Presentation
We report the case of a young female who presented to us with acute hypoxemic respiratory failure secondary to acute lupus pneumonitis as initial presenting manifestation of lupus. [lungindia.com]
In the present study, direct admission to the ICU was not related to the prognosis. [journals.plos.org]
presented in table 4 ⇓. [erj.ersjournals.com]
It is associated with progressive pulmonary disability, irreversible lung damage, and mortality in some occupational settings. 1-5 Patients often present with intermittent chills, fever, cough, and shortness of breath that begin four to eight hours after [labcorp.com]
[…] by, last update March 17, 2019 aka Pulmonary Puzzler 008 A 30 year old male presents with a 3 day history of fevers and increasing breathlessness. On presentation he is noted to be severely hypoxic with sats of 80% on room air. [lifeinthefastlane.com]
Entire Body System
- Fever
This change may first manifest as fever, hypoxemia on bedside pulse oxymetry monitoring, or a change in secretions. [clinicaladvisor.com]
Signs and symptoms of pneumonia include fever, chills, cough, shortness of breath, and fatigue. [medicinenet.com]
Acute illness is characterized by sudden onset of malaise, chills, fever, cough, shortness of breath, and nausea 4 to 8 hours after exposure to the offending agent. [healthcentral.com]
Meduri and coworkers 20 found that only 42% of patients with fever and infiltrates on the chest radiograph had pneumonia; most had fever due to infectious foci other than pneumonia. [thorax.bmj.com]
Other symptoms include fever, chills, nausea, headaches, muscle aches, and chest pain. [news-medical.net]
- Inflammation
This causes atelectasis (a collapse of lung tissue) and then inflammation of the lung tissue. Inflammation may affect different parts of the lung — bronchi, alveoli or pleura. Diagnostic tools include examination and x-rays. [intellectbreathing.com]
Other lymphocytes participate directly in inflammation after subsequent antigen exposure. [merckmanuals.com]
They can reduce the inflammation in your lungs and help you breathe. These can be given through an inhaler, pill, or injection. [healthline.com]
Source: iStock Pneumonia facts Pneumonia is a lung disease characterized by inflammation of the airspaces in the lungs, most commonly due to an infection. [medicinenet.com]
Pneumonia causes inflammation of a section of lung that impairs air exchange. Pneumonia is caused by an immune response to pathogens that colonize an area of the lung. [ems1.com]
- Fatigue
Signs and symptoms of pneumonia include fever, chills, cough, shortness of breath, and fatigue. [medicinenet.com]
Once daily T-piece trials are preferable to multiple short trials, probably because fatigued respiratory muscles are given sufficient time to recover between trials. [aic.cuhk.edu.hk]
Additional symptoms may include chills, sweating, aching, and fatigue. Most cases involve typical episodes that are mild and short and may be misdiagnosed. [healthcentral.com]
It’s important to be aware of: increased difficulty breathing, shortness of breath, or wheezing restlessness, confusion, slurring of speech, or irritability unexplained weakness or fatigue that lasts more than a day changes in sputum, including color, [healthline.com]
[…] feel breathless, even when resting rapid heartbeat fever feeling generally unwell sweating and shivering loss of appetite chest pain – which gets worse when breathing or coughing Less common symptoms include: coughing up blood (haemoptysis) headaches fatigue [nhs.uk]
- Malaise
Common initial symptoms include myalgia, arthralgia, pyrexia, chills, and malaise. Severe exertional dyspnea develops over a matter of days to weeks 13. AIP is characterized histologically by diffuse alveolar damage (DAD) 2. [radiopaedia.org]
Acute illness is characterized by sudden onset of malaise, chills, fever, cough, shortness of breath, and nausea 4 to 8 hours after exposure to the offending agent. [healthcentral.com]
The following may also occur: Dyspnoea Sharp chest pain Worsening cough Fever/chills Tachycardia Pleuritic chest pain Headaches Malaise Muscle pains Cyanosis due to poorly oxygenated blood Loss of appetite Rapid breathing Wheezing or grunting during breathing [physio-pedia.com]
Malaise and weight loss may be observed. Physical signs include the following: Crackles or a pleural rub may be heard; in some cases auscultation is normal. [aboutcancer.com]
The patient may also describe the following: Cough with purulent sputum Fever or chills Malaise, myalgias Rigors may be present or absent Shortness of breath, dyspnea on exertion Pleuritic chest pain Putrid expectoration (a clue to anaerobic bacterial [emedicine.medscape.com]
- Asymptomatic
PATHOLOGY — The pathologic and clinical changes in the lung following irradiation may be divided into five phases The immediate phase begins within hours to days following radiation exposure, and is generally asymptomatic. [aboutcancer.com]
Human CMV is thought to infect 70% of adults but generally remains asymptomatic and silent, although it may be reactivated and produce lesions at any time during the life of the host. [anesthesiology.pubs.asahq.org]
Respiratoric
- Pneumonia
Files Sedation for Patients with Pneumonitis or Pneumonia Requiring Ventilation: Guidelines for Use Rapid Response Published : August 17, 2009 [cadth.ca]
The specific organism name may also be used to describe the types of pneumonia, such as pneumococcal ( Streptococcus pneumoniae ) pneumonia or Legionella pneumonia. [medicinenet.com]
[…] to develop hospital-acquired pneumonia Mycoplasmal Pneumonia (also known as 'walking pneumonia') It is similar to bacterial pneumonia, whereby the mycoplasmas proliferate and spread - causing infection. [7] Pneumocystis carinii Pneumonia Pneumocystis [physio-pedia.com]
What causes pneumonia? Pneumonia is usually the result of a pneumococcal infection, caused by bacteria called Streptococcus pneumoniae. [nhs.uk]
Pneumonia Also called: Bronchopneumonia Pneumonia is an infection in one or both of the lungs. Many germs, such as bacteria, viruses, and fungi, can cause pneumonia. You can also get pneumonia by inhaling a liquid or chemical. [icdlist.com]
- Pharyngitis
Swallowing disorders: oesophageal stricture, dysphagia, stroke, bulbar palsy, pharyngeal disease (eg, malignancy), neuromuscular disorders (eg, multiple sclerosis). [patient.info]
Historically, aspiration pneumonia referred to an infection caused by less virulent bacteria, primarily oral pharyngeal anaerobes, after a large volume aspiration event. [emedicine.medscape.com]
Definition Pulmonary aspiration is defined by the inhalation of oro-pharyngeal or gastric contents into the larynx and the respiratory tract. [ceaccp.oxfordjournals.org]
Nasal and pharyngeal swab samples were obtained, with the determination of antigenemia and polymerase chain reaction (PCR) testing as protocol in application to patients with suspected H1N1 viral infection. [medintensiva.org]
- Sneezing
For example, you should: cover your mouth and nose with a handkerchief or tissue when you cough or sneeze throw away used tissues immediately – germs can live for several hours after they leave your nose or mouth wash your hands regularly to avoid transferring [nhs.uk]
- Pulmonary Disorder
My Uncle ended up in the hospital diagnosed with congestive heart failure brought on by pneumonia and Acute Chronic Obstructive Pulmonary Disorder(COPD). [healthquestions.medhelp.org]
- Nasal Congestion
Signs and Symptoms of Pneumonia Pneumonia often starts with symptoms typical of a cold or upper respiratory infection, like sore throat, nasal congestion, and cough. [medicinenet.com]
Gastrointestinal
- Vomiting
In this case, we talked about vomit. If somebody was vomiting, our epiglottis is open, we can actually aspirate the vomit into our lungs. [khanacademy.org]
Aspiration pneumonia: This type of pneumonia can develop when you inhale food, drink, gum, vomit, or saliva into your lungs. [verywell.com]
[…] even when resting rapid heartbeat fever feeling generally unwell sweating and shivering loss of appetite chest pain – which gets worse when breathing or coughing Less common symptoms include: coughing up blood (haemoptysis) headaches fatigue nausea or vomiting [nhs.uk]
Sometimes a child's only sign may be rapid breathing and often when pneumonia exist in the lower part of the lungs, no breathing problems may be present but rather fever, abdominal pain or vomiting. [physio-pedia.com]
Other types of pneumonia that are commonly referenced include the following: Aspiration pneumonia develops as a result of inhaling food or drink, saliva, or vomit into the lungs. [medicinenet.com]
- Nausea
Other symptoms include fever, chills, nausea, headaches, muscle aches, and chest pain. [news-medical.net]
Acute illness is characterized by sudden onset of malaise, chills, fever, cough, shortness of breath, and nausea 4 to 8 hours after exposure to the offending agent. [healthcentral.com]
Presentation Nonspecific symptoms - eg, fever, headache, nausea, vomiting, anorexia, myalgia, weight loss. Cough. Dyspnoea. Pleuritic chest pain. Purulent sputum. [patient.info]
[…] breathless, even when resting rapid heartbeat fever feeling generally unwell sweating and shivering loss of appetite chest pain – which gets worse when breathing or coughing Less common symptoms include: coughing up blood (haemoptysis) headaches fatigue nausea [nhs.uk]
Fever, sweating, and/or chills Cough, often severe, that produces phlegm Shortness of breath Difficulty breathing Chest pain when coughing or breathing deeply Feeling weak Fatigue Changes in mental status in people age 65 or older Loss of appetite Nausea [verywell.com]
Cardiovascular
- Hypertension
English animal models in animal models of pulmonary hypertension, chronic oral administration of bosentan reduced pulmonary vascular resistance and reversed pulmonary vascular and right ventricular hypertrophy. [mymemory.translated.net]
Regardless of the source of injury, ARDS is characterized by an acute onset, bilateral airspace infiltrates on chest X-ray, and hypoxemia (PaO2/FIO2 < 300), assuming no evidence of left atrial hypertension. [openanesthesia.org]
Diagnostic criteria include acute onset, profound hypoxemia, bilateral pulmonary infiltrates, and the absence of left atrial hypertension. [aafp.org]
[…] brain trauma. hello doctor,recently one of my relatives suddenly fell unconsious at her residence,immediately she was rushed to a very famous hospital where they diagonised her of brainstem bleed with left cerebellar haemmorhage,she had a history of hypertension [healthquestions.medhelp.org]
Results of recent studies call this practice into question, however, and hyperventilation is no longer used in many institutions, except as a temporary emergency measure while other treatments for intracranial hypertension are initiated. [courses.washington.edu]
Neurologic
- Irritability
However, aspiration may cause: Chemical pneumonitis: chemical irritation of the lungs, which may progress to acute respiratory distress syndrome and/or bacterial infection. [patient.info]
It’s important to be aware of: increased difficulty breathing, shortness of breath, or wheezing restlessness, confusion, slurring of speech, or irritability unexplained weakness or fatigue that lasts more than a day changes in sputum, including color, [healthline.com]
She was irritable but oriented to time, place, and person. Respiratory examination revealed diffuse bilateral fine inspiratory crackles. The rest of the physical examination was unremarkable. [lungindia.com]
The emphasis of this article is the more common causes of infectious pneumonias, but there are others that may be caused by noninfectious lung irritants like inhalation of chemicals, foods, gasses, liquids, and/or dust. [medicinenet.com]
Workup
Microbiology
- Legionella Pneumophila
Rapid urine tests are available to identify Streptococcus pneumoniae and Legionella pneumophila. [medicinenet.com]
pneumophila, Mycoplasma pneumoniae, and Chlamydophila pneumoniae. [physio-pedia.com]
Muder RRYu VLWoo AH Mode of transmission of Legionella pneumophila: a critical review. Arch Intern Med. 1986;1461607- 1612 Google Scholar Crossref 80. Roig JAguilar XRuiz J et al. [jamanetwork.com]
Moreover, the pathogens of atypical pneumonia, such as Mycoplasma pneumoniae, Chlamydia pneumoniae and Legionella pneumophila, were identified by an acute-phase serologic test (complement fixation and particle agglutination methods) and ImmunoCard test [karger.com]
A urine sample was tested for Legionella pneumophila serogroup 1 antigen using an enzyme-linked immunosorbent assay. Conventional and molecular methods were used to identify the microorganisms responsible for CAP as previously described [17], [18]. [journals.plos.org]
Pulmonary Function Test
- Decreased Lung Compliance
Neutrophils damage the vascular endothelium and alveolar epithelium, leading to pulmonary edema, hyaline membrane formation, decreased lung compliance, and difficult air exchange. [aafp.org]
Hypertrophy
- Ventricular Hypertrophy
English animal models in animal models of pulmonary hypertension, chronic oral administration of bosentan reduced pulmonary vascular resistance and reversed pulmonary vascular and right ventricular hypertrophy. [mymemory.translated.net]
Treatment
Because it is typically diagnosed at an advanced stage, chemotherapy (CT) remains the cornerstone of treatment, however, conventional treatment of NSCLC has apparently reached a plateau of effectiveness in improving survival of patients. [jtd.amegroups.com]
Treatment in Normal Healthy Adults For young and middle-age adults who have contracted community-acquired pneumonia and who were in good physical health before getting sick, treatment typically occurs at home. [news-medical.net]
But because of the blood clot I did not receive usual treatment for pneumonia because they were afraid to dislodge the blood clot. [healthquestions.medhelp.org]
Therapeutic exercises for pneumonia treatment include conditioning and breathing exercises. [intellectbreathing.com]
Without treatment, patients have a higher incidence of cavitation and abscess formation. [nps.org.au]
Prognosis
Even despite mechanical ventilation, it often carries a grave prognosis with > 70% mortality at ~ 3 months 1. [radiopaedia.org]
In the present study, direct admission to the ICU was not related to the prognosis. [journals.plos.org]
Prognosis and patient counseling. VAP worsens the prognosis across the broad range of diagnoses that initially account for hospitalization and the need for mechanical ventilation. VI. Patient Safety and Quality Measures A. [clinicaladvisor.com]
Prognosis This depends on the underlying cause, general well-being of the patient, presence of complications, speed of diagnosis and effective treatment. [patient.info]
S27 - 72 ) 2 Prospective comparison of three validated prediction rules for prognosis in community-acquired pneumonia, Am J Med, 2005, vol. 118 (pg. 384 - 92 ) 3 Defining community acquired pneumonia severity on presentation to hospital: an international [academic.oup.com]
Etiology
Applicable To Ventilator associated pneumonitis Use Additional Use Additional Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10data.com]
The organisms most often implicated are bacteria; viral etiology is infrequent. [ijpmonline.org]
Acute interstitial pneumonitis (AIP), also known as Hamman-Rich syndrome is a rapidly progressive non-infectious interstitial lung disease of unknown etiology. It is considered the only acute process among the idiopathic interstitial pneumonias. [radiopaedia.org]
Codes with this note are Etiology codes and must be followed by a Manifestation code or codes. [icd.codes]
The etiology of VAP is related to aspiration of contaminated secretions along the endotracheal tube and down to the lower airways, where droplets of secretions can transfer bacteria to the lung and lead to pneumonia. [clinicaladvisor.com]
Epidemiology
Pneumonitis: # Title Authors Year 1 Difference in the phenotypes of bronchoalveolar lavage lymphocytes in patients with summer-type hypersensitivity pneumonitis, farmer's lung, ventilation pneumonitis, and bird fancier's lung: report of a nationwide epidemiologic [malacards.org]
This review summarizes the epidemiology, pathogenesis, diagnosis, and treatment of VAP and touches on a number of practical steps to prevent VAP in neonates. [neoreviews.aappublications.org]
The recommendations are endorsed by the American College of Chest Physicians, American Healthcare Association, Association for Professionals of Infection Control and Epidemiology, Infectious Diseases Society of America, Society for Healthcare Epidemiology [safecarecampaign.org]
Risk factors and follow-up epidemiology. Am J Respir Crit Care Med 160: 923–929. View Article Google Scholar 33. [journals.plos.org]
Further Reading Pneumonia Pneumonia Classification Pneumonia Cause Pneumonia Diagnosis Pneumonia Epidemiology [news-medical.net]
Pathophysiology
[Journal Article] CO Curr Opin Infect Dis 2019 Jan 22 Neill S, Dean N CONCLUSIONS: Aspiration pneumonia and pneumonitis are part of the pneumonia continuum and share similarities in pathophysiology, microbiology, and treatment. [unboundmedicine.com]
Introduction Definition restricted lung expansion results in reduced lung volumes (TLC and FVC) Pathophysiology poor breathing mechanics with normal lung function muscle weakness polio and myasthenia gravis chest wall limitation kyphosis, scoliosis, and [medbullets.com]
Moreover, based on the pathophysiology of VAP, tracheotomy could be protective against VAP. Therefore, the present retrospective case–control study was performed to determine the relationship between VAP and tracheotomy. [erj.ersjournals.com]
A 27 Pathophysiology The pathophysiology of ARDS is not completely understood. [aafp.org]
The pathophysiology, clinical presentation, treatment, and complications of each of these entities are different. [2] This article concentrates on chemical pneumonitis and aspiration pneumonia. [emedicine.medscape.com]
Prevention
VAP Prevention Resources The CDC’s latest recommendations can be found in Guidelines for Preventing Health-Care-Associated Pneumonia. [americansentinel.edu]
[…] ventilator-associated pneumonia prevention strategies. [safecarecampaign.org]
Very few randomized trials have been conducted in neonates to evaluate methods to prevent VAP, and thus most neonatal VAP prevention recommendations are based on adult trials. [neoreviews.aappublications.org]
Preventing pneumonia is always better than treating it. Vaccines are available to prevent pneumococcal pneumonia and the flu. Other preventive measures include washing your hands frequently and not smoking. [icdlist.com]
The UOS acts to prevent the reflux of oesophageal contents into the pharynx in conscious individuals. [ceaccp.oxfordjournals.org]