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Venezuelan Hemorrhagic Fever

Guanarito Hemorrhagic Fever


Presentation

  • Some presentations of the virus are also characterized by vascular damage, bleeding diathesis, fever, and multiple organ involvement. Clinical diagnosis of VHF has proven to be difficult based on the nonspecific symptoms.[en.wikipedia.org]
  • Epidemiological and clinical data are presented on 165 cases of Venezuelan hemorrhagic fever (VHF), a newly emerging viral zoonosis caused by Guanarito virus (of the family Arenaviridae).[ncbi.nlm.nih.gov]
  • Leukopenia and thrombocytopenia are almost universally present, and proteinuria is common.[ahcmedia.com]
  • The book presents a multimodality approach to diagnosis, integrating cytologic, radiologic, surgical, and clinical pathologic features of each disease.[books.google.com]
  • […] citation file: Ris (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager 2019 Oxford University Press Close Navbar Search Filter Mobile Microsite Search Term Close search filter search input Abstract Epidemiological and clinical data are presented[doi.org]
Sore Throat
  • Venezuelan hemorrhagic fever (VHF) is a severe disease characterised by fever, malaise, sore throat, followed by abdominal pain, diarrhea, a variety of hemorrhagic manifestations and convulsions.[utmb.influuent.utsystem.edu]
  • Principal symptoms among the patients with VHF included fever, malaise, headache, arthralgia, sore throat, vomiting, abdominal pain, diarrhea, convulsions, and a variety of hemorrhagic manifestations.[ncbi.nlm.nih.gov]
  • The infection has symptom fever, has symptom headache, has symptom myalgia, has symptom sore throat, has symptom weakness, has symptom anorexia, has symptom nausea, has symptom vomiting, has symptom convulsions, has symptom epistaxis, has symptom bleeding[malacards.org]
  • Key features of VHF include gradual onset of a febrile illness with sore throat, headache, myalgia, and other non-specific symptoms. Conjunctivitis, lymphadenopathy, and facial edema may occur.[ahcmedia.com]
Pharyngitis
  • Venezuelan hemorrhagic fever a febrile disease caused by the Guanarito virus in Venezuela and characterized by headache, arthralgia, pharyngitis, leukopenia, thrombocytopenia, and hemorrhagic manifestations.[medical-dictionary.thefreedictionary.com]
  • A description of clinical presentations of Venezuelan hemorrhagic fever includes "fever, toxicity, headache, arthralgia, diarrhoea, conjunctivitis, pharyngitis, leucopenia, thrombocytopenia, and haemorrhagic manifestations.[rense.com]
  • The onset is gradual with fever and malaise, tachypnea, relative bradycardia, hypotension, circulatory shock, conjeunctival injection, pharyngitis, lymphadenopathy, encephalitis, myalgia, back pain, headache and dizziness, as well as hyperesthesia of[google.com]
Suggestibility
  • These data suggest that S. alstoni usually develops a persistent nonimmunizing infection with Guanarito virus, while Z. brevicauda develops an immunizing infection.[ncbi.nlm.nih.gov]
  • Epidemiological informations suggest that VHF has a cyclic behaviour, with epidemic periods of high incidence, every 4-5 years. During the interepidemic periods few VHF cases are reported.[utmb.influuent.utsystem.edu]
  • The book also includes a resource center describing places to start searches on the World Wide Web, guidelines for finding and evaluating information, suggested study projects, and strategies for encouraging communication among course participants.[books.google.com]
  • The results of analyses of the primary structures of the glycoproteins of the 8 strains of Guanarito virus isolated from humans suggested that these strains would be highly cross-reactive in neutralization assays.[ncbi.nlm.nih.gov]
  • One rodent isolate included a mixture of two phylogenetically distinct genotypes, suggesting a dual infection. Copyright 2000 Academic Press.[ncbi.nlm.nih.gov]
Convulsions
  • Venezuelan hemorrhagic fever (VHF) is a severe disease characterised by fever, malaise, sore throat, followed by abdominal pain, diarrhea, a variety of hemorrhagic manifestations and convulsions.[utmb.influuent.utsystem.edu]
  • It causes fever and malaise followed by hemorrhagic manifestations and convulsions. Some presentations of the virus are also characterized by vascular damage, bleeding diathesis, fever, and multiple organ involvement.[en.wikipedia.org]
  • Principal symptoms among the patients with VHF included fever, malaise, headache, arthralgia, sore throat, vomiting, abdominal pain, diarrhea, convulsions, and a variety of hemorrhagic manifestations.[ncbi.nlm.nih.gov]
  • The infection has symptom fever, has symptom headache, has symptom myalgia, has symptom sore throat, has symptom weakness, has symptom anorexia, has symptom nausea, has symptom vomiting, has symptom convulsions, has symptom epistaxis, has symptom bleeding[malacards.org]
  • Most patients begin to improve after 1 or 2 weeks, but the disease takes a more serious course in about a third; some patients develop a hemorrhagic diathesis; some develop severe neurological deterioration marked by delirium, coma, and convulsions; and[medical-dictionary.thefreedictionary.com]
Seizure
  • In contrast, recent seizures or observed seizures at the time of admission were associated with a very poor outcome-16 (72.7%) of 22 died.[ahcmedia.com]
  • Seizures occur in some people with meningitis or encephalitis. Viruses cause a wide array of skin infections. Herpes simplex viruses (HSV) cause some of the most common skin infections.[livestrong.com]
  • Often, victims have seizures and lapse into a coma prior to death. Hemorrhagic diseases are difficult to treat. One reason is because of the rapid progression of the disease.[science.jrank.org]
Hyperesthesia
  • Neurological manifestations, such as tremor of tongue and hands, diminished deep tendon reflexes, lethargy, and hyperesthesia, often occur.[medical-dictionary.thefreedictionary.com]
  • The onset is gradual with fever and malaise, tachypnea, relative bradycardia, hypotension, circulatory shock, conjeunctival injection, pharyngitis, lymphadenopathy, encephalitis, myalgia, back pain, headache and dizziness, as well as hyperesthesia of[google.com]
Neurologic Manifestation
  • Neurological manifestations, such as tremor of tongue and hands, diminished deep tendon reflexes, lethargy, and hyperesthesia, often occur.[medical-dictionary.thefreedictionary.com]
  • The New World arenavirus Junin virus (JUNV) causes Argentine HF, a severe illness with hemorrhagic and neurological manifestations and a case fatality of 15 to 30%, whereas the arenaviruses Machupo virus (MACV) and Guanarito virus (GTOV) emerged as causative[dx.doi.org]
Neck Stiffness
  • The symptoms of these central nervous system infections overlap and can include fever, headache, neck stiffness and light sensitivity. Mental status changes are common, including confusion, mood instability, extreme lack of energy and possibly coma.[livestrong.com]

Treatment

  • Treatment is supportive, with careful attention to fluid and electrolyte balance. If untreated, the case fatality rate may reach 30% or more. With aggressive treatment, the usual prognosis is complete recovery.[medical-dictionary.thefreedictionary.com]
  • Treatment and prevention for the VHF virus are limited and there are currently no licensed vaccines available that can act to prevent the disease. However, once infected, Ribavirin, an anti-viral drug given intravenously, is one way to treat VHF.[en.wikipedia.org]
  • treatment of arenavirus infection.[google.com]
  • Thus, passive antibody therapy may prove beneficial in the treatment of human disease caused by strains of Guanarito virus that are enzootic in the region in which Venezuelan hemorrhagic fever is endemic.[ncbi.nlm.nih.gov]
  • In many cases, treatment for a viral illness involves relieving symptoms until the body's immune system clears the infection.[livestrong.com]

Prognosis

Etiology

  • Abstract This paper characterizes Guanarito virus, the etiologic agent of Venezuelan hemorrhagic fever.[ncbi.nlm.nih.gov]
  • The objective of this work was to determine the prevalence of infection with Guanarito virus, the etiologic agent of VHF, among wild rodents and humans living within an endemic focus of the disease.[ncbi.nlm.nih.gov]
  • Abstract Abstract This paper characterizes Guanarito virus, the etiologic agent of Venezuelan hemorrhagic fever.[ajtmh.org]
  • 1994) DOI: 10.1111/j.1749-6632.1994.tb19863.x Reference PMID: 10479119 Authors Fulhorst CF, Ksiazek TG, Peters CJ, Tesh RB Title Experimental infection of the cane mouse Zygodontomys brevicauda (family Muridae) with guanarito virus (Arenaviridae), the etiologic[genome.jp]
  • De manzione and colleagues in venezuela and the United States evaluated 165 cases of Venezuelan hemorrhagic fever (VHF) identified since the initial discovery of this disease and its etiologic agent, Guanarito virus, in 1989.[ahcmedia.com]

Epidemiology

  • Article Navigation From the Regional Research Unit, Portuguesa State Division of Health, Guanare, Venezuela; Department of Virology, National Institute of Hygiene “Rafael Rangel,” and the Division of Epidemiology, Ministry of Health and Social Assistance[doi.org]
  • Abstract During February 1992, field studies on the epidemiology of Venezuelan hemorrhagic fever (VHF) were carried out in a rural area of Portuguesa State in central Venezuela.[ncbi.nlm.nih.gov]
  • Epidemiological informations suggest that VHF has a cyclic behaviour, with epidemic periods of high incidence, every 4-5 years. During the interepidemic periods few VHF cases are reported.[utmb.influuent.utsystem.edu]
  • Venezuelan hemorrhagic fever: Clinical and epidemiological studies of 168 cases. Clin Infect Dis 1998;26:308-313.[ahcmedia.com]
  • Tesh RB, Wilson ML, Salas R: Field studies on the epidemiology of Venezuelan hemorrhagic fever: implication of the cotton rat _Sigmodon alstoni_ as the probable rodent reservoir.[healthmap.org]
Sex distribution
Age distribution

Prevention

  • , Venezuela ; Department of Pathology, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas, USA ; and Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention[doi.org]
  • Treatment and prevention for the VHF virus are limited and there are currently no licensed vaccines available that can act to prevent the disease. However, once infected, Ribavirin, an anti-viral drug given intravenously, is one way to treat VHF.[en.wikipedia.org]
  • The Centers for Disease Control and Prevention was immediately notified after the vial was discovered missing Wednesday. Copyright 2013 The Associated Press. All rights reserved.[web.archive.org]
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.[cdc.gov]

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