Patients with vitreous hemorrhage commonly present with painless unilateral floaters with or without visual loss. Mild hemorrhage is associated with floaters, cobwebs, shadows, a red hue or haze. Severe hemorrhage diminishes visual clarity or causes scotomas which is worse in the morning time due to blood settling on the macula. Physicians should try to identify the underlying cause by determining whether patients have a history of trauma, diabetes, ocular surgery, high myopia, sickle cell anemia, leukemia and carotid artery disease. Examination should consist of indirect ophthalmoscopy with scleral depression and gonioscopy to assess neovascularization. If blood obscures view of posterior pole, intraocular pressure (IOP) and B-scan ultrasonography should be performed. Etiology of vitreous hemorrhage may be determined through dilated examination of contralateral eye.
Vitreous hemorrhage is easily detected using a microscope with a split beam set off-axis on highest magnification to identify red blood cells just posterior to the lens. In some cases, where view of the retina is possible, the source of the vitreous hemorrhage can be identified. Preretinal vitreous hemorrhages are found in the subhyaloid space and are often boat-shaped. Dispered vitreous hemorrhage is less defined and varies from a few red blood cells in the body of the vitreous to total covering of the posterior pole.

• Anemia

  Underlying diseases that may cause vitreous hemorrhage include diabetes, hypertension, carotid artery disease and sickle cell anemia. [symptoma.com]

  Vitreous hemorrhage due to Terson syndrome, anemia, Valsalva retinopathy, shaken baby syndrome, and retinal macroaneurysm rarely breaks through the internal limiting membrane or into the subretinal space. [emedicine.medscape.com]

  […] retinal detachment, a new leaky blood vessel (neovascularization caused by Diabetic Retinopathy, Retinal Artery or Vein Occlusion, Macular Degeneration, Carotid Artery Stenosis, etc.) or another underlying disease such as hypertension or sickle cell anemia [premieridaho.com]

  These disease states include diabetes, hypertension, sickle cell anemia, and carotid artery disease. Diabetics are particularly susceptible because the disease triggers the growth of new blood vessels within the eye. [maculacenter.com]

  There are many possible causes of vitreous hemorrhage, including systemic diseases such as: Diabetes mellitus Sickle cell anemia Also, with aging the vitreous gel liquefies and separates from the retina, creating a posterior vitreous detachment. [vrssurgery.com]

• Congestive Heart Failure

  Myocardial infarction, other cardiac event requiring hospitalization, stroke, transient ischemic attack, or treatment for acute congestive heart failure within 4 months prior to randomization. [clinicaltrials.gov]

• Malaise

  However, he then exhibited general malaise and was diagnosed as having secondary AML in May 2012. [karger.com]

• Aspiration

  Transcorneal, transzonular fine-needle aspiration biopsy of the vitreous confirmed the presence of dehemoglobinized vitreous red blood cells without tumor. [ncbi.nlm.nih.gov]

  In December 2012, the patient underwent 25-gauge pars plana vitrectomy combined with phacoemulsification and aspiration (PEA). [karger.com]

• Heart Failure

  Myocardial infarction, other cardiac event requiring hospitalization, stroke, transient ischemic attack, or treatment for acute congestive heart failure within 4 months prior to randomization. [clinicaltrials.gov]

  Although he was treated with combined chemotherapy and radiation, tumor lysis syndrome occurred with renal and heart failure complications. [karger.com]

• Macula

  A "congenital retinal macrovessel" (CRM) is an aberrant retinal vessel (frequently a vein) that traverses the central macula and supplies or drains both above and below the horizontal raphe. [ncbi.nlm.nih.gov]

  A macular hole often develops as part of the natural aging process, when the vitreous gel thins and separates from the macula. This can pull on the macula and cause a hole to form. [midhudsonretina.com]

• Blurred Vision

  The episodes of blurred vision vanished completely, and the IOP returned to normal levels without therapy. [ncbi.nlm.nih.gov]

  Loss of vision, blurred vision and floaters Vitreous hemorrhages may be of different degrees. Severe bleedings may cause a sudden and complete loss of vision, while mild ones cause blurred vision or the appearance of floaters. [icrcat.com]

  When a person does notice the sudden appearance of floaters, spider webs, spots in front of the eye, or blurred vision, they should immediately call their eye doctor. [brooklynretina.com]

• Visual Impairment

  Also, the essential fatty acids including omega-3 from fish oil and flaxseed oil. [10] See also [ edit ] Visual impairment References [ edit ] Further reading [ edit ] Currie AD, Bentley CR, Bloom PA (March 2001). [en.wikipedia.org]

  A retinal detachment can develop and result in permanent visual impairment What happens after the surgery? Following surgery, the vision will be blurred for a few weeks due to mild swelling and the dilating eye drops. [terraceeyecentre.com.au]

  The diagnosis of intraocular cysticercosis has special importance due to high risk of visual impairment. [springerplus.springeropen.com]

  Many community organizations and agencies offer information about low vision counseling, training, and other special services for people with visual impairment. [nei.nih.gov]

  Global estimates of visual impairment. Br J Ophthalmol 2012; 96 : 614–618. 3. The Diabetic Retinopathy Study Research Group. Photocoagulation treatment of proliferative diabetic retinopathy. [nature.com]

• Vitreous Floaters

  Risk of retinal tears in patients with vitreous floaters. Am J Ophthalmol 1983;96:783-787. 7. Jaffe NS. Vitreous detachments. In: The Vitreous in Clinical Ophthalmology. St. Louis: CV Mosby Co., 1969:83-98. 8. Tabotabo MM, Karp LA, Benson WE. [reviewofophthalmology.com]

• Cotton Wool Spots

  Retinal hemorrhages, pre- and subretinal hemorrhages, cotton wool spots, optic disc edema, and invasion of neoplastic cells, among others, are some of the various ocular complications that have been reported for leukemia over the years [ 1 ]. [karger.com]

• Suggestibility

  The damage to peripapillary tissues demonstrated by fluorescein leakage suggests that intracranial hypertension affects peripapillary structures through the intervaginal space of the optic nerve sheath. [ncbi.nlm.nih.gov]

  The observations suggested a therapeutic potential for anti-VEGF agents in the treatment of vitreous hemorrhage caused by proliferative diabetic retinopathy. [medpagetoday.com]

• Confusion

  Similarities in the clinical presentation of Congenital Nonattachment of the Retina may cause diagnotic confusion. [disorders.eyes.arizona.edu]

  With longstanding vitreous haemorrhage the posterior hyaloid face can produce a significant high spike on standardised A-scan, which could be confused with retinal detachment. This confusion can often be avoided by performing kinetic scanning. [ijo.in]

• Papilledema

  Optic nerve sheath fenestration was performed in an effort to promote regression of the papilledema and the shunt vessels. Our case illustrates a rare complication of optociliary shunt vessels in the setting of papilledema. [ncbi.nlm.nih.gov]

Physicians should try to determine etiology by asking patients if they have a history of trauma, diabetes, ocular surgery, high myopia, sickle cell anemia, leukemia and carotid artery disease. Examination should consist of indirect ophthalmoscopy with scleral depression and gonioscopy to assess neovascularization. Vitreous hemorrhage is easily identified using a microscope with a split beam set off-axis on highest magnification to identify red blood cells just posterior to the lens. In cases where view of the retina is possible the source of the vitreous hemorrhage should be identified. If the fundus is concealed by blood, corneal opacification or cataract ultrasonography must be performed, which will reveal if the retina is attached, an intraocular foreign body is present and if a posterior vitreous detachment has occurred. Previous studies have shown that using ultrasonography physicians may inappropriately identify a vitreous hemorrhage as a retinal detachment. To distinguish between vitreous hemorrhage and retinal detachment it is important to know that 1) retinal detachment can be followed back to the optic disk, 2) vitreous hemorrhages remain horizontal upon side to side eye movement and 3) vitreous hemorrhages are often located in the middle of the posterior eye. Acute vitreous hemorrhages may not appear organized or structured at first, however, over time these structures may become organized into a linear structure.

Effective treatment will address the underlying cause, therefore, it is important to determine the cause of vitreous hemorrhage if possible [9] [10]. Patients often require only outpatient treatment. Hospitalization is rarely necessary for vitreous hemorrhage, although in cases with severe hyphema in unreliable or noncompliant patients close observation in a hospital setting is needed. Patients should get plenty of bed rest with the head elevated 30-45º and occasional bilateral patching to allow examination of the superior fundus once blood settles. Anticlotting drugs such as aspirin should be avoided. Surgery to address the underlying cause of vitreous hemorrhage should be performed as soon as possible for best results. Types of surgeries may include; closure of retinal breaks or treatment of retinal vascular disease with laser photocoagulation or cryotherapy, reattachment surgery of detached retinas or surgical removal of vitreous blood. Vitreous blood should be removed with surgery if;

1. there is an associated detached retina,
2. hemorrhage has been present for greater than two to three months,
3. hemorrhage in patients with juvenile-onset diabetes,
4. children still susceptible to amblyopia,
5. retinal traction is observed,
6. hemorrhage is associated with rubeosis and
7. hemorrhage is associated with hemolytic glaucoma.

Prognosis of vitreous hemorrhage is highly variable and depends on underlying cause and extent of hemorrhage. Typically, patients with an established vitreous hemorrhage that hasn’t damaged the retina maintain good vision. Long-standing blood in the vitreous produces ghost cells which can block the trabecular meshwork and subsequently cause vitreous hemorrhage-induced glaucoma. The trabecular meshwork may be blocked by red blood cell debris (hemolytic glaucoma) or the endothelial cells of the trabecular meshwork may be damaged by iron released from red blood cells (hemosiderotic glaucoma). Hemosiderotic glaucoma is usually a result of recurrent vitreous hemorrhages over many years. A long-standing vitreous hemorrhage in children younger than two years of age may cause myopic shift and amblyopia. The risk of vitreous hemorrhage in high myopic individuals increases due to a higher incidence of retinal tears and detachment. Patients with vitreous hemorrhage caused by diabetic retinopathy or age-related macular degeneration typically have a worse prognosis than patients whose vitreous hemorrhage arises from posterior vitreous detachment.

Risk factors for developing vitreous hemorrhage include diabetic retinopathy, retinal vein or artery occlusion, retinal tears with or without detachment and posterior vitreous detachment. Patients with severe myopia that have retinal tears are at a much higher risk for developing vitreous hemorrhage. The leading cause of vitreous hemorrhage in children and infants is trauma, including shaken baby syndrome [5] [6] [7].

In adults, the most common cause of vitreous hemorrhage is diabetic retinopathy which accounts for 31.5-54% of cases in the United States (US), 19.1% in Sweden and 6% in London [8]. Vitreous hemorrhage may also be caused by retinal tear, rhegmatogenous retinal detachment, retinal neovascularization, sickle cell retinopathy, posterior vitreous detachment with retinal vascular tear, macroaneurysm, macular degeneration, terson syndrome and trauma. In younger people, the most common cause of vitreous hemorrhage is trauma, including shaken baby syndrome [6] [7]. Children and adults with congenital retinoschisis and pars planitis may also develop vitreous hemorrhage due to their conditions. The most common causes of vitreous hemorrhage in blacks are diabetes and sickle cell disease and in elderly whites the most common causes are retinal tears, retinal vein occlusion and diabetic retinopathy. 6.4-18% of vitreous hemorrhages are due to rare causes and from 2-7.6% of cases no specific cause may be identified. The prevalence and demographic of this disease parallels very closely the prevalence of the causative diseases listed above.

There are three main classifications of vitreous hemorrhage which include; 1) abnormal vessels (prone to bleeding), 2) stress induced vessel rupture or 3) blood from an adjacent source. In diseases such as diabetic retinopathy, sickle cell retinopathy, retinal vein occlusion or ocular ischemic syndrome ischemia occurs, leading to neovascularization which results in abnormal retinal vessels that are prone to bleeding. The mechanism for this is the release of angiogenic factors, such as vascular endothelial growth factor (VEGF), due to low oxygen which induces neovascularization of the retina with blood vessels that lack tight junctions and are therefore leaky. Also, contraction of these newly formed blood vessels provides additional stress that can rupture these fragile vessels. High levels of mechanical force can induce the rupture of normal vessels leading to hemorrhage. Conditions that cause vitreous traction on the retinal blood vessels, such as posterior vitreous detachment, may provide enough stress to rupture retinal blood vessels, which can occur with or without a retinal tear or detachment. In these cases, clinicians should be aware that the possibility of retinal break is rather high (70-95%). In younger individuals, blunt or perforating trauma may directly damage normal blood vessels causing vitreous hemorrhage. Certain pathologies affecting tissue adjacent to the vitreous can cause vitreous hemorrhage by extending through the internal limiting membrane of the vitreous. This may occur due to hemorrhage from retinal macroaneurysms, tumors or chorodial neovascularization. In Terson’s syndrome, which is a rare cause of vitreous hemorrhage, subarachnoid hemorrhage leads to a rise in intracranial pressure which causes retinal veins to rupture leading to extravasation of blood into the vitreous.
Vitreous hemorrhage can cause a number of complications including hemosiderosis bulbi with photoreceptor toxicity, glaucoma, severe floaters and myopic shift (in infants).

Risk factors for systemic vascular diseases, including diabetes and hypertension, should be controlled. Smoking is also discouraged to decrease risk of vitreous hemorrhage. Patients at high risk for retinopathy should receive regular dilated fundus exams. Eye trauma should be avoided by wearing eye protection while performing certain activities, such as metal work, firing guns and playing sports with small quickly moving balls (eg. racquetball).

The vitreous body (or vitreous) is the space between lens and the retina that is filled with a gel-like substance, composed of 99% water and 1% collagen and hyaluronic acid, known as vitreous humor. This structure takes up 80% of the eye which is approximately 4 mL in adults. When blood is found in this area, which is anterior to the zonular fibers and posterior lens capsule, lateral to the nonpigmented epithelium of the ciliary body and posterior to the lamina limitans interna of the eye, it is referred to as a vitreous hemorrhage. Since blood within the vitreous cannot be easily distinguished from blood in the subinternal limiting membrane and the preretinal area, all of these conditions are considered different types of vitreous hemorrhage [1] [2] [3] [4].

Vitreous hemorrhage is blood in the portion of the eye located between the lens and the retina (the vitreous body) which may cause sudden changes in vision. This condition may be caused by a burst blood vessel in the eye, trauma to the eye, a retinal tear or detachment, new blood vessel formation in the eye or an underlying disease. Underlying diseases that may cause vitreous hemorrhage include diabetes, hypertension, carotid artery disease and sickle cell anemia. Of these diseases, diabetes is associated with the highest risk since new blood vessel formation in the eye is stimulated by diabetes. The reason new blood vessels cause bleeding is because of their fragile nature. Older patients, over the age of 50, have higher incidence of vitreous hemorrhage although it can occur at any age. In younger patients, the most common cause of vitreous hemorrhage is trauma, including shaken baby syndrome [6] [7].
Symptoms of vitreous hemorrhage include blurry vision that occurs suddenly, light flashes, floaters (spots floating across your vision) and in severe cases blindness. Treatment for vitreous hemorrhage may be simple observation if the physician believes the condition will resolve on its own (which may take months). In severe cases patients may require surgery to remove blood from the eye through a process known as a vitrectomy. Recovery from vitrectomy usually takes around 6 weeks. Investigational research is being done into drugs that help dissolve the abnormalities within the vitreous but these drugs are pending approval from the food and drug administration (FDA).

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