We present the tenth case of vaginal Ewing sarcoma and the fourth to be confirmed by molecular studies. [squ.pure.elsevier.com]

Although rare, Ewing sarcoma can present as a vaginal mass. Extraosseous Ewing sarcoma can present as a vaginal mass. [journals.lww.com]

She succumbed to metastatic disease 22 months after the initial presentation. [annsaudimed.net]

Consequently they are malignant.2 CLINICAL PRESENTATION: Mostly asymptomatic. Others presenting as a lump near introitus which may cause problems with micturition, defecation or intercourse. Bleeding or discharges are late features. 4. [jemds.com]

Here, we are presenting a rare case of primary vaginal myeloid sarcoma in a geriatric female patient without initial presentation of acute myeloid leukemia (AML). [ncbi.nlm.nih.gov]

• Abdominal Lymphadenopathy

  CECT abdomen revealed liver metastasis both right and left kidneys normal other organs and biliary tree were normal; no abdominal lymphadenopathy was evident. [medcraveonline.com]

• Hiccup

  Side effects Headache, dizziness, nausea, flatulence and hiccup. Irritation in the mouth and esophagus using chewing gum/ lozenges/inhalator Skin irritations while using patches. [oncolex.org]

• Hepatomegaly

  She had slightly painful deep palpation of the right hypochondrium and epigastrium (suspected hepatomegaly) without signs of peritoneal irritation. She was tachycardic (130 bpm), but the remaining vitals were normal. [scielo.br]

• Cyanosis

  There was no icterus, no clubbing, no cyanosis, no pedal edema. There was no significant lymphadenopathy. Her blood pressure was 120/80 mm Hg and her pulse rate was 72/min. she was afebrile. R.S, C.V.S and C.N.S were clinically normal. [jemds.com]

• Vaginal Discharge

  Vaginal discharge About 10% of women with uterine sarcomas have a vaginal discharge that does not have any visible blood. A discharge is most often a sign of infection or another non-cancer condition, but it also can be a sign of cancer. [cancer.org]

  Some women have other abnormal vaginal discharge that doesn’t appear to have blood in it. [seattlecca.org]

  […] bleeding may be postcoital, intermenstrual, or postmenopausal. watery vaginal discharge dyspareunia Evaluation Biopsy most lesions occur in the upper 1/3 of the vagina Treatment planning should be individualized depending upon the location, size, and [medbullets.com]

  Other symptoms of vaginal cancer include: Abnormal vaginal discharge Difficulty or pain when urinating Pain during sexual intercourse Pain in the pelvic area (the lower part of the abdomen between the hip bones) Pain in the back or legs Swelling in the [cancer.net]

  […] doctor: Vaginal discharge or bleeding that is not normal for you. [mcancer.org]

• Dyspareunia

  […] initially be asymptomatic Local pruritus, possibly with burning sensation and pain Reddish, blackish, and/or whitish patches of discoloration Lumps or growths of various shapes, often wart-like lesions or ulcers Vulvar bleeding or discharge Dysuria, dyspareunia [amboss.com]

  […] grape-like mass in young girls (< 4 years) can prolapse out of vagina spindle-shaped tumor cells stain positive for desmin Presentation Symptoms abnormal vaginal bleeding may be postcoital, intermenstrual, or postmenopausal. watery vaginal discharge dyspareunia [medbullets.com]

  Most patients with vaginal leiomyosarcoma present with an asymptomatic vaginal mass, but may also experience vaginal, rectal or bladder pain, vaginal discharge or bleeding, difficulty in micturition or, rarely, dyspareunia. [ijabmr.org]

  Of the nine previously reported cases, eight presented with painless vaginal masses, one involving the rectovaginal septum that was associated with dyspareunia. Grossly, all appeared solid with only three having a cystic component. [annsaudimed.net]

  Painful sexual intercourse or dyspareunia. Pain in the pelvic area. Tumor in the vaginal mucosa. [cancerwall.com]

• Postcoital Bleeding

  […] and a history of postcoital and intermenstrual bleeding over the previous two months. [scielo.br]

  Bleeding is postmenopausal in about 70% of patients, which is consistent with the peak age of 60 years for squamous cell carcinoma, the most common type. Menorrhagia, intermenstrual bleeding, and postcoital bleeding have also been reported. [emedicine.medscape.com]

For staging workup, CT- chest was done in the cancer institute. CT -chest was normal. Rhabdomyosarcoma was ruled out as Desmin was negative. [jemds.com]

Biopsy and histopathologic workup are crucial to the definitive diagnosis and management strategy. [dovepress.com]

[…] resonance imaging (MRI) Bone scanning Ultrasonography Echocardiography Biopsy Open or core needle biopsy: To obtain tissue sampling for diagnosis and molecular studies Bone marrow aspiration and biopsy: To assess for metastatic spread to bone marrow See Workup [emedicine.medscape.com]

• Hyponatremia

  The progression of the disease was also documented in the serum samples, which revealed thrombocytopenia of 47,000/uL, hyponatremia, hypomagnesemia and elevated liver parameters (aspartate transaminase [AST]/alanine transaminase [ALT] double the upper [scielo.br]

The following are treatment options for sarcoma of the vagina. Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan. Surgery You may be offered surgery for sarcoma of the vagina. [cancer.ca]

The complications are dependent upon the stage of the cancer and may also include complications related to treatment Treatment for Undifferentiated Sarcoma of Vagina is mainly through surgery and other supplementary treatment measures. [dovemed.com]

Since there was not much of discrimination in the plan of treatment modalities among different types of sarcoma except for rhabdomyosarcoma, the treatment was planned. [jemds.com]

However, the treatment options evidence a lack of high-quality data and there are no randomized trials defining the treatment for vaginal cancer, given its rarity. 4 6 Instead, the treatment management is extrapolated from cervical or anal cancers and [scielo.br]

[…] the individual: Older individuals generally have poorer prognosis than younger individuals Individuals with bulky disease have a poorer prognosis Involvement of the regional lymph nodes, which can adversely affect the prognosis Involvement of vital organs [dovemed.com]

Its grave prognosis is stressed. [journals.co.za]

Prognosis may be associated with tumor grade and stage. © 2015 Japan Society of Obstetrics and Gynecology. [ncbi.nlm.nih.gov]

Vaginal cancer is closely related to vulvar cancer in terms of etiology and histology, but it occurs inside the vagina (typically the posterior third of the vaginal wall), rather than the vulva. [amboss.com]

The book provides a description at length of the epidemiology, etiology, pathological anatomy, prognosis, diagnosis, differential diagnosis, imaging and comprehensive therapy of each primary, relapsed, and metastasized tumor including surgery, chemo-, [books.google.es]

This suggests that a single etiologic factor is unlikely. [health.am]

The possible etiologies as well as literature review of similar cases are presented and discussed. [academic.oup.com]

Comparing mortality of vaginal sarcoma, squamous cell carcinoma, and adenocarcinoma in the surveillance, epidemiology, and end results database Talayeh Ghezelayagh; Jose Alejandro Rauh-Hain; Whitfield B. [mgh-ita.org]

The epidemiology of sarcomas of the uterus. J Natl Cancer Inst 1986;76:399–402. 18. Toro JR, Travis LB, Wu HJ, Zhu K, Fletcher CD, Devesa SS. [journals.lww.com]

The book provides a description at length of the epidemiology, etiology, pathological anatomy, prognosis, diagnosis, differential diagnosis, imaging and comprehensive therapy of each primary, relapsed, and metastasized tumor including surgery, chemo-, [books.google.es]

METHODS: Women with primary invasive vaginal sarcomas, squamous cell carcinomas, and adenocarcinomas diagnosed between 1988 and 2010 were identified within the National Cancer Institute's Surveillance, Epidemiology, and End Results database. [ncbi.nlm.nih.gov]

Etiology and Pathophysiology Women with a history of cervical malignancy have a higher probability of developing squamous cell malignancy in the vagina even after hysterectomy. [unboundmedicine.com]

Pathophysiology The tumor is believed to arise from primitive muscle cells, but tumors can occur anywhere in the body; however, a primary bone rhabdomyosarcoma has not been reported. [emedicine.medscape.com]

Version Xiaodong Feng Anti-Angiogenesis Therapy for Cancer Treatment: An Overview for Clinicians PPT Version | PDF Version Muhammad Attique khan Shahid Nuclear Physics PPT Version Aly-Moussa Virology PPT Version | PDF Version Sivaramakrishna Koganti Pathophysiological [omicsonline.org]

[…] of HIV HIV Transmission and Prevention in Specific Populations Systematic Review of HIV Behavioral Prevention Research in African Americans Lynae A. [hivinsite.ucsf.edu]

Epidemiology & prevention Imaging Screening Treatments Antibodies & immunotherapy Cell therapy & stem cells Complications Cytotoxics Drug development Hormones/endocrine Radiotherapy Supportive care Surgery Targeted molecules Transplantation Vaccines [ecancer.org]

Prevention **Avoid HPV exposure** Gardasil was originally only approved for use in women to prevent cervical cancer, but it is now also approved to prevent vulvar and vaginal cancers and pre-cancers (in women) and to prevent anal cancers and pre-cancers [slideshare.net]

Clinical trials look at new ways to prevent, find and treat cancer.Find out more about clinical trials . [cancer.ca]

Prevention There are no definite ways to prevent this cancer. You can increase your chance of early detection by getting regular yearly pelvic examinations and Pap smears. References Hacker NF. Vulvar and vaginal cancer. [umms.org]