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Vinyl Chloride Poisoning

Vinyl Chloride Toxicity


Presentation

  • Articles GC Analysis of Volatiles in Water on SPB -1 after SPME using 100 μm PDMS Fiber From our library of Articles, Sigma-Aldrich presents GC Analysis of Volatiles in Water on SPB -1 after SPME using 100 μm PDMS Fiber Keywords: Chromatography, Flame[sigmaaldrich.com]
  • Dioxins are now present throughout the environment and the food chain. Everyone is exposed to them in their diets, particularly through fatty foods such as dairy, meat, fish and eggs.[greenpeace.org]
  • Choose Wisely PVC production and disposal also present significant problems and potential for exposure to other toxic chemicals such as dioxins and hydrogen chloride gas. Remember, it is always better to be safe than sorry.[ronandlisa.com]
  • ." - Chemical Manufacturers Association, Trip Report, October 1974 (view entire document) "It was the consensus of those present that ... it would be appropriate to release such information [about the research project] to the press.[chemicalindustryarchives.org]
  • There are more than 80 different types of welding and associated processes, presenting unique challenges to worker safety.[episervices.com]
Fatigue
  • Short-term exposure to moderate levels of vinyl chloride in the air can result in a headache, vertigo, loss of consciousness, and fatigue. Nervous system damage is also possible.[ifediba.com]
  • […] the liver and hepatocellular carcinoma. [4] There is strong evidence from both human and animal studies that vinyl chloride causes cancer via a genotoxic mechanism. [4] Acute inhalation exposure to vinyl chloride can cause dizziness, nausea, headache, fatigue[carexcanada.ca]
  • Many cases of HAS are asymptomatic when they are diagnosed accidently, and the most common initial complaints are nonspecific symptoms such as right upper quarterant pain, fatigue, weakness, and weight loss [ 1 ], making it rarely diagnosed antemortem[bmcgastroenterol.biomedcentral.com]
Splenomegaly
Abdominal Pain
  • pain DM, liver rupture no none TAE none 24 D NA Hsiao [ 17 ] F 82 abdominal fullness, abdominal pain, nausea HTN, CRI, PUD, L/C no none none none 42 M CD34 Ho et al. [ 3 ] F 68 abdominal pain uremia in HD, HTN, ureteral papilloma, liver rupture no none[bmcgastroenterol.biomedcentral.com]
Arthralgia
  • […] contact with it during its monomer state. 2 Chronic intoxication by the gaseous monomer VCM is linked to several symptoms such as: 3 asthenia and dizziness, 3 Raynaud's syndrome, 4 , 5 digestive ulcera with nausea and anorexia, 3 systemic symptoms of arthralgia[bmjopen.bmj.com]
Uremia
Headache
  • Short-term exposure to moderate levels of vinyl chloride in the air can result in a headache, vertigo, loss of consciousness, and fatigue. Nervous system damage is also possible.[ifediba.com]
  • The gas can cause dizziness, drowsiness, and headache when inhaled. At very high levels, the EPA reports, vinyl chloride can cause loss of consciousness, lung and kidney irritation, and in extreme cases, death.[popularmechanics.com]
  • Symptoms of Vinyl Chloride Exposure Drowsiness Loss of coordination Hallucination Disorientation Nausea Headache Burning or tingling of the fingers or toes Slow breathing Organ damage (liver, lungs, kidneys, heart) Spleen enlargement Liver enlargement[schmidtlaw.com]
  • High levels of exposure can cause headaches, stomach ulcers, skin allergies, nausea, weakness, unconsciousness, and sometimes death. Contact with liquid vinyl chloride can cause frostbite.[bagoliefriedman.com]
  • […] angiosarcoma of the liver and hepatocellular carcinoma. [4] There is strong evidence from both human and animal studies that vinyl chloride causes cancer via a genotoxic mechanism. [4] Acute inhalation exposure to vinyl chloride can cause dizziness, nausea, headache[carexcanada.ca]
Sleep Disturbance
  • disturbances, unconsciousness, and in high concentrations, death. [5,6] Chronic exposure to vinyl chloride is associated with a number of non-cancer health effects in different organs and tissues, including the liver, skin, and bones, as well as the[carexcanada.ca]

Treatment

  • Significant updates on bariatric surgery, Barrett's esophagus, endoscopic ultrasound, endosonography, treatment of liver disease, and much more keep you current on the latest advances.[books.google.com]
  • These products are mixtures of many chemicals created by high-temperature treatment of beech and other woods, coal, or from the resin of the creosote bush.[ifediba.com]
  • Chloracne lesions are particularly painful, can be permanently disfiguring and are resistant to treatment. Removal from exposure is the most important intervention and the condition does resolve eventually.[cape.ca]
  • If symptoms such as inflammation or irritation develop, IMMEDIATELY call a physician or go to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.[cameochemicals.noaa.gov]
  • Four patients received conservative treatment only.[bmcgastroenterol.biomedcentral.com]

Prognosis

Etiology

Epidemiology

  • Defense attorneys must be adept at analyzing the epidemiological studies and comfortable with arguing dose response relationships at trials.[smsm.com]
  • Vinyl chloride has been shown to cause liver, brain, and lung cancer, as well as lymphatic and hematopoietic malignancies (such as lymphoma and leukemia) in multiple epidemiologic studies.[bagoliefriedman.com]
  • It was this announcement that resulted in significant health and safety investigations, regulatory changes, and an expansion of the vinyl chloride monomer toxicity and epidemiological studies.[episervices.com]
  • View Article PubMed Google Scholar Mansell CJ, Locarnini SA: Epidemiology of hepatitis C in the East. Semin Liver Dis. 1995, 15: 15-32. 10.1055/s-2007-1007260.[bmcgastroenterol.biomedcentral.com]
  • These researchers pointed to other recent epidemiologic studies in children conducted in Norway, Finland, Sweden, and Russia that also found links between PVC, phthalates, and respiratory problemsxx.[chej.org]
Sex distribution
Age distribution

Pathophysiology

Prevention

  • Atlanta, GA: Centers for Disease Control and Prevention, 2006. Available online. Last accessed December 28, 2018. International Agency for Research on Cancer.[cancer.gov]
  • Online: (20 October 2009). x Center for Disease Control and Prevention. “Childhood overweight and obesity.” Online: (20 October 2009). xi Center for Disease Control and Prevention. 2005.[chej.org]
  • While vinyl chloride exposure has been linked to other types of cancer, recovery may be prevented because it is more difficult to prove causation.[jernlaw.com]
  • Prevent entry into waterways, sewers, basements or confined areas. Isolate area until gas has dispersed.[cameochemicals.noaa.gov]

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