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Ventricular Septal Rupture

Ventricular septal rupture (VSR) is a rare condition that carries significant morbidity and mortality. It occurs as a complication of myocardial infarction affecting the interventricular septum. The introduction of thrombolytic therapy has reduced its incidence.


Ventricular septal rupture (VSR) commonly occurs as a result of myocardial infarction (MI). VSR is a rare condition that occurs in 0.3% of individuals who have suffered MI, and it carries high morbidity and mortality [1]. Although the introduction of thrombolytic therapy has resulted in the reduction of VSR incidence, cases still occur [2] [3]. Risk factors include advanced age, female sex, chronic renal diseases, and cardiovascular diseases [4] [5].

Typically VSR may present as worsening of a patient's condition after recent MI, following a short period of clinical stability and usually with complaints of chest pain and dyspnea [6]. Mitral valve regurgitation (MVR) may present in a similar way as VSR and is thus one of the main differential diagnoses, notwithstanding that MVR complicates one in five cases of VSR. Upon examination, a significant percentage of patients have a loud holosystolic murmur, most prominent in the left sternal border, which may radiate to several areas in the chest. In addition, there is commonly a parasternal thrill. Murmurs produced by both VSR and MVR may radiate to the axilla, however, an MVR murmur is usually loudest at the apex and can be heard during diastole.

Further complications of VSR that may ensue are low cardiac output, which in turn leads to cardiogenic shock. In such cases, the characteristic murmur is less intense, and a thrill may be completely absent. There is a prominent second heart sound, pulmonary hypertension, and possibly tricuspid regurgitation as well.

An atypical presentation has been described with features of VSR emerging as the first manifestation of the disease, after a silent MI [7].

Atrial Septal Defect
  • CONCLUSION: Transcatheter closure of post-AMI VSR using Atrial Septal Defect, Ventricular Septal Defect, and Patent Ductus Arteriosus occluders is feasible and effective.[ncbi.nlm.nih.gov]
  • Experience of a north Italian referral hospital. Cardiovasc Surg 2003;11:149-54. 11. Barker TA, Ramnarine IR, Woo EB, Grayson AD, Au J, Fabri BM, et al.[saudija.org]
Epigastric Pain
  • A 53-year-old Caucasian male presented with epigastric pain for three days and electrocardiographic evidence for an acute inferior wall myocardial infarction. Coronary angiography revealed a total occlusion of the proximal right coronary artery.[ncbi.nlm.nih.gov]
Chest Pain
  • A 60-years-old male patient, with the history of chronic smoking, presented with progressing chest pain for last 3 days.[ncbi.nlm.nih.gov]
  • Typically VSR may present as worsening of a patient's condition after recent MI, following a short period of clinical stability and usually with complaints of chest pain and dyspnea.[symptoma.com]
  • pain and heaviness.Initial physical examination showed parastemal Ⅲ-Ⅳ systolic murmur.ECG showed a complete right bundle branch conduction blockage.Chest X-ray showed bilateral pulmonary contusion without rib fracture.MB isoenzyme of creatine kinase[cmj.yiigle.com]
  • We report the case of a 61-year-old man who was admitted to our hospital because of syncope and intermittent chest pain with a precordial murmur.[pubfacts.com]
  • Texto Completo A 69-year-old man was admitted with chest pain lasting for four days. The electrocardiogram showed ST elevation in the inferior leads, with Q waves and inverted T waves.[elsevier.pt]
Heart Disease
  • Provides a clinically based approach to echocardiography, with an in-depth discussion of the main cardiac events seen in practice, including adult congenital heart disease.[books.google.com]
  • Clinical Topics: Acute Coronary Syndromes, Cardiac Surgery, Congenital Heart Disease and Pediatric Cardiology, Geriatric Cardiology, Heart Failure and Cardiomyopathies, Invasive Cardiovascular Angiography and Intervention, Valvular Heart Disease, Cardiac[acc.org]
  • Zhonghua Xin Xue Guan Bing Za Zhi 2013 Mar;41(3):195-8 Coronary Heart Disease Center, Cardiovascular Institute and Fuwai Hospital, China Academy Medical Science and Peking Union Medical College, Beijing 100037, China.[pubfacts.com]
  • These individuals should receive follow-up care at a center that specializes in congenital heart disease. Consult your child's doctor regarding the specific outlook for your child.[stanfordchildrens.org]
  • disease; or iatrogenic shock.[onlinejacc.org]
  • OBJECTIVES: Ventricular septal rupture (VSR) is a rare but feared complication after myocardial infarction (MI). The objective of this study was to investigate the effects of thrombolytic therapy on the patterns of VSR following MI.[ncbi.nlm.nih.gov]
  • Electronic address: Objectives : Ventricular septal rupture (VSR) is a rare but feared complication after myocardial infarction (MI).[pubfacts.com]
  • On day 2, the IABP support could be withdrawn and the patient was shifted to the ward later. However,, on 4 th post-operative day, patient became drowsy, dyspneic and hemodynamically unstable.[saudija.org]
Intracranial Hemorrhage
  • Surgery was planned, but he died from extensive subarachnoid and intracranial hemorrhage.[ncbi.nlm.nih.gov]
  • Direct transthoracic ultrasonography revealed a ventricular septal rupture, located in the middle part of the septum, akinesia of the middle and distal parts of the septum, a left ventricular antero-apical aneurysm and global hypokinesia (the ejection[tmj.ro]


Medical history and medical imaging are major parts of the diagnostic process. Imaging modalities include:

  • ECG: Which may show signs of myocardial infarction, as well as its location [8].
  • Chest radiograph: Cardiomegaly and features of congestive heart failure may be present, and are easily seen on a plain film.
  • Right heart catheterization: This is a dated method that is no longer commonly used in diagnosis.
  • Doppler echocardiography (DE): DE can also be used as a diagnostic modality [9] [10]. It provides information on the location and extent of rupture, as well as about cardiac function, with a high sensitivity and specificity. The transesophageal method may prove more accurate in severely ill patients.
  • Radionuclide scintigraphy: This test is able to measure the amount of blood shunted through the septal defect, as well as ventricular function.
  • Left ventriculography: This can also be used to diagnose septal rupture.
  • Coronary angiography: This imaging technique is useful in planning a future intervention, particularly revascularization.
  • Anesthesiologists must avoid maneuvers that tend to decrease PVR/SVR ratio such as hypocapnia and hyperoxemia. Efforts should be made to maintain normocapnia and normoxia by controlled oxygen supplementation to these patients.[saudija.org]



  • We analyzed the short-term prognosis factors of VSR and established the short-term prognosis index of VSR (SPIV) based on the Logistic regression analysis to stratify patients with VSR.[ncbi.nlm.nih.gov]


  • This paper describes a case with a complex VSR with intramyocardial dissection tract extending throughout the right ventricle and yielding a left to right shunt; where the potential role of ischemia was suspected, but the precise etiology of septal rupture[ncbi.nlm.nih.gov]
  • Cardiogenic Shock Complicating Acute Myocardial Infarction - Etiologies, Management and Outcome: A Report from the SHOCK Trial Registry. J Am Coll Cardiol. 2000;36:1063-70. 6. Birnbaum Y, Fishbein NC, Blanche C, et al.[degruyter.com]
  • The randomized trial was restricted to patients with predominant LV pump failure; thus, those with a mechanical etiology of CS were excluded. Such patients were followed prospectively as part of the SHOCK Trial Registry, however.[onlinejacc.org]


  • The epidemiologic design was of an exposed (David infarct exclusion, n 42) versus a nonexposed (Daggett direct closure, n 68) cohort with 3 endpoints: postoperative morbidity, 30-day mortality, and long-term survival.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution


  • However, a growing number of studies consider this anomaly a relevant pathophysiological phenomenon with serious pathological consequences.[ncbi.nlm.nih.gov]
  • Interventricular septal rupture complicating acute myocardial infarction: From pathophysiologic features to the role of invasive and noninvasive diagnostic modalities in current management. Am J Med. 1992;93:683-88.[msjonline.org]
  • Topaz O, Taylor A: Interventricular septal rupture complicating acute myocardial infarction: From pathophysiologic features to the role of invasive and noninvasive diagnostic modalities in current management. Am J Med 1992;93:683–688.[karger.com]


  • For the infarct lesion, this approach provides excellent results with sufficient closure of the VSR and prevention of the ventricular remodeling for five years.[ncbi.nlm.nih.gov]
  • In addition, increased stiffness of the patch around the septal defect prevented deformity of the patch and reduced stress on the suture line.[link.springer.com]
  • Reduction of afterload is required to prevent tension in the suture line of newly repaired septum during the post-bypass period. To achieve these goals, nitroglycerin infusion was started.[saudija.org]



  1. Crenshaw BS, Granger CB, Birnbaum Y, et al. Risk factors, angiographic patterns, and outcomes in patients with ventricular septal defect complicating acute myocardial infarction. GUSTO-I (Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries) Trial Investigators. Circulation. 2000;101(1):27–32.
  2. Ledakowicz-Polak A, Polak L, Zielińska M. Ventricular septal defect complicating acute myocardial infarction-still an unsolved problem in the invasive treatment era. Cardiovasc Pathol. 2011;20(2):93–98.
  3. Figueras J, Alcalde O, Barrabés JA, et al. Changes in hospital mortality rates in 425 patients with acute ST-elevation myocardial infarction and cardiac rupture over a 30-year period. Circulation. 2008;118(25):2783–2789.
  4. Moreyra AE, Huang MS, Wilson AC, Deng Y, Cosgrove NM, Kostis JB. Trends in incidence and mortality rates of ventricular septal rupture during acute myocardial infarction. Am J Cardiol. 2010;106(8):1095-1100.
  5. Lopez-Sendon J, Gurfinkel EP, Lopez de Sa E, et al. Factors related to heart rupture in acute coronary syndromes in the Global Registry of Acute Coronary Events. Eur Heart J. 2010;31(12):1449-1456.
  6. Figueras J, Cortadellas J, Soler-Soler J. Comparison of ventricular septal and left ventricular free wall rupture in acute myocardial infarction. Am J Cardiol 1998;81(4):495-497.
  7. Cox FF, Morshuis WJ, Plokker T, et al. Early mortality after surgical repair of postinfarction ventricular septal rupture: importance of rupture location. Ann Thorac Surg 1996;61(6):1752–1758.
  8. Parry G, Goudevenos J, Adams PC, Reid DS. Septal rupture after myocardial infarction: is very early surgery really worthwhile? Eur Heart J. 1992;13(3):373-382.
  9. Smyllie JH, Sutherland GR, Geuskens R, Dawkins K, Conway N, Roelandt JR. Doppler color flow mapping in the diagnosis of ventricular septal rupture and acute mitral regurgitation after myocardial infarction. J Am Coll Cardiol 1990;15(6):1449-1455
  10. Fortin DF, Sheikh KH, Kisslo J. The utility of echocardiography in the diagnostic strategy of postinfarction ventricular septal rupture: a comparison of two-dimensional echocardiography versus Doppler color flow imaging. Am Heart J. 1991;121(1 Pt 1):25-32.

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Last updated: 2019-07-11 20:25