of unknown etiology. Since March 8, 2007, CDC and the U.S. [jamanetwork.com]
On July 8, an infectious disease physician who was consulted raised the possibility of suspected VACV infection, among other more common viral or bacterial etiologies, because of histopathologic changes noted in the patient's eye specimens. [cdc.gov]
Epidemiology
Weekly Epidemiological Record = Relevé épidémiologique hebdomadaire, 96 (05/06), 33 - 39. https://apps.who.int/iris/handle/10665/339331 Revue Weekly Epidemiological Record = Relevé épidémiologique hebdomadaire, 96 (05/06): 33 - 39 Documents associés [apps.who.int]
This report describes the patient's clinical course and the associated epidemiologic investigation. [ncbi.nlm.nih.gov]
Epidemiologic Investigation Epidemiologic Investigation After receiving notification of the laboratory result, Alaska state health officials interviewed the patient and learned that she lived alone and had never been vaccinated against smallpox. [jamanetwork.com]
The coverage of each virus is comprehensive, covering the biology, molecular biology, and ecology of the virus as well as the clinical and epidemiological aspects of these viruses in humans and animals. [books.google.ro]
WHO 1986, Committee on Orthopoxvirus Infections, Weekly Epidemiological Records, vol. 38, pp. 289–93. [press-files.anu.edu.au]
Pathophysiology
[…] in a million during routine vaccination during 1963-1968 for smallpox Deaths fatality rate: 15% Progressive vaccinia is a rare cutaneous condition caused by the vaccinia virus, characterized by painless, but progressive, necrosis and ulceration.[4] Pathophysiology [en.wikipedia.org]
Prevention
Shi); Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China (L.-B. Cui, K.-C. Zhao, Z.-M. Tan, X.-L. Guo, X. Huo, C.-J. Bao); Jiangyin Center for Disease Control and Prevention, Wuxi (M.-H. [wwwnc.cdc.gov]
Soluble Sulf was successful in preventing mortality, but not morbidity, in a lethal mouse model infection with VACV-WR. [ncbi.nlm.nih.gov]