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Vibrio Vulnificus

Beneckea Vulnifica


Presentation

  • These four cases illustrate the wide range of clinical presentations associated with this organism.[ncbi.nlm.nih.gov]
  • We present a case of a 40-year-old man with decompensated alcoholic liver cirrhosis presenting with atraumatic cellulitis of one extremity and severe sepsis that rapidly progressed to compartment syndrome despite broad-spectrum antibiotics.[ncbi.nlm.nih.gov]
  • Fatal septicaemia usually presents with fever, shock, and large haemorrhagic bullae on the legs. This report is about a man who had severe V. vulnificus septicaemia but presented with atypical features of leg pain and diffuse purpuric skin lesions.[ncbi.nlm.nih.gov]
  • We present a case of Vibrio vulnificus septicemia presenting as purpura fulminans, which can often result in a catastrophic course.[ncbi.nlm.nih.gov]
  • We describe a patient who presented with septic arthritis as the first clinical manifestation of a V vulnificus infection. The organism was subsequently identified in a synovial fluid aspirate.[ncbi.nlm.nih.gov]
Camping
  • In the present study, the roles of cyclic adenosine monophosphate (cAMP) receptor protein (CRP) in V. vulnificus pathogenesis were investigated.[ncbi.nlm.nih.gov]
  • Also, transcription factor HlyU and cAMP receptor protein (CRP) mediate additive activation and host-dependent induction of plpA Molecular biological analyses revealed that plpA expression is controlled via the promoter, P plpA , and that HlyU and CRP[ncbi.nlm.nih.gov]
  • Camp (eds.), Gulf of Mexico–Origins, Waters, and Biota. Biodiversity. Texas A&M Press, College Station Liu J.Y. [Ruiyu] (ed.). (2008). Checklist of marine biota of China seas. China Science Press. 1267 pp.[gbif.org]
  • Consistent with these observations, the sid operon was up-regulated in response to low glucose levels through binding of the cAMP-receptor protein (CRP) complex to a region upstream of the operon.[ncbi.nlm.nih.gov]
  • Camp (eds.), Gulf of Mexico–Origins, Waters, and Biota. Biodiversity. Texas A&M Press, College Station [details] additional source Liu J.Y. [Ruiyu] (ed.). (2008). Checklist of marine biota of China seas. China Science Press. 1267 pp.[marinespecies.org]
Productive Cough
  • The fourth case is that of a 32-year-old, human immunodeficiency virus-positive, hepatitis C-positive woman with cirrhosis who presented with productive cough, chills, fever, and red spots on her extremities and buttocks.[ncbi.nlm.nih.gov]
Photophobia
  • The second case was that of a 43-year-old Asian man employed as an oyster shucker who presented with complaints of redness, tearing, and photophobia of the right eye.[ncbi.nlm.nih.gov]
Heel Pain
  • A case of alcoholic liver cirrhosis developed acute left heel pain and swelling 2 days after ingesting raw fish. Two sets of blood cultures indicated V. vulnificus. HLA-B27 was negative. Ultrasonography revealed left Achilles tendinitis.[ncbi.nlm.nih.gov]

Workup

HLA-B27
  • HLA-B27 was negative. Ultrasonography revealed left Achilles tendinitis. Fluid aspirated from the left retrocalcaneal bursa was sterile. The patient recovered completely 3 weeks after treatment.[ncbi.nlm.nih.gov]

Treatment

  • These patients were divided into 3 groups according to the time between admission and surgical treatment as follows: those who received surgical treatment less than 12 hours after admission, those who received treatment 12 to 24 hours after admission,[ncbi.nlm.nih.gov]
  • Furthermore, psammaplin A treatment significantly suppressed the growth of V. vulnificus. Taken together, these results indicate that psammaplin A may be a potential agent for the prevention and treatment of V. vulnificus infections.[ncbi.nlm.nih.gov]
  • Prompt recognition of this life-threatening infection and adequate treatment with antibiotics is vital.[ncbi.nlm.nih.gov]
  • Prompt initiation of antibiotic treatment, especially before the onset of septic shock, provides the best outcomes.[ncbi.nlm.nih.gov]
  • We retrospectively reviewed 100 cases to evaluate the effectiveness of our treatment protocol and identify independent predictors of mortality to improve clinical outcomes.[ncbi.nlm.nih.gov]

Prognosis

  • To improve the likelihood of patient survival, an early prognosis of patient outcome is clinically important for emergency/trauma department doctors.[ncbi.nlm.nih.gov]
  • Once a bloodstream infection occurs, the prognosis is grim: About 50 percent of V. vulnificus bloodstream infections are fatal, according to the Florida Department of Health .[yahoo.com]
  • The worst prognosis is in those people arriving at hospital in a state of shock.[en.wikipedia.org]

Etiology

  • Vibrio vulnificus, the etiologic pathogen of the compartment syndrome, was isolated from wound and blood cultures. The patient was treated with systemic antibiotic treatment and multiple forearm fasciotomies.[ncbi.nlm.nih.gov]
  • Abstract Vibrio vulnificus biotype 2 is the etiological agent of warm-water vibriosis, a disease that affects eels and other teleosts, especially in fish farms.[ncbi.nlm.nih.gov]
  • Abstract The halophile Vibrio vulnificus is an etiologic agent of human mortality from seafood-borne infections. We applied whole-genome sequencing and comparative analysis to investigate the evolution of this pathogen.[ncbi.nlm.nih.gov]
  • […] of diseases in human communities. 2. the field of medicine concerned with the determination of the specific causes of localized outbreaks of infection, such as hepatitis, of toxic disorders, such as lead poisoning, or any other disease of recognized etiology[vdh.virginia.gov]
  • Significant SSTIs can also follow marine injuries and exposures in travelers, and the etiologies are often marine bacteria.[doi.org]

Epidemiology

  • Bulletin Archive Contact Us Laurie Forlano, DO, MPH, State Epidemiologist Director, Office of Epidemiology 109 Governor Street, 6th Floor East Richmond, VA 23219 Phone: (804) 864-8141 Fax: (804) 864-8139 Contact Us by Email[vdh.virginia.gov]
  • To describe the epidemiology, pathophysiology, diagnosis, treatment, and prevention of Vibrio vulnificus, a rare organism that surfaced following Huricane Katrina and caused serious problems for many victims.[ncbi.nlm.nih.gov]
  • The objective of this report was to use this case to discuss clinical aspects, microbiological diagnosis and treatment of the infection caused by this agent, besides the review of epidemiology, associated risk factors and prevention before consuming or[ncbi.nlm.nih.gov]
  • Study Objective: To describe the clinical and epidemiologic features of Vibrio vulnificus infections. Design: Case series based on notifiable disease report forms and patient medical records.[annals.org]
  • Abstract In this study, we performed a retrospective, quantitative analysis of the epidemiological aspects and risk factors of Vibrio vulnificus infections in Korea from 2001 to 2010.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • To describe the epidemiology, pathophysiology, diagnosis, treatment, and prevention of Vibrio vulnificus, a rare organism that surfaced following Huricane Katrina and caused serious problems for many victims.[ncbi.nlm.nih.gov]
  • The TonB1 and TonB2 systems are relatively well characterized, while the pathophysiological function of the TonB3 system is still elusive.[ncbi.nlm.nih.gov]

Prevention

  • Mutation of the vvpM gene appeared to play major role in the prevention of IL-1β production due to V. vulnificus infection in macrophage.[ncbi.nlm.nih.gov]
  • Prompt recognition and immediate treatment with antibiotics and possibly surgical débridement may prevent amputation or death.[ncbi.nlm.nih.gov]
  • To describe the epidemiology, pathophysiology, diagnosis, treatment, and prevention of Vibrio vulnificus, a rare organism that surfaced following Huricane Katrina and caused serious problems for many victims.[ncbi.nlm.nih.gov]
  • The objective of this report was to use this case to discuss clinical aspects, microbiological diagnosis and treatment of the infection caused by this agent, besides the review of epidemiology, associated risk factors and prevention before consuming or[ncbi.nlm.nih.gov]
  • Because of the high morbidity and mortality associated with V. vulnificus infections, effective treatment includes preventive measures to educate high-risk individuals, early search for and recognition of the disease, aggressive antibiotic therapy, supportive[ncbi.nlm.nih.gov]

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