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Vitamin A


Presentation

  • We report the first case of an adult presenting with respiratory symptoms caused by hepatic hydrothorax secondary to vitamin A intoxication. The patient was a 52-year-old woman who presented to the hospital with progressive dyspnea.[ncbi.nlm.nih.gov]
  • Pityriasis rubra pilaris (PRP) is a rare skin disorder with versatile clinical presentations. A 62-year-old Caucasian woman with progressive erythroderma and classic adult (type I) PRP is presented.[ncbi.nlm.nih.gov]
  • We report a case of a 24-year-old man who presented with a complaint of reduced mouth opening and a burning sensation. On examination, he was clinically diagnosed with oral submucous fibrosis (OSF).[ncbi.nlm.nih.gov]
  • We present a patient with Shwachman-Diamond Syndrome who developed liver fibrosis, portal hypertension and very severe hepatopulmonary syndrome as a consequence of chronic vitamin A intoxication.[ncbi.nlm.nih.gov]
Scotoma
  • We report two clinical cases of particular interest: a 7-year-old boy developed striking erythema in the face and upper thorax; a 16-year-old girl who reported unexpected visual disturbances, including scotomas and tunneling vision.[ncbi.nlm.nih.gov]
Bony Swelling
  • A 4-year-old boy presented with severe bone pains, refusal to walk, diffuse bony swelling of forelimbs, skin changes and abdominal pain, with symptoms evolving over 6 weeks.[ncbi.nlm.nih.gov]
Alopecia
  • Herein we present the case of a 60-year-old male with symptoms of muscle soreness, alopecia, nail dystrophy, and ascites.[ncbi.nlm.nih.gov]
  • Early symptoms of chronic toxicity are sparsely distributed, coarse hair; alopecia of the eyebrows; dry, rough skin; dry eyes; and cracked lips. Later, severe headache, pseudotumor cerebri, and generalized weakness develop.[merck.com]
  • The more commonly recognized signs and symptoms include skeletal abnormalities, bone tenderness and pain, increased intracranial pressure, desquamation, brittle nails, mouth fissures, alopecia, fever, headache, lethargy, irritability, weight loss, vomiting[nap.edu]
Yellow Discoloration of the Skin
  • Search for more papers by this author First published: 30 November 2004 Cited by: 7 Abstract Abstract: Carotenemia is a condition characterized by yellow discoloration of the skin and elevated blood carotene levels.[dx.doi.org]
  • The carotenoid forms (such as beta-carotene as found in carrots), give no such symptoms, but excessive dietary intake of beta-carotene can lead to carotenodermia, a harmless but cosmetically displeasing orange-yellow discoloration of the skin. [37] [38[en.wikipedia.org]

Workup

  • (See Prognosis, Workup , Treatment , and Medication .) Vitamin A An important fat-soluble vitamin, vitamin A’s basic molecule is a retinol, or vitamin A alcohol.[emedicine.com]
  • (See Prognosis, Workup, Treatment, and Medication .) Vitamin A An important fat-soluble vitamin, vitamin A’s basic molecule is a retinol, or vitamin A alcohol.[emedicine.medscape.com]
Right Pleural Effusion
  • Evaluation demonstrated mild elevation of her liver function tests, ascites, and a right pleural effusion. The patient consumed a variety of vitamins, including vitamin A.[ncbi.nlm.nih.gov]
Hyponatremia
  • We present three adult cases (one of whom was pregnant) admitted to our University Hospital who were diagnosed to have measles and who had uncommon clinical features such as hepatitis and hyponatremia.[ncbi.nlm.nih.gov]
Human Papillomavirus
  • Common warts (verruca vulgaris) are benign epithelial proliferations associated with human papillomavirus (HPV) infection.[ncbi.nlm.nih.gov]

Treatment

  • The warts resisted treatment with salicylic acid, apple cider vinegar and an over-the-counter blend of essential oils marketed for the treatment of warts.[ncbi.nlm.nih.gov]
  • Extrahepatic tissue VA concentrations displayed treatment effects ( P 0.0077); groups that received treatments had higher VA concentrations than controls at early time points.[ncbi.nlm.nih.gov]
  • Sublingual vitamin A may represent a viable and efficacious treatment modality for vitamin A deficiency.[ncbi.nlm.nih.gov]
  • Consideration should be given to reducing vitamin A supplementation during voriconazole treatment.[ncbi.nlm.nih.gov]
  • Vitamin A seems to be very effective in the treatment of radiation-induced anorectal damage, with little toxicity and expense.[ncbi.nlm.nih.gov]

Prognosis

  • Failure to recognize this entity may undermine the visual prognosis already compromised by delayed corneal wound healing, increased susceptibility to bacterial infection, frequently debilitated general health, and lack of compliance.[doi.org]
  • Prognosis is good when vitamin A intake is reduced. Vitamin A and vitamin A derivatives, such as the acne medication isotretinoin, can cause birth defects when taken in excess during pregnancy.[britannica.com]
  • (See Prognosis, Workup , Treatment , and Medication .) Vitamin A An important fat-soluble vitamin, vitamin A’s basic molecule is a retinol, or vitamin A alcohol.[emedicine.com]
  • (See Prognosis, Workup, Treatment, and Medication .) Vitamin A An important fat-soluble vitamin, vitamin A’s basic molecule is a retinol, or vitamin A alcohol.[emedicine.medscape.com]

Etiology

  • : Emergency physicians should consider acute vitamin A intoxication in the differential diagnosis of patients with headache, flushing, desquamation, nausea, and vomiting of unknown etiology.[ncbi.nlm.nih.gov]
  • Karakalios DG, Rekate HL, Khayata MH, Apostolides PJ: Elevated intracranial venous pressure as a universal mechanism in pseudotumor cererbi of various etiologies . Neurology 1996, 46 :198–202.[doi.org]
  • Although some researchers have expressed concern that androgens such as testosterone may be involved in the etiology of prostate cancer, from vitamin A we can expect only more good news.[westonaprice.org]
  • On the etiology of scurvy. J Hyg (Lond) 1907 ; 7 : 634 -671. Drummond JC . Note on the role of the anti-scorbutic factor in nutrition. Biochem J 1919 ; 13 : 77 -80. Carr FH , Price EA. Colour reactions attributed to vitamin A.[clinchem.org]

Epidemiology

  • Article navigation Department of Ophthalmology, Johns Hopkins School of Medicine; Departments of Molecular Microbiology and Immunology, Epidemiology (Program of Infectious Diseases), and International Health (Center for Human Nutrition), Johns Hopkins[doi.org]
  • There is no effective treatment of norovirus infection, though vitamin A has been suggested to have an antiviral effect in an epidemiological study. We demonstrated that vitamin A significantly inhibited murine norovirus replication.[ncbi.nlm.nih.gov]
  • Methods We performed a cross-sectional, epidemiological study of 180 mother-newborn dyads. Maternal and UC blood samples and BM were collected. VA intake by the mother over 30 days was assessed using a questionnaire.[ncbi.nlm.nih.gov]
  • Abnormal oxidation products of carotenoids can cause toxicity in animal models and may have caused the increased incidence of lung cancer seen in 2 epidemiologic studies of the effects of high-dose beta-carotene supplementation.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • […] in 2003–2006 33% of the United States population aged 1 year and older took a multivitamin supplement in a given month. [3] In a 2009 survey, 56% of US consumers said they take vitamins or supplements, with 44% saying they take them daily. [4] (See Pathophysiology[emedicine.com]
  • Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med. 1997;337(20):1419-1428. (PubMed) 29. Wang Z, Boudjelal M, Kang S, Voorhees JJ, Fisher GJ.[lpi.oregonstate.edu]

Prevention

  • Vitamin A and beta-carotene may form a complex with iron, keeping it soluble in the intestinal lumen and preventing the inhibitory effect of phytates and polyphenols on iron absorption.[ncbi.nlm.nih.gov]
  • Cell motility is reduced, the adhesiveness of cells increases and pattern formation is prevented.[ncbi.nlm.nih.gov]
  • […] printable version Vitamin A deficiency Safe vitamin A dosage during pregnancy and lactation Geneva, World Health Organization, 1998 Cover Vitamin A supplements: a guide to their use in the treatment and prevention of vitamin A deficiency and xerophthalmia[who.int]
  • May Help Prevent Cancer Vitamin A is a powerful antioxidant, which can prevent certain forms of cancer.[organicfacts.net]

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