The primary presentation of mild vitamin B12 deficiency is anemia. Severe deficiency symptoms include fatigue, pale skin, rapid heartbeat, sore tongue, diarrhea or constipation, bleeding gums and weight loss . Symptoms of vitamin B2 deficiency are angular stomatitis and cheilosis, that are gradually replaced by superficial linear cracks. These cracks can get infected by Candida leading to white lesions. Seborrheic dermatitis affects ears, scrotum, nasolabial folds and eyelids which later become reddish. Symptoms of vitamin B6 deficiency in adults include depression, seizures and confusion. Peripheral neuropathy, pellagra with glossitis, seborrheic dermatitis and cheilosis are also the symptoms of Vit.B6 deficiency.
Entire Body System
Weight Loss The individual may lose weight as a general aspect of the malnutrition the often accompanies this vitamin deficiency. 2. [fitday.com]
[…] person consumes at least 140 pounds of sugar a year which robs the body of its vitamin B stores Drugs: both recreational and prescription drugs deplete vitamin B Toxins: poisons in the environment and personal care products deplete vitamin B complex Malnutrition [greenmedinfo.com]
[…] sugar, glucose including IV glucose or feeding given to patients in hospital Chronic alcohol excess, which is often the commonest and most serious cause High dietary intake of thiaminases (enzymes that destroy thiamine) from betel nuts and raw fish Malnutrition [stewartnutrition.co.uk]
Peripheral neuropathy may occur as a result of malnutrition, for which there are many causes including poor nutrition caused by an unbalanced diet and/or alcoholism. [foundationforpn.org]
- Peripheral Neuropathy
Symptoms can include peripheral neuropathy, a pellagra-like syndrome, anemia, and seizures, which, particularly in infants, may not resolve when treated with anticonvulsants. [merckmanuals.com]
Centre For Peripheral Neuropathy, University of Chicago [health24.com]
Much of the damage is to the large dorsal-root ganglion neurons; the peripheral nerve fibres also demyelinate, so that peripheral neuropathy also occurs. [britannica.com]
Other deficiencies, like peripheral neuropathy, can be permanent. According to the National Institutes of Health (NIH), between 28 and 35 percent of the population in the United States take vitamin supplements containing vitamin B6. [medicalnewstoday.com]
Neurologic Vitamin B12 deficiency can cause paresthesia, peripheral neuropathy, and a serious irreversible deficiency disease known as subacute combined degeneration of the spinal cord, with demyelination damage to both the corticospinal and dorsal columns [news-medical.net]
- Neurologic Manifestation
RESULTS: In total, 47 (0.7%) bariatric surgical patients (Roux-en-Y gastric bypass n 36, sleeve gastrectomy n 9, and duodenal switch n 2) developed neurologic manifestations secondary to vitamin B deficiencies. [ncbi.nlm.nih.gov]
Vitamin B 12 deficiency is associated with various symptoms, of which the haematological and neurological manifestations are the most prominent. [nature.com]
The neurological manifestations include myelopathy (disease of the spinal cord), neuropathy (disease of the nerves), sensory disturbances, gait abnormalities, and weakness, while the psychiatric problems range from cognitive and behavioral disturbances [brainblogger.com]
Pathophysiology Of Neurological Manifestations Cyanocobalamin mediates two important enzymatic reactions in humans. [ispub.com]
manifestations because of low B 12. [pharmacytimes.com]
Diagnosis of vitamin B12 deficiency is performed by measuring the levels of vitamin B12 and folate in the blood. Complete blood count is also done to look for anemia. If diagnosis of intrinsic factor deficiency is considered important, Schilling test is also performed. Most common diagnostic tool for Vitamin B6 deficiency is measuring the levels of serum pyridoxal phosphate. Urinary excretion of riboflavin is measured for diagnosing vitamin B2 deficiency. Diagnosis is also performed by therapeutic trial.
The treatment for vitamin B12 deficient patients consists of vitamin B12 injections  . Riboflavin of 5 mg to 10 mg orally once a day is given as a supplement along with other water soluble vitamins to treat vitamin B2 deficiency. In adults, the deficiency of vitamin B6 is treated using pyridoxine 50 mg to 100 mg orally once a day. People taking isoniazid can also be prescribed with pyridoxine of 30 mg to 50 mg orally once a day. High doses of pyridoxine are effective in the case of inborn errors of metabolism. For pyridoxine deficiency from metabolic demand, large amounts of pyridoxine are necessary.
The prognosis of vitamin B2 deficiency is extremely good when vitamin B2 supplements along with a well-balanced diet are taken. Several patients taking treatment with these supplements will recover in a few weeks period. Negative prognosis is related to conditions like alcoholism, anorexia nervosa or bulimia nervosa. These diseases prevent the patient from taking healthy diet and vitamin supplements .
The primary deficiency of vitamin B6 can result from depletion of B6 rich foods in the body. Secondary deficiency is caused by malabsorption, under-nutrition, the use of pyridoxine inactivating drugs and enhanced metabolic demand as seen in hyperthyroidism. Rare intricate errors in metabolism can influence metabolism of pyridoxine. Primary riboflavin deficiency occurs due to insufficient intake of fortified cereals, animal products and milk. Secondary riboflavin deficiency occurs due to chronic diarrhea, liver disorders, peritoneal dialysis, malabsorption syndrome, hemodialysis, chronic alcoholism, long-term use of barbiturates. Autoimmune disorders, pernicious anemia, atrophic gastritis, Crohn’s disease, celiac disease, weight-loss surgery, Grave’s disease and long-term use of acid-reducing drugs are some of the causes of vitamin B12 deficiency .
Framingham offspring study found that 39 percent of US adults are at a higher risk for vitamin B12 deficiency with serum vit. B12 < 258 picoMol/L or <350picograms/mL. Prevalence of vitamin B12 deficiency is observed in 5% to 15% of population. This deficiency is higher in developing countries. Low serum vitamin B12 was <148picomols/L or <200 picograms/mL in 25% to 70% of the population studied. According to the national institute of health, deficiency of Vit. B6 is considered as rare in the United States. When present, it can lead to anemia. A European population based study revealed higher plasma concentrations of vitamin B2 and B6 to be associated with a lower risk in colorectal cancer  .
During cobalamin deficiency, methylmalonic acid and homocysteine levels increase in the blood. The gastrointestinal and hematologic anomalies in this condition might be due to deficiency in DNA synthesis in the quickly dividing cells of bone marrow and gastrointestinal tract. Neurological effects of this condition are thought to be due to the incorporation of cobalamin based synthesis of succinyl CoA into branched chain fatty acids leading to abnormal myelination. Cobalamin in the food is attached to the salivary protein called “R binders” at lower pH in the stomach. Higher duodenal pH promotes the transfer of cobalamin to the proteins of gastric parietal cell protein called intrinsic factor. Cells of ileum absorb the cobalamin-intrinsic factor complex  .
The fuel that is essential for the body consists of a nutritious diet containing carbohydrates, proteins and fats. B vitamins help the body to make use of this fuel. As a result, the human body lacks energy in the absence of vitamin B.. Other B-group vitamins play an important role in the multiplication of cells by making new DNA. Vitamin B supplements are known for suppressing the deficiencies of other vitamins. DNA and red blood cells are made in the body with the help of vitamin B12. Diseases of small intestine, thinning of stomach lining and surgery that removes part of the stomach are some of the reasons for vitamin B12 deficiency. There are eight types of vitamin B. They are B1 or thiamine, B2 or riboflavin, niacin, pantothenic acid, biotin, vitamin B6 or pyridoxine, folate and vitamin B12 . Riboflavin is associated with carbohydrate metabolism and acts as a coenzyme in the oxidation-reduction reactions. Deficiency of riboflavin leads to sore throat, lesions of lips and mucosa of the mouth. If B6 vitamin is excessively processed, it will get depleted from the resultant food. Secondary deficiency results from various conditions.
Vitamin B deficiency does not allow the human body to synthesize carbohydrates, fats and proteins. Therefore, the body will not be able to utilize the necessary fuel it needs. Vitamin B deficiency leads to lack of energy in the body. Some of the symptoms of vitamin B12 deficiency include fatigue, rapid heartbeat and sore throat. Some of the symptoms of vitamin B6 include pellagra, depression and seizures. Some of the symptoms of vitamin B2 include angular stomatitis and cheilosis. Vitamin B6 and vitamin B2 deficiency can be treated by providing 50 mg to 100 mg of pyridoxine orally once a day, and 5 mg to 10 mg of riboflavin orally once a day. Vitamin B12 injection serves best for vitamin B12 deficiency.
- Stabler SP. Clinical practice. Vitamin B12 deficiency. N Engl J Med 2013; 368:149.
- Marcuard SP, Albernaz L, Khazanie PG. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12). Ann Intern Med 1994; 120:211.
- Figlin E, Chetrit A, Shahar A, et al. High prevalences of vitamin B12 and folic acid deficiency in elderly subjects in Israel. Br J Haematol 2003; 123:696.
- Lindenbaum J, Rosenberg IH, Wilson PW, et al. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994; 60:2.
- Dali-Youcef N, Andrès E. An update on cobalamin deficiency in adults. QJM 2009; 102:17.
- Remacha AF, Cadafalch J. Cobalamin deficiency in patients infected with the human immunodeficiency virus. Semin Hematol 1999; 36:75.
- Okada A, Koike H, Nakamura T, et al. Slowly progressive folate-deficiency myelopathy: report of a case. J Neurol Sci 2014; 336:273.
- Kumar S. Vitamin B12 deficiency presenting with an acute reversible extrapyramidal syndrome. Neurol India 2004; 52:507.
- Carmel R. How I treat cobalamin (vitamin B12) deficiency. Blood 2008; 112:2214.
- Butler CC, Vidal-Alaball J, Cannings-John R, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials. Fam Pract 2006; 23:279.